Abstract：
:Benzo(a)pyrene and 210Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic interaction between the two agents appeared to occur when benzo(a)pyrene exposure followed 4 months after 210Po exposure. Most of this effect could be ascribed, however, to a potentiating effect of subsequent 0.9% NaCl solution instillations on 210Po carcinogenesis. These results emphasize the fact that seemingly innocuous stimuli may significantly potentiate lung carcinogenesis. The implications of these findings in terms of the interactions between alpha-radiation and cigarette smoke in human populations are discussed.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Little JB,McGandy RB,Kennedy ARsubject
Has Abstractpub_date
1978-07-01 00:00:00pages
1929-35issue
7eissn
0008-5472issn
1538-7445journal_volume
38pub_type
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