Different concanavalin A binding patterns of malignant and nonmalignant mouse mammary epithelia in monolayer culture.

abstract：:Recent work on a variety of normal and malignant cell lines has shown that induction and secretion of biologically active TGF-beta may occur after exposure to all-trans-retinoic acid (RA), coincident with decreased growth rate and/or differentiation. This study evaluates the expression and regulation of transforming g...

journal_title：Cancer research

authors： Cohen PS,Letterio JJ,Gaetano C,Chan J,Matsumoto K,Sporn MB,Thiele CJ

更新日期：1995-06-01 00:00:00

abstract：:Tumor-initiating properties of complete carcinogens such as 7,12-dimethylbenz(a)anthracene (DMBA) are well known but not the mechanism of DMBA-mediated tumor promotion. Our hypothesis is that interleukin (IL)-1alpha, an early proinflammatory cytokine that initiates a cascade of other cytokines and growth factors, is u...

journal_title：Cancer research

authors： Li X,Eckard J,Shah R,Malluck C,Frenkel K

更新日期：2002-01-15 00:00:00

abstract：:The chemotherapeutic agent paclitaxel disrupts microtubule dynamics causing mitotic arrest, which leads to cell death. However, in paclitaxel-resistant tumor cells, treatment with paclitaxel induces abnormal progression through prophase resulting in a multimininucleated phenotype. Multimininucleation and subsequent po...

journal_title：Cancer research

authors： Panvichian R,Orth K,Day ML,Day KC,Pilat MJ,Pienta KJ

更新日期：1998-10-15 00:00:00

abstract：:Noninvasive, nonmetastatic BW5147 T-lymphoma cells were transfected with the activated human c-Ha-ras oncogene and were examined subsequently for the acquisition of invasive properties in vitro and of metastatic potential in vivo. It was found that several transfectants harboring the ras gene had become invasive in vi...

journal_title：Cancer research

authors： Collard JG,Schijven JF,Roos E

更新日期：1987-02-01 00:00:00

abstract：:The tumor localization of various anti-CD5 immunotoxins (ITs) was studied in vivo in BALB/c nude mice bearing human ascitic Ichikawa tumor cells. Plasma and ascitic clearance of IT as well as the number of intact IT molecules taken up per tumor cell was measured with a highly sensitive immunoenzymometric assay. This a...

journal_title：Cancer research

authors： Rostaing-Capaillon O,Casellas P

更新日期：1990-05-15 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. ...

journal_title：Cancer research

authors： Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM

更新日期：2012-11-01 00:00:00

abstract：:Colony-stimulating factor-1 (CSF-1) and its receptor (CSF-1R) have been implicated in the pathogenesis and progression of various types of cancer, including breast cancer. This is based on high levels of circulating CSF-1 in patient sera with aggressive disease and increased CSF-1R staining in the tumor tissues. Howev...

journal_title：Cancer research

authors： Patsialou A,Wyckoff J,Wang Y,Goswami S,Stanley ER,Condeelis JS

更新日期：2009-12-15 00:00:00

abstract：:Sunitinib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma (RCC). While treatment improves progression-free survival, most patients relapse. We hypothesized that patient relapse can stem from the development of a lymphatic network driven by the production of the main growth factor ...

journal_title：Cancer research

authors： Dufies M,Giuliano S,Ambrosetti D,Claren A,Ndiaye PD,Mastri M,Moghrabi W,Cooley LS,Ettaiche M,Chamorey E,Parola J,Vial V,Lupu-Plesu M,Bernhard JC,Ravaud A,Borchiellini D,Ferrero JM,Bikfalvi A,Ebos JM,Khabar KS,Grép

更新日期：2017-03-01 00:00:00

abstract：:ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk ...

journal_title：Cancer research

authors： Park JM,Terabe M,Steel JC,Forni G,Sakai Y,Morris JC,Berzofsky JA

更新日期：2008-03-15 00:00:00

abstract：:The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. We examined the association between dietary cadmium expo...

journal_title：Cancer research

authors： Julin B,Wolk A,Bergkvist L,Bottai M,Akesson A

更新日期：2012-03-15 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the antibody, however, lacked the ability to induce cell death. The antigen was purified, and characterized by co...

journal_title：Cancer research

authors： Zhong LT,Manzi A,Skowronski E,Notterpek L,Fluharty AL,Faull KF,Masada I,Rabizadeh S,Varsanyi-Nagy M,Ruan Y,Oh JD,Butcher LL,Bredesen DE

更新日期：2001-08-01 00:00:00

abstract：:Increasing evidence argues that the success of an anticancer treatment may rely on immunoadjuvant side effects including the induction of immunogenic tumor cell death. Based on the assumption that this death mechanism is a similar prerequisite for the efficacy of an active immunotherapy using killed tumor cells, we ex...

journal_title：Cancer research

authors： Zappasodi R,Pupa SM,Ghedini GC,Bongarzone I,Magni M,Cabras AD,Colombo MP,Carlo-Stella C,Gianni AM,Di Nicola M

更新日期：2010-11-15 00:00:00

abstract：:When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and ulceration of the nearby stomach and intestines before achieving tum...

journal_title：Cancer research

authors： Fujimoto TN,Colbert LE,Huang Y,Molkentine JM,Deorukhkar A,Baseler L,de la Cruz Bonilla M,Yu M,Lin D,Gupta S,Cabeceiras PK,Kingsley CV,Tailor RC,Sawakuchi GO,Koay EJ,Piwnica-Worms H,Maitra A,Taniguchi CM

更新日期：2019-05-01 00:00:00

abstract：:Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that persistent coculturing of immortalized prostate epithelial cells with macrophages, without adding any carcinogens, induces prostate tumorigenesis and that indu...

journal_title：Cancer research

authors： Fang LY,Izumi K,Lai KP,Liang L,Li L,Miyamoto H,Lin WJ,Chang C

更新日期：2013-09-15 00:00:00

abstract：:MicroRNAs (miRNAs) are a new class of short noncoding regulatory RNAs (18-25 nucleotides) that are involved in diverse developmental and pathologic processes. Altered miRNA expression has been associated with several types of human cancer. However, most studies did not establish whether miRNA expression changes occurr...

journal_title：Cancer research

authors： Sempere LF,Christensen M,Silahtaroglu A,Bak M,Heath CV,Schwartz G,Wells W,Kauppinen S,Cole CN

更新日期：2007-12-15 00:00:00

abstract：:A complex of polyinosinic-polycytidylic acid [poly(I) x poly(C)] and cationic liposome (LIC) inhibited the growth of many tumor cell lines at low concentration in vitro, but poly(I) x poly(C) alone had no such antiproliferative effect. The IC50 values of LIC against the tumor cells ranged from 0.1 to 1000 ng/ml. LIC h...

journal_title：Cancer research

authors： Hirabayashi K,Yano J,Inoue T,Yamaguchi T,Tanigawara K,Smyth GE,Ishiyama K,Ohgi T,Kimura K,Irimura T

更新日期：1999-09-01 00:00:00

abstract：:New sublines of Chinese hamster CHL cells stably expressing human NAT1 or NAT2 N-acetyltransferases or O-acetyltransferase of Salmonella typhimurium were established, and their sensitivities to carcinogenic nitroarenes and aromatic amines were compared using the in vitro micronucleus test. The subline expressing human...

journal_title：Cancer research

authors： Watanabe M,Matsuoka A,Yamazaki N,Hayashi M,Deguchi T,Nohmi T,Sofuni T

更新日期：1994-04-01 00:00:00

abstract：:Correlation was greater than 90% between feline leukemia virus (FeLV), group-specific antigen (GSA) in leukocytes, and viral infectivity (VI) in serum or plasma from 132 cats infected with either the Rickard strain of FeLV, the Snyder-Theilen strain of feline sarcoma virus, or field strains of FeLV. Detection of GSA i...

journal_title：Cancer research

authors： Hoover EA,Olsen RG,Mathes LE,Schaller JP

更新日期：1977-10-01 00:00:00

abstract：:A body of evidence has shown the existence of a nuclear phosphoinositide cycle in different cell types. The cycle is endowed with kinases as well as phosphatases and phospholipase C (PLC). Among the PLC isozymes, the beta family is characterized by a long COOH-terminal tail that contains a cluster of lysine residues r...

journal_title：Cancer research

authors： Matteucci A,Faenza I,Gilmour RS,Manzoli L,Billi AM,Peruzzi D,Bavelloni A,Rhee SG,Cocco L

更新日期：1998-11-15 00:00:00

abstract：:C/EBPα is an essential transcription factor involved in regulating the expression or function of certain cell-cycle regulators, including in breast cancer cells. Although protein arginine methyltransferases have been shown to play oncogenic roles in a variety of cancers, little is known about the role of arginine meth...

journal_title：Cancer research

authors： Liu LM,Sun WZ,Fan XZ,Xu YL,Cheng MB,Zhang Y

更新日期：2019-06-01 00:00:00

abstract：:Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of the transcription ...

journal_title：Cancer research

authors： Bracken CP,Gregory PA,Kolesnikoff N,Bert AG,Wang J,Shannon MF,Goodall GJ

更新日期：2008-10-01 00:00:00

abstract：:We have previously shown that topotecan, a topoisomerase I poison, inhibits hypoxia-inducible factor (HIF)-1alpha protein accumulation by a DNA damage-independent mechanism. Here, we report that daily administration of topotecan inhibits HIF-1alpha protein expression in U251-HRE glioblastoma xenografts. Concomitant wi...

journal_title：Cancer research

authors： Rapisarda A,Zalek J,Hollingshead M,Braunschweig T,Uranchimeg B,Bonomi CA,Borgel SD,Carter JP,Hewitt SM,Shoemaker RH,Melillo G

更新日期：2004-10-01 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:Diethyldithiocarbamate (DDTC) has been shown to protect against the toxicity of cis-diamminedichloroplatinum(II) (DDP) without inhibition of antitumor effect. We report here that DDTC is unreactive toward DDP complexes in which both chlorides have been replaced by guanine residues but removes platinum from a variety o...

journal_title：Cancer research

authors： Bodenner DL,Dedon PC,Keng PC,Borch RF

更新日期：1986-06-01 00:00:00

abstract：:In continuation of earlier studies on murine neoplastic liver lesions, we characterized by histochemical methods the phenotype of hepatocellular adenomas and carcinomas induced by single injections of diethylnitrosamine (1.25, 2.5, or 5.0 micrograms/g of body weight) in 15-day-old C57BL/6 x male C3H F1 mice. The hepat...

journal_title：Cancer research

authors： Hacker HJ,Mtiro H,Bannasch P,Vesselinovitch SD

更新日期：1991-04-01 00:00:00

abstract：:Retinoids have been found to be promising chemopreventive agents that play an important role in regulating cell growth, differentiation, and apoptosis. The action of retinoids is mediated by retinoid receptors (retinoic acid receptors and retinoid X receptors), which are nuclear transcription factors that, when bound ...

journal_title：Cancer research

authors： Kim HT,Kong G,Denardo D,Li Y,Uray I,Pal S,Mohsin S,Hilsenbeck SG,Bissonnette R,Lamph WW,Johnson K,Brown PH

更新日期：2006-12-15 00:00:00

abstract：:Coded skin fibroblast cell strains from ataxia telangiectasia (AT) families and apparently normal individuals were obtained from two different sources. AT homozygous strains were clearly identified on the basis of marked hypersensitivity to cell killing by X-irradiation. AT heterozygotes were intermediate in their cyt...

journal_title：Cancer research

authors： Nagasawa H,Kraemer KH,Shiloh Y,Little JB

更新日期：1987-01-15 00:00:00

abstract：:p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharo...

journal_title：Cancer research

authors： Shimada A,Kato S,Enjo K,Osada M,Ikawa Y,Kohno K,Obinata M,Kanamaru R,Ikawa S,Ishioka C

更新日期：1999-06-15 00:00:00