Abstract：
:The pharmacokinetics of vinblastine in humans was examined using a radioimmunoassay specific for both the Vinca alkaloids and aromatic ring [3H]vinblastine. The data were consistent with a three-compartment open model system with the following values, alpha phase: t1/2=3.90+/-1.46 min; Vc=16.8+/-7.1 liters. beta phase:t1/2=53.0+/-13.0 min; Vbeta=79.0+/-52.0 liters; gamma phase:t1/2=1173.0+/-65.0 min; Vgamma=1656.0+/-717.0 liters. Most significant was the finding that vinblastine is metabolized to deacetylvinblastine and that this compound is more biologically active on a weight basis than the parent. No other biologically active metabolites appeared to be present in urine or in stool.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Owellen RJ,Hartke CA,Hains FOsubject
Has Abstractpub_date
1977-08-01 00:00:00pages
2597-602issue
8 Pt 1eissn
0008-5472issn
1538-7445journal_volume
37pub_type
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