Targeting leukemia-initiating cells in acute lymphoblastic leukemia (ALL).

abstract：:We examined whether herpes simplex virus thymidine kinase (HSV-TK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region...

journal_title：Cancer research

authors： Koshikawa N,Takenaga K,Tagawa M,Sakiyama S

更新日期：2000-06-01 00:00:00

abstract：:We have cloned an alternatively spliced form of cyclin-dependent kinase (CDK) inhibitor p15 from human placenta. The alternative splice arises from an alternative 5' donor site in intron 1. An in-frame stop codon within the new exon, called exon 1beta, leads to translation of a Mr 10,000 protein identical to the NH2 t...

journal_title：Cancer research

authors： Tsubari M,Tiihonen E,Laiho M

更新日期：1997-07-15 00:00:00

abstract：:Hepatocellular carcinoma is among the most common and lethal cancers in humans. Hepatocellular carcinoma is commonly associated with physical or functional inactivation of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing chronic cycles of hepatocyte death and regeneratio...

journal_title：Cancer research

authors： Farazi PA,Glickman J,Horner J,Depinho RA

更新日期：2006-05-01 00:00:00

abstract：:Frontline anticancer therapies such as chemotherapy and irradiation often slow tumor growth, but tumor regrowth and spread to distant sites usually occurs after the conclusion of treatment. We recently showed that macrophages could be used to deliver large quantities of a hypoxia-regulated, prostate-specific oncolytic...

journal_title：Cancer research

authors： Muthana M,Rodrigues S,Chen YY,Welford A,Hughes R,Tazzyman S,Essand M,Morrow F,Lewis CE

更新日期：2013-01-15 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) are activated simultaneously under a variety of stress conditions. They also share several common signaling pathways for their activation in response to cytokines or growth factors. Recent studies, however, demonstrated a new form of interplay bet...

journal_title：Cancer research

authors： Zhang Y,Chen F

更新日期：2004-03-15 00:00:00

abstract：:The growth of solid tumors and the formation of metastases are dependent on neoangiogenesis. One of the most important factors in inducing the formation of new blood vessels is the vascular endothelial growth factor (VEGF), which acts specifically on endothelial cells. VEGF is expressed and secreted by almost all soli...

journal_title：Cancer research

authors： Barleon B,Siemeister G,Martiny-Baron G,Weindel K,Herzog C,Marmé D

更新日期：1997-12-01 00:00:00

abstract：:verapamil, a calcium-influx blocker, enhanced the cytotoxicity of vincristine (VCR) in vitro 6- to 12-fold in eight human hemopoietic tumor cell lines established from acute lymphatic leukemia, acute myelogenous leukemia, and Burkitt's lymphoma. Great enhancement of VCR cytotoxicity was obtained in a VCR-resistant sub...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1983-05-01 00:00:00

abstract：:A truncated retinoblastoma (RB) protein of approximately 94 kDa (RB94), lacking the NH2 -terminal 112 amino acid residues of the full-length RB, has been found to have great efficacy in tumor suppression. This study investigated the role of adenovirus-mediated RB94 (Ad-RB94) gene therapy for human head and neck squamo...

journal_title：Cancer research

authors： Li D,Day KV,Yu S,Shi G,Liu S,Guo M,Xu Y,Sreedharan S,O'Malley BW Jr

更新日期：2002-08-15 00:00:00

abstract：:Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the tumor microenvironment are not well understood. Here we present...

journal_title：Cancer research

authors： Allen JK,Armaiz-Pena GN,Nagaraja AS,Sadaoui NC,Ortiz T,Dood R,Ozcan M,Herder DM,Haemmerle M,Gharpure KM,Rupaimoole R,Previs RA,Wu SY,Pradeep S,Xu X,Han HD,Zand B,Dalton HJ,Taylor M,Hu W,Bottsford-Miller J,Moreno

更新日期：2018-06-15 00:00:00

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. microRNAs are known to be critical players in the formation of the leukemic phenotype. In this study, we report downregulation of the miR-181a/b gene cluster in APL blasts...

journal_title：Cancer research

authors： Bräuer-Hartmann D,Hartmann JU,Wurm AA,Gerloff D,Katzerke C,Verga Falzacappa MV,Pelicci PG,Müller-Tidow C,Tenen DG,Niederwieser D,Behre G

更新日期：2015-08-15 00:00:00

abstract：:Critical roles played by some protein kinases in neoplastic transformation and progression provide a rationale for developing selective, small-molecule kinase inhibitors as antineoplastic drugs. Protein kinase Cepsilon (PKCepsilon) is a rational target for cancer therapy, because it is oncogenic and prometastatic in t...

journal_title：Cancer research

authors： Chu F,Koomen JM,Kobayashi R,O'Brian CA

更新日期：2005-11-15 00:00:00

abstract：:The human colon cancer cell line HCT does not express any detectable HLA class I antigens on the cell surface. RNA blot analyses showed that HCT cells synthesize easily detectable levels of heavy chains as well as beta 2-microglobulin (beta 2m) transcripts. Experiments of immunoprecipitation revealed the presence of i...

journal_title：Cancer research

authors： Gattoni-Celli S,Kirsch K,Timpane R,Isselbacher KJ

更新日期：1992-03-01 00:00:00

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:Human prostate cancer is associated with a reactive stroma typified by an increase in the proportion of myofibroblast type cells and elevated synthesis of extracellular matrix proteins. Increased vascular density has been identified in the reactive stroma compartment adjacent to both precancerous and cancerous prostat...

journal_title：Cancer research

authors： McAlhany SJ,Ressler SJ,Larsen M,Tuxhorn JA,Yang F,Dang TD,Rowley DR

更新日期：2003-09-15 00:00:00

abstract：:These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]-thymidine is characterized by a rapid initial velocity that approximates membrane transport followed by a slower rate of uptake t...

journal_title：Cancer research

authors： Yalowich JC,Goldman ID

更新日期：1984-03-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. While showing clinical efficacy in a subset of tumors, rapamycin and rapalogs are specific and allosteric inhibitors of mTOR complex 1 (mTORC1), but they do not directly inhibit mTOR complex 2 (mTORC2), an emer...

journal_title：Cancer research

authors： Yu K,Toral-Barza L,Shi C,Zhang WG,Lucas J,Shor B,Kim J,Verheijen J,Curran K,Malwitz DJ,Cole DC,Ellingboe J,Ayral-Kaloustian S,Mansour TS,Gibbons JJ,Abraham RT,Nowak P,Zask A

更新日期：2009-08-01 00:00:00

abstract：:Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the past three decades. HNSCCs often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important progno...

journal_title：Cancer research

authors： Patel V,Marsh CA,Dorsam RT,Mikelis CM,Masedunskas A,Amornphimoltham P,Nathan CA,Singh B,Weigert R,Molinolo AA,Gutkind JS

更新日期：2011-11-15 00:00:00

abstract：:Small molecule inhibitors of DNA repair are emerging as potent and selective anticancer therapies, but the sheer magnitude of the protein networks involved in DNA repair processes poses obstacles to discovery of effective candidate drugs. To address this challenge, we used a subtractive combinatorial selection approac...

journal_title：Cancer research

authors： Moeller BJ,Sidman RL,Pasqualini R,Arap W

更新日期：2011-03-01 00:00:00

abstract：:The characteristics of EMT6 tumors in young adult (3- to 4-month-old) and aged (20- to 28-month-old) BALB/c KaRw mice were compared. The number of tumor cells implanted s.c. necessary to cause tumors in 50% of the injection sites was lower in aging than in young adult mice (69 and 138 cells for young adult mice versus...

journal_title：Cancer research

authors： Rockwell S

更新日期：1981-02-01 00:00:00

abstract：:Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogeni...

journal_title：Cancer research

authors： Bertotti A,Comoglio PM,Trusolino L

更新日期：2005-12-01 00:00:00

abstract：:Combination of chemotherapy and immunotherapy to increase the effectiveness of an antitumor immune response is currently regarded as an attractive antitumor strategy. In a pilot clinical trial, we have recently documented an increase of melanoma antigen A (Melan-A)-specific, tumor-reactive, long-lasting effector-memor...

journal_title：Cancer research

authors： Palermo B,Del Bello D,Sottini A,Serana F,Ghidini C,Gualtieri N,Ferraresi V,Catricalà C,Belardelli F,Proietti E,Natali PG,Imberti L,Nisticò P

更新日期：2010-09-15 00:00:00

abstract：:The present study was designed to determine whether alterations in host metabolism associated with progressive tumor growth were a result of the anorexia frequently observed with cancer or could be attributed to other direct tumor effects. Rates of tyrosine flux, oxidation, and incorporation into protein, as well as f...

journal_title：Cancer research

authors： Kawamura I,Moldawer LL,Keenan RA,Batist G,Bothe A Jr,Bistrian BR,Blackburn GL

更新日期：1982-03-01 00:00:00

abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

journal_title：Cancer research

authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

更新日期：2018-02-15 00:00:00

abstract：:Increased age is regularly linked with heightened cancer risk, but recent research suggests a flattening around age 80. We report that, independent of cancer site or time period, most incidence rates decrease in the more elderly and drop to or toward zero near the ceiling of human life span. For all major organ sites,...

journal_title：Cancer research

authors： Harding C,Pompei F,Lee EE,Wilson R

更新日期：2008-06-01 00:00:00

abstract：:Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented the stratification of patient populations who are most likely to benef...

journal_title：Cancer research

authors： Wu X,Yeerna H,Goto Y,Ando T,Wu VH,Zhang X,Wang Z,Amornphimoltham P,Murphy AN,Tamayo P,Chen Q,Lippman SM,Gutkind JS

更新日期：2019-09-01 00:00:00

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00

abstract：:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a fac...

journal_title：Cancer research

authors： Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

更新日期：1986-03-01 00:00:00

abstract：:2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine present in pyrolysate products of meat and fish and has been shown to induce tumors in the colon, mammary gland, and possibly lymphatic system. Experiments were designed to examine the lymphoma-inducing capacity o...

journal_title：Cancer research

authors： Rao CV,Rivenson A,Zang E,Steele V,Kelloff G,Reddy BS

更新日期：1996-08-01 00:00:00