Role of the acetylation polymorphism in determining susceptibility of cultured rabbit hepatocytes to DNA damage by aromatic amines.

abstract：:Global blood flow (TBF), tumor vascular resistance, laser Doppler flow in superficial tumor areas, and mean arterial blood pressure were evaluated in rats bearing s.c. DS sarcomas. Measurements were performed before and after i.v. administration of rhTNF-alpha 2 or recombinant human lymphotoxin (rhLT) (1 mg/kg). Upon ...

journal_title：Cancer research

authors： Kluge M,Elger B,Engel T,Schaefer C,Seega J,Vaupel P

更新日期：1992-04-15 00:00:00

abstract：:The ErbB2 receptor tyrosine kinase is overexpressed in approximately 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2(+) breast cancer. We observe that LRIG1 protein levels are signific...

journal_title：Cancer research

authors： Miller JK,Shattuck DL,Ingalla EQ,Yen L,Borowsky AD,Young LJ,Cardiff RD,Carraway KL 3rd,Sweeney C

更新日期：2008-10-15 00:00:00

abstract：:Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid kinase balancing the intracellular level of key signaling sphingolipids, modulates the transcription factor hypoxia inducible factor 1alpha (HIF-1alpha), master regulator of hypoxia. SphK1 activity is stimulated under low oxygen ...

journal_title：Cancer research

authors： Ader I,Brizuela L,Bouquerel P,Malavaud B,Cuvillier O

更新日期：2008-10-15 00:00:00

abstract：:Overexpression of the nuclear phosphoprotein p53 is one of the most common abnormalities in primary human cancer and appears to be due to point mutation within a highly conserved region of the p53 gene which then encodes for a mutant, more stable protein. In this study different stages of breast cancer progression wer...

journal_title：Cancer research

authors： Davidoff AM,Kerns BJ,Iglehart JD,Marks JR

更新日期：1991-05-15 00:00:00

abstract：:Two newly synthesized nitrosoureido sugars have been evaluated for their antitumor activity and diabetogenic potential in a number of in vitro and in vivo preclinical tumor model systems. 2-Amino-2-deoxy-N'-methyl-N'-nitrosoureido-1,3,4,6-tetra-O-acetyl-alpha- D- mannopyranose (MAZ), a lipophilic mannosamine derivativ...

journal_title：Cancer research

authors： Bernacki RJ,Wilson GL,Mossman BT,Angelino N,Kanter PM,Korytnyk W

更新日期：1985-02-01 00:00:00

abstract：:The p75 and p110 isoforms of the CUX1 homeodomain protein are overexpressed in breast tumors and cancer cell lines. To assess and compare the ability of these short CUX1 isoforms in driving mammary tumor development, we used site-specific transgenesis into the Hprt locus to generate transgenic mice expressing p75 or p...

journal_title：Cancer research

authors： Cadieux C,Kedinger V,Yao L,Vadnais C,Drossos M,Paquet M,Nepveu A

更新日期：2009-09-15 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:Loss of expression of the apoptosis protease activator protein-1 (APAF-1) in human melanoma is thought to promote resistance to programmed cell death by preventing caspase-9 activation. However, the role of the APAF-1-dependent pathway in apoptosis activated by cellular stress and/or DNA damage has been recently quest...

journal_title：Cancer research

authors： Zanon M,Piris A,Bersani I,Vegetti C,Molla A,Scarito A,Anichini A

更新日期：2004-10-15 00:00:00

abstract：:Cytochromes P-450IIB1 and P-450IIB2 were recently shown to be inducible in rat hepatocyte cultures maintained on a reconstituted extracellular tumor matrix (Matrigel) as indicated by increases in P-450IIB1 and -IIB2 mRNAs and immunoreactive proteins (J. Cell. Physiol., 134: 309-323, 1988). Here we show that treatment ...

journal_title：Cancer research

authors： Sinclair PR,Bement WJ,Haugen SA,Sinclair JF,Guzelian PS

更新日期：1990-09-01 00:00:00

abstract：:Groups of 120 male and 120 female rats were exposed by inhalation to 0, 2, 6, or 15 ppm formaldehyde vapor 6 hr/day, 5 days/week, for 18 months of a 24-month study. The present communication describes interim findings based on data available after 18 months of exposure. Squamous cell carcinomas occurred in the nasal c...

journal_title：Cancer research

authors： Swenberg JA,Kerns WD,Mitchell RI,Gralla EJ,Pavkov KL

更新日期：1980-09-01 00:00:00

abstract：:Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas IR-A rather signals proliferative effects. IR-B is predominantly expressed in the adult liver. Here, we show that the alternative splicing of IR pre-mRNA is dysre...

journal_title：Cancer research

authors： Chettouh H,Fartoux L,Aoudjehane L,Wendum D,Clapéron A,Chrétien Y,Rey C,Scatton O,Soubrane O,Conti F,Praz F,Housset C,Rosmorduc O,Desbois-Mouthon C

更新日期：2013-07-01 00:00:00

abstract：:We review and compare statistical methods for the analysis of in vivo tumor growth experiments. The methods most commonly used are deficient in that they have either low power or misleading type I error rates. We propose a set of multivariate statistical modeling methods that correct these problems, illustrating their...

journal_title：Cancer research

authors： Heitjan DF,Manni A,Santen RJ

更新日期：1993-12-15 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:Solid human tumors and their surrounding microenvironment are hypothesized to coevolve in a manner that promotes tumor growth, invasiveness, and spread. Mouse models of cancer have focused on genetic changes in the epithelial tumor cells and therefore have not robustly tested this hypothesis. We have recently develope...

journal_title：Cancer research

authors： Wallace JA,Li F,Leone G,Ostrowski MC

更新日期：2011-02-15 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous melanin deposition, and increased risk of cancer, mainly in the gastrointestinal tract. We examined mutations of the LKB1, beta-catenin, APC, K-ras, and p53 genes in 27 gastrointestinal hamartomatous polyps f...

journal_title：Cancer research

authors： Miyaki M,Iijima T,Hosono K,Ishii R,Yasuno M,Mori T,Toi M,Hishima T,Shitara N,Tamura K,Utsunomiya J,Kobayashi N,Kuroki T,Iwama T

更新日期：2000-11-15 00:00:00

abstract：:PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of acute myelogenous leukemia (AML) and associated with poor survival. We found that stable expression of PRL-3 confers cytokine independence and growth advantage of AML cells. However, how PRL-3 mediates these functions in AML is not known. To ...

journal_title：Cancer research

authors： Chong PS,Zhou J,Cheong LL,Liu SC,Qian J,Guo T,Sze SK,Zeng Q,Chng WJ

更新日期：2014-06-01 00:00:00

abstract：:Members of the INK4 family of cyclin-dependent kinase (CDK) inhibitors specifically bind and inhibit the G1-specific CDK molecules CDK4 and CDK6. One of the INK4 molecules, p16, is also known as multiple tumor suppressor and has been found to be mutated or deleted in various tumors and cell lines. We have previously i...

journal_title：Cancer research

authors： Noh SJ,Li Y,Xiong Y,Guan KL

更新日期：1999-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of treatment with recombinant interleukin-2 (rIL-2) and lymphokine-activated killer cells in patients with advanced bladder cancer and to study the induced changes in the distribution of leukocyte subsets in blood and tumor. Nine patients with metastatic transitio...

journal_title：Cancer research

authors： Hermann GG,Geertsen PF,von der Maase H,Steven K,Andersen C,Hald T,Zeuthen J

更新日期：1992-02-01 00:00:00

abstract：:Effective radiation treatment of thoracic tumors is often limited by radiosensitivity of surrounding tissues. Several experimental studies have suggested variations in radiosensitivity of different pulmonary regions. Mice and rat studies in part contradict each other and urge for a more detailed analysis. This study w...

journal_title：Cancer research

authors： Novakova-Jiresova A,van Luijk P,van Goor H,Kampinga HH,Coppes RP

更新日期：2005-05-01 00:00:00

abstract：:CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Here we report that CD44 is a novel biomarker for non-small cell lung tumors, squamous metaplasia of the lung, and activated type II pneumocytes. We have examined the expression of CD44 in 12 human l...

journal_title：Cancer research

authors： Penno MB,August JT,Baylin SB,Mabry M,Linnoila RI,Lee VS,Croteau D,Yang XL,Rosada C

更新日期：1994-03-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:Macrophage migration inhibition responses of mice immunized with mutant polyoma viruses or with cells transformed and/or infected by them have been studied. The macrophage migration inhibition reaction revealed individual differences. In several cases, mice immunized with a mutant virus responded preferentially or exc...

journal_title：Cancer research

authors： Szigeti R,Dalianis T,Ramqvist T,Ito Y,Klein G

更新日期：1984-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to radiotherapy, chemotherapy, or a combination of these modalities, and surgery remains the only curative intervention for localized disease. Although cancer-associated fibroblasts (CAF) are abundant in PDAC tumors, the effects of radiotherapy on CAFs and th...

journal_title：Cancer research

authors： Pereira PMR,Edwards KJ,Mandleywala K,Carter LM,Escorcia FE,Campesato LF,Cornejo M,Abma L,Mohsen AA,Iacobuzio-Donahue CA,Merghoub T,Lewis JS

更新日期：2020-04-15 00:00:00

abstract：:In 1984, we reported that while immunoreactive levels of serum alpha-1 proteinase inhibitor (API) increased significantly in nine patients with advanced solid tumors, the functional activity of the inhibitor, as measured by the serum trypsin inhibitory capacity, did not increase proportionately. This suggested that a ...

journal_title：Cancer research

authors： Chawla RK,Lawson DH,Sarma PR,Nixon DW,Travis J

更新日期：1987-02-15 00:00:00

abstract：:Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CA...

journal_title：Cancer research

authors： Fultang L,Gamble LD,Gneo L,Berry AM,Egan SA,De Bie F,Yogev O,Eden GL,Booth S,Brownhill S,Vardon A,McConville CM,Cheng PN,Norris MD,Etchevers HC,Murray J,Ziegler DS,Chesler L,Schmidt R,Burchill SA,Haber M,De Sant

更新日期：2019-02-01 00:00:00

abstract：:Fluorescein-labeled dextrans (FITC-D) from 3 to 5000 kDa (Stokes' radii from 1 to 40 nm) were used to study influx from the plasma into the peritoneum and efflux from the peritoneal cavity into the plasma in normal and ascites tumor-bearing mice and in mice whose peritoneal vessels had been rendered hyperpermeable by ...

journal_title：Cancer research

authors： Nagy JA,Herzberg KT,Masse EM,Zientara GP,Dvorak HF

更新日期：1989-10-01 00:00:00

abstract：:The rate of repopulation of surviving cells increases during fractionated radiotherapy and limits the ability to control tumors. Repopulation is likely to be more important during the longer intervals between courses of chemotherapy and is a potential cause of clinical resistance to chemotherapy. To evaluate the rate ...

journal_title：Cancer research

authors： Wu L,Tannock IF

更新日期：2003-05-01 00:00:00

abstract：:Monoclonal antibodies (mabs) have considerable potential for specific cancer treatment. However, due to the antigen heterogeneity and especially the low uptake in solid tumors, mabs have not been used successfully in most clinical trials to date. This study investigates the effects of a mab-cobra venom factor (CVF) co...

journal_title：Cancer research

authors： Juhl H,Sievers M,Baltzer K,Helmig F,Wolf H,Brenner W,Kalthoff H

更新日期：1995-12-01 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. To explore the penetrance of p63 in bladder carcinogenesis, we performed expression and mutation analyses of two major isotypes, TAp63 and deltaNp63, in 63 bladder...

journal_title：Cancer research

authors： Park BJ,Lee SJ,Kim JI,Lee SJ,Lee CH,Chang SG,Park JH,Chi SG

更新日期：2000-07-01 00:00:00

abstract：:We examined several parameters of urine excretion during a two-year initiation-promotion experiment in male Fischer rats using four weeks of N-[4-(5-nitro-2-furyl)-2-thiazoly]formamide at 0.2% of the diet as the initiating agent and either 5% sodium saccharin or 2% L-tryptophan in the diet as promoting agents. Rats fe...

journal_title：Cancer research

authors： Demers DM,Fukushima S,Cohen SM

更新日期：1981-01-01 00:00:00