Antisense oligonucleotides specific for transforming growth factor beta2 inhibit the growth of malignant mesothelioma both in vitro and in vivo.

abstract：:Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a dual-function phosphatase with tumor suppressor function compromised in a wide spectrum of cancers. Because tissue polarity and architecture are crucial modulators of normal and malignant behavior, we postulated that PTEN may play a role in maintena...

journal_title：Cancer research

authors： Fournier MV,Fata JE,Martin KJ,Yaswen P,Bissell MJ

更新日期：2009-05-15 00:00:00

abstract：:When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and ulceration of the nearby stomach and intestines before achieving tum...

journal_title：Cancer research

authors： Fujimoto TN,Colbert LE,Huang Y,Molkentine JM,Deorukhkar A,Baseler L,de la Cruz Bonilla M,Yu M,Lin D,Gupta S,Cabeceiras PK,Kingsley CV,Tailor RC,Sawakuchi GO,Koay EJ,Piwnica-Worms H,Maitra A,Taniguchi CM

更新日期：2019-05-01 00:00:00

abstract：:Cancer metastasis is a leading cause of cancer morbidity and mortality. More needs to be learned about mechanisms that control this process. In particular, the role of chemokine receptors in metastasis remains controversial. Here, using a highly metastatic breast cancer (4T1) model, we show that lung metastasis is a f...

journal_title：Cancer research

authors： Olkhanud PB,Baatar D,Bodogai M,Hakim F,Gress R,Anderson RL,Deng J,Xu M,Briest S,Biragyn A

更新日期：2009-07-15 00:00:00

abstract：:This report describes a case of lymphoid blast crisis of a chronic myelocytic leukemia with the occurrence of a double chromosomal population carrying a Philadelphia chromosome. Fifty-five % of the cells have 28 chromosomes, and 36% show the exact duplicate of the near haploid chromosome complement. The similarities b...

journal_title：Cancer research

authors： Kessous A,Colombies P,Pris J,Clement D

更新日期：1980-04-01 00:00:00

abstract：:A human immunoglobulin that binds prostatic acid phosphatases (PAP) was isolated from the serum of normal individuals by affinity chromatography using a PAP-Sepharose solid adsorbent. The yield of isolated protein, termed PAP-binding globulin (PAPBG), ranged from 4.7 to 16.3 microgram/ml serum. As shown by immunoelect...

journal_title：Cancer research

authors： Papsidero LD,Wojcieszyn JW,Horoszewicz JS,Leong SS,Murphy GP,Chu TM

更新日期：1980-08-01 00:00:00

abstract：:The purpose of these studies was to select in vitro tumor cells that were resistant to macrophage-mediated lysis. Seven different heterogeneous murine neoplasms (four fibrosarcomas, a melanoma, a rhabdomyosarcoma, and an osteogenic sarcoma) and one cloned line of a fibrosarcoma were incubated in vitro with syngeneic t...

journal_title：Cancer research

authors： Fogler WE,Fidler IJ

更新日期：1985-01-01 00:00:00

abstract：:Patients with disseminated Ewing's family of tumors (ESFT) often experience drug-resistant relapse. We hypothesize that targeting minimal residual disease with the cytotoxic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR; fenretinide) may decrease relapse. We determined the following: (a) 4-HPR cytotoxicity against 12...

journal_title：Cancer research

authors： Batra S,Reynolds CP,Maurer BJ

更新日期：2004-08-01 00:00:00

abstract：:Photodynamic therapy (PDT), an experimental cancer treatment employing a photosensitizer and visible light, is a highly efficient inducer of apoptosis (or programmed cell death) in mouse L5178Y lymphoma cells, resulting in extensive DNA fragmentation within 1-2 h. The major targets for PDT are in cellular membranes, a...

journal_title：Cancer research

authors： Agarwal ML,Larkin HE,Zaidi SI,Mukhtar H,Oleinick NL

更新日期：1993-12-15 00:00:00

abstract：:Stromal-epithelial interactions and the bioactive molecules produced by these interactions maintain tissue homeostasis and influence carcinogenesis. Bioactive prostaglandins produced by prostaglandin synthases and secreted by the prostate into seminal plasma are thought to support reproduction, but their endogenous ef...

journal_title：Cancer research

authors： Kim J,Yang P,Suraokar M,Sabichi AL,Llansa ND,Mendoza G,Subbarayan V,Logothetis CJ,Newman RA,Lippman SM,Menter DG

更新日期：2005-07-15 00:00:00

abstract：:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was elut...

journal_title：Cancer research

authors： Dowell BL,Segars JH,Metzgar RS

更新日期：1981-01-01 00:00:00

abstract：:Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the key inflammasome adaptor apoptosis-related speck-like protein contai...

journal_title：Cancer research

authors： Deswaerte V,Nguyen P,West A,Browning AF,Yu L,Ruwanpura SM,Balic J,Livis T,Girard C,Preaudet A,Oshima H,Fung KY,Tye H,Najdovska M,Ernst M,Oshima M,Gabay C,Putoczki T,Jenkins BJ

更新日期：2018-03-01 00:00:00

abstract：:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a fac...

journal_title：Cancer research

authors： Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

更新日期：1986-03-01 00:00:00

abstract：:Adenocarcinoma of the rete testis is an exceptionally rare and malignant testicular neoplasm. Although treatment of pregnant women with diethylstilbestrol (DES) results in reproductive tract abnormalities in their male offspring, increased incidence of testicular tumors has not been verified. However, recently three c...

journal_title：Cancer research

authors： Newbold RR,Bullock BC,McLachlan JA

更新日期：1985-10-01 00:00:00

abstract：:The purpose of this study was to determine the effect of route of hepatic administration of drug on the regional pharmacokinetics and systemic exposure of 5-fluorouracil (FUra) and 5-bromo-2-deoxyuridine (BrdUrd). A total of 13 mixed-breed male and female dogs were used in these acute studies. Each dog was administere...

journal_title：Cancer research

authors： Kuan HY,Smith DE,Ensmiger WD,Knol JA,DeRemer SJ,Yang Z,Stetson PL

更新日期：1996-10-15 00:00:00

abstract：:In cell lines of human small cell carcinoma of the lung (SCCL) and in all subclones of one of the cell lines, cells were observed which completely interiorized other cells, leading to death of the interiorized cells and sometimes to complete autodestruction of the cultures. This phenomenon, which we have called "canni...

journal_title：Cancer research

authors： Brouwer M,de Ley L,Feltkamp CA,Elema J,Jongsma AP

更新日期：1984-07-01 00:00:00

abstract：:The formation of a microvascular endothelium plays a critical role in the growth and metastasis of established tumors. The ability of a fragment from the first type III repeat of fibronectin (III(1C)), anastellin, to suppress tumor growth and metastasis in vivo has been reported to be related to its antiangiogenic pro...

journal_title：Cancer research

authors： Ambesi A,Klein RM,Pumiglia KM,McKeown-Longo PJ

更新日期：2005-01-01 00:00:00

abstract：:Sézary syndrome is the leukemic form of cutaneous T-cell lymphoma characterized by circulating neoplastic CD4+ T-cells. Although peripheral blood mononuclear cells from patients with Sézary syndrome have been shown to respond poorly to mitogens, we found that mitogen-activated peripheral blood mononuclear cells from f...

journal_title：Cancer research

authors： Abrams JT,Ghosh SK,DeFreitas E

更新日期：1993-11-15 00:00:00

abstract：:2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A) is a new deoxyadenosine analogue that is resistant to phosphorolytic cleavage and deamination. Studies with a variety of cell lines demonstrated that Cl-F-ara-A is a potent cytotoxic agent; in cell-free systems, its triphosphate (Cl-F-ara-ATP) i...

journal_title：Cancer research

authors： Xie C,Plunkett W

更新日期：1995-07-01 00:00:00

abstract：:Infection with Helicobacter pylori is a major cause of gastric cancer (GC). The association likely has been underestimated in the past due to disease-related clearance of the infection. On the other hand, only a minority of the infected individuals develop GC, and better risk stratification is therefore highly desirab...

journal_title：Cancer research

authors： Gao L,Michel A,Weck MN,Arndt V,Pawlita M,Brenner H

更新日期：2009-08-01 00:00:00

abstract：:Human epithelial cell lines derived from both carcinomatous and nomalignant tissues were characterized with respect to the presence and distribution of fibronectin by immunofluorescence microscopy. In cell lines derived from nonmalignant tissues or from primary carcinomas, fibronectin was found predominantly in an ext...

journal_title：Cancer research

authors： Smith HS,Riggs JL,Mosesson MW

更新日期：1979-10-01 00:00:00

abstract：:To examine the oxygen-dependence of glucose consumption in solid tumors, we monitored gradients of glucose, lactate, and hypoxia in R3230Ac and FSA tumors growing in Fischer 344 rats. Bioluminescence imaging, detection of Hoechst 33342, and immunostaining of the hypoxia marker EF5 [2-8-N-(2,2,3,3,3-pentafluoropropyl)a...

journal_title：Cancer research

authors： Schroeder T,Yuan H,Viglianti BL,Peltz C,Asopa S,Vujaskovic Z,Dewhirst MW

更新日期：2005-06-15 00:00:00

abstract：:The ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3; Edelfosine) has been shown to be a rapid inducer of apoptosis in human leukemic cells and has been considered as a promising drug in cancer treatment. Here we have found that ET-18-OCH3 induced apoptosis not only in human tumor cell lin...

journal_title：Cancer research

authors： Mollinedo F,Fernández-Luna JL,Gajate C,Martín-Martín B,Benito A,Martínez-Dalmau R,Modolell M

更新日期：1997-04-01 00:00:00

abstract：:In continuation of earlier studies on murine neoplastic liver lesions, we characterized by histochemical methods the phenotype of hepatocellular adenomas and carcinomas induced by single injections of diethylnitrosamine (1.25, 2.5, or 5.0 micrograms/g of body weight) in 15-day-old C57BL/6 x male C3H F1 mice. The hepat...

journal_title：Cancer research

authors： Hacker HJ,Mtiro H,Bannasch P,Vesselinovitch SD

更新日期：1991-04-01 00:00:00

abstract：:Malignant astrocytoma is one of the most deadly primary central nervous system tumors. Although significant progress has been made in understanding the molecular pathways that lead to the development of these tumors in adults, comparatively little analysis has been done in childhood astrocytomas, which are less common...

journal_title：Cancer research

authors： Pollack IF,Finkelstein SD,Burnham J,Holmes EJ,Hamilton RL,Yates AJ,Finlay JL,Sposto R,Children's Cancer Group.

更新日期：2001-10-15 00:00:00

abstract：:The role of acidic glycosphingolipids in cell growth and differentiation was investigated using the multipotent leukemia cell line K562. When GM3 was added to cell culture media, the growth of K562 cells was remarkably inhibited and the cells were shown to have megakaryocytoid morphology. Ultrastructural study demonst...

journal_title：Cancer research

authors： Nakamura M,Kirito K,Yamanoi J,Wainai T,Nojiri H,Saito M

更新日期：1991-04-01 00:00:00

abstract：:Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

journal_title：Cancer research

authors： Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

更新日期：2019-01-01 00:00:00

abstract：:The shedding of membrane vesicles from the cell surface is a vital process considered to be involved in cell-cell and cell-matrix interactions and in tumor progression. By immunoelectron microscopic analysis of surface replicas of 8701-BC human breast carcinoma cells, we observed that membrane vesicles shed from plasm...

journal_title：Cancer research

authors： Dolo V,Ginestra A,Cassarà D,Violini S,Lucania G,Torrisi MR,Nagase H,Canevari S,Pavan A,Vittorelli ML

更新日期：1998-10-01 00:00:00

abstract：:Cultured explants of mouse mammary gland were investigated for their capacity to secrete a cathepsin B-like cysteine proteinase. This enzyme had been shown previously to be secreted excessively from cultured explants of human breast tumors and spontaneous mouse mammary carcinomas. We now show that secretion is also ob...

journal_title：Cancer research

authors： Recklies AD,White C,Mitchell J,Poole AR

更新日期：1985-05-01 00:00:00

abstract：:Phenacetin was mutagenic in Salmonella typhimurium TA100 in plate assays when liver fractions from Aroclor-treated hamsters, but not rats, were used. Its known or putative metabolites were synthesized; of these, N-hydroxyphenacetin and N-acetoxyphenacetin were found to be mutagenic in liquid and plate assays, both req...

journal_title：Cancer research

authors： Camus AM,Friesen M,Croisy A,Bartsch H

更新日期：1982-08-01 00:00:00

abstract：:This study investigated the effect of recombinant human tumor necrosis factor (rhTNF) on hydroxyl radical production by established cell lines in vitro, and its implication in the killing of tumor cells by rhTNF. During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells (2 X 10(7) cells) in the presenc...

journal_title：Cancer research

authors： Yamauchi N,Kuriyama H,Watanabe N,Neda H,Maeda M,Niitsu Y

更新日期：1989-04-01 00:00:00