Characterization and assay of progesterone receptor in human mammary carcinoma.

abstract：:Determination of estrogen receptor content in 82 breast cancer specimens with immunocytochemical estrogen receptor assay (ER-EIA) (Abbott) was compared with our routinely used binding assay using 125I-estradiol as radioligand with Scatchard plot analysis of the binding data. Although the estrogen receptor content meas...

journal_title：Cancer research

authors： Heubner A,Beck T,Grill HJ,Pollow K

更新日期：1986-08-01 00:00:00

abstract：:In mice, 4-nitrobenzylidene malononitrile (AG1714), which belongs to the tyrphostin family, reduced toxicity induced by doxorubicin and cisplatin without impairing their antitumor efficacy. AG1714 reduced mortality induced by doxorubicin and cisplatin. It prevented, in a dose-dependent manner, cisplatin-induced nephro...

journal_title：Cancer research

authors： Novogrodsky A,Weisspapir M,Patya M,Meshorer A,Vanichkin A

更新日期：1998-06-01 00:00:00

abstract：:The tumorigenicities of 7-methylbenz[c]acridine (7MB[c]ACR) and its five metabolically possible trans-dihydrodiols were determined in two mouse tumor models. In initiation-promotion studies on mouse skin, a single topical application of 0.15 to 0.75 mumol of compound was followed 9 days later by twice weekly applicati...

journal_title：Cancer research

authors： Chang RL,Levin W,Wood AW,Shirai N,Ryan AJ,Duke CC,Jerina DM,Holder GM,Conney AH

更新日期：1986-09-01 00:00:00

abstract：:We have recently reported that cultured human monocytes are susceptible to lysis by autologous lymphokine-activated killer (LAK) cells. In an attempt to modulate the sensitivity of monocytes to LAK-mediated lysis, monocytes were cultured in the presence of recombinant human granulocyte-macrophage colony-stimulating fa...

journal_title：Cancer research

authors： Blanchard DK,Serbousek D,Djeu JY

更新日期：1989-09-15 00:00:00

abstract：:We have previously shown that treatment of C57BL/6 mice with specific anti-B16 melanoma monoclonal antibody (Mab) significantly reduced the number of established liver metastases. In this paper we show that when treatment with Mab was applied to mice bearing both liver and lung micrometastases, the number of liver met...

journal_title：Cancer research

authors： Eisenthal A,Cameron RB,Uppenkamp I,Rosenberg SA

更新日期：1988-12-15 00:00:00

abstract：:Nitromidazole and nitrofuran derivatives comprise a large family of compounds, some of which have been shown to be hypoxic cell specific radiosensitizers in vivo and in vitro. The effects of metronidazole (2-methyl-5-nitroimidazole-1-ethanol) and nitrofurazone (5-nitro-2-furaldehyde semicarbazone) were studied on cell...

journal_title：Cancer research

authors： Mohindra JK,Rauth AM

更新日期：1976-03-01 00:00:00

abstract：:Treatment of exponentially growing 9L monolayer cells with graded concentrations of methotrexate or 5-fluorouracil (5-FUra) resulted in approximately 95% cell kill, corresponding to the percentage of cells in this system labeled by autoradiography (98%). Additional cell kill could be obtained if 5-FUra was administere...

journal_title：Cancer research

authors： Weizsaecker M,Hoshino T,Deen DF,Kobayashi S

更新日期：1981-10-01 00:00:00

abstract：:In vitro maturation was induced with 12-O-tetradecanoylphorbol-13-acetate in leukemic cell samples from patients with chronic lymphocytic leukemia (n = 10) and prolymphocytic leukemia (n = 4). The cells were studied for morphology, for immunological markers using the fluorescence activated cell sorter, and for acid ph...

journal_title：Cancer research

authors： Ziegler-Heitbrock HW,Munker R,Dörken B,Gaedicke G,Thiel E

更新日期：1986-04-01 00:00:00

abstract：:Latent prostate tumors are commonly found with similar frequency in many countries and ethnic groups. In contrast, aggressive prostate cancer (PC) is significantly less prevalent among Asian men, where the intake of soy products is very high. High consumption of foods containing soy results in high plasma, urine, and ...

journal_title：Cancer research

authors： Mentor-Marcel R,Lamartiniere CA,Eltoum IE,Greenberg NM,Elgavish A

更新日期：2001-09-15 00:00:00

abstract：:A vitamin E derivative, vitamin E succinate (VES; RRR-alpha-tocopheryl succinate), and a vitamin E analogue, 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid (alpha-TEA), induce human breast, prostate, colon, lung, cervical, and endometrial tumor cells in culture to undergo apoptosis but ...

journal_title：Cancer research

authors： Anderson K,Simmons-Menchaca M,Lawson KA,Atkinson J,Sanders BG,Kline K

更新日期：2004-06-15 00:00:00

abstract：:DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, i...

journal_title：Cancer research

authors： Wu W,Kemp BL,Proctor ML,Gazdar AF,Minna JD,Hong WK,Mao L

更新日期：1999-04-15 00:00:00

abstract：:Phase I evaluation of spiromustine was performed using an every-3-week schedule and a weekly X 3 schedule. Neurotoxicity was the dose-limiting toxicity presenting as alterations in cortical integrative functions (orientation, language, coordination), leading to a decrease in the level of consciousness. Traditional cri...

journal_title：Cancer research

authors： Pazdur R,Redman BG,Corbett T,Phillips M,Baker LH

更新日期：1987-08-01 00:00:00

abstract：:Erythrocytes containing micronuclei serve as an indicator of genotoxic exposure in splenectomized individuals. Micronucleated erythrocytes, derived from cytogenetically damaged RBC precursors, are not selectively removed from peripheral blood in individuals who lack splenic function. The relationship between micronucl...

journal_title：Cancer research

authors： Smith DF,MacGregor JT,Hiatt RA,Hooper NK,Wehr CM,Peters B,Goldman LR,Yuan LA,Smith PA,Becker CE

更新日期：1990-08-15 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:Given that there are millions of single-nucleotide polymorphisms (SNPs) in the entire human genome, a major difficulty faced by scientists in planning costly population-based genotyping is to choose target SNPs that are most likely to affect phenotypic functions and ultimately contribute to disease development. Althou...

journal_title：Cancer research

authors： Zhu Y,Spitz MR,Amos CI,Lin J,Schabath MB,Wu X

更新日期：2004-03-15 00:00:00

abstract：:There have been few reported visual observations of metastatic cancer cell arrest in vivo. To seek evidence that inducible vascular adhesive properties can regulate hepatic metastasis, groups of 9-14 c57bl/6 mice were given 1.5 microg of interleukin-1alpha (IL-1alpha) 4 h before the injection of 3 x 10(5) B16F1 melano...

journal_title：Cancer research

authors： Scherbarth S,Orr FW

更新日期：1997-09-15 00:00:00

abstract：:Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility m...

journal_title：Cancer research

authors： Wokolorczyk D,Gliniewicz B,Sikorski A,Zlowocka E,Masojc B,Debniak T,Matyjasik J,Mierzejewski M,Medrek K,Oszutowska D,Suchy J,Gronwald J,Teodorczyk U,Huzarski T,Byrski T,Jakubowska A,Górski B,van de Wetering T,Walczak

更新日期：2008-12-01 00:00:00

abstract：:Dissemination of tumor to the leptomeninges and cerebrospinal fluid represents a common pattern of metastasis for many cancers; however, few chemotherapeutic agents are available for intrathecal (i.t.) use and treatment results are often poor. We studied the neurotoxicity and pharmacokinetics of i.t. 4-hydroperoxycycl...

journal_title：Cancer research

authors： Phillips PC,Than TT,Cork LC,Hilton J,Carson BS,Colvin OM,Grochow LB

更新日期：1992-11-15 00:00:00

abstract：:Some clinical studies suggest that timing of surgery during specific menstrual phases may influence the chances of survival for premenopausal women with breast cancer, whereas other studies failed to find this effect. Because most breast cancer deaths are attributable to metastases, we hypothesized that aspects of the...

journal_title：Cancer research

authors： Vantyghem SA,Postenka CO,Chambers AF

更新日期：2003-08-15 00:00:00

abstract：:Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by in vivo passag...

journal_title：Cancer research

authors： Wang X,Schoenhals JE,Li A,Valdecanas DR,Ye H,Zang F,Tang C,Tang M,Liu CG,Liu X,Krishnan S,Allison JP,Sharma P,Hwu P,Komaki R,Overwijk WW,Gomez DR,Chang JY,Hahn SM,Cortez MA,Welsh JW

更新日期：2017-02-15 00:00:00

abstract：:Concanavalin A (Con A) binding of fixed malignant and nonmalignant C3H/He mouse mammary epithelia in monolayer cultures was examined with markers and labels of various sizes. In Con A-mediated hemadsorption, high epithelial cell densities resulted in the adsorbance of more guinea pig red blood cells per culture dish b...

journal_title：Cancer research

authors： Mitani H,Murakami A,Tanaka H

更新日期：1984-02-01 00:00:00

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:To elicit specific cellular immune responses against cancer, the development of efficient devices to deliver tumor antigen peptides to the MHC class I pathway constitutes a central issue. We report here a novel formula of hydrophobized polysaccharide nanoparticles, which can deliver a HER2 oncoprotein containing an ep...

journal_title：Cancer research

authors： Gu XG,Schmitt M,Hiasa A,Nagata Y,Ikeda H,Sasaki Y,Akiyoshi K,Sunamoto J,Nakamura H,Kuribayashi K,Shiku H

更新日期：1998-08-01 00:00:00

abstract：:The platelet-derived endothelial cell growth factor (PD-ECGF) level was significantly (P < 0.05) increased in 8 of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the eight patients with high PD-ECGF (>10,000 pg/mg protein) in metastatic lymph node lesions was extremely poor. On the othe...

journal_title：Cancer research

authors： Fujimoto J,Sakaguchi H,Hirose R,Wen H,Tamaya T

更新日期：1999-07-01 00:00:00

abstract：:Chemokines play the key role in initiating immune responses by regulating the attraction and homing of immune cells to the lymphoid and nonlymphoid tissues. CXCL14 is a chemokine that in tumors may act as chemoattractant for monocytes and dendritic cells (DC), which may modulate antitumor immune responses in certain c...

journal_title：Cancer research

authors： Song EY,Shurin MR,Tourkova IL,Gutkin DW,Shurin GV

更新日期：2010-06-01 00:00:00

abstract：:Frequent loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) has been reported in many types of human malignancies, including gastric carcinoma. One of the targets of 5q-LOH in colorectal carcinoma is certainly the adenomatous polyposis coli (APC) gene on 5q21. However, other evidence has suggested the p...

journal_title：Cancer research

authors： Tamura G,Ogasawara S,Nishizuka S,Sakata K,Maesawa C,Suzuki Y,Terashima M,Saito K,Satodate R

更新日期：1996-02-01 00:00:00

abstract：:Meningiomas constitute the second most common central nervous system tumor, and yet relatively little is known about the molecular events that are important for the pathogenesis and malignant progression of these tumors. We have used serial analysis of gene expression to compare the transcriptomes of nonneoplastic men...

journal_title：Cancer research

authors： Cuevas IC,Slocum AL,Jun P,Costello JF,Bollen AW,Riggins GJ,McDermott MW,Lal A

更新日期：2005-06-15 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homologue (PTEN) is involved in cell proliferation, adhesion, and apoptosis. PTEN overexpression in mammary epithelium leads to reduced cell number and impaired differentiation and secretion. In contrast, overexpression of the proto-oncogene Wnt-1 in mammary epithelium leads...

journal_title：Cancer research

authors： Zhao H,Cui Y,Dupont J,Sun H,Hennighausen L,Yakar S

更新日期：2005-08-01 00:00:00

abstract：:The ability of culture dishes coated with an extracellular matrix (ECM) to act as a suitable substrate for human ovarian carcinoma cells in vitro has been examined. The plating efficiency on ECM was 30 to 80% (dispersed tumor cells from solid tumor tissue and effusions) with active proliferation of tumor cells being o...

journal_title：Cancer research

authors： Crickard K,Crickard U,Yoonessi M

更新日期：1983-06-01 00:00:00

abstract：:The cellular effects of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and N1,N8-bis(ethyl)spermidine (BES), an apparent regulator of the enzyme were compared in cultured L1210 cells. Unlike DFMO, BES has no direct inhibitory effect on ODC activity. Rather the polyamine analogue i...

journal_title：Cancer research

authors： Porter CW,Ganis B,Vinson T,Marton LJ,Kramer DL,Bergeron RJ

更新日期：1986-12-01 00:00:00