Clinical implication of expression of platelet-derived endothelial cell growth factor (PD-ECGF) in metastatic lesions of uterine cervical cancers.

abstract：:To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA) coupled with representational difference analysis. Of 42 CpG islands identified by MCA/representational difference analysis, 7 CpG islands [methylated in carcinoma of the pancreas (MICP)] w...

journal_title：Cancer research

authors： Ueki T,Toyota M,Skinner H,Walter KM,Yeo CJ,Issa JP,Hruban RH,Goggins M

更新日期：2001-12-01 00:00:00

abstract：:Disulfiram (DSF) and its metabolites, diethyldithiocarbamic acid (DDC) and diethylamine (DEA), were studied as pretreatments in combination with the alkylating agent nitrogen mustard (HN2) on the cytotoxicity of HN2 against both leukemia cells and normal hematopoietic stem cells. Both time intervals and dose relations...

journal_title：Cancer research

authors： Valeriote F,Grates HE

更新日期：1989-12-01 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) protects cells from the apoptotic effects of hydrophobic bile acids and some other cytotoxic agents. We observed the opposite result when assessing the effects of UDCA on the apoptotic response to mitochondrial photodamage induced by photodynamic therapy (PDT). Two photosensitizers with pre...

journal_title：Cancer research

authors： Kessel D,Caruso JA,Reiners JJ Jr

更新日期：2000-12-15 00:00:00

abstract：:Previously, we have shown that metastasis-associated protein 1 (MTA1) overexpression in transgenic mice was accompanied by high incidence of spontaneous B-cell lymphomas including diffuse large B-cell lymphomas (DLBCL). To understand the molecular basis of lymphoma in MTA1-transgenic (MTA1-TG) mice, we wished to ident...

journal_title：Cancer research

authors： Balasenthil S,Gururaj AE,Talukder AH,Bagheri-Yarmand R,Arrington T,Haas BJ,Braisted JC,Kim I,Lee NH,Kumar R

更新日期：2007-08-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. Anti-HPV16 E7 intracellular single-chain antibodies (scFvs) were constructed to down-regulate HPV16 E7 oncoprotein in HPV DNA-containing cell lines. In these studies, we transfected anti-E7 scFvs...

journal_title：Cancer research

authors： Wang-Johanning F,Gillespie GY,Grim J,Rancourt C,Alvarez RD,Siegal GP,Curiel DT

更新日期：1998-05-01 00:00:00

abstract：:The deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene on chromosome 18q21, encodes a neural cell adhesion molecule family protein that is most highly expressed in the nervous system. To address the hypothesis that DCC may play a role in glioma development and/or progression, we examined DCC ex...

journal_title：Cancer research

authors： Reyes-Mugica M,Rieger-Christ K,Ohgaki H,Ekstrand BC,Helie M,Kleinman G,Yahanda A,Fearon ER,Kleihues P,Reale MA

更新日期：1997-02-01 00:00:00

abstract：:The objective of this investigation was to study the effects of maytansine on the cell cycle kinetics of HeLa cells. The results of this study indicate that maytansine is a very potent mitotic inhibitor and that it has no effect on macromolecular synthesis. Maytansine-induced cytotoxicity was dependent upon the positi...

journal_title：Cancer research

authors： Rao PN,Freireich EJ,Smith ML,Loo TL

更新日期：1979-08-01 00:00:00

abstract：:The ability of all-trans-retinoic acid (RA) to modulate the growth and squamous differentiation of four head and neck squamous cell carcinoma cell lines (183, 886, 1483, and SqCC/Y1) was examined, and the relationship of their state of squamous differentiation and RA responsiveness to the expression of cytosolic RA-bi...

journal_title：Cancer research

authors： Zou CP,Clifford JL,Xu XC,Sacks PG,Chambon P,Hong WK,Lotan R

更新日期：1994-10-15 00:00:00

abstract：:Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a key role in metazoan development regulating the Retinal Determination Gene Network. Herein, the DACH1 gene was expressed in normal prostate epithelial cells with reduced expression in huma...

journal_title：Cancer research

authors： Wu K,Katiyar S,Witkiewicz A,Li A,McCue P,Song LN,Tian L,Jin M,Pestell RG

更新日期：2009-04-15 00:00:00

abstract：:The G protein-coupled formylpeptide receptor (FPR), which mediates leukocyte migration in response to bacterial and host-derived chemotactic peptides, promotes the chemotaxis, survival, and tumorigenesis of highly malignant human glioblastoma cells. Because glioblastoma cells may also express other receptors for growt...

journal_title：Cancer research

authors： Huang J,Hu J,Bian X,Chen K,Gong W,Dunlop NM,Howard OM,Wang JM

更新日期：2007-06-15 00:00:00

abstract：:Cranial radiotherapy induces progressive and debilitating declines in cognition that may, in part, be caused by the depletion of neural stem cells. The potential of using stem cell replacement as a strategy to combat radiation-induced cognitive decline was addressed by irradiating athymic nude rats followed 2 days lat...

journal_title：Cancer research

authors： Acharya MM,Christie LA,Lan ML,Giedzinski E,Fike JR,Rosi S,Limoli CL

更新日期：2011-07-15 00:00:00

abstract：:Recent advances in animal modeling, imaging technology, and functional genomics have permitted precise molecular observations of the metastatic process. However, a comprehensive understanding of the premetastatic niche remains elusive, owing to the limited tools that can map subtle differences in molecular mediators i...

journal_title：Cancer research

authors： Paidi SK,Rizwan A,Zheng C,Cheng M,Glunde K,Barman I

更新日期：2017-01-15 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] inhibited the secretion of gamma-interferon from human T-lymphocytes activated by the calcium ionophore, A23187, or phytohemagglutinin with or without 12-O-tetradecanoylphorbol-13-acetate. The agent also inhibited cell proliferation and interleukin 2 secretion by these cells. Th...

journal_title：Cancer research

authors： Matsui T,Takahashi R,Nakao Y,Koizumi T,Katakami Y,Mihara K,Sugiyama T,Fujita T

更新日期：1986-11-01 00:00:00

abstract：:Using OST6 and OST7 monoclonal antibodies against human osteosarcoma cells, a solid-phase radioimmunosandwich assay was developed to quantitate a human osterosarcoma-associated antigen in a total of 242 sera from healthy adults and patients with various diseases. The levels of the antigen in sera were high in patients...

journal_title：Cancer research

authors： Tanaka C,Yamamuro T,Masuda T,Tanaka H,Matsumoto M,Kotoura Y,Tsuji T,Toguchida J,Miyama-Inaba M,Ueda M

更新日期：1986-09-01 00:00:00

abstract：:Blood vessels deliver oxygen and nutrients to tissues, and vascular networks are spatially organized to meet the metabolic needs for maintaining homeostasis. In contrast, the vasculature of tumors is immature and leaky, resulting in insufficient delivery of nutrients and oxygen. Vasculogenic processes occur normally i...

journal_title：Cancer research

authors： Sasajima J,Mizukami Y,Sugiyama Y,Nakamura K,Kawamoto T,Koizumi K,Fujii R,Motomura W,Sato K,Suzuki Y,Tanno S,Fujiya M,Sasaki K,Shimizu N,Karasaki H,Kono T,Kawabe J,Ii M,Yoshiara H,Kamiyama N,Ashida T,Bardeesy N,

更新日期：2010-08-01 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell-killing can produce a potent costimulatory danger signal and release of tumor epitopes fo...

journal_title：Cancer research

authors： Cerullo V,Pesonen S,Diaconu I,Escutenaire S,Arstila PT,Ugolini M,Nokisalmi P,Raki M,Laasonen L,Särkioja M,Rajecki M,Kangasniemi L,Guse K,Helminen A,Ahtiainen L,Ristimäki A,Räisänen-Sokolowski A,Haavisto E,Oksanen M,

更新日期：2010-06-01 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:Epidemiological data have provided clues to the etiological factors involved in large bowel cancer development. High intake of dietary fat tends to promote colon carcinogenesis. Studies in metabolic epidemiology have shown that the high dietary fat affects the metabolic activity of gut bacteria as well as the levels o...

journal_title：Cancer research

authors： Reddy BS

更新日期：1981-09-01 00:00:00

abstract：:L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decreas...

journal_title：Cancer research

authors： Wang Q,Bailey CG,Ng C,Tiffen J,Thoeng A,Minhas V,Lehman ML,Hendy SC,Buchanan G,Nelson CC,Rasko JE,Holst J

更新日期：2011-12-15 00:00:00

abstract：:Two subclones of L1210 murine leukemia (L1210-46.1 and L1210-56.3) were isolated in the absence of selective agents. Subclone 56.3 appeared to be more sensitive than was subclone 46.1 to treatment with dexamethasone, 1-beta-D-arabinofuranosyl cytosine, vincristine, and X-irradiation. No differences between the parent ...

journal_title：Cancer research

authors： Brouwer M,Smets LA,Jongsma AP

更新日期：1983-06-01 00:00:00

abstract：:Antiangiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of antiangiogenic drugs to delay tumor progression and extend survival is limited, due to either innate or acquired drug resistance. Furthermore, there are currently no validated biomarkers that predict which mRCC pat...

journal_title：Cancer research

authors： Robinson SP,Boult JKR,Vasudev NS,Reynolds AR

更新日期：2017-08-01 00:00:00

abstract：:Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex viral mutant that replicates in and kills tumor cells in a relatively selective fashion. It also expresses, in infected cells, the cyclophosphamide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2...

journal_title：Cancer research

authors： Aghi M,Chou TC,Suling K,Breakefield XO,Chiocca EA

更新日期：1999-08-15 00:00:00

abstract：:We have examined three methods that may be useful for improving the therapeutic efficacy of antibody-targeted radionuclides. The principal limitation of radioimmunotherapy is myelotoxicity and thrombocytopenia. These are due mainly to the length of time the radioantibody remains in the blood. The clearance time of a r...

journal_title：Cancer research

authors： Sharkey RM,Blumenthal RD,Hansen HJ,Goldenberg DM

更新日期：1990-02-01 00:00:00

abstract：:We established a cisplatin-resistant human ovarian cancer cell line (HAC2/0.1) from the parent cell line (HAC2/P) by continuous exposure of HAC2/P to 0.1 microgram of cisplatin/ml. Drug sensitivity determined by colony assay revealed that HAC2/0.1 was 2.4 times as resistant to cisplatin as the parental cell line. HAC2...

journal_title：Cancer research

authors： Niimi S,Nakagawa K,Sugimoto Y,Nishio K,Fujiwara Y,Yokoyama S,Terashima Y,Saijo N

更新日期：1992-01-15 00:00:00

abstract：:New sublines of Chinese hamster CHL cells stably expressing human NAT1 or NAT2 N-acetyltransferases or O-acetyltransferase of Salmonella typhimurium were established, and their sensitivities to carcinogenic nitroarenes and aromatic amines were compared using the in vitro micronucleus test. The subline expressing human...

journal_title：Cancer research

authors： Watanabe M,Matsuoka A,Yamazaki N,Hayashi M,Deguchi T,Nohmi T,Sofuni T

更新日期：1994-04-01 00:00:00

abstract：:The critical region on human chromosome 3p21.3 harboring a putative lung cancer tumor suppressor gene (TSG) was previously defined by allelotyping and recently refined by overlapping homozygous deletions. We report the construction of a 700-kb (cosmid and one P1 phage) clone contig covering the deletion overlap and it...

journal_title：Cancer research

authors： Wei MH,Latif F,Bader S,Kashuba V,Chen JY,Duh FM,Sekido Y,Lee CC,Geil L,Kuzmin I,Zabarovsky E,Klein G,Zbar B,Minna JD,Lerman MI

更新日期：1996-04-01 00:00:00

abstract：:PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity. During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and subsequent poly(ADP-ribose)-dependent DNA repair. PARP-1 inhibition is a promising new way to sel...

journal_title：Cancer research

authors： Steffen JD,Tholey RM,Langelier MF,Planck JL,Schiewer MJ,Lal S,Bildzukewicz NA,Yeo CJ,Knudsen KE,Brody JR,Pascal JM

更新日期：2014-01-01 00:00:00

abstract：:Since tumor suppressor gene DCC exhibits amino acid sequence homology to the neural cell adhesion molecule, there is a possibility that DCC might be related to tumor metastasis. In the present study, we examined 51 cases of primary esophageal carcinomas with regard to point mutations and loss of the DCC gene. We detec...

journal_title：Cancer research

authors： Miyake S,Nagai K,Yoshino K,Oto M,Endo M,Yuasa Y

更新日期：1994-06-01 00:00:00

abstract：:The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers in relation to disease progression and drives cellular transformation, tumorigenesis, and metastatic progression in experimental models. Enhanced eIF4E function results from eIF4E overexpression and/or activation of th...

journal_title：Cancer research

authors： Graff JR,Konicek BW,Carter JH,Marcusson EG

更新日期：2008-02-01 00:00:00

abstract：:In this study we describe the establishment of a leukemic cell line (BNML-CL/ara-C), originating from the 1-beta-D-arabinofuranosylcytosine (ara-C)-resistant brown Norway rat myelocytic leukemia model (BNML/ara-C), that retains the in vivo generated ara-C resistance. Its biological and biochemical characteristics have...

journal_title：Cancer research

authors： Richel DJ,Colly LP,Arkesteijn GJ,Arentsen-Honders MW,Kerster MG,ter Riet PM,Willemze R

更新日期：1990-10-15 00:00:00