Abstract：
:Maximum rates of nitrofuran reduction by intact mammalian cells and homogenates of mouse liver are obtained under anaerobic conditions, although significant reduction does occur with gas mixtures containing 5% oxygen and less. Single-strand breaks in DNA, measured as a decrease in the sedimentation constant on alkaline sucrose gradients, are produced in mammalian L929, KB, AND BHK-21 cells in vitro and Ehrlich ascites cells in vivo by several nitrofuran derivatives under hypoxic conditons.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Olive PL,McCalla DRsubject
Has Abstractpub_date
1975-03-01 00:00:00pages
781-4issue
3eissn
0008-5472issn
1538-7445journal_volume
35pub_type
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