Alterations of choline phospholipid metabolism in ovarian tumor progression.

abstract：:Calcium is universally required for cell growth and proliferation. Calmodulin is the main intracellular receptor for calcium. Although calcium and calmodulin are well known to be required for cell cycle regulation, the target pathways for their action remain poorly defined. Potential targets include the calcium/calmod...

journal_title：Cancer research

authors： Rodriguez-Mora OG,LaHair MM,McCubrey JA,Franklin RA

更新日期：2005-06-15 00:00:00

abstract：:The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited ...

journal_title：Cancer research

authors： Tantin D,Schild-Poulter C,Wang V,Haché RJ,Sharp PA

更新日期：2005-12-01 00:00:00

abstract：:The cytotoxicity of a diphtheria toxin-human epidermal growth factor fusion protein (DAB(389)EGF) was tested against 14 human glioma cell lines. After cells were cultured for 48 h with various concentrations of DAB(389)EGF, the percentage reduction in thymidine incorporation was determined. For 13 of 14 cell lines, po...

journal_title：Cancer research

authors： Liu TF,Cohen KA,Ramage JG,Willingham MC,Thorburn AM,Frankel AE

更新日期：2003-04-15 00:00:00

abstract：:Two molecular species of the pleotropic cytokine interleukin 1 (IL-1) are produced as products of two distinct genes transcribed by cells of the monocyte-macrophage lineage. We have shown previously that a significant proportion of human melanoma cell lines express IL-1 biological activity, but it has not been demonst...

journal_title：Cancer research

authors： Shabon U,Bennicelli JL,Guerry DP 4th,Koprowski H,Ricciardi RP

更新日期：1991-06-15 00:00:00

abstract：:The present studies were performed to delineate the effect of high-dose methotrexate with citrovorum factor rescue on the measurable compartments of human granulopoiesis, including peripheral blood cells and bone marrow stem cells committed to granulopoiesis-monocytopoiesis. Parameters of granulopoiesis were determine...

journal_title：Cancer research

authors： Schremi W,Lohrmann HP

更新日期：1979-10-01 00:00:00

abstract：:DNA mismatch binding in vitro, resistance to DNA methylation damage, and spontaneous mutation rates were examined in human colorectal adenocarcinoma cell lines. Of 11 cell lines, 3 (DLD1, HCT15, and LoVo) were defective in mismatch binding. All three lines had a mutator phenotype. These properties indicate that DLD1 a...

journal_title：Cancer research

authors： Branch P,Hampson R,Karran P

更新日期：1995-06-01 00:00:00

abstract：:Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We repo...

journal_title：Cancer research

authors： Ponti D,Costa A,Zaffaroni N,Pratesi G,Petrangolini G,Coradini D,Pilotti S,Pierotti MA,Daidone MG

更新日期：2005-07-01 00:00:00

abstract：:Immunohistochemical localization of CA 125 using murine monoclonal antibody OC 125 was performed on fresh frozen tissue from 44 endometrial adenocarcinomas and 26 benign endometria. Immunohistochemical evaluation incorporated both intensity and distribution of staining (CA 125 HSCORE). Thirty-seven cancers (84%) and 2...

journal_title：Cancer research

authors： Berchuck A,Soisson AP,Clarke-Pearson DL,Soper JT,Boyer CM,Kinney RB,McCarty KS Jr,Bast RC Jr

更新日期：1989-04-15 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00

abstract：:Extravasation of tumor cells is a pivotal step in metastasis formation. This step is initiated by an interaction of extravasating tumor cells with endothelial cells. Among the molecules mediating tumor-endothelium interactions are selectins and their fucosylated ligands. In a previous study, we demonstrated that the f...

journal_title：Cancer research

authors： Zipin A,Israeli-Amit M,Meshel T,Sagi-Assif O,Yron I,Lifshitz V,Bacharach E,Smorodinsky NI,Many A,Czernilofsky PA,Morton DL,Witz IP

更新日期：2004-09-15 00:00:00

abstract：:[3H]Pregn-4-ene-3,20-dione ([3H]progesterone)-receptor complexes from human mammary carcinoma were found to be stabilized in the presence of glycerol. The dissociation rate constant was lowered and the equilibrium dissociation constant was decreased (KD=3 nM in the absence of glycerol and 1.1 nM in the presence of 30%...

journal_title：Cancer research

authors： Pichon MF,Milgrom E

更新日期：1977-02-01 00:00:00

abstract：:A monoclonal antibody (5E8) has been used to identify and structurally characterize a previously unreported macromolecule present on the surface of human lung tumors. This antibody was derived from a hybrid clone that was produced using spleen cells of mice immunized with a surgically excised squamous cell carcinoma. ...

journal_title：Cancer research

authors： Zylstra S,Chen FA,Ghosh SK,Repasky EA,Rao U,Takita H,Bankert RB

更新日期：1986-12-01 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in enhancing cellular sensitivity to cis-diamminedichloroplatinum(II) (CP). We have synthesized a series of novel analogues of lyngbyatoxin A (7-linalylindolactam V), a natural tumor promoter and a potent activator of PKC, and investigated the effects of these synthetic compo...

journal_title：Cancer research

authors： Basu A,Kozikowski AP,Sato K,Lazo JS

更新日期：1991-05-15 00:00:00

abstract：:The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung ca...

journal_title：Cancer research

authors： Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA

更新日期：2018-01-01 00:00:00

abstract：:The selective ubiquitination of proteins by ubiquitin E3 ligases plays an important regulatory role in control of cell differentiation, growth, and transformation and their dysregulation is often associated with pathologic outcomes, including tumorigenesis. RNF5 is an E3 ubiquitin ligase that has been implicated in mo...

journal_title：Cancer research

authors： Bromberg KD,Kluger HM,Delaunay A,Abbas S,DiVito KA,Krajewski S,Ronai Z

更新日期：2007-09-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) functions as a tumor suppressor of the prostate through mechanisms that remain unresolved. Although TGF-beta receptors directly activate both Smads 2 and 3, to date, Smad3 has been shown to be the essential mediator of most Smad-dependent TGF-beta responses, including control...

journal_title：Cancer research

authors： Yang J,Wahdan-Alaswad R,Danielpour D

更新日期：2009-03-15 00:00:00

abstract：:Transgenic mice have been previously established that express v-rasHa or v-fos exclusively in the epidermis by means of a targeting vector based on the human keratin 1 gene (HK1). Epidermal expression of v-rasHa (HK1.ras) or v-fos (HK1.fos) resulted in hyperplasia, hyperkeratosis, and later, in benign tumors. To asses...

journal_title：Cancer research

authors： Greenhalgh DA,Quintanilla MI,Orengo CC,Barber JL,Eckhardt JN,Rothnagel JA,Roop DR

更新日期：1993-11-01 00:00:00

abstract：:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusio...

journal_title：Cancer research

authors： Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

更新日期：2016-11-15 00:00:00

abstract：:Hereditary renal carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that ionizing radiation induces additional tumors in a linear dose-response relationship, suggesting that in heter...

journal_title：Cancer research

authors： Kubo Y,Mitani H,Hino O

更新日期：1994-05-15 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the int...

journal_title：Cancer research

authors： Pasello M,Michelacci F,Scionti I,Hattinger CM,Zuntini M,Caccuri AM,Scotlandi K,Picci P,Serra M

更新日期：2008-08-15 00:00:00

abstract：:Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. GPx2 silencing...

journal_title：Cancer research

authors： Emmink BL,Laoukili J,Kipp AP,Koster J,Govaert KM,Fatrai S,Verheem A,Steller EJ,Brigelius-Flohé R,Jimenez CR,Borel Rinkes IH,Kranenburg O

更新日期：2014-11-15 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible transcription factors (Hifs) 1 and 2. Disruption of this pathway has been proposed as a cancer therapy. Here, we use short interfering RNAs to compare specific i...

journal_title：Cancer research

authors： Sowter HM,Raval RR,Moore JW,Ratcliffe PJ,Harris AL

更新日期：2003-10-01 00:00:00

abstract：:Steroid sulfatase (STS) hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate. In the present study, we have measured STS mRNA levels in 97 breast cancers by reverse transcription-PCR using a fluorescent primer in the presence of an internal standard RNA ...

journal_title：Cancer research

authors： Utsumi T,Yoshimura N,Takeuchi S,Ando J,Maruta M,Maeda K,Harada N

更新日期：1999-01-15 00:00:00

abstract：:Pyrazine diazohydroxide (PZDH) is a novel antineoplastic agent that appears to form DNA adducts via the reactive pyrazine diazonium ion and produces substantial antitumor activity in preclinical models. We conducted a phase I trial to determine the maximally tolerated dose of PZDH that could be administered as a 5-min...

journal_title：Cancer research

authors： Vogelzang NJ,Mick R,Janisch L,Berezin F,Schilsky RL,Ratain MJ

更新日期：1994-01-01 00:00:00

abstract：:The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bear...

journal_title：Cancer research

authors： Barbazán J,Alonso-Alconada L,Elkhatib N,Geraldo S,Gurchenkov V,Glentis A,van Niel G,Palmulli R,Fernández B,Viaño P,Garcia-Caballero T,López-López R,Abal M,Vignjevic DM

更新日期：2017-07-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to improve early diagnostic and therapeutic strategies. Mutations and inactivation of activin-like kinase (ALK4) have been demonstrated to favor PDAC onset. Surpr...

journal_title：Cancer research

authors： Zhao Y,Wu Z,Chanal M,Guillaumond F,Goehrig D,Bachy S,Principe M,Ziverec A,Flaman JM,Collin G,Tomasini R,Pasternack A,Ritvos O,Vasseur S,Bernard D,Hennino A,Bertolino P

更新日期：2020-08-15 00:00:00

abstract：:Rats implanted with RG-2 gliomas were administered i.v. RMP-7 and [14C]carboplatin. Changes in the permeability of the blood-brain barrier to carboplatin were determined using quantitative autoradiography. i.v. infusions of RMP-7 induced an increase in the permeability of the vascular barrier within the tumor to carbo...

journal_title：Cancer research

authors： Elliott PJ,Hayward NJ,Dean RL,Blunt DG,Bartus RT

更新日期：1996-09-01 00:00:00

abstract：:A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a lambda gt10 rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this cl...

journal_title：Cancer research

authors： Roth JS,Hsieh LL,Peraino C,Weinstein IB

更新日期：1990-03-15 00:00:00

abstract：:The monoblast-like human histiocytic lymphoma cell line, U-937, is induced to differentiate into monocyte-like cells by incubation with 0.1 to 1.0 microM retinoic acid (RA). These induced cells are phagocytic, reduce nitroblue tetrazolium, and show an increased hexose monophosphate shunt activity, consistent with mono...

journal_title：Cancer research

authors： Olsson IL,Breitman TR

更新日期：1982-10-01 00:00:00