Abstract：
:Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are approximately 100-fold more resistant to killing by S(N)1 type methylating agents than MMR-proficient controls, the sensitivity differences reported for the other agents were typically <2-fold. To test whether these differences were linked to factors other than MMR status, we studied the cytotoxicities of mitomycin C, chloroethylcyclohexyl nitrosourea, melphalan, psoralen-UVA, etoposide, camptothecin, ionizing radiation, and cis-dichlorodiaminoplatinum (cisplatin) in a strictly isogenic system. We now report that MMR deficiency reproducibly desensitized cells solely to cisplatin.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Papouli E,Cejka P,Jiricny Jdoi
10.1158/0008-5472.CAN-04-0513subject
Has Abstractpub_date
2004-05-15 00:00:00pages
3391-4issue
10eissn
0008-5472issn
1538-7445pii
64/10/3391journal_volume
64pub_type
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