Prospective correlative chemosensitivity testing in high-dose intraarterial chemotherapy for liver metastases.

abstract：:Hepatocellular carcinoma is among the most common and lethal cancers in humans. Hepatocellular carcinoma is commonly associated with physical or functional inactivation of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing chronic cycles of hepatocyte death and regeneratio...

journal_title：Cancer research

authors： Farazi PA,Glickman J,Horner J,Depinho RA

更新日期：2006-05-01 00:00:00

abstract：:Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In t...

journal_title：Cancer research

authors： Gopinathan L,Tan SL,Padmakumar VC,Coppola V,Tessarollo L,Kaldis P

更新日期：2014-07-15 00:00:00

abstract：:Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that develop from other parts of the renal tubular system. To eluci...

journal_title：Cancer research

authors： Polascik TJ,Cairns P,Epstein JI,Fuzesi L,Ro JY,Marshall FF,Sidransky D,Schoenberg M

更新日期：1996-04-15 00:00:00

abstract：:Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regu...

journal_title：Cancer research

authors： Hofman P,Cherfils-Vicini J,Bazin M,Ilie M,Juhel T,Hébuterne X,Gilson E,Schmid-Alliana A,Boyer O,Adriouch S,Vouret-Craviari V

更新日期：2015-03-01 00:00:00

abstract：:The chemotherapeutic agent paclitaxel disrupts microtubule dynamics causing mitotic arrest, which leads to cell death. However, in paclitaxel-resistant tumor cells, treatment with paclitaxel induces abnormal progression through prophase resulting in a multimininucleated phenotype. Multimininucleation and subsequent po...

journal_title：Cancer research

authors： Panvichian R,Orth K,Day ML,Day KC,Pilat MJ,Pienta KJ

更新日期：1998-10-15 00:00:00

abstract：:[D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP) was identified out of a panel of novel SP analogues as the most potent inhibitor of small cell lung cancer (SCLC) cell growth. This analogue inhibited proliferation of H-510 and H-69 SCLC cells in liquid culture and in semisolid media (IC50, 5 microM). Colony formation stimula...

journal_title：Cancer research

authors： Seckl MJ,Higgins T,Widmer F,Rozengurt E

更新日期：1997-01-01 00:00:00

abstract：:Benzo(a)pyrene and 210Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic i...

journal_title：Cancer research

authors： Little JB,McGandy RB,Kennedy AR

更新日期：1978-07-01 00:00:00

abstract：:ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. Inhibition of histone deacetylase 6 (HDAC6) suppresses the growth of ARID1A...

journal_title：Cancer research

authors： Fukumoto T,Fatkhutdinov N,Zundell JA,Tcyganov EN,Nacarelli T,Karakashev S,Wu S,Liu Q,Gabrilovich DI,Zhang R

更新日期：2019-11-01 00:00:00

abstract：:Tumor antigen-induced inhibition of leukocyte adherence was adapted and modified for use in glass test tubes for the study of cell-mediated antitumor immunity to human adenocarcinoma of the breast. Peripheral blood leukocytes from 40 to 47 patients with proven breast cancer responded to an antigenic extract of breast ...

journal_title：Cancer research

authors： Grosser N,Thomson DM

更新日期：1975-09-01 00:00:00

abstract：:Allelic loss of chromosome region 3p21.3 occurs early and frequently in non-small-cell lung cancer, and numerous tumor suppressor genes at this locus may be targets of inactivation. Using an incident case series study of non-small-cell lung cancer, we sought to determine the prevalence of loss of heterozygosity (LOH) ...

journal_title：Cancer research

authors： Marsit CJ,Hasegawa M,Hirao T,Kim DH,Aldape K,Hinds PW,Wiencke JK,Nelson HH,Kelsey KT

更新日期：2004-12-01 00:00:00

abstract：:Mitochondrial dysfunctions are frequently reported in cancer cells, but their direct involvement in tumorigenesis remains unclear. To understand this relation, we stimulated mitochondrial activity by overexpression of the mitochondrial triiodothyronine receptor (p43) in human dermal fibroblasts. In all clones, this st...

journal_title：Cancer research

authors： Grandemange S,Seyer P,Carazo A,Bécuwe P,Pessemesse L,Busson M,Marsac C,Roger P,Casas F,Cabello G,Wrutniak-Cabello C

更新日期：2005-05-15 00:00:00

abstract：:The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismatches that occur at ...

journal_title：Cancer research

authors： Turner DP,Cortellino S,Schupp JE,Caretti E,Loh T,Kinsella TJ,Bellacosa A

更新日期：2006-08-01 00:00:00

abstract：:Increased protein expression of the G1 cyclins D1 and E is reported in invasive non-small cell lung carcinoma. However, during transformation of the bronchial epithelium, overexpression of these species occurs, and their relationship to aberrant expression of p53 and retinoblastoma (Rb) has not been described previous...

journal_title：Cancer research

authors： Lonardo F,Rusch V,Langenfeld J,Dmitrovsky E,Klimstra DS

更新日期：1999-05-15 00:00:00

abstract：:The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Pla...

journal_title：Cancer research

authors： Leyva A,van Groeningen CJ,Kraal I,Gall H,Peters GJ,Lankelma J,Pinedo HM

更新日期：1984-12-01 00:00:00

abstract：:Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host and consequently to allow for high levels of long-term, donor-type engraftment after bone marrow transplantation (BMT). Such a property...

journal_title：Cancer research

authors： Westerhof GR,Ploemacher RE,Boudewijn A,Blokland I,Dillingh JH,McGown AT,Hadfield JA,Dawson MJ,Down JD

更新日期：2000-10-01 00:00:00

abstract：:The presence of specific antitumor immunity was examined by the tube leukocyte adherence inhibition (LAI) assay in patients with carcinomas of the larynx. Peripheral blood leukocytes (PBL) from patients with larynx cancer gave positive reactions in the LAI assay with the antigen prepared from the carcinoma of the lary...

journal_title：Cancer research

authors： Holán V,Síbl O,Hasek M

更新日期：1979-02-01 00:00:00

abstract：:The evidence for tumor suppressor genes at 8p is well supported by many somatic deletion studies and genetic linkage studies. However, it remains a challenge to pinpoint the tumor suppressor genes at 8p primarily because the implicated regions are broad. In this study, we attempted to narrow down the implicated region...

journal_title：Cancer research

authors： Chang BL,Liu W,Sun J,Dimitrov L,Li T,Turner AR,Zheng SL,Isaacs WB,Xu J

更新日期：2007-05-01 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) are activated simultaneously under a variety of stress conditions. They also share several common signaling pathways for their activation in response to cytokines or growth factors. Recent studies, however, demonstrated a new form of interplay bet...

journal_title：Cancer research

authors： Zhang Y,Chen F

更新日期：2004-03-15 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00

abstract：:Endocrine therapies effectively improve the outcomes of patients with estrogen receptor (ER)-positive breast cancer. However, the emergence of drug-resistant tumors creates a core clinical challenge. In breast cancer cells rendered resistant to the antiestrogen fulvestrant, we defined causative mechanistic roles for t...

journal_title：Cancer research

authors： Shibata T,Watari K,Izumi H,Kawahara A,Hattori S,Fukumitsu C,Murakami Y,Takahashi R,Toh U,Ito KI,Ohdo S,Tanaka M,Kage M,Kuwano M,Ono M

更新日期：2017-01-15 00:00:00

abstract：:Treatment of non-T/non-B human leukemic cell line REH with 5 X 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) at 37 degrees resulted in their adherence to culture flasks by 24 to 36 hr and, after 72 hr, the entire surface of the flask/coverslips became covered with macrophage-like cells containing pseudopodia. Wr...

journal_title：Cancer research

authors： Srivastava BI,Koga M,Srivastava P

更新日期：1984-07-01 00:00:00

abstract：:Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug resistance (MDR) in cancer is a major challenge for microtubule inhibitors in their clinical implementation. From a high-throughput drug screen using cells transformed by oncogenic RAS, we ident...

journal_title：Cancer research

authors： Ning N,Yu Y,Wu M,Zhang R,Zhang T,Zhu C,Huang L,Yun CH,Benes CH,Zhang J,Deng X,Chen Q,Ren R

更新日期：2018-10-15 00:00:00

abstract：:A synergistic interaction of Bcl-2 and c-Myc plays a role in lymphomagenesis in mice and in some patients as well. Progression of follicular lymphoma to a more aggressive lymphoma is seen in the majority of patients, and approximately 10% of the transformed lymphomas have a translocation of c-myc in addition to the tr...

journal_title：Cancer research

authors： Arcinas M,Heckman CA,Mehew JW,Boxer LM

更新日期：2001-07-01 00:00:00

abstract：:Inactivation of p53 by human papillomavirus 16/18 E6 plays a crucial role in cervical tumorigenesis. To investigate the involvement of HPV16/18 in lung tumorigenesis, the association between HPV16 or HPV18 E6 and p53 protein expression in 122 lung tumors was evaluated by immunohistochemistry, and data showed that HPV1...

journal_title：Cancer research

authors： Cheng YW,Wu MF,Wang J,Yeh KT,Goan YG,Chiou HL,Chen CY,Lee H

更新日期：2007-11-15 00:00:00

abstract：:DNA topoisomerase I (topo I) has been identified as a principal target of a plant alkaloid camptothecin (CPT) and its derivative (CPT-11). The latter compound is expected to be a clinically useful antitumor agent. Three human tumor cell lines resistant to CPT (A549/CPT, HT-29/CPT, St-4/CPT) were isolated in vitro, and...

journal_title：Cancer research

authors： Sugimoto Y,Tsukahara S,Oh-hara T,Isoe T,Tsuruo T

更新日期：1990-11-01 00:00:00

abstract：:We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determ...

journal_title：Cancer research

authors： Russell JS,Raju U,Gumin GJ,Lang FF,Wilson DR,Huet T,Tofilon PJ

更新日期：2002-04-15 00:00:00

abstract：:p53 is regulated at multiple levels. We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. These drugs reduced the basal levels of p53 protein at nanomolar concentrations in a dose-, time-, and cancer ...

journal_title：Cancer research

authors： Wang Z,Zheng M,Li Z,Li R,Jia L,Xiong X,Southall N,Wang S,Xia M,Austin CP,Zheng W,Xie Z,Sun Y

更新日期：2009-08-15 00:00:00

abstract：:Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors might contribute to the process of tumor promoter-induced transformation. To establish a stable reporter cell system, two report...

journal_title：Cancer research

authors： Li JJ,Westergaard C,Ghosh P,Colburn NH

更新日期：1997-08-15 00:00:00

abstract：:CD99 is a Mr 32,000 transmembrane molecule that shows a high level of expression on cells of the hemopoietic system as well as on Ewing tumor cells. Within the hematopoietic system, CD99 has been implicated in cell adhesion and cell death, participating in this way in the differentiation of T-cell precursors. In this ...

journal_title：Cancer research

authors： Scotlandi K,Baldini N,Cerisano V,Manara MC,Benini S,Serra M,Lollini PL,Nanni P,Nicoletti G,Bernard G,Bernard A,Picci P

更新日期：2000-09-15 00:00:00

abstract：:Previous data on the effects of a single dose of hydroxyurea on C3H mouse duodenum and mammary tumors from a fast growing line (S102F) were used to predict times that may be optimal (i.e., minimize killing of the duodenal S-phase cells while enhancing the killing of tumor S-phase cells) for the administration of subse...

journal_title：Cancer research

authors： Dethlefsen LA,Sorensen SP,Riley RM

更新日期：1975-03-01 00:00:00