Abstract：
:The anthracycline antineoplastic agents Adriamycin and N-trifluoroacetyl-Adriamycin-14-valerate were assayed in vivo and in vitro for ability to produce DNA lesions recognized by the UVRABC endonuclease, a DNA repair enzyme of Escherichia coli which recognizes large, bulky lesions in DNA. We found that, while both drugs produce DNA lesions, only the lesions produced by Adriamycin were toxic. Hence, anthracycline antineoplastic activity may be related to production of large, bulky lesions in DNA, while toxicity may correlate with toxicity measured in a simple E. coli DNA repair mutant test system.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kacinski BM,Rupp WDsubject
Has Abstractpub_date
1984-08-01 00:00:00pages
3489-92issue
8eissn
0008-5472issn
1538-7445journal_volume
44pub_type
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