Leukemia derived growth factors produced by human malignant T-lymphoid cell lines.

Abstract:

:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a factor. All three factors, i.e., the LDGF from MOLT-4f, CCRF-CEM, and CCRF-HSB-2 are similar to each other both in biological activity and in physicochemical characteristics. In addition to their autocrine activity, these LDGFs stimulate the growth of other malignant T-lymphoid cell lines, but they do not stimulate B-lymphoblastoid or myeloid cell lines. The results therefore suggest that these LDGFs are T-cell specific.

journal_name

Cancer Res

journal_title

Cancer research

authors

Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

1219-23

issue

3

eissn

0008-5472

issn

1538-7445

journal_volume

46

pub_type

杂志文章
  • Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi.

    abstract::Mucinous colorectal cancers exhibit a characteristic set of molecular genetic alterations and may be derived from progenitor cells committed to the goblet cell lineage. Previously, we demonstrated that the MUC2 mucin gene promoter drives transgene reporter expression with high specificity in small intestinal goblet ce...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gum JR Jr,Hicks JW,Gillespie AM,Rius JL,Treseler PA,Kogan SC,Carlson EJ,Epstein CJ,Kim YS

    更新日期:2001-04-15 00:00:00

  • Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells.

    abstract::Mounting evidence suggests a role for matrix metalloproteinase (MMP)-2 in the malignant progression of breast cancer cells. We showed previously that H-Ras, but not N-Ras, induced invasion of MCF10A human breast epithelial cells through Rac-MKK3/6-p38 pathway resulted in MMP-2 up-regulation. Activation of p38 pathway ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-1461

    authors: Song H,Ki SH,Kim SG,Moon A

    更新日期:2006-11-01 00:00:00

  • Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate.

    abstract::Photoimmunotherapy (using a monoclonal antibody-targeted photosensitizer and red light) may be a strategy to overcome the limitations inherent in photodynamic therapy of liver tumors. The aims of this study were (a) to test the efficacy of selective treatment of hepatic metastases of colorectal cancer in an orthotopic...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Del Governatore M,Hamblin MR,Shea CR,Rizvi I,Molpus KG,Tanabe KK,Hasan T

    更新日期:2000-08-01 00:00:00

  • Enhancement of antitumor transplantation resistance in rats by appropriately timed administration of busulfan.

    abstract::Enhancement of specific transplantation resistance to a syngeneic tumor (KMT-17) was observed in WKA rats by treatment with the antileukemia drug busulfan (BU) (15 mg/kg) 5 days before and 5 days after immunization with X-irradiated KMT-17 tumor cells. Rats immunized with X-irradiated KMT-17 cells and then treated wit...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Mizushima Y,Sendo F,Takeichi N,Hosohawa M,Kobayashi H

    更新日期:1981-07-01 00:00:00

  • Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

    abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) has been shown to induce apoptosis specifically in cancer cells while sparing normal tissues. Unfortunately not all cancer cells respond to TRAIL; therefore, TRAIL sensitizing agents are currently being explored. We have identified synthetic trit...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-3319

    authors: Hyer ML,Croxton R,Krajewska M,Krajewski S,Kress CL,Lu M,Suh N,Sporn MB,Cryns VL,Zapata JM,Reed JC

    更新日期:2005-06-01 00:00:00

  • Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.

    abstract::E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell matrix adhesion receptors. We show here that inhibition of E-cadheri...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-5167

    authors: Sawada K,Mitra AK,Radjabi AR,Bhaskar V,Kistner EO,Tretiakova M,Jagadeeswaran S,Montag A,Becker A,Kenny HA,Peter ME,Ramakrishnan V,Yamada SD,Lengyel E

    更新日期:2008-04-01 00:00:00

  • Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

    abstract::PTEN/MMAC1 is a major new tumor suppressor gene that encodes a dual-specificity phosphatase with sequence similarity to the cytoskeletal protein tensin. Recently, we reported that PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits cell migration, spreading, and focal adhesion formation. Here, the effects o...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tamura M,Gu J,Takino T,Yamada KM

    更新日期:1999-01-15 00:00:00

  • Long-term effects of prenatal and neonatal administration of 5beta-dihydrotestosterone on normal and neoplastic mammary development in mice.

    abstract::The long-term effects on mammary glands of 5beta-dihydrotestosterone, considered to be biologically inactive, were studied in female SHN mice with mammary tumor, virus. 5beta-Dihydrotestosterone was adminstered to mothers for 4 days from Day 12 to Day 15 of pregnancy (prenatal treatment) and to pups for 5 days of post...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yanai R,Mori T,Nagasawa H

    更新日期:1977-12-01 00:00:00

  • Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis.

    abstract::In previous studies, we reported that key antioxidant and DNA repair genes are regulated differently in normal bronchial epithelial cells of lung cancer cases compared with non-lung cancer controls. In an effort to develop a biomarker for lung cancer risk, we evaluated the transcript expressions of 14 antioxidant, DNA...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-09-1568

    authors: Blomquist T,Crawford EL,Mullins D,Yoon Y,Hernandez DA,Khuder S,Ruppel PL,Peters E,Oldfield DJ,Austermiller B,Anders JC,Willey JC

    更新日期:2009-11-15 00:00:00

  • Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.

    abstract::This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single ...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Brunner TB,Hahn SM,Gupta AK,Muschel RJ,McKenna WG,Bernhard EJ

    更新日期:2003-09-15 00:00:00

  • Interferon effect on collagen and fibronectin distribution in the extracellular matrix of murine sarcoma virus-transformed cells.

    abstract::The transformation of murine BALB/c embryonic fibroblasts by murine sarcoma virus, Moloney strain, followed by prolonged treatment with murine interferon, resulted in the appearance of a new cell population (MSV-IF+). These MSV-IF+ cells are characterized by the recovery of a normal phenotype, contact inhibition, and ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gerfaux J,Rousset S,Chany-Fournier F,Chany C

    更新日期:1981-09-01 00:00:00

  • In situ hybridization analysis of interstitial C-heterochromatin in marker chromosomes of two human melanomas.

    abstract::Two distinct marker chromosomes, presenting with intercalated C- and distamycin A-Dapi-positive regions, were observed in a metastatic and a primary melanoma. To establish the origin of these heterochromatic sequences, we performed in situ hybridization analysis using specific probes for human repetitive DNA. The mark...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Doneda L,Ginelli E,Agresti A,Larizza L

    更新日期:1989-01-15 00:00:00

  • Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment.

    abstract::We have investigated the ability of tamoxifen to regulate members of the transforming growth factor beta (TGF-beta) family in human breast cancers in vivo. Using immunohistochemical techniques, we find that 3 months of tamoxifen treatment causes a consistent induction of extracellular TGF-beta 1 in breast cancer biops...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Butta A,MacLennan K,Flanders KC,Sacks NP,Smith I,McKinna A,Dowsett M,Wakefield LM,Sporn MB,Baum M

    更新日期:1992-08-01 00:00:00

  • Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts.

    abstract::Monoclonal antibodies (MAbs) targeted to glioma-associated antigens may allow the selective delivery of imaging and therapeutic agents to brain tumors; the use of MAb fragments may be a strategy to further improve tumor uptake of such agents relative to normal tissues. In this study, we have examined the in vivo local...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Colapinto EV,Humphrey PA,Zalutsky MR,Groothuis DR,Friedman HS,de Tribolet N,Carrel S,Bigner DD

    更新日期:1988-10-15 00:00:00

  • Cytogenetic characterization of B-cell lymphomas from severe combined immunodeficiency disease mice given injections of lymphocytes from Epstein-Barr virus-positive donors.

    abstract::We analyzed the karyotype of 27 B-cell lymphomas of human origin that developed in mice with severe combined immunodeficiency disease following the injection of peripheral blood leukocytes from Epstein-Barr virus-seropositive donors. Three tumors had clonal abnormalities detected with conventional techniques, 2 had tr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Thangavelu M,Snyder L,Anastasi J,Le Beau MM,Kirven M,Picchio G,Mosier DE,Rowley JD

    更新日期:1992-09-01 00:00:00

  • Multimodal elucidation of choline metabolism in a murine glioma model using magnetic resonance spectroscopy and 11C-choline positron emission tomography.

    abstract::The metabolites, transporters, and enzymes involved in choline metabolism are regarded as biomarkers for disease progression in a variety of cancers, but their in vivo detection is not ideal. Both magnetic resonance spectroscopy [MRS using chemical shift imaging (CSI) total choline (tCho)] and C-choline positron emiss...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-2532

    authors: Wehrl HF,Schwab J,Hasenbach K,Reischl G,Tabatabai G,Quintanilla-Martinez L,Jiru F,Chughtai K,Kiss A,Cay F,Bukala D,Heeren RM,Pichler BJ,Sauter AW

    更新日期:2013-03-01 00:00:00

  • Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

    abstract::The human AP endonuclease (Ape1 or ref-1) DNA base excision repair (BER) enzyme is a multifunctional protein that has an impact on a wide variety of important cellular functions including oxidative signaling, transcription factor regulation, and cell cycle control. It acts on mutagenic AP (baseless) sites in DNA as a ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Robertson KA,Bullock HA,Xu Y,Tritt R,Zimmerman E,Ulbright TM,Foster RS,Einhorn LH,Kelley MR

    更新日期:2001-03-01 00:00:00

  • Selective loss of human leukocyte antigen class I allele expression in advanced renal cell carcinoma.

    abstract::The expression of human leukocyte antigen (HLA) class I alleles was analyzed in 65 renal cell carcinomas using one-dimensional isoelectric focusing. Normal organ tissue and peripheral blood lymphocytes were used as controls. The patients were serologically typed using the standard microcytotoxicity test. Forty-two pat...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Luboldt HJ,Kubens BS,Rübben H,Grosse-Wilde H

    更新日期:1996-02-15 00:00:00

  • Pharmacology studies of 1-beta-D-arabinofuranosylcytosine in pediatric patients with leukemia and lymphoma after a biochemically optimal regimen of loading bolus plus continuous infusion of the drug.

    abstract::In an attempt to maximize the therapeutic index and to overcome the large variations in 1-beta-D-arabinofuranosylcytosine (ara-C) plasma levels and host toxicities that have been documented with standard HDara-C regimens (3 g/m2 over 3 h every 12 h x 8 or x12 doses), pediatric patients with acute lymphocytic leukemia ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Avramis VI,Weinberg KI,Sato JK,Lenarsky C,Willoughby ML,Coates TD,Ozkaynak MF,Parkman R

    更新日期:1989-01-01 00:00:00

  • Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene.

    abstract::Loss or attenuated expression of the tumor-suppressor gene FHIT is associated paradoxically with poor progression of human tumors. Fhit promotes apoptosis and regulates reactive oxygen species; however, the mechanism by which Fhit inhibits tumor growth in animals remains unclear. In this study, we used a multidiscipli...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-13-3279

    authors: Hu B,Ying X,Wang J,Piriyapongsa J,Jordan IK,Sheng J,Yu F,Zhao P,Li Y,Wang H,Ng WL,Hu S,Wang X,Wang C,Zheng X,Li W,Curran WJ,Wang Y

    更新日期:2014-04-15 00:00:00

  • Distal nephron renal tumors: microsatellite allelotype.

    abstract::Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that develop from other parts of the renal tubular system. To eluci...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Polascik TJ,Cairns P,Epstein JI,Fuzesi L,Ro JY,Marshall FF,Sidransky D,Schoenberg M

    更新日期:1996-04-15 00:00:00

  • Cytotoxicity of 5,6-dihydroxytryptamine in dimethylhydrazine-induced carcinomas of rat colon.

    abstract::Male Sprague-Dawley rats were given weekly s.c. injections of 1,2-dimethylhydrazine (21 mg/kg) for 20 weeks. The injections were then discontinued, and, after an interval of 2 to 8 weeks, experimental animals were given i.p. injections of 5,6-dihydroxytryptamine (5,6DHT) at a dose of 40 mg/kg and sacrificed at interva...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tutton PJ,Barkla DH

    更新日期:1977-04-01 00:00:00

  • Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment.

    abstract::Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapie...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-15-1490

    authors: Stiff A,Trikha P,Wesolowski R,Kendra K,Hsu V,Uppati S,McMichael E,Duggan M,Campbell A,Keller K,Landi I,Zhong Y,Dubovsky J,Howard JH,Yu L,Harrington B,Old M,Reiff S,Mace T,Tridandapani S,Muthusamy N,Caligiuri MA

    更新日期:2016-04-15 00:00:00

  • Reduced immunoglobulin E and allergy among adults with glioma compared with controls.

    abstract::We and others have reported previously that adults with glioma are 1.5- to 4-fold less likely than controls to report a variety of allergic conditions. The consistent nature of this relationship calls for a biological explanation so that preventative or therapeutic modalities can be explored. We enrolled 403 newly dia...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-1706

    authors: Wiemels JL,Wiencke JK,Patoka J,Moghadassi M,Chew T,McMillan A,Miike R,Barger G,Wrensch M

    更新日期:2004-11-15 00:00:00

  • Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells.

    abstract::Laminin (LN)-5, a heterotrimer of alpha3, beta3, and gamma2 chains, has been suggested to be involved in tumor cell invasion. The present immunohistochemical study investigated the distribution of the LN gamma2 chain in 48 different human gastric adenocarcinomas. The immunohistochemical analysis showed two distinct pa...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Koshikawa N,Moriyama K,Takamura H,Mizushima H,Nagashima Y,Yanoma S,Miyazaki K

    更新日期:1999-11-01 00:00:00

  • Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). Nevertheless, most individuals infected with HTLV-1 do not develop ATL. To attempt to identify genetic factors promoting the progression to ATL, we investigated in HTLV-1 carriers the relationship between ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tsukasaki K,Miller CW,Kubota T,Takeuchi S,Fujimoto T,Ikeda S,Tomonaga M,Koeffler HP

    更新日期:2001-05-01 00:00:00

  • Chicken fetal and adult antigen expression on erythroleukemia cells before and after induced differentiation.

    abstract::Avian erythroblastosis virus strain R (AEV)-transformed, cloned erythroleukemia cells from three different ages of SC strain chickens were analyzed before and after differentiation induced by 1.0 mM butyric acid for expression of chicken fetal antigens (CFAs) and chicken adult antigens (CAAs) and for hemoglobin expres...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Nelson CH,Allison JP,Kline K,Sanders BG

    更新日期:1982-11-01 00:00:00

  • Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms.

    abstract::The diagnostic value of elevated human chorionic gonadotropin (hCG) and its free alpha (hCG alpha) and beta (hCG beta) subunit serum levels as specific tumor markers for nongonadal malignancies is controversial. In the present report, different monoclonal based immunoradiometric assays specific for hCG and its free hC...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Marcillac I,Troalen F,Bidart JM,Ghillani P,Ribrag V,Escudier B,Malassagne B,Droz JP,Lhommé C,Rougier P

    更新日期:1992-07-15 00:00:00

  • Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma.

    abstract::Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt th...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-3947

    authors: Shiftan L,Israely T,Cohen M,Frydman V,Dafni H,Stern R,Neeman M

    更新日期:2005-11-15 00:00:00

  • Inhibition of mouse alpha/beta-interferon of the multiplication of alpha/beta-interferon-resistant Friend erythroleukemia cells cocultured with mouse hepatocytes.

    abstract::Administration of alpha/beta-interferon (IFN) exerts a marked antitumor effect in DBA/2 mice given injections i.v. of large numbers of IFN-alpha/beta-resistant erythroleukemia cells (FLC). To investigate the possible mechanisms of FLC tumor inhibition in the liver of interferon-treated mice, we developed an in vitro m...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yasui H,Proietti E,Vignaux F,Eid P,Gresser I

    更新日期:1990-06-15 00:00:00