Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture.

abstract：:The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the a...

journal_title：Cancer research

authors： Martinez I,Dimaio D

更新日期：2011-08-15 00:00:00

abstract：:Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented the stratification of patient populations who are most likely to benef...

journal_title：Cancer research

authors： Wu X,Yeerna H,Goto Y,Ando T,Wu VH,Zhang X,Wang Z,Amornphimoltham P,Murphy AN,Tamayo P,Chen Q,Lippman SM,Gutkind JS

更新日期：2019-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression correlates with microvessel density, stage, malignant ascites, metastasis, and survival in ovarian cancer. By transducing VEGF165 into a nontumorigenic rat ovarian surface epithelial cell line (ROSE199), we investigated the direct effect of an angiogenic phenotype o...

journal_title：Cancer research

authors： Schumacher JJ,Dings RP,Cosin J,Subramanian IV,Auersperg N,Ramakrishnan S

更新日期：2007-04-15 00:00:00

abstract：:The numbers of ultraviolet light (UV)-induced pyrimidine dimers in the DNA of neonatal BALB/c mouse skin were measured by assessing the sensitivity of the DNA to Micrococcus luteus UV endonuclease. Irradiation of neonatal BALB/c mice with FS40 sunlamps caused a dose-dependent induction of endonuclease-sensitive sites ...

journal_title：Cancer research

authors： Ananthaswamy HN,Fisher MS

更新日期：1981-05-01 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function of inflammation. TAM in established tumors generally have an M2 phenotype with defective production of interleukin-12 (IL-12) and high IL-10. Here, we report that defective responsiveness of ...

journal_title：Cancer research

authors： Saccani A,Schioppa T,Porta C,Biswas SK,Nebuloni M,Vago L,Bottazzi B,Colombo MP,Mantovani A,Sica A

更新日期：2006-12-01 00:00:00

abstract：:The deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene on chromosome 18q21, encodes a neural cell adhesion molecule family protein that is most highly expressed in the nervous system. To address the hypothesis that DCC may play a role in glioma development and/or progression, we examined DCC ex...

journal_title：Cancer research

authors： Reyes-Mugica M,Rieger-Christ K,Ohgaki H,Ekstrand BC,Helie M,Kleinman G,Yahanda A,Fearon ER,Kleihues P,Reale MA

更新日期：1997-02-01 00:00:00

abstract：:Calyculin A, isolated from a marine sponge, has a novel spiro ketal skeleton. Structurally unrelated to okadaic acid, calyculin A bound to the okadaic acid receptors in particulate and soluble fractions of mouse skin. The biochemical and tumor-promoting activities of calyculin A were studied with those of okadaic acid...

journal_title：Cancer research

authors： Suganuma M,Fujiki H,Furuya-Suguri H,Yoshizawa S,Yasumoto S,Kato Y,Fusetani N,Sugimura T

更新日期：1990-06-15 00:00:00

abstract：:Approximately one third of breast cancers grow independently of estrogen, lack detectable estrogen receptor (ER) protein, and rarely respond to hormonal treatment. Previous studies correlated the lack of ER gene expression in ER-negative breast tumor cells with hypermethylation of a CpG island in the 5' region of the ...

journal_title：Cancer research

authors： Ferguson AT,Lapidus RG,Baylin SB,Davidson NE

更新日期：1995-06-01 00:00:00

abstract：:In a hospital-based case-control study of 124 (105 male and 19 female) histologically confirmed malignant mesothelioma cases and age- and sex-matched controls, the role of cigarette smoking and the risk of asbestos exposure was investigated. Exposure to asbestos for at least 1 year was likely for 78% of male cases and...

journal_title：Cancer research

authors： Muscat JE,Wynder EL

更新日期：1991-05-01 00:00:00

abstract：:The aim of this investigation was to corroborate the relationship between DNA ploidy and chromosomal variation in surgically removed colorectal cancers. For 101 specimens from 21 advanced colorectal cancers, the numerical variations in chromosomes 7, 17, and 18 among cells were measured by fluorescence in situ hybridi...

journal_title：Cancer research

authors： Miyazaki M,Furuya T,Shiraki A,Sato T,Oga A,Sasaki K

更新日期：1999-10-15 00:00:00

abstract：:Effective radiation treatment of thoracic tumors is often limited by radiosensitivity of surrounding tissues. Several experimental studies have suggested variations in radiosensitivity of different pulmonary regions. Mice and rat studies in part contradict each other and urge for a more detailed analysis. This study w...

journal_title：Cancer research

authors： Novakova-Jiresova A,van Luijk P,van Goor H,Kampinga HH,Coppes RP

更新日期：2005-05-01 00:00:00

abstract：:The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murine and human intestinal cancers. Usp28 was previously shown to interact with its...

journal_title：Cancer research

authors： Diefenbacher ME,Chakraborty A,Blake SM,Mitter R,Popov N,Eilers M,Behrens A

更新日期：2015-04-01 00:00:00

abstract：:Ligand-induced activation of peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits proliferation in cancer cells in vitro and in vivo; however, the downstream targets remain undefined. We report the identification of a peroxisome proliferator response element in the promoter region of the Na(+)/H(+) tr...

journal_title：Cancer research

authors： Kumar AP,Quake AL,Chang MK,Zhou T,Lim KS,Singh R,Hewitt RE,Salto-Tellez M,Pervaiz S,Clément MV

更新日期：2009-11-15 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its injury of cells and induction of diarrhea, without reducing its antitumor activity, was investigated in rats. Oxonic acid was found to inhibit the phosphorylation of 5-FU to 5-fluorouridine...

journal_title：Cancer research

authors： Shirasaka T,Shimamoto Y,Fukushima M

更新日期：1993-09-01 00:00:00

abstract：:The first recombinant endostatin that elicited strong antitumor activity was expressed in Escherichia coli and administered as a suspension. Under these conditions, the protein retained its full antiangiogenic activity. Lack of requirement for a folded structure prompted us to investigate antitumor properties of synth...

journal_title：Cancer research

authors： Tjin Tham Sjin RM,Satchi-Fainaro R,Birsner AE,Ramanujam VM,Folkman J,Javaherian K

更新日期：2005-05-01 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigen expression in neuroblastoma may play a role in the oncogenicity of this embryonal tumor of childhood. Since N-myc amplification in neuroblastoma tumors is associated with rapid tumor progression (33) and N-myc decreases Class I MHC antigen expression in rat neurob...

journal_title：Cancer research

authors： Cooper MJ,Hutchins GM,Mennie RJ,Israel MA

更新日期：1990-06-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) promotes a multitude of diverse biological processes, including growth arrest of epithelial cells and proliferation of fibroblasts. Although the TGF-beta signaling pathways that promote inhibition of epithelial cell growth are well characterized, less is known about the mecha...

journal_title：Cancer research

authors： Rahimi RA,Andrianifahanana M,Wilkes MC,Edens M,Kottom TJ,Blenis J,Leof EB

更新日期：2009-01-01 00:00:00

abstract：:Neoplastic transformation mediated by ras oncogenes is associated with down-regulation of gene expression. We have constructed a subtracted complementary DNA library from preneoplastic rat 208F fibroblasts by hybridizing with mRNA from a ras-transformed subclone. One of the complementary DNA clones identified by this ...

journal_title：Cancer research

authors： Hajnal A,Klemenz R,Schäfer R

更新日期：1993-10-01 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00

abstract：:Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, th...

journal_title：Cancer research

authors： Shachaf CM,Felsher DW

更新日期：2005-06-01 00:00:00

abstract：:Pleural fluid from a child previously treated for rhabdomyosarcoma produced colonies in vitro. Cells from these colonies appeared to have the light and electron microscopic appearance of rhabdomyosarcoma cells. In this case, the malignant nature of the effusion had been suspected because of the patient's previous hist...

journal_title：Cancer research

authors： Altman AJ,Crussi FG,Rierden WJ,Baehner RL

更新日期：1975-07-01 00:00:00

abstract：:The pharmacokinetics of N-nitrosodimethylamine was studied in patas monkeys following i.v. doses of 0.5, 1.0, and 5.0 mg/kg and a p.o. dose of 1.0 mg/kg, and in Swiss mice at i.v. doses of 1.0 and 2.0 mg/kg. In the patas monkey the pharmacokinetics was linear over the i.v. dose range studied. The mean clearance (Cl), ...

journal_title：Cancer research

authors： Gombar CT,Harrington GW,Pylypiw HM Jr,Anderson LM,Palmer AE,Rice JM,Magee PN,Burak ES

更新日期：1990-07-15 00:00:00

abstract：:The MRP (multidrug resistance protein) gene, a member of the ubiquitous superfamily of ATP-binding cassette transporters, is associated with the multidrug resistance of mammalian cells to natural product anticancer agents. We have previously shown that abrogation of MRP expression by gene targeting leads to hypersensi...

journal_title：Cancer research

authors： Rappa G,Lorico A,Flavell RA,Sartorelli AC

更新日期：1997-12-01 00:00:00

abstract：:Cloned cell lines derived from the androgen-responsive Shionogi 115 mouse mammary carcinoma, when cultured in the presence of 3.5 X 10(-8) M testosterone, retain their responsiveness to testosterone and 5alpha-dihydrotestosterone and exhibit fibroblast-like morphology; their growth is poorly regulated by cell density....

journal_title：Cancer research

authors： Yates J,King RJ

更新日期：1978-11-01 00:00:00

abstract：:: TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here, we investigate the expression of TRIM29 in cutaneous head and neck squam...

journal_title：Cancer research

authors： Yanagi T,Watanabe M,Hata H,Kitamura S,Imafuku K,Yanagi H,Homma A,Wang L,Takahashi H,Shimizu H,Hatakeyama S

更新日期：2018-12-15 00:00:00

abstract：:Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMCs), and SMC-derived extracellular matrix. Tests of the relative effec...

journal_title：Cancer research

authors： Bogenmann E,Mark C,Isaacs H,Neustein HB,De Clerck YA,Laug WE,Jones PA

更新日期：1983-03-01 00:00:00

abstract：:Viral vectors for cancer can be classified into those that do not replicate (replication-defective vectors) and those that selectively replicate in neoplastic cells (replication-conditional or oncolytic vectors). Both of these can deliver anticancer cDNAs for therapeutic purposes. Opposite hypotheses can be made regar...

journal_title：Cancer research

authors： Ichikawa T,Chiocca EA

更新日期：2001-07-15 00:00:00