Abstract:
:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a factor. All three factors, i.e., the LDGF from MOLT-4f, CCRF-CEM, and CCRF-HSB-2 are similar to each other both in biological activity and in physicochemical characteristics. In addition to their autocrine activity, these LDGFs stimulate the growth of other malignant T-lymphoid cell lines, but they do not stimulate B-lymphoblastoid or myeloid cell lines. The results therefore suggest that these LDGFs are T-cell specific.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JLsubject
Has Abstractpub_date
1986-03-01 00:00:00pages
1219-23issue
3eissn
0008-5472issn
1538-7445journal_volume
46pub_type
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