Abstract：
:Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination of the immunoglobulin (IG) genes in B cells. It has recently been proposed that AID, as the newly identified DNA mutator in man, may be instrumental in initiation and progression of B-cell non-Hodgkin's lymphomas (B-NHL). We quantitatively measured, by real-time reverse-transcription PCR, expression of AID and of the error-prone DNA polymerase iota in normal B cells and a comprehensive panel of B-NHL entities. In pre- and postgerminal center (GC)-type B-NHLs like in normal naive and memory cells, AID did not exceed background levels. However, half of Burkitt lymphomas tested were found to express AID, at most at levels comparable with those found in normal GC B cells. Thirty percent of diffuse large B-cell lymphomas also transcribed AID, some at supraphysiological levels. Of follicular lymphoma cases, only 25% expressed significant amounts of AID. Moreover, within the group of GC-type B-NHLs, a statistically significant correlation between AID and polymerase iota expression was found. By contrast, we observed no correlation between AID expression and mutation load neither with the degree of intraclonal diversity of IG variable heavy chain genes. Interestingly, in two of seven follicular lymphomas with clinical and histological progression, selective outgrowth of AID-expressing clones occurred, suggestive for a role of the somatic diversification machinery in lymphoma transformation.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Smit LA,Bende RJ,Aten J,Guikema JE,Aarts WM,van Noesel CJsubject
Has Abstractpub_date
2003-07-15 00:00:00pages
3894-8issue
14eissn
0008-5472issn
1538-7445journal_volume
63pub_type
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