Abstract：
:Nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) are activated simultaneously under a variety of stress conditions. They also share several common signaling pathways for their activation in response to cytokines or growth factors. Recent studies, however, demonstrated a new form of interplay between these two allies. Inhibition of NF-kappaB by ikkbeta or rela gene deficiency sensitizes stress responses through enhanced or prolonged activation of JNK. Conversely, sustained activation of NF-kappaB inhibits cytokine-induced JNK activation. The mechanisms of how NF-kappaB and JNK become rivals for each other are under extensive debate.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Zhang Y,Chen Fdoi
10.1158/0008-5472.can-03-3361subject
Has Abstractpub_date
2004-03-15 00:00:00pages
1902-5issue
6eissn
0008-5472issn
1538-7445journal_volume
64pub_type
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