Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.

abstract：:This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single ...

journal_title：Cancer research

authors： Brunner TB,Hahn SM,Gupta AK,Muschel RJ,McKenna WG,Bernhard EJ

更新日期：2003-09-15 00:00:00

abstract：:Twenty-eight patients with metastatic malignant melanoma received anti-p97 murine monoclonal antibody (96.5) infused over 2 h at doses between 1 and 20 mg coupled to either 2.5 or 5.0 mCi of 111In by the bifunctional chelating agent diethyltriaminepentaacetic acid. Clearance of 111In from plasma closely fit an open, o...

journal_title：Cancer research

authors： Rosenblum MG,Murray JL,Haynie TP,Glenn HJ,Jahns MF,Benjamin RS,Frincke JM,Carlo DJ,Hersh EM

更新日期：1985-05-01 00:00:00

abstract：:Aryl hydrocarbon hydroxylase (AHH) and microsomal cytochromes were measured in tissues of human features aborted by prostaglandins. Cytochrome P-450 concentrations and AHH activity were about 4 times higher in adrenal glands than in liver. AHH was present in testes, ovaries, and vagina and uterus at levels equal to or...

journal_title：Cancer research

authors： Rifkind AB,Tseng L,Hirsch MB,Lauersen NH

更新日期：1978-06-01 00:00:00

abstract：:ABBV-075 is a potent and selective BET family bromodomain inhibitor that recently entered phase I clinical trials. Comprehensive preclinical characterization of ABBV-075 demonstrated broad activity across cell lines and tumor models, representing a variety of hematologic malignancies and solid tumor indications. In mo...

journal_title：Cancer research

authors： Bui MH,Lin X,Albert DH,Li L,Lam LT,Faivre EJ,Warder SE,Huang X,Wilcox D,Donawho CK,Sheppard GS,Wang L,Fidanze S,Pratt JK,Liu D,Hasvold L,Uziel T,Lu X,Kohlhapp F,Fang G,Elmore SW,Rosenberg SH,McDaniel KF,Kati

更新日期：2017-06-01 00:00:00

abstract：:The induction of phase 2 detoxifying enzymes, such as UDP-glucuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione), provides an effective means of protection against a variety of carcinogens. Transcription fa...

journal_title：Cancer research

authors： Iida K,Itoh K,Kumagai Y,Oyasu R,Hattori K,Kawai K,Shimazui T,Akaza H,Yamamoto M

更新日期：2004-09-15 00:00:00

abstract：:Breast tumor cytosol has been analyzed for the presence of a progesterone-binding protein (PBCP), commonly present in benign breast cysts in huge concentrations. In 377 primary carcinoma investigated PBCP was present in measurable quantities in 60.7% using "rocket" immunoelectrophoresis. Concentrations of PBCP ranged ...

journal_title：Cancer research

authors： Lea OA,Kvinnsland S,Thorsen T

更新日期：1987-12-01 00:00:00

abstract：:The anticancer effects of red wine have attracted considerable attention. Resveratrol (3,5,4'-trihydroxy-trans -stilbene) is a well-known polyphenolic compound of red wine with cancer chemopreventive activity. However, the basis for this activity is unclear. We studied leukotriene A(4) hydrolase (LTA(4)H) as a relevan...

journal_title：Cancer research

authors： Oi N,Jeong CH,Nadas J,Cho YY,Pugliese A,Bode AM,Dong Z

更新日期：2010-12-01 00:00:00

abstract：:Alterations in the expression of the epidermal growth factor (EGF) receptor ErbB family are frequently encountered in a number of human cancers. Two of these receptors, ErbB3 and ErbB4, are known to bind a family of related proteins termed heregulins (HRGs) or neu differentiation factors. In biologically relevant syst...

journal_title：Cancer research

authors： Lewis GD,Lofgren JA,McMurtrey AE,Nuijens A,Fendly BM,Bauer KD,Sliwkowski MX

更新日期：1996-03-15 00:00:00

abstract：:O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the...

journal_title：Cancer research

authors： Crone TM,Goodtzova K,Edara S,Pegg AE

更新日期：1994-12-01 00:00:00

abstract：:The long-standing strategy for the treatment of metastatic prostate cancer has been to reduce androgenic stimulation of tumor growth by removal of the testes, the primary site of testosterone synthesis. However, a low level of androgenic stimulation may continue, even after castration, by the conversion of adrenal and...

journal_title：Cancer research

authors： Klus GT,Nakamura J,Li JS,Ling YZ,Son C,Kemppainen JA,Wilson EM,Brodie AM

更新日期：1996-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranea...

journal_title：Cancer research

authors： Zhang S,Phelan CM,Zhang P,Rousseau F,Ghadirian P,Robidoux A,Foulkes W,Hamel N,McCready D,Trudeau M,Lynch H,Horsman D,De Matsuda ML,Aziz Z,Gomes M,Costa MM,Liede A,Poll A,Sun P,Narod SA

更新日期：2008-04-01 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00

abstract：:Endocannabinoids have been implicated in cancer. Increasing endogenous 2-arachidonoylglycerol (2-AG) by blocking its metabolism inhibits invasion of androgen-independent prostate cancer (PC-3 and DU-145) cells. Noladin ether (a stable 2-AG analog) and exogenous CB1 receptor agonists possess similar effects. Conversely...

journal_title：Cancer research

authors： Nithipatikom K,Endsley MP,Isbell MA,Falck JR,Iwamoto Y,Hillard CJ,Campbell WB

更新日期：2004-12-15 00:00:00

abstract：:Polymeric interstitial chemotherapy increases survival of humans with recurrent gliomas and animals with transplanted tumors in the brain, but the relationship between rates of drug release from polymer implants and drug concentration in brain tissue is unknown. This work presents a pharmacokinetic framework for appli...

journal_title：Cancer research

authors： Fung LK,Ewend MG,Sills A,Sipos EP,Thompson R,Watts M,Colvin OM,Brem H,Saltzman WM

更新日期：1998-02-15 00:00:00

abstract：:S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was shown to provide marked protection against development of radiation-induced leg contractures in C3Hf/Kam mice whose legs were exposed to single doses of gamma-radiation. The radiation doses ranged from 3300 to 6200 rads delivered to the right hind thighs ...

journal_title：Cancer research

authors： Hunter N,Milas L

更新日期：1983-04-01 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:We have demonstrated the intracellular expression of sex hormone-binding globulin (SHBG) exon VII splicing variant mRNA in human uterine endometrial cancer using the reverse transcription-PCR-Southern blot and DNA sequencing analyses. Analysis of the missing base pairs proved that they corresponded to the entire exon ...

journal_title：Cancer research

authors： Misao R,Nakanishi Y,Fujimoto J,Tamaya T

更新日期：1997-12-15 00:00:00

abstract：:We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). Because colorectal metastasis to the lun...

journal_title：Cancer research

authors： Banerjee D,Gorlick R,Liefshitz A,Danenberg K,Danenberg PC,Danenberg PV,Klimstra D,Jhanwar S,Cordon-Cardo C,Fong Y,Kemeny N,Bertino JR

更新日期：2000-05-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). Nevertheless, most individuals infected with HTLV-1 do not develop ATL. To attempt to identify genetic factors promoting the progression to ATL, we investigated in HTLV-1 carriers the relationship between ...

journal_title：Cancer research

authors： Tsukasaki K,Miller CW,Kubota T,Takeuchi S,Fujimoto T,Ikeda S,Tomonaga M,Koeffler HP

更新日期：2001-05-01 00:00:00

abstract：:Although the aromatase inhibitor anastrozole has been shown to be very effective in the treatment of hormone-dependent postmenopausal breast cancer, some patients with advanced disease will develop resistance to treatment. To investigate therapeutic strategies to overcome resistance to anastrozole treatment, we have u...

journal_title：Cancer research

authors： Macedo LF,Sabnis GJ,Goloubeva OG,Brodie A

更新日期：2008-05-01 00:00:00

abstract：:Liver X receptors function as central transcriptional regulators for lipid homeostasis, for which agonists have been developed as potential drugs for treatment of cardiovascular diseases and metabolic syndromes. Because dysregulation of lipid metabolism has been implicated in sex hormone-dependent cancers, we investig...

journal_title：Cancer research

authors： Fukuchi J,Kokontis JM,Hiipakka RA,Chuu CP,Liao S

更新日期：2004-11-01 00:00:00

abstract：:Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive. In this study, we uncover distinct and novel functions for these kinases in regulating tumor formation and metastatic coloniza...

journal_title：Cancer research

authors： Dai M,Boudreault J,Wang N,Poulet S,Daliah G,Yan G,Moamer A,Burgos SA,Sabri S,Ali S,Lebrun JJ

更新日期：2020-12-28 00:00:00

abstract：:The platelet-derived endothelial cell growth factor (PD-ECGF) level was significantly (P < 0.05) increased in 8 of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the eight patients with high PD-ECGF (>10,000 pg/mg protein) in metastatic lymph node lesions was extremely poor. On the othe...

journal_title：Cancer research

authors： Fujimoto J,Sakaguchi H,Hirose R,Wen H,Tamaya T

更新日期：1999-07-01 00:00:00

abstract：:Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote anisotropic fiber orientation, tw...

journal_title：Cancer research

authors： Stanisavljevic J,Loubat-Casanovas J,Herrera M,Luque T,Peña R,Lluch A,Albanell J,Bonilla F,Rovira A,Peña C,Navajas D,Rojo F,García de Herreros A,Baulida J

更新日期：2015-01-15 00:00:00

abstract：:We have screened 57 cases of primary, nonfunctional, pituitary adenomas for loss of heterozygosity of markers on chromosome 9p. Using a panel of 11 microsatellite markers, we found hemizygous deletion with at least one of the markers in 18 tumors (31.5%). The frequency of loss was similar in both noninvasive (8 of 26;...

journal_title：Cancer research

authors： Farrell WE,Simpson DJ,Bicknell JE,Talbot AJ,Bates AS,Clayton RN

更新日期：1997-07-01 00:00:00

abstract：:The interactions of tumorigenic cells with the extracellular matrix play a critical role in the establishment of metastases. Thrombospondin (TSP) is prominent at sites of tissue injury and promotes the attachment, spreading, and motility of several cell types. We have investigated the relationship between human carcin...

journal_title：Cancer research

authors： Yabkowitz R,Mansfield PJ,Dixit VM,Suchard SJ

更新日期：1993-01-15 00:00:00

abstract：:A number of studies have shown that the extracellular pH (pHe) in cancers is typically lower than that in normal tissue and that an acidic pHe promotes invasive tumor growth in primary and metastatic cancers. Here, we investigate the hypothesis that increased systemic concentrations of pH buffers reduce intratumoral a...

journal_title：Cancer research

authors： Silva AS,Yunes JA,Gillies RJ,Gatenby RA

更新日期：2009-03-15 00:00:00

abstract：:Aromatase plays a critical role in breast cancer development by converting androgen to estrogen. In this report, results are presented to demonstrate that estrogen, the product of aromatase, can up-regulate its expression. Estrogen receptor (ER) transient transfection experiments were performed using the SK-BR-3 breas...

journal_title：Cancer research

authors： Kinoshita Y,Chen S

更新日期：2003-07-01 00:00:00