Dietary fat and its relationship to large bowel cancer.

abstract：:Receptor for advanced glycation end products (RAGE) and its ligands are overexpressed in multiple cancers. RAGE has been implicated in tumorigenesis and metastasis, but little is known of the mechanisms involved. In this study, we define a specific functional role for an alternate splice variant termed RAGE splice var...

journal_title：Cancer research

authors： Kalea AZ,See F,Harja E,Arriero M,Schmidt AM,Hudson BI

更新日期：2010-07-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the regional nodes and distant sites would guide the development of novel diagnostic, prognostic, and therapeutic targets. The aim of our study ...

journal_title：Cancer research

authors： Xia G,Kumar SR,Masood R,Zhu S,Reddy R,Krasnoperov V,Quinn DI,Henshall SM,Sutherland RL,Pinski JK,Daneshmand S,Buscarini M,Stein JP,Zhong C,Broek D,Roy-Burman P,Gill PS

更新日期：2005-06-01 00:00:00

abstract：:DNA polymerase beta is a nuclear protein essential to DNA repair in mammalian cells. A high frequency of mutations in this gene has been reported in colorectal cancers. To clarify the tumorigenesis steps of human prostate cancers in the molecular basis, we examined the entire coding region of the human DNA polymerase ...

journal_title：Cancer research

authors： Dobashi Y,Shuin T,Tsuruga H,Uemura H,Torigoe S,Kubota Y

更新日期：1994-06-01 00:00:00

abstract：:Chronic exposure to UV radiation (UVR), especially in the UVA (315-400 nm) and UVB (280-315 nm) spectrum of sunlight, is the major risk factor for the development of nonmelanoma skin cancer. UVR is a complete carcinogen, which both initiates and promotes carcinogenesis. We found that protein kinase C epsilon (PKCepsil...

journal_title：Cancer research

authors： Wheeler DL,Martin KE,Ness KJ,Li Y,Dreckschmidt NE,Wartman M,Ananthaswamy HN,Mitchell DL,Verma AK

更新日期：2004-11-01 00:00:00

abstract：:In Drosophila melanogaster, the wings apart-like (wapl) gene encodes a protein that regulates heterochromatin structure. Here, we characterize a novel human homologue of wapl (termed human WAPL; hWAPL). The hWAPL mRNA was predominantly expressed in uterine cervical cancer, with weak expression in all other normal and ...

journal_title：Cancer research

authors： Oikawa K,Ohbayashi T,Kiyono T,Nishi H,Isaka K,Umezawa A,Kuroda M,Mukai K

更新日期：2004-05-15 00:00:00

abstract：:Multidrug resistance (MDR) can be mediated, in part, by overexpression of P-glycoprotein (P-gp) and is characterized by broad resistance to several structurally, chemically, and pharmacologically distinct chemotherapeutic compounds. It has been hypothesized that immunological approaches to cytolysis may be used to ove...

journal_title：Cancer research

authors： McGrath MS,Rosenblum MG,Philips MR,Scheinberg DA

更新日期：2003-01-01 00:00:00

abstract：:The pharmacodynamic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) in patient plasma and its active anabolite 1-beta-D-arabinofuranosylcytosine-5-triphosphate (ara-CTP) in circulating and bone marrow blast cells were studied in 20 pediatric patients with acute leukemia. ara-C (3 g/m2) was administered as a sh...

journal_title：Cancer research

authors： Avramis VI,Biener R,Krailo M,Finklestein J,Ettinger L,Willoughby M,Siegel SE,Holcenberg JS

更新日期：1987-12-15 00:00:00

abstract：:We tested the influence of recombinant human interleukin (rhIL)-l3 and rhIL-4 on clonal growth of human breast cancer cell lines. rhIL-13 and rhIL-4 inhibited clonal growth of three of nine lines to approximately 50% of controls (ED50, 0.5 ng/ml). rhIl-13 reduced [3H]thymidine incorporation in all three cell lines: tw...

journal_title：Cancer research

authors： Serve H,Oelmann E,Herweg A,Oberberg D,Serve S,Reufi B,Mücke C,Minty A,Thiel E,Berdel WE

更新日期：1996-08-01 00:00:00

abstract：:This study was undertaken to examine relationships of the phenotype of malignant cells to target cell properties and to events early in the transformation process. Eighteen transformed lines were obtained by Kirsten murine sarcoma virus infection of cells from adrenal glands of rats ages 4 to 30 weeks, at first or sec...

journal_title：Cancer research

authors： Auersperg N,Wan MW,Sanderson RA,Wong KS,Mauldin D

更新日期：1981-05-01 00:00:00

abstract：:Metastasis is the defining feature of advanced malignancy, yet remains challenging to study in laboratory environments. Here, we describe a high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology. First, we generated several stable cell lines from melanomas of transgenic mitfa-BRAF...

journal_title：Cancer research

authors： Heilmann S,Ratnakumar K,Langdon E,Kansler E,Kim I,Campbell NR,Perry E,McMahon A,Kaufman C,van Rooijen E,Lee W,Iacobuzio-Donahue C,Hynes R,Zon L,Xavier J,White RM

更新日期：2015-10-15 00:00:00

abstract：:The appearance of chemically induced mammary gland carcinomas in virgin female Sprague-Dawley rats was blocked by the administration of D,L-2-difluoromethylornithine (DFMO) in drinking water during the stage of tumor promotion. Rats were given injections s.c. at 50 days of age with either 35 mg of 1-methyl-1-nitrosour...

journal_title：Cancer research

authors： Thompson HJ,Meeker LD,Herbst EJ,Ronan AM,Minocha R

更新日期：1985-03-01 00:00:00

abstract：:When L1210 cells growing logarithmically were exposed for 8 hr to a nonlethal dose of 5-fluorouracil (FU) (0.25 microgram/ml), the percentage of cells in S phase increased from 74.9% in the asynchronous culture to 93% in the FU-treated culture. This resulted in increased cell-kill by S-phase-specific inhibitors [1-bet...

journal_title：Cancer research

authors： Bhuyan BK,Blowers CL,Neil GL,Bono VH,Day KJ

更新日期：1977-09-01 00:00:00

abstract：:The hypothesis that microvesicle-mediated miRNA transfer converts noncancer stem cells into cancer stem cells (CSC) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how microvesicles derived from cancer-associated fibroblasts (CAF) ...

journal_title：Cancer research

authors： Sansone P,Berishaj M,Rajasekhar VK,Ceccarelli C,Chang Q,Strillacci A,Savini C,Shapiro L,Bowman RL,Mastroleo C,De Carolis S,Daly L,Benito-Martin A,Perna F,Fabbri N,Healey JH,Spisni E,Cricca M,Lyden D,Bonafé M,Bromb

更新日期：2017-04-15 00:00:00

abstract：:Resistance of tumors to irradiation or chemotherapeutic agents is thought to be one of the reasons why patients who present with early malignancies may not be cured. Much is now known about the molecular mechanisms that underlie drug resistance, but until recently little was known about genetic contributions to radiat...

journal_title：Cancer research

authors： McKenna WG,Weiss MC,Endlich B,Ling CC,Bakanauskas VJ,Kelsten ML,Muschel RJ

更新日期：1990-01-01 00:00:00

abstract：:Recently we have reported synergistic effects between glycine-extended gastrin (G-gly) and amidated gastrin-17 on acid secretion in short-term infusion studies. In the present study, we examined the long-term effect of G-gly on the atrophy-promoting effects of amidated gastrin in the mouse stomach with or without Heli...

journal_title：Cancer research

authors： Cui G,Koh TJ,Chen D,Zhao CM,Takaishi S,Dockray GJ,Varro A,Rogers AB,Fox JG,Wang TC

更新日期：2004-11-15 00:00:00

abstract：:Calorie restriction has been shown to inhibit epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, including insulin-like growth factor I (IGF-I). Previously, we identified a relationship between elevated tissue IGF-I levels and enhanced susceptibility to chemically induc...

journal_title：Cancer research

authors： Moore T,Carbajal S,Beltran L,Perkins SN,Yakar S,Leroith D,Hursting SD,Digiovanni J

更新日期：2008-05-15 00:00:00

abstract：:In an attempt to maximize the therapeutic index and to overcome the large variations in 1-beta-D-arabinofuranosylcytosine (ara-C) plasma levels and host toxicities that have been documented with standard HDara-C regimens (3 g/m2 over 3 h every 12 h x 8 or x12 doses), pediatric patients with acute lymphocytic leukemia ...

journal_title：Cancer research

authors： Avramis VI,Weinberg KI,Sato JK,Lenarsky C,Willoughby ML,Coates TD,Ozkaynak MF,Parkman R

更新日期：1989-01-01 00:00:00

abstract：:Induction of mRNA for BIK proapoptotic protein by doxorubicin or gamma-irradiation requires the DNA-binding transcription factor activity of p53. In MCF7 cells, pure antiestrogen fulvestrant also induces BIK mRNA and apoptosis. Here, we provide evidence that, in contrast to doxorubicin or gamma-irradiation, fulvestran...

journal_title：Cancer research

authors： Hur J,Bell DW,Dean KL,Coser KR,Hilario PC,Okimoto RA,Tobey EM,Smith SL,Isselbacher KJ,Shioda T

更新日期：2006-10-15 00:00:00

abstract：:The initiation and promotion of cancer is thought to result from a series of genetic mutations, some of which may be inherited. Our analysis of 337 lung cancer families suggested that, after allowing for an individual's pack-years of tobacco use, the pattern of disease was best explained by Mendelian codominant inheri...

journal_title：Cancer research

authors： Sellers TA,Potter JD,Bailey-Wilson JE,Rich SS,Rothschild H,Elston RC

更新日期：1992-05-01 00:00:00

abstract：:The growth inhibitory effects of combinations of antifolates on hepatoma cells in culture have been examined. In these studies methotrexate or the lipophilic inhibitors of dihydrofolate reductase were used with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolate (PDDF). Under certain conditions partial ...

journal_title：Cancer research

authors： Galivan J,Nimec Z,Rhee M

更新日期：1987-10-15 00:00:00

abstract：:The macrophage content of spontaneous metastases has been quantified morphometrically for a panel of rodent tumors at different stages of metastatic tumor growth. Using a histochemical technique to selectively stain macrophages, we have evaluated the relative content of macrophages in spontaneous pulmonary metastases ...

journal_title：Cancer research

authors： Bugelski PJ,Corwin SP,North SM,Kirsh RL,Nicolson GL,Poste G

更新日期：1987-08-01 00:00:00

abstract：:Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common malignancy of young men. Using genome-wide gene expression profiling, we identified >200 genes highly expressed in testicular ...

journal_title：Cancer research

authors： Almstrup K,Hoei-Hansen CE,Wirkner U,Blake J,Schwager C,Ansorge W,Nielsen JE,Skakkebaek NE,Rajpert-De Meyts E,Leffers H

更新日期：2004-07-15 00:00:00

abstract：:Several studies have suggested that calmodulin (CAM) levels increase in cells as a consequence of transformation by RNA tumor viruses. This study examines factors affecting CAM levels in normal and transformed chick embryo fibroblasts. Significant differences in CAM levels of normal and transformed cells were observed...

journal_title：Cancer research

authors： Veigl ML,Vanaman TC,Branch ME,Sedwick WD

更新日期：1984-08-01 00:00:00

abstract：:Human cancer cell lines are commonly used in basic cancer research to understand the behavior of primary tumors. Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of the cancer cell. However, no comprehensive study defines the DNA methylation environment present in the established cance...

journal_title：Cancer research

authors： Paz MF,Fraga MF,Avila S,Guo M,Pollan M,Herman JG,Esteller M

更新日期：2003-03-01 00:00:00

abstract：:T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional. Environmental stress produces ep...

journal_title：Cancer research

authors： Koss B,Shields BD,Taylor EM,Storey AJ,Byrum SD,Gies AJ,Washam CL,Choudhury SR,Hyun Ahn J,Uryu H,Williams JB,Krager KJ,Chiang TC,Mackintosh SG,Edmondson RD,Aykin-Burns N,Gajewski TF,Wang GG,Tackett AJ

更新日期：2020-11-01 00:00:00

abstract：:DNA mismatch repair (MMR) plays a key role in the cytotoxic response of human cells to methylating agents, however, the cascade of events leading to cell cycle arrest and cell death has yet to be characterized. We studied the role of MMR in the transcriptional response to DNA methylation damage in two human cellular m...

journal_title：Cancer research

authors： di Pietro M,Marra G,Cejka P,Stojic L,Menigatti M,Cattaruzza MS,Jiricny J

更新日期：2003-12-01 00:00:00

abstract：:The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating WOMEN FOR 40 DIFFERENT AND comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quant...

journal_title：Cancer research

authors： Buehring GC,Williams RR

更新日期：1976-10-01 00:00:00

abstract：:A novel monoclonal antibody was raised by immunization of mice with colorectal tumor cell lines. The fusion was screened by immunohistochemistry for binding to primary colorectal tumors. Subsequent analysis on primary disaggregated colorectal tumors show that the antibody recognizes a cell surface antigen expressed by...

journal_title：Cancer research

authors： Durrant LG,Harding SJ,Green NH,Buckberry LD,Parsons T

更新日期：2006-06-01 00:00:00

abstract：:The effects of streptozotocin (SZ) and N-nitrosobis(2-oxopropyl)amine (BOP), separately or in combination, on the pancreas, common duct, and gallbladder, all target tissues of BOP, were studied in Syrian golden hamsters. Groups of hamsters were treated with either a single dose (20 mg/kg body weight) of BOP (BOP group...

journal_title：Cancer research

authors： Pour PM,Kazakoff K,Carlson K

更新日期：1990-03-01 00:00:00

abstract：:Culture of human peripheral blood leukocytes with interleukin 2 (IL-2) stimulates their differentiation into lymphokine-activated killer (LAK) cells, with a broad range of cytotoxicity against fresh tumor cells and tumor cell lines (Grimm et al., J. Exp. Med., 155: 1823-1841, 1982). We chose to utilize a molecular app...

journal_title：Cancer research

authors： Kovacs EJ,Beckner SK,Longo DL,Varesio L,Young HA

更新日期：1989-02-15 00:00:00