Molecular interactions of the combined effects of bleomycin and x-rays on mammalian cell survival.

abstract：:Tumor cell-derived selectin ligands mediate contact to the endothelium, platelets, and leukocytes through binding to selectins that facilitates metastasis. Here, we describe the mechanism of how endogenous (non-tumor derived) selectin ligands contribute to metastasis using α(1,3)fucosyltransferase 7 (Fuc-TVII(-/-))-de...

journal_title：Cancer research

authors： Hoos A,Protsyuk D,Borsig L

更新日期：2014-02-01 00:00:00

abstract：:A model for cell detachment which may influence metastasis in vivo is described involving the transfer of hamster melanoma cells from aggregates of those tumor cells to hamster fibroblast aggregates. The aggregates were made by the spontaneous association of cultured cells. Tumor and fibroblast aggregates were then in...

journal_title：Cancer research

authors： Umbreit JN,Erbe RW

更新日期：1979-06-01 00:00:00

abstract：:The cytotoxic effect of methotrexate (MTX) for mouse bone marrow cells has been studied by in vitro of the granulocyte precursor cell (CFU-C) in a medium containing dialyzed fetal calf serum and dialyzed L-cell supernatant. The formation of 50-cell colonies was inhibited to 50% of control by 10(-8) M MTX. Further incr...

journal_title：Cancer research

authors： Pinedo HM,Zaharko DS,Bull JM,Chabner BA

更新日期：1976-12-01 00:00:00

abstract：:U.S. Latinas have a lower incidence of breast cancer compared with non-Latina White women. This difference is partially explained by differences in the prevalence of known risk factors. Genetic factors may also contribute to this difference in incidence. Latinas are an admixed population with most of their genetic anc...

journal_title：Cancer research

authors： Fejerman L,John EM,Huntsman S,Beckman K,Choudhry S,Perez-Stable E,Burchard EG,Ziv E

更新日期：2008-12-01 00:00:00

abstract：:Karyotypic and molecular genetic evidence has indicated that deletion or rearrangement of both chromosomes 3 and 13 may be important in the pathology of human small cell lung cancer (SCLC). The retinoblastoma susceptibility gene, RB, on chromosome 13 band q14, has previously been shown to be altered in SCLC [J. W. Har...

journal_title：Cancer research

authors： Hensel CH,Hsieh CL,Gazdar AF,Johnson BE,Sakaguchi AY,Naylor SL,Lee WH,Lee EY

更新日期：1990-05-15 00:00:00

abstract：:Phosphorylation of histone H3 at Ser-10 is required for maintenance of properchromosome dynamics during mitosis. AIM-1, a mammalian Ipl1/aurora kinase involved in H3 phosphorylation, is transcriptionally overexpressed in many tumor cell lines. Increased expression of the AIM-1 gene has been observed in human colorecta...

journal_title：Cancer research

authors： Ota T,Suto S,Katayama H,Han ZB,Suzuki F,Maeda M,Tanino M,Terada Y,Tatsuka M

更新日期：2002-09-15 00:00:00

abstract：:Alkaline hydrolysate of dialyzed formaldehyde-treated RNA, in which 39% of purine nucleotides are modified to methylene bis derivatives (R-CH2-R'), displays cytotoxic activity toward cultured human tumor cells. The alkaline hydrolysate of dialyzed formaldehyde-treated RNA is substantially less toxic to normal human em...

journal_title：Cancer research

authors： Feldman MY,Balabanova H,Bachrach U,Pyshnov M

更新日期：1977-02-01 00:00:00

abstract：:An extract of a human cervical squamous carcinoma was used to produce rabbit antiserum with immunoreactivity against an antigen in several types of normal and neoplastic tissues. This antigen was abundant in cervical cancer as well as in normal adult and fetal kidney and liver. The antigen had a beta mobility in immun...

journal_title：Cancer research

authors： Goldenberg DM,Garner TF,Pant KD,van Nagell JR Jr

更新日期：1978-05-01 00:00:00

abstract：:One of the major problems in the diagnosis of localized prostatic tumors is to predict the aggressiveness of an individual tumor, which is presumably associated with chance to progression. In an attempt to find molecular markers that are specific for aggressive prostatic cancer cells, we compared steady-state mRNA lev...

journal_title：Cancer research

authors： Bussemakers MJ,van de Ven WJ,Debruyne FM,Schalken JA

更新日期：1991-01-15 00:00:00

abstract：:By subjecting radiosensitive human neuroblastoma IMR 32 cells to a regime of fractionated X-irradiation, a radioresistant variant, XRIMR 32, was obtained. Radiation resistance of XRIMR 32 cells was demonstrated by clonogenic and spheroid regrowth delay assays. The XRIMR 32 cultures were phenotypically unstable, with t...

journal_title：Cancer research

authors： Russell J,Wheldon TE,Stanton P

更新日期：1995-11-01 00:00:00

abstract：:The interaction between platelets and tumor cells is important in the formation of pulmonary metastasis. We previously established the 8F11 monoclonal antibody (mAb) by immunizing rats with the NL-17 cell line, a highly metastatic variant of mouse colon adenocarcinoma 26. 8F11 could inhibit the platelet aggregation in...

journal_title：Cancer research

authors： Kato Y,Fujita N,Yano H,Tsuruo T

更新日期：1997-07-15 00:00:00

abstract：:There is evidence from experimental work that hypoxia induces apoptosis in apoptosis-sensitive neoplastic cells and that this apoptotic sensitivity is lost during malignant progression. Oxygenation profiles and apoptotic indices in human squamous cell cancer of the uterine cervix have been determined, and a subgroup o...

journal_title：Cancer research

authors： Höckel M,Schlenger K,Höckel S,Vaupel P

更新日期：1999-09-15 00:00:00

abstract：:Acute endothelial cell apoptosis and microvascular compromise couple gastrointestinal tract irradiation to reproductive death of intestinal crypt stem cell clonogens (SCCs) following high-dose radiation. Genetic or pharmacologic inhibition of endothelial apoptosis prevents intestinal damage, but as the radiation dose ...

journal_title：Cancer research

authors： Rotolo JA,Mesicek J,Maj J,Truman JP,Haimovitz-Friedman A,Kolesnick R,Fuks Z

更新日期：2010-02-01 00:00:00

abstract：:We showed that the PEA3 transcriptional factor interacted with LKB1, a serine/threonine kinase, which is somatically mutated in lung cancer. This interaction occurred through the ETS domain of PEA3 and the kinase domain of LKB1. Mutation of LKB1 in lung cancer cells stabilized PEA3. Reintroduction of wild-type (WT) LK...

journal_title：Cancer research

authors： Upadhyay S,Liu C,Chatterjee A,Hoque MO,Kim MS,Engles J,Westra W,Trink B,Ratovitski E,Sidransky D

更新日期：2006-08-15 00:00:00

abstract：:We examined the genetic requirements for the Myc family of oncogenes in normal Sonic hedgehog (Shh)-mediated cerebellar granule neuronal precursor (GNP) expansion and in Shh pathway-induced medulloblastoma formation. In GNP-enriched cultures derived from N-myc(Fl/Fl) and c-myc(Fl/Fl) mice, disruption of N-myc, but not...

journal_title：Cancer research

authors： Hatton BA,Knoepfler PS,Kenney AM,Rowitch DH,de Alborán IM,Olson JM,Eisenman RN

更新日期：2006-09-01 00:00:00

abstract：:In this study, we identified 53 aberrantly hypermethylated DNA sequences in adult T-cell leukemia (ATL) cells using methylated CpG island amplification/representational difference analysis method. We also observed a proportionate increase in the methylation density of these regions with disease progression. Seven gene...

journal_title：Cancer research

authors： Yasunaga J,Taniguchi Y,Nosaka K,Yoshida M,Satou Y,Sakai T,Mitsuya H,Matsuoka M

更新日期：2004-09-01 00:00:00

abstract：:Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been s...

journal_title：Cancer research

authors： Hogarty MD,Winter CL,Liu X,Guo C,White PS,Look AT,Brodeur GM,Maris JM

更新日期：2002-11-15 00:00:00

abstract：:Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the subset of patients who could benefit from adjuvant therapy. A retrospect...

journal_title：Cancer research

authors： Tan P,Cady B,Wanner M,Worland P,Cukor B,Magi-Galluzzi C,Lavin P,Draetta G,Pagano M,Loda M

更新日期：1997-04-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently recur, making the discovery of novel therapeutic targets for this disease imperative. Our previous analysis of the molecular mechanisms of action of bromodomain and extraterminal protein inhibitors (BETi) ...

journal_title：Cancer research

authors： Sahni JM,Gayle SS,Webb BM,Weber-Bonk KL,Seachrist DD,Singh S,Sizemore ST,Restrepo NA,Bebek G,Scacheri PC,Varadan V,Summers MK,Keri RA

更新日期：2017-10-01 00:00:00

abstract：:5-iododeoxyuridine (IdUrd) is highly effective in inducing the production of endogenous viruses (e.g., RNA-containing murine leukemia virus) from a variety of cell lines that normally do not release such viruses. For the activation of murine leukemia virus by IdUrd, its incorporation into cellular DNA is necessary. We...

journal_title：Cancer research

authors： Chattopadhyay SK,Jay G,Lander MR,Levine AS

更新日期：1979-05-01 00:00:00

abstract：:Bleomycin was administered to six patients with advanced cancer. Multiple parameters of both antibody- and cell-mediated immunity were followed serially to characterize the effects of bleomycin on immunocompetence in humans. Antibody-mediated immunity, including primary vaccination with keyhole limpet hemocyanin, was ...

journal_title：Cancer research

authors： Lehane DE,Hurd E,Lane M

更新日期：1975-10-01 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:Quantitation of D-beta-hydroxybutyrate dehydrogenase (BDH) in normal rat hepatocytes was compared with that in two rat hepatoma cell lines, H4-II-EC3 and RLT-3C. BDH activity in normal rat hepatocyte mitochondria was 321 nmol/min/mg, which was greatly reduced to 10.7 nmol/min/mg and 1.7 nmol/min/mg in H4-II-EC3 and RL...

journal_title：Cancer research

authors： Zhang WW,Churchill S,Lindahl R,Churchill P

更新日期：1989-05-01 00:00:00

abstract：:The chemokine receptor CXCR4 plays a central role in organ-specific homing and tumor spreading and is induced by hypoxia. B lymphocytes are exposed to low oxygen tensions during their development, but the influence of hypoxia on their physiology is poorly understood. Here, we show that hypoxia is associated with up-re...

journal_title：Cancer research

authors： Piovan E,Tosello V,Indraccolo S,Masiero M,Persano L,Esposito G,Zamarchi R,Ponzoni M,Chieco-Bianchi L,Dalla-Favera R,Amadori A

更新日期：2007-09-15 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination of the immunoglobulin (IG) genes in B cells. It has recently been proposed that AID, as the newly identified DNA mutator in man, may be instrumental in initiation and progression of B-cell non-Hodgkin's ly...

journal_title：Cancer research

authors： Smit LA,Bende RJ,Aten J,Guikema JE,Aarts WM,van Noesel CJ

更新日期：2003-07-15 00:00:00

abstract：:APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall biological function remains unclear. Using a yeast two-hybrid system, we attempted t...

journal_title：Cancer research

authors： Nakagawa H,Koyama K,Murata Y,Morito M,Akiyama T,Nakamura Y

更新日期：2000-01-01 00:00:00

abstract：:Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are approximately 100-fold more resistant to killing by S(N)1 type methylating agents than MMR-proficient controls, the sensitivity differences repor...

journal_title：Cancer research

authors： Papouli E,Cejka P,Jiricny J

更新日期：2004-05-15 00:00:00

abstract：:Despite descriptions of light-mediated therapy in ancient texts and the discovery of photodynamic therapy (PDT) in the early 1900s, the landmark article in 1978 in Cancer Research by Dougherty and his colleagues at the Roswell Park Cancer Institute remains rightly viewed as the starting point for clinical PDT in moder...

journal_title：Cancer research

authors： Cengel KA,Simone CB 2nd,Glatstein E

更新日期：2016-05-01 00:00:00

abstract：:Postpartum mammary gland involution is a tissue remodeling event that occurs in all mammals in the absence of nursing or after weaning to return the gland to the pre-pregnant state. The tissue microenvironment created by involution has proven to be tumor promotional. Here we report that the GPI-linked protein semaphor...

journal_title：Cancer research

authors： Elder AM,Tamburini BAJ,Crump LS,Black SA,Wessells VM,Schedin PJ,Borges VF,Lyons TR

更新日期：2018-11-15 00:00:00

abstract：:Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are significantly associated with tumor growth and metastasis. Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). This cyclop...

journal_title：Cancer research

authors： Grau R,Iñiguez MA,Fresno M

更新日期：2004-08-01 00:00:00