Near haploid cell line in lymphoid blast crisis of Ph1-positive chronic myeloid leukemia.

abstract：:Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of genetic material. We used a mix of ...

journal_title：Cancer research

authors： Zheng X,Lundberg M,Karlsson A,Johansson M

更新日期：2003-10-15 00:00:00

abstract：:Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissu...

journal_title：Cancer research

authors： Soto-Pantoja DR,Terabe M,Ghosh A,Ridnour LA,DeGraff WG,Wink DA,Berzofsky JA,Roberts DD

更新日期：2014-12-01 00:00:00

abstract：:The diagnostic value of elevated human chorionic gonadotropin (hCG) and its free alpha (hCG alpha) and beta (hCG beta) subunit serum levels as specific tumor markers for nongonadal malignancies is controversial. In the present report, different monoclonal based immunoradiometric assays specific for hCG and its free hC...

journal_title：Cancer research

authors： Marcillac I,Troalen F,Bidart JM,Ghillani P,Ribrag V,Escudier B,Malassagne B,Droz JP,Lhommé C,Rougier P

更新日期：1992-07-15 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00

abstract：:It has been postulated that the expression of the ribonucleoprotein telomerase is necessary to overcome cellular senescence and that malignant tumors must express telomerase to maintain their immortality. In most human adult tissues, telomerase activity is not detected. In contrast, several murine tissues express vari...

journal_title：Cancer research

authors： Bednarek A,Budunova I,Slaga TJ,Aldaz CM

更新日期：1995-10-15 00:00:00

abstract：:Recent characterization of abnormal phosphatidylcholine metabolism in tumor cells by nuclear magnetic resonance (NMR) has identified novel fingerprints of tumor progression that are potentially useful as clinical diagnostic indicators. In the present study, we analyzed the concentrations of phosphatidylcholine metabol...

journal_title：Cancer research

authors： Iorio E,Mezzanzanica D,Alberti P,Spadaro F,Ramoni C,D'Ascenzo S,Millimaggi D,Pavan A,Dolo V,Canevari S,Podo F

更新日期：2005-10-15 00:00:00

abstract：:The metabolism of the rat esophageal carcinogen N-nitrosomethylbenzylamine (NMBzA) was studied using microsomes prepared from liver and esophageal mucosa of untreated male Sprague-Dawley rats. NMBzA was extensively metabolized to benzaldehyde, benzyl alcohol, and formaldehyde by hepatic microsomes. The rate of metabol...

journal_title：Cancer research

authors： Labuc GE,Archer MC

更新日期：1982-08-01 00:00:00

abstract：:The ability of osteosarcoma cells to form lung metastases has been inversely correlated to cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to circumvent FasL-mediated apoptosis upon entrance into the FasL(+) lung microenvironment. However, the mechanism of Fas regulation remains unclear. H...

journal_title：Cancer research

authors： Huang G,Nishimoto K,Zhou Z,Hughes D,Kleinerman ES

更新日期：2012-02-15 00:00:00

abstract：:BALB/cJ X C57BL/10Sn F1 (hereafter called B10F1) hybrids resist challenge with the BALB/c plasmacytoma, MPC-11, by a radiation-sensitive, silica-insensitive mechanism, whereas BALB/cJ X BALB.B F1 (hereafter called BALB.BF1) hybrids are as susceptible to MPC-11 as are homozygous BALB/c mice themselves. To investigate t...

journal_title：Cancer research

authors： Marsili MA,Walker MC,Phillips-Quagliata JM

更新日期：1986-01-01 00:00:00

abstract：:Pheochromocytomas are tumors originating from chromaffin cells, the large majority of which are sporadic neoplasms. The genetic and molecular events determining their tumorigenesis continue to remain unknown. On the other hand, RET germ-line mutations cause the inheritance of familial tumors in multiple endocrine neop...

journal_title：Cancer research

authors： Le Hir H,Colucci-D'Amato LG,Charlet-Berguerand N,Plouin PF,Bertagna X,de Franciscis V,Thermes C

更新日期：2000-03-01 00:00:00

abstract：:Biallelic somatic mutations of TCF1 coding for hepatocyte nuclear factor 1alpha (HNF1alpha) are found in 50% of the hepatocellular adenoma (HCA) cases usually associated with oral contraception. In rare cases, HNF1alpha germ line mutations could also predispose to familial adenomatosis. In order to identify new geneti...

journal_title：Cancer research

authors： Jeannot E,Poussin K,Chiche L,Bacq Y,Sturm N,Scoazec JY,Buffet C,Van Nhieu JT,Bellanné-Chantelot C,de Toma C,Laurent-Puig P,Bioulac-Sage P,Zucman-Rossi J

更新日期：2007-03-15 00:00:00

abstract：:Tumor-specific immune tolerance limits the effectiveness of cancer vaccines. In addition, tumor vaccines alone have a limited potential for the treatment of measurable tumor burdens. This highlights the importance of identifying more potent cancer vaccine strategies for clinical testing. We tested immune-modulating do...

journal_title：Cancer research

authors： Machiels JP,Reilly RT,Emens LA,Ercolini AM,Lei RY,Weintraub D,Okoye FI,Jaffee EM

更新日期：2001-05-01 00:00:00

abstract：:Vaccines represent an attractive treatment modality for the management of cancer primarily because of their specificity and generation of immunologic memory important for controlling recurrences. However, the efficacy of therapeutic vaccines may require formulations that not only generate effective immune responses bu...

journal_title：Cancer research

authors： Sharma RK,Elpek KG,Yolcu ES,Schabowsky RH,Zhao H,Bandura-Morgan L,Shirwan H

更新日期：2009-05-15 00:00:00

abstract：:Pancreatic ductal carcinoma is characterized by a profound chemoresistance. As we have shown previously, these tumor cells can develop chemoresistance by interleukin (IL)-1beta in an autocrine and nuclear factor-kappaB-dependent fashion. Because pancreatic ductal carcinoma contains many mesenchymal stromal cells, we f...

journal_title：Cancer research

authors： Müerköster S,Wegehenkel K,Arlt A,Witt M,Sipos B,Kruse ML,Sebens T,Klöppel G,Kalthoff H,Fölsch UR,Schäfer H

更新日期：2004-02-15 00:00:00

abstract：:The renal handling of cis-diamminedichloroplatinum (CP) was investigated by measuring the renal clearance of creatinine, inulin, and free platinum in ten cancer patients. Free platinum clearances exceeded the glomerular filtration rate in all time periods. For example, at 1 to 2 hr, the mean clearance of free platinum...

journal_title：Cancer research

authors： Jacobs C,Coleman CN,Rich L,Hirst K,Weiner MW

更新日期：1984-08-01 00:00:00

abstract：:The possible alteration of transformation-related antigens in cells that revert to a normal phenotype but that continue to retain the viral genome, has been investigated in [3H]glucosamine-labeled extracts of rat cells exhibiting a reversible temperature-dependent restriction in the expression of transformation and in...

journal_title：Cancer research

authors： Rieber M,Bacalao J,Rieber M

更新日期：1977-04-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:Mouse leukemia (P388) cells were incubated in cell culture medium containing nitrogen mustard [2-chloro-N-(2-chloroethyl)-N-methylethanamine] for 4 h. The nucleophosmin immunoband with a molecular weight of 37,000 (p37; other molecular weights are similarly designated) was observed in both control and nitrogen mustard...

journal_title：Cancer research

authors： Chan PK

更新日期：1989-06-15 00:00:00

abstract：:Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic ...

journal_title：Cancer research

authors： Turner DP

更新日期：2015-05-15 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00

abstract：:Hollow organs lined by columnar epithelial cells normally secrete mucins and their proteolytic fragments vectorially into the lumen. These heterogeneously O-glycosylated molecules are known to aberrantly enter the bloodstream in the setting of epithelial carcinomas and possibly during injury or inflammation. We have r...

journal_title：Cancer research

authors： Wahrenbrock MG,Varki A

更新日期：2006-02-15 00:00:00

abstract：:Aspects of the metabolism of phorbol myristate acetate (PMA) in mouse skin were investigated. Phorbolol myristate acetate (PHMA), a potential metabolite of PMA in mouse skin, was prepared from PMA by NaBH4 reduction of the C-5 carbonyl group of PMA to a secondary alcohol. The structure of PHMA was assigned on the basi...

journal_title：Cancer research

authors： Segal A,Van Duuren BL,Maté U

更新日期：1975-08-01 00:00:00

abstract：:Urine from 22 patients with a variety of disseminated cancers and from an equivalent number of nonmalignant controls of similar age and sex was tested for the presence of transforming growth factor (TGF) activity as measured by the ability to promote the growth in soft agar of nontransformed indicator cells. Cancer pa...

journal_title：Cancer research

authors： Sherwin SA,Twardzik DR,Bohn WH,Cockley KD,Todaro GJ

更新日期：1983-01-01 00:00:00

abstract：:The uptake of m-[125I]iodobenzylguanidine (mIBG), a compound structurally analogous to the antihypertensive drug guanethidine, was examined in various human cell lines. Of three neuroblastoma lines, SK-N-LO, IMR-32, and SK-N-SH, only the last showed specific uptake of the compound. In contrast, only a nonspecific upta...

journal_title：Cancer research

authors： Buck J,Bruchelt G,Girgert R,Treuner J,Niethammer D

更新日期：1985-12-01 00:00:00

abstract：:Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. Wi...

journal_title：Cancer research

authors： Ying TS,Sarma DS,Farber E

更新日期：1981-06-01 00:00:00

abstract：:Mortality surveys and death certificate studies have suggested an association between leukemia and farming. To investigate whether exposure to carcinogens in an agricultural setting is related to risk of leukemia, the authors conducted a population-based case-control interview study of 578 white men with leukemia and ...

journal_title：Cancer research

authors： Brown LM,Blair A,Gibson R,Everett GD,Cantor KP,Schuman LM,Burmeister LF,Van Lier SF,Dick F

更新日期：1990-10-15 00:00:00

abstract：:Cancer stem-like cells (CSC) may be critical to maintain the malignant behavior of solid and hematopoietic cancers. Recently, patients with endometrial cancer whose tumors expressed high levels of aldehyde dehydrogenase (ALDH), a detoxifying enzyme characteristic of many progenitor and stem cells, exhibited a relative...

journal_title：Cancer research

authors： van der Zee M,Sacchetti A,Cansoy M,Joosten R,Teeuwssen M,Heijmans-Antonissen C,Ewing-Graham PC,Burger CW,Blok LJ,Fodde R

更新日期：2015-09-01 00:00:00

abstract：:The human checkpoint kinase 2 (Chk2) plays a central role in regulation of the cellular response to DNA damage, resulting in cell cycle arrest, DNA repair, or apoptosis depending on severity of DNA damage and the cellular context. Chk2 inhibitors are being developed as sensitizers for chemotherapeutic agents. In contr...

journal_title：Cancer research

authors： Chen CR,Wang W,Rogoff HA,Li X,Mang W,Li CJ

更新日期：2005-07-15 00:00:00

abstract：:We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of the 53 monoassocia...

journal_title：Cancer research

authors： Sumi Y,Nagura H,Miyakawa M

更新日期：1990-01-15 00:00:00

abstract：:Fibroblast growth factor (FGF) 8, also known as androgen-induced growth factor, was originally isolated from an androgen-dependent mouse mammary Shionogi carcinoma SC-3 cell line, in which it was shown to have androgen-regulated properties. We previously demonstrated that Fgf 8 transcripts were detected in several hum...

journal_title：Cancer research

authors： Tanaka A,Furuya A,Yamasaki M,Hanai N,Kuriki K,Kamiakito T,Kobayashi Y,Yoshida H,Koike M,Fukayama M

更新日期：1998-05-15 00:00:00