Different ionic forms of estrogen receptor in rat uterus and human breast carcinoma.

abstract：:Autologous hematopoietic stem cell transplantation after myelosuppressive chemotherapy is used for the treatment of high-risk breast cancer and other solid tumors. However, contamination of the autologous graft with tumor cells may adversely affect outcomes. Human hematopoietic bone marrow cells are resistant to herpe...

journal_title：Cancer research

authors： Wu A,Mazumder A,Martuza RL,Liu X,Thein M,Meehan KR,Rabkin SD

更新日期：2001-04-01 00:00:00

abstract：:Human breast cancer (HBC) cell growth suppression by okadaic acid (OA) was previously found to involve elevated expression of oncogenes c-myc and c-fos and apoptosis. Since, c-Myc influences diverse pathways of cell growth, we hypothesized that elevated levels of c-Myc are involved in HBC growth suppression. Here, we ...

journal_title：Cancer research

authors： Zhang L,Wali A,Ramana CV,Rishi AK

更新日期：2007-11-01 00:00:00

abstract：:The influences of pure human pluripotent colony-stimulating factor, highly purified pluripoietin alpha, pure recombinant human tumor necrosis factor alpha, pure recombinant human gamma-interferon, and natural prostaglandin E1 (PGE1) were evaluated on colony formation of multipotential and erythroid progenitor cells in...

journal_title：Cancer research

authors： Lu L,Welte K,Gabrilove JL,Hangoc G,Bruno E,Hoffman R,Broxmeyer HE

更新日期：1986-09-01 00:00:00

abstract：:To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes includ...

journal_title：Cancer research

authors： Kadota M,Sato M,Duncan B,Ooshima A,Yang HH,Diaz-Meyer N,Gere S,Kageyama S,Fukuoka J,Nagata T,Tsukada K,Dunn BK,Wakefield LM,Lee MP

更新日期：2009-09-15 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:The radionuclide of choice for use in diagnosis in most nuclear medicine diagnostic procedures is 99mTc. It is important, therefore, to establish whether there is potential clinical efficacy of an antitumor antigen directed monoclonal antibody labeled with 99mTc. We have investigated the potential use of a 99mTc label...

journal_title：Cancer research

authors： Brown BA,Dearborn CB,Drozynski CA,Sands H

更新日期：1990-02-01 00:00:00

abstract：:Antineoplastic drug resistance is a major obstacle to improved treatment of most adult cancers in humans. Novobiocin, an antibacterial agent which inhibits the eukaryotic topoisomerase II enzyme, increases the cytotoxicity of several alkylating agents in vitro by the formation of lethal DNA-DNA interstrand cross-links...

journal_title：Cancer research

authors： Eder JP,Wheeler CA,Teicher BA,Schnipper LE

更新日期：1991-01-15 00:00:00

abstract：:Defective repair of sunlight-induced DNA photodamage, coupled with an unusually high occurrence of multiple primary basal cell carcinomas (BCCs), is the major characteristic of xeroderma pigmentosum. Our recent work has indicated that this etiological paradigm may apply to skin cancer patients without an apparent here...

journal_title：Cancer research

authors： Wei Q,Matanoski GM,Farmer ER,Hedayati MA,Grossman L

更新日期：1994-01-15 00:00:00

abstract：:Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells roll on E-selectin(+) BMEC through E-selectin ligand-binding interactions under shear flow, and prostate cancer cells ex...

journal_title：Cancer research

authors： Barthel SR,Hays DL,Yazawa EM,Opperman M,Walley KC,Nimrichter L,Burdick MM,Gillard BM,Moser MT,Pantel K,Foster BA,Pienta KJ,Dimitroff CJ

更新日期：2013-01-15 00:00:00

abstract：:We have shown that a mutant derivative of Chinese hamster ovary CHO-K1 cells, ADR-5, which shows hypersensitivity to topoisomerase II (topo II)-inhibitory drugs, is cross-sensitive to the site-selective cyclic AMP analogue 8-chloro-cyclic AMP. We tested the hypothesis that overexpression of the type I alpha regulatory...

journal_title：Cancer research

authors： North PS,Davies SL,Ciardiello F,Damiano V,Bianco C,Pepe S,Bianco AR,Harris AL,Hickson ID,Tortora G

更新日期：1994-08-01 00:00:00

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:The effects of various forms of tocopherol (vitamin E) on the growth and differentiation of mouse melanoma (B-16) and mouse fibroblast (L-cells) cells in culture were studied. D-alpha-tocopherol acid succinate induced morphological alterations and growth inhibition in melanoma cells. When vitamin E acid succinate was ...

journal_title：Cancer research

authors： Prasad KN,Edwards-Prasad J

更新日期：1982-02-01 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:The effects of N-5-dimethyl-9-(2-methoxy-4-methylsulfonylamino)-phenylamino-4- acridinecarboxamide (CI-921; NSC 343499), a lipophilic and water-soluble derivative of amsacrine (NSC 249992), on cell viability, growth, clonogenicity, and progression through the cell cycle were investigated in suspension cultures of Frie...

journal_title：Cancer research

authors： Traganos F,Bueti C,Darzynkiewicz Z,Melamed MR

更新日期：1987-01-15 00:00:00

abstract：:Lipid peroxidation is considered a unifying mechanistic pathway through which known risk factors induce renal cell carcinoma (RCC). We hypothesized that genes selected a priori for their role in lipid peroxidation would modify cancer risk. We genotyped 635 single nucleotide polymorphisms (SNP) in 38candidate genes in ...

journal_title：Cancer research

authors： Moore LE,Brennan P,Karami S,Menashe I,Berndt SI,Dong LM,Meisner A,Yeager M,Chanock S,Colt J,Schwartz K,Davis F,Zaridze D,Mattveev V,Janout V,Kollarova H,Bencko V,Navratilova M,Szeszenia-Dabrowska N,Mates D,Holcato

更新日期：2009-10-15 00:00:00

abstract：:The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of mitochondrial fission factor (MFF1 and MFF2), a molecule that controls mitochondrial size and shape, that is, mitochondrial dynamics, were overexpressed in pa...

journal_title：Cancer research

authors： Seo JH,Chae YC,Kossenkov AV,Lee YG,Tang HY,Agarwal E,Gabrilovich DI,Languino LR,Speicher DW,Shastrula PK,Storaci AM,Ferrero S,Gaudioso G,Caroli M,Tosi D,Giroda M,Vaira V,Rebecca VW,Herlyn M,Xiao M,Fingerman D,Ma

更新日期：2019-12-15 00:00:00

abstract：:Several in vitro cell systems were exposed to hematoporphyrin derivative (HPD): established lines of rat kangaroo epithelial kidney; normal mouse embryonic fibroblasts; and differentiated neonatal rat myocardial cells. The uptake of HPD (25 to 100 micrograms/ml) by individual cells occurred rapidly over a 2-hr period ...

journal_title：Cancer research

authors： Berns MW,Dahlman A,Johnson FM,Burns R,Sperling D,Guiltinan M,Siemens A,Walter R,Wright W,Hammer-Wilson M,Wile A

更新日期：1982-06-01 00:00:00

abstract：:Increasing evidence argues that the success of an anticancer treatment may rely on immunoadjuvant side effects including the induction of immunogenic tumor cell death. Based on the assumption that this death mechanism is a similar prerequisite for the efficacy of an active immunotherapy using killed tumor cells, we ex...

journal_title：Cancer research

authors： Zappasodi R,Pupa SM,Ghedini GC,Bongarzone I,Magni M,Cabras AD,Colombo MP,Carlo-Stella C,Gianni AM,Di Nicola M

更新日期：2010-11-15 00:00:00

abstract：:O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the...

journal_title：Cancer research

authors： Crone TM,Goodtzova K,Edara S,Pegg AE

更新日期：1994-12-01 00:00:00

abstract：:A modified method was developed for measuring the frequency of variant erythrocytes at the glycophorin A locus using a single beam cell sorter (SBS). Fluorescein- or phycoerythrin-labeled monoclonal antibodies specific for the M or N glycophorin A alleles were used for the SBS assay. To prevent contamination of nuclea...

journal_title：Cancer research

authors： Kyoizumi S,Nakamura N,Hakoda M,Awa AA,Bean MA,Jensen RH,Akiyama M

更新日期：1989-02-01 00:00:00

abstract：:The tumor suppressor gene p53 regulates G1 checkpoint prior to the initiation of DNA synthesis, which can either induce G1 arrest or signal apoptosis. The involvement of p53 in apoptosis may also be related to its ability to down-regulate transcription of the bcl-2 gene. The bcl-2 gene product prevents most types of a...

journal_title：Cancer research

authors： Upadhyay S,Li G,Liu H,Chen YQ,Sarkar FH,Kim HR

更新日期：1995-10-15 00:00:00

abstract：:Protection of spermatogenesis from cytotoxic drug-induced damage has been investigated in the rat. Complete germinal aplasia was observed at 8 and 11 weeks after four doses of procarbazine hydrochloride administered weekly (150 mg/kg, first dose; 100 mg/kg, 3 subsequent doses). Pretreatment of rats for 6 weeks plus co...

journal_title：Cancer research

authors： Delic JI,Bush C,Peckham MJ

更新日期：1986-04-01 00:00:00

abstract：:The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma family of proteins in 235 specimens of lung cancer show the tightest inverse association between the histological grading in the most aggressive tum...

journal_title：Cancer research

authors： Claudio PP,Howard CM,Pacilio C,Cinti C,Romano G,Minimo C,Maraldi NM,Minna JD,Gelbert L,Leoncini L,Tosi GM,Hicheli P,Caputi M,Giordano GG,Giordano A

更新日期：2000-01-15 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:Many tumors contain extensive regions of hypoxia. Because hypoxic cells are markedly more resistant to killing by radiation, repeated attempts have been made to improve the oxygenation of tumors to enhance radiotherapy. We have studied the oxygenation of tumor xenografts in nude mice after treatment with the farnesylt...

journal_title：Cancer research

authors： Cohen-Jonathan E,Evans SM,Koch CJ,Muschel RJ,McKenna WG,Wu J,Bernhard EJ

更新日期：2001-03-01 00:00:00

abstract：:Reduced expression of neural cell adhesion molecule (NCAM) has been implicated in the progression to tumor malignancy in cancer patients. Previously, we have shown that the loss of NCAM function causes the formation of lymph node metastasis in a transgenic mouse model of pancreatic beta cell carcinogenesis (Rip1Tag2)....

journal_title：Cancer research

authors： Crnic I,Strittmatter K,Cavallaro U,Kopfstein L,Jussila L,Alitalo K,Christofori G

更新日期：2004-12-01 00:00:00

abstract：:During a 2-yr study of carcinogenesis by CdCl2 in male Wistar [Crl:(WI)BR] rats, weekly clinical observations during the last 6 mo of the study revealed many cases of persistent tumor-like masses at the site of the metal identification tags in the ears of the animals. A total of 14 tumors (mostly compound osteosarcoma...

journal_title：Cancer research

authors： Waalkes MP,Rehm S,Kasprzak KS,Issaq HJ

更新日期：1987-05-01 00:00:00

abstract：:Tumor-initiating properties of complete carcinogens such as 7,12-dimethylbenz(a)anthracene (DMBA) are well known but not the mechanism of DMBA-mediated tumor promotion. Our hypothesis is that interleukin (IL)-1alpha, an early proinflammatory cytokine that initiates a cascade of other cytokines and growth factors, is u...

journal_title：Cancer research

authors： Li X,Eckard J,Shah R,Malluck C,Frenkel K

更新日期：2002-01-15 00:00:00

abstract：:Loss of von Hippel-Lindau (VHL) gene function leads to VHL disease, which is characterized by vascular tumors of the central nervous system, renal clear cell carcinomas, and pheochromocytomas. Pheochromocytomas express high levels of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. PC...

journal_title：Cancer research

authors： Bauer AL,Paulding WR,Striet JB,Schnell PO,Czyzyk-Krzeska MF

更新日期：2002-03-15 00:00:00

abstract：:Multiple myeloma is a B-cell malignancy characterized by the uncontrolled growth of plasma cells in the bone marrow and the development of osteolytic bone disease. Myeloma cells express the receptor activator of nuclear factor kappaB ligand (RANKL), induce RANKL expression in the bone marrow, and down-regulate express...

journal_title：Cancer research

authors： Heath DJ,Vanderkerken K,Cheng X,Gallagher O,Prideaux M,Murali R,Croucher PI

更新日期：2007-01-01 00:00:00