Beta 2-microglobulin expression in human embryonal neuroblastoma reflects its developmental regulation.

abstract：:Alkaline phosphatase was extracted from human gastric carcinoma cells (KMK-2) under long-term culture, and its biochemical and biological properties were investigated. The enzyme was extremely heat labile and was inhibited significantly by L-homoarginine, but only slightly by L-phenylalanine, so that it was classified...

journal_title：Cancer research

authors： Tokumitsu SI,Tokumitsu K,Kohnoe K,Takeuchi T

更新日期：1979-11-01 00:00:00

abstract：:This work confirms the previous observation that a single application of N-hydroxy-2-fluorenylacetamide or N-hydroxy-3-fluorenylacetamide to the mammary gland of the rat induced a high incidence of tumors, whereas the corresponding arylamides, N-2-fluorenylacetamide (2-FAA) and N-3-fluorenylacetamide, were only weakly...

journal_title：Cancer research

authors： Malejka-Giganti D,Rydell RE,Gutmann HR

更新日期：1977-01-01 00:00:00

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:3,4-Dihydro-2,2-dimethyl-2H-naptho[1,2,-b]pyran-5,6-dione (beta-lapachone) is a novel DNA repair inhibitor. It was tested for synergistic X-ray-induced lethality in combination with several halogenated pyrimidine radiosensitizers. Logarithmic-phase growing human epidermoid laryngeal carcinoma (HEp-2) cells were allowe...

journal_title：Cancer research

authors： Boothman DA,Greer S,Pardee AB

更新日期：1987-10-15 00:00:00

abstract：:Mammary tumor induction was examined in female Fischer rats fed a low-corn oil, a high-corn oil, a high-lard, a high-beef tallow, or a high-coconut oil diet since weaning. The diets were prepared by adding the experimental fat to a basal diet containing sufficient essential fatty acids for growth. These diets differed...

journal_title：Cancer research

authors： Chan PC,Ferguson KA,Dao TL

更新日期：1983-03-01 00:00:00

abstract：:A crucial ingredient of any hyperthermia procedure is the accurate measurement of achieved temperature. In this paper, we present some accuracy and resolution suggestions and address the problem of temperature measurements when electromagnetic energy is used as the mode of heating. In such cases, conventional metallic...

journal_title：Cancer research

authors： Christensen DA

更新日期：1979-06-01 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:Vaccine strategies for treatment of human papillomavirus-induced cervical cancer are based on either the recombinant E7 fusion oncoprotein or E7 CTL peptides. The therapeutic potential of the E7-based vaccine depends on the use of different adjuvants. In this study, we describe for the first time the expression of the...

journal_title：Cancer research

authors： Franconi R,Di Bonito P,Dibello F,Accardi L,Muller A,Cirilli A,Simeone P,Donà MG,Venuti A,Giorgi C

更新日期：2002-07-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) kinase 4 (MKK4) is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins. The MKK4 protein has been implicated in activation of JNK1 and p38 MAPK on phosphorylation by conserved kinase pathways. A recent report on the deletion and mutat...

journal_title：Cancer research

authors： Su GH,Hilgers W,Shekher MC,Tang DJ,Yeo CJ,Hruban RH,Kern SE

更新日期：1998-06-01 00:00:00

abstract：:Several properties of four 1-deaza-7,8-dihydropteridines were compared with those of each other and with those of colchicine, nocodazole, podophyllotoxin, and vincristine. Compound NSC 370147 was more active than the other compounds of this type with respect to inhibition of proliferation of cultured L1210 cells and t...

journal_title：Cancer research

authors： Bowdon BJ,Waud WR,Wheeler GP,Hain R,Dansby L,Temple C Jr

更新日期：1987-03-15 00:00:00

abstract：:In order to examine the effects of the overexpression of c-erbB-2 (HER-2, neu) on human bronchial epithelial cells, a human c-erbB-2 expression vector was introduced into the simian virus 40 large T-antigen-immortalized human bronchial epithelial cell line BEAS-2B. Isolation of multiple clonal cell lines after selecti...

journal_title：Cancer research

authors： Noguchi M,Murakami M,Bennett W,Lupu R,Hui F Jr,Harris CC,Gerwin BI

更新日期：1993-05-01 00:00:00

abstract：:Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endotheli...

journal_title：Cancer research

authors： Ngwa VM,Edwards DN,Philip M,Chen J

更新日期：2019-08-15 00:00:00

abstract：:Cyclophosphamide treatment of adult male rats leads to sustained decreases in several liver microsomal cytochrome P450 (CYP) activities, including CYP 2C11-catalyzed cyclophosphamide activation, via a process that is associated with a feminization of the overall pattern of liver enzyme expression (G. A. LeBlanc and D....

journal_title：Cancer research

authors： Chang TK,Waxman DJ

更新日期：1993-06-01 00:00:00

abstract：:Cell aggregation is frequently impaired during the growth of primary tumors and the formation of metastatic lesions. Cell aggregation depends on cell-cell adhesion; however, no rigorous approach exists to monitor and quantify it accurately in the absence of the confounding factors of cell-substrate adhesion and the re...

journal_title：Cancer research

authors： Saias L,Gomes A,Cazales M,Ducommun B,Lobjois V

更新日期：2015-06-15 00:00:00

abstract：:Accumulation of sulfolipids associated with elevated levels of glycolipid sulfotransferase activities has previously been demonstrated in renal cell carcinoma cells. To investigate the role of protein kinase C in the synthesis of sulfolipids, the effects of 12-O-tetradecanoylphorbol-13-acetate and protein kinase C inh...

journal_title：Cancer research

authors： Kobayashi T,Honke K,Gasa S,Sugiura M,Miyazaki T,Ishizuka I,Makita A

更新日期：1993-06-01 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:Nur77 is a steroid orphan receptor that plays a critical role in regulating proliferation, differentiation, and apoptosis, including acting as a switch for Bcl-2 function. We previously reported that the octaketide cytosporone B (Csn-B) is a natural agonist for Nur77. In this study, we synthesized a series of Csn-B an...

journal_title：Cancer research

authors： Liu JJ,Zeng HN,Zhang LR,Zhan YY,Chen Y,Wang Y,Wang J,Xiang SH,Liu WJ,Wang WJ,Chen HZ,Shen YM,Su WJ,Huang PQ,Zhang HK,Wu Q

更新日期：2010-05-01 00:00:00

abstract：:The Th2 cytokines interleukin (IL)-4 and -13 are acknowledged regulators of lymphocyte proliferation and activation. They have also been well studied in the regulation of various myeloid-derived populations in tumor biology. It has become clear, however, that both cytokines can have direct effects on epithelial tumor ...

journal_title：Cancer research

authors： Hallett MA,Venmar KT,Fingleton B

更新日期：2012-12-15 00:00:00

abstract：:Interleukin-6 (IL-6) and the subsequent Janus-activated kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of multiple myeloma. Here, we compared the sensitivity and specificity of a novel pan-JAK inhibitor, tetracyclic pyridone 6 (P6), with that of AG490 in a panel of myeloma-derived c...

journal_title：Cancer research

authors： Pedranzini L,Dechow T,Berishaj M,Comenzo R,Zhou P,Azare J,Bornmann W,Bromberg J

更新日期：2006-10-01 00:00:00

abstract：:The expression of human leukocyte antigen (HLA) class I alleles was analyzed in 65 renal cell carcinomas using one-dimensional isoelectric focusing. Normal organ tissue and peripheral blood lymphocytes were used as controls. The patients were serologically typed using the standard microcytotoxicity test. Forty-two pat...

journal_title：Cancer research

authors： Luboldt HJ,Kubens BS,Rübben H,Grosse-Wilde H

更新日期：1996-02-15 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:A quantitative assessment of rate-limiting steps in metastasis has always been challenging because of the difficulty of detecting small tumor cell populations. We have developed a highly sensitive assay for monitoring the metastatic dissemination of human tumor cells in the chick embryo and used this assay to investig...

journal_title：Cancer research

authors： Zijlstra A,Mellor R,Panzarella G,Aimes RT,Hooper JD,Marchenko ND,Quigley JP

更新日期：2002-12-01 00:00:00

abstract：:It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs). ...

journal_title：Cancer research

authors： Song P,Sekhon HS,Jia Y,Keller JA,Blusztajn JK,Mark GP,Spindel ER

更新日期：2003-01-01 00:00:00

abstract：:The SMAD4 (DPC4) gene was initially isolated as a candidate tumor suppressor from the convergent site of homozygous deletions on 18q in a panel of pancreatic carcinoma cell lines. It encodes a common cytoplasmic signaling molecule shared by the transforming growth factor-beta, activin, and bone morphogenic pathways. W...

journal_title：Cancer research

authors： Takaku K,Miyoshi H,Matsunaga A,Oshima M,Sasaki N,Taketo MM

更新日期：1999-12-15 00:00:00

abstract：:We have examined three methods that may be useful for improving the therapeutic efficacy of antibody-targeted radionuclides. The principal limitation of radioimmunotherapy is myelotoxicity and thrombocytopenia. These are due mainly to the length of time the radioantibody remains in the blood. The clearance time of a r...

journal_title：Cancer research

authors： Sharkey RM,Blumenthal RD,Hansen HJ,Goldenberg DM

更新日期：1990-02-01 00:00:00

abstract：:The pattern of proliferation of epithelial cells in esophageal epithelium was studied by means of [3H]deoxythymidine labeling of esophageal epithelium in subjects from Huixian, Henan Province, China, a high-risk geographical region for esophageal cancer. Comparisons were made among patterns of cell proliferation obser...

journal_title：Cancer research

authors： Wang LD,Lipkin M,Qui SL,Yang GR,Yang CS,Newmark HL

更新日期：1990-05-01 00:00:00

abstract：:The cellular effects of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and N1,N8-bis(ethyl)spermidine (BES), an apparent regulator of the enzyme were compared in cultured L1210 cells. Unlike DFMO, BES has no direct inhibitory effect on ODC activity. Rather the polyamine analogue i...

journal_title：Cancer research

authors： Porter CW,Ganis B,Vinson T,Marton LJ,Kramer DL,Bergeron RJ

更新日期：1986-12-01 00:00:00

abstract：:Cancer-secreted, extracellular vesicle (EV)-encapsulated miRNAs enable cancer cells to communicate with each other and with noncancerous cells in tumor pathogenesis and response to therapies. Here, we show that treatment with a sublethal dose of chemotherapeutic agents induces breast cancer cells to secrete EV with th...

journal_title：Cancer research

authors： Shen M,Dong C,Ruan X,Yan W,Cao M,Pizzo D,Wu X,Yang L,Liu L,Ren X,Wang SE

更新日期：2019-07-15 00:00:00

abstract：:3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

journal_title：Cancer research

authors： Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

更新日期：1997-01-01 00:00:00

abstract：:We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. A...

journal_title：Cancer research

authors： Pospisil P,Wang K,Al Aowad AF,Iyer LK,Adelstein SJ,Kassis AI

更新日期：2007-03-01 00:00:00