Abstract:
:This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single or combined agents in preclinical studies stands in contrast with only moderate effects in clinical Phase II-III trials. These results reveal a substantial gap in the understanding of the complex activity of FTIs and their interactions with cytotoxic agents. We conclude that the rational combination of FTIs with other therapies, taking into account the biological activities of the individual agents, may improve the clinical results obtained with FTIs.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Brunner TB,Hahn SM,Gupta AK,Muschel RJ,McKenna WG,Bernhard EJsubject
Has Abstractpub_date
2003-09-15 00:00:00pages
5656-68issue
18eissn
0008-5472issn
1538-7445journal_volume
63pub_type
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