Prognostic significance of cell kinetics in laryngeal squamous cell carcinoma: clinicopathological associations.

abstract：:Normal bronchial epithelial cells (NBECs) are at risk for damage from inhaled and endogenous oxidative species and from epoxide metabolites of inhaled polycyclic aromatic hydrocarbons. Epidemiological and in vitro data suggest that interindividual variation in this risk may result from variation in NBEC expression of ...

journal_title：Cancer research

authors： Crawford EL,Khuder SA,Durham SJ,Frampton M,Utell M,Thilly WG,Weaver DA,Ferencak WJ,Jennings CA,Hammersley JR,Olson DA,Willey JC

更新日期：2000-03-15 00:00:00

abstract：:Elevated levels of nitric oxide (NO) and reactive nitrogen species (RNS) may link inflammation to the initiation, promotion, and progression of cancer. Traditionally, this link has been thought to be mediated by the effects of NO/RNS in generating DNA damage. However, this damage also stimulates DNA repair responses w...

journal_title：Cancer research

authors： Yakovlev VA

更新日期：2013-01-15 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was inc...

journal_title：Cancer research

authors： He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Y

更新日期：2016-10-01 00:00:00

abstract：:To study the relationships between different DNA repair pathways, we established a set of clones in which one specific DNA repair gene was silenced using long-term RNA interference in HeLa cell line. We focus here on genes involved in either nucleotide excision repair (XPA and XPC) or nonhomologous end joining (NHEJ; ...

journal_title：Cancer research

authors： Despras E,Pfeiffer P,Salles B,Calsou P,Kuhfittig-Kulle S,Angulo JF,Biard DS

更新日期：2007-03-15 00:00:00

abstract：:Enhanced activation of Akt occurs in Cowden's disease, an inherited syndrome of follicular thyroid, breast, colon, and skin tumors, via inactivation of its regulatory protein, PTEN. Whereas PTEN inactivation is uncommon in sporadic thyroid cancer, activation of growth factor pathways that signal through Akt is frequen...

journal_title：Cancer research

authors： Ringel MD,Hayre N,Saito J,Saunier B,Schuppert F,Burch H,Bernet V,Burman KD,Kohn LD,Saji M

更新日期：2001-08-15 00:00:00

abstract：:Well-coupled mitochondria of hematopoietic tumors were isolated from mouse erythroleukemia and rat chloroma tumors grown in male DBA/2J mice and Long-Evans rats, respectively. We used erythroleukemia and chloroma mitochondria to determine their ability to utilize glutamine as an energy source for adenosine triphosphat...

journal_title：Cancer research

authors： Abou-Khalil WH,Yunis AA,Abou-Khalil S

更新日期：1983-05-01 00:00:00

abstract：:Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Both EST and STS have been suggested to play important roles in regulating the in situ production of estrogens in human breast carcinoma tissu...

journal_title：Cancer research

authors： Suzuki T,Nakata T,Miki Y,Kaneko C,Moriya T,Ishida T,Akinaga S,Hirakawa H,Kimura M,Sasano H

更新日期：2003-06-01 00:00:00

abstract：:The development of mouse models with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgene as mutational targets provides an excellent opportunity to compare the mutant frequency (Mf) and types of mutations induced in vivo in different sequence contexts. To this end, a study was...

journal_title：Cancer research

authors： Walker VE,Gorelick NJ,Andrews JL,Craft TR,deBoer JG,Glickman BW,Skopek TR

更新日期：1996-10-15 00:00:00

abstract：:The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about how it is negative...

journal_title：Cancer research

authors： Wang H,Liu K,Geng M,Gao P,Wu X,Hai Y,Li Y,Li Y,Luo L,Hayes JD,Wang XJ,Tang X

更新日期：2013-05-15 00:00:00

abstract：:Paclitaxel has been shown to activate Raf-1 and cause phosphorylation of Bcl-2, which has been correlated with paclitaxel-induced apoptosis of cancer cells. In the present studies, we demonstrate that in human AML HL-60 cells that express Bcl-2 but little Bcl-xL (HL-60/neo cells), paclitaxel-induced phosphorylation of...

journal_title：Cancer research

authors： Ibrado AM,Liu L,Bhalla K

更新日期：1997-03-15 00:00:00

abstract：:The Na+/H+ exchanger is involved in a variety of cellular processes, including regulation of intracellular pH and possibly the control of cell growth and proliferation. To study the role of the Na+/H+ exchanger in tumor growth, human sodium proton exchanger-deficient (HSPD) mutants were derived from the human bladder ...

journal_title：Cancer research

authors： Rotin D,Steele-Norwood D,Grinstein S,Tannock I

更新日期：1989-01-01 00:00:00

abstract：:Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been s...

journal_title：Cancer research

authors： Hogarty MD,Winter CL,Liu X,Guo C,White PS,Look AT,Brodeur GM,Maris JM

更新日期：2002-11-15 00:00:00

abstract：:Mammary tumor induction was examined in female Fischer rats fed a low-corn oil, a high-corn oil, a high-lard, a high-beef tallow, or a high-coconut oil diet since weaning. The diets were prepared by adding the experimental fat to a basal diet containing sufficient essential fatty acids for growth. These diets differed...

journal_title：Cancer research

authors： Chan PC,Ferguson KA,Dao TL

更新日期：1983-03-01 00:00:00

abstract：:Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwan who had no history of cancer had serum iron levels tested at the time of recruitment (1997-2008). Initially measured iron le...

journal_title：Cancer research

authors： Wen CP,Lee JH,Tai YP,Wen C,Wu SB,Tsai MK,Hsieh DP,Chiang HC,Hsiung CA,Hsu CY,Wu X

更新日期：2014-11-15 00:00:00

abstract：:Alterations of the distal portion of the short arm of chromosome 1 (1p) are among the earliest abnormalities of human colorectal tumors. Loss of heterozygosity analysis has previously revealed a smallest region of overlapping deletion (SRO) B, at 1p35-36.1, deleted in 48% of sporadic tumors. From this region we have n...

journal_title：Cancer research

authors： Praml C,Savelyeva L,Perri P,Schwab M

更新日期：1998-11-15 00:00:00

abstract：:Previous cytogenetic analysis has revealed frequent losses of chromosome 1p21-22 in human malignant mesothelioma, suggesting that the loss or inactivation of a tumor suppressor gene's) residing at this site may contribute to the tumorigenic conversion of mesothelial cells. To more precisely define the location of the ...

journal_title：Cancer research

authors： Lee WC,Balsara B,Liu Z,Jhanwar SC,Testa JR

更新日期：1996-10-01 00:00:00

abstract：:This work confirms the previous observation that a single application of N-hydroxy-2-fluorenylacetamide or N-hydroxy-3-fluorenylacetamide to the mammary gland of the rat induced a high incidence of tumors, whereas the corresponding arylamides, N-2-fluorenylacetamide (2-FAA) and N-3-fluorenylacetamide, were only weakly...

journal_title：Cancer research

authors： Malejka-Giganti D,Rydell RE,Gutmann HR

更新日期：1977-01-01 00:00:00

abstract：:We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to prote...

journal_title：Cancer research

authors： Jimenez JJ,Yunis AA

更新日期：1992-09-15 00:00:00

abstract：:Previous studies have shown that activation of the signal transducer and activator of transcription 5 (STAT5) plays an essential role in leukemogenesis mediated through constitutive activated protein tyrosine kinases (PTK). Because PIM-1 is a STAT5 target gene, we analyzed the role of the family of PIM serine/threonin...

journal_title：Cancer research

authors： Adam M,Pogacic V,Bendit M,Chappuis R,Nawijn MC,Duyster J,Fox CJ,Thompson CB,Cools J,Schwaller J

更新日期：2006-04-01 00:00:00

abstract：:Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. Early studies focused on the role ...

journal_title：Cancer research

authors： Samanta D,Semenza GL

更新日期：2016-11-15 00:00:00

abstract：:Several studies have suggested that calmodulin (CAM) levels increase in cells as a consequence of transformation by RNA tumor viruses. This study examines factors affecting CAM levels in normal and transformed chick embryo fibroblasts. Significant differences in CAM levels of normal and transformed cells were observed...

journal_title：Cancer research

authors： Veigl ML,Vanaman TC,Branch ME,Sedwick WD

更新日期：1984-08-01 00:00:00

abstract：:During the last 2 yr more than 100 independent isolates of human T-cell leukemia virus type III have been obtained in this laboratory. Most isolates were from peripheral blood T-lymphocytes established in cell culture from acquired immunodeficiency syndrome (AIDS) and acquired immunodeficiency syndrome-related complex...

journal_title：Cancer research

authors： Markham PD,Salahuddin SZ,Popovic M,Patel A,Veren K,Fladager A,Orndorff S,Gallo RC

更新日期：1985-09-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

journal_title：Cancer research

authors： Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

更新日期：2015-01-01 00:00:00

abstract：:The Sonic hedgehog (Shh) signaling pathway plays a critical role in normal cerebellar development and has been implicated in medulloblastomas, common malignant childhood tumors of the cerebellum. To test whether Shh mis-expression is sufficient for medulloblastoma formation, we used ultrasound biomicroscopy-guided in ...

journal_title：Cancer research

authors： Weiner HL,Bakst R,Hurlbert MS,Ruggiero J,Ahn E,Lee WS,Stephen D,Zagzag D,Joyner AL,Turnbull DH

更新日期：2002-11-15 00:00:00

abstract：:The cytochrome P-450 in hepatic microsomes prepared from rats pretreated with hematoporphyrin derivative was shown to be rapidly destroyed in the presence of long-wave ultraviolet light. The photocatalytic destruction of the heme-protein was dependent on both the dose of ultraviolet light and of hematoporphyrin deriva...

journal_title：Cancer research

authors： Das M,Dixit R,Mukhtar H,Bickers DR

更新日期：1985-02-01 00:00:00

abstract：:Collagenase-3 (matrix metalloproteinase 13; MMP-13), a protease originally identified in breast carcinoma, is characterized by a potent degrading activity against a wide spectrum of extracellular matrix proteins. The aims of this study were to localize and identify the MMP-13-expressing cells in invasive human breast ...

journal_title：Cancer research

authors： Nielsen BS,Rank F,López JM,Balbin M,Vizoso F,Lund LR,Danø K,López-Otín C

更新日期：2001-10-01 00:00:00

abstract：:In the past 3 years, altered expression of the HEF1/CAS-L/NEDD9 scaffolding protein has emerged as contributing to cancer metastasis in multiple cancer types. However, whereas some studies have identified elevated NEDD9 expression as prometastatic, other work has suggested a negative role in tumor progression. We here...

journal_title：Cancer research

authors： Izumchenko E,Singh MK,Plotnikova OV,Tikhmyanova N,Little JL,Serebriiskii IG,Seo S,Kurokawa M,Egleston BL,Klein-Szanto A,Pugacheva EN,Hardy RR,Wolfson M,Connolly DC,Golemis EA

更新日期：2009-09-15 00:00:00

abstract：:The effect of dietary fat concentration and saturation on high energy phosphate metabolites and phospholipid turnover in transplanted line 168 murine mammary tumors was studied using surface coil 31P-nuclear magnetic resonance spectroscopy. Female BALB/c mice were fed one of five diets each containing at least the min...

journal_title：Cancer research

authors： Buckman DK,Erickson KL,Ross BD

更新日期：1987-11-01 00:00:00

abstract：:The standard systemic treatment for prostate cancer (PCa) is androgen ablation, which causes tumor regression by inhibiting activity of the androgen receptor (AR). Invariably, PCa recurs with a fatal androgen-refractory phenotype. Importantly, the growth of androgen-refractory PCa remains dependent on the AR through v...

journal_title：Cancer research

authors： Dehm SM,Schmidt LJ,Heemers HV,Vessella RL,Tindall DJ

更新日期：2008-07-01 00:00:00