Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6.

abstract：:Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK), includ...

journal_title：Cancer research

authors： Leonard B,Brand TM,O'Keefe RA,Lee ED,Zeng Y,Kemmer JD,Li H,Grandis JR,Bhola NE

更新日期：2018-08-01 00:00:00

abstract：:Two human pancreatic cell lines, MIA PaCa 2 and Capan 2, were treated by photodynamic therapy in vitro with Photophrin (0.01-25 micrograms/ml; 24 h) and then light (1-50 J/cm2; lambda = 630 nm). The following model was fit to 6 datasets with weighted nonlinear regression: [sequence: see text] The symbols are: E, cell ...

journal_title：Cancer research

authors： Moesta KT,Greco WR,Nurse-Finlay SO,Parsons JC,Mang TS

更新日期：1995-07-15 00:00:00

abstract：:Thirty-seven consecutive patients with germ cell cancers (34 testicular, three extragonadal) and elevated serum levels of alpha-fetoprotein (AFP) and/or human chorionic gonadotropin (HCG) were treated with vinblastine, bleomycin, and cis-diamminedichloroplatinum induction chemotherapy. The AFP and/or HCG normalized in...

journal_title：Cancer research

authors： Vogelzang NJ,Lange PH,Goldman A,Vessela RH,Fraley EE,Kennedy BJ

更新日期：1982-11-01 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:In previous studies, we have demonstrated that transferrin-gallium inhibits cellular proliferation by a mechanism whereby cellular iron utilization is impaired. Since indium, a similar class 3A metal, has not been well studied, we examined its effects on cellular iron uptake and cellular proliferation. In these studie...

journal_title：Cancer research

authors： Moran PL,Seligman PA

更新日期：1989-08-01 00:00:00

abstract：:Human embryonic lung fibroblasts (F-136-35-56) capable of growing in medium containing DL-homocysteine instead of L-methionine and human acute lymphoblastic leukemia cells (CCRF-HSB-2) with absolute methionine requirement exhibited dose-dependent growth inhibition when semipurified L-methionine-degrading enzyme (L-met...

journal_title：Cancer research

authors： Kreis W,Baker A,Ryan V,Bertasso A

更新日期：1980-03-01 00:00:00

abstract：:A transplanted rat lymphosarcoma (SGT-4), induced by Gross virus and inoculated s.c. into the foot of a normal syngeneic rat, initially grew but ultimately regressed. The tumor cells metastasized to the regional popliteal, lumbar, and inguinal lymph nodes and formed massive metastatic foci there. These lymph node meta...

journal_title：Cancer research

authors： Kodama T,Gotohda E,Takeichi N,Kuzumaki N,Kobayashi H

更新日期：1975-07-01 00:00:00

abstract：:Resistance of tumors to irradiation or chemotherapeutic agents is thought to be one of the reasons why patients who present with early malignancies may not be cured. Much is now known about the molecular mechanisms that underlie drug resistance, but until recently little was known about genetic contributions to radiat...

journal_title：Cancer research

authors： McKenna WG,Weiss MC,Endlich B,Ling CC,Bakanauskas VJ,Kelsten ML,Muschel RJ

更新日期：1990-01-01 00:00:00

abstract：:Sensitivities to sister chromatid exchange (SCE) induction by chemicals of peripheral lymphocytes from 26 cancer patients were estimated under conditions identical to those for healthy humans which had been reported (Cancer Res., 43: 439-442, 1983). The sensitive individual was defined as one whose cells give a mean i...

journal_title：Cancer research

authors： Oikawa A,Horaguchi K,Sugawara R,Kikuchi J,Tohda H,Takahashi K,Wakui A,Yamauchi A,Nakada T

更新日期：1986-02-01 00:00:00

abstract：:The concentration of estrogenic, androgenic, progestational, and adrenocortical steroid hormones in body fluids of mature intact Sprague-Dawley female rats was increased by s.c. implantation of 5 to 7 mg NaCl pellets containing 1 to 20% steroid 48 hr before administration p.o. of either 7,12-dimethylbenz(a) anthracene...

journal_title：Cancer research

authors： Lemon HM

更新日期：1975-05-01 00:00:00

abstract：:Cardiotoxicity limits the use of anthracyclines which are potent anticancer agents. In the isolated rat heart, we investigated the mechanism of acute anthracycline cardiotoxicity and compared a new anthracycline, carminomycin, with daunomycin which is in established use. Daunomycin 1.75 X 10(-5) M produced a fall in c...

journal_title：Cancer research

authors： Saman S,Jacobs P,Opie LH

更新日期：1984-04-01 00:00:00

abstract：:The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor formation. Ribavirin administration blocked the growth of p...

journal_title：Cancer research

authors： Pettersson F,Del Rincon SV,Emond A,Huor B,Ngan E,Ng J,Dobocan MC,Siegel PM,Miller WH Jr

更新日期：2015-03-15 00:00:00

abstract：:Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory ...

journal_title：Cancer research

authors： Hosoi A,Takeda Y,Furuichi Y,Kurachi M,Kimura K,Maekawa R,Takatsu K,Kakimi K

更新日期：2008-05-15 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed "stromal cells") that can promote or inhibit tumorigenesis by mechanisms that have not been fully elucidated. Here, we postulated that stromal cells in the tumor microenv...

journal_title：Cancer research

authors： Zhong L,Roybal J,Chaerkady R,Zhang W,Choi K,Alvarez CA,Tran H,Creighton CJ,Yan S,Strieter RM,Pandey A,Kurie JM

更新日期：2008-09-01 00:00:00

abstract：:Aromatase, an endomembrane-bound cytochrome P450, is the key enzyme of estrogen biosynthesis. Aromatase inhibitors, therefore, are clinically important tools in the treatment of estrogen-dependent tumor growth. To improve the specificity of these tools, inhibition at the nucleic acid level was examined. An antisense o...

journal_title：Cancer research

authors： Ackermann K,Fauss J,Pyerin W

更新日期：1994-09-15 00:00:00

abstract：:Monoclonal antibodies (mAb) are widely used in the treatment of non-Hodgkin's lymphoma and autoimmune diseases. Although the mechanism of action in vivo is not always known, the therapeutic activity of several approved mAbs depends on the binding of the Fcgamma regions to low-affinity Fcgamma receptors (FcgammaR) expr...

journal_title：Cancer research

authors： Stavenhagen JB,Gorlatov S,Tuaillon N,Rankin CT,Li H,Burke S,Huang L,Vijh S,Johnson S,Bonvini E,Koenig S

更新日期：2007-09-15 00:00:00

abstract：:The phospholipids of both mitochondrial and microsomal membranes from normal liver, host liver, and Morris hepatoma 7777 were isolated, separated, and quantitated. The total as well as the individual fatty acid concentrations and compositions were determined. The total phosphlipids isolated from tumor mitochondria wer...

journal_title：Cancer research

authors： Reitz RC,Thompson JA,Morris HP

更新日期：1977-02-01 00:00:00

abstract：:DIS3-like 3'-5' exoribonuclease 2 (DIS3L2) degrades aberrant RNAs, however, its function in tumorigenesis remains largely unexplored. Here, aberrant DIS3L2 expression promoted human hepatocellular carcinoma (HCC) progression via heterogeneous nuclear ribonucleoproteins (hnRNP) U-mediated alternative splicing. DIS3L2 d...

journal_title：Cancer research

authors： Xing S,Li Z,Ma W,He X,Shen S,Wei H,Li ST,Shu Y,Sun L,Zhong X,Huangfu Y,Su L,Feng J,Zhang X,Gao P,Jia WD,Zhang H

更新日期：2019-10-01 00:00:00

abstract：:Phospholipase D (PLD) has emerged as a critical regulator of cell proliferation and survival signaling. We show for the first time that elevated expression of PLD isozymes attenuates expression of the tumor suppressors early growth response-1 (Egr-1) and the phosphatase and tensin homologue deleted on chromosome 10 (P...

journal_title：Cancer research

authors： Kim J,Lee YH,Kwon TK,Chang JS,Chung KC,Min DS

更新日期：2006-01-15 00:00:00

abstract：:DNA damage response (DDR) pathways maintain genomic stability. A 657del5 mutation of NBS1, a key DDR component, causing the rare cancer-predisposing Nijmegen breakage syndrome has been reported nearly exclusively in Slavic populations. In this study, we describe the first identification in a Japanese population of an ...

journal_title：Cancer research

authors： Ebi H,Matsuo K,Sugito N,Suzuki M,Osada H,Tajima K,Ueda R,Takahashi T

更新日期：2007-12-01 00:00:00

abstract：:Increased age is regularly linked with heightened cancer risk, but recent research suggests a flattening around age 80. We report that, independent of cancer site or time period, most incidence rates decrease in the more elderly and drop to or toward zero near the ceiling of human life span. For all major organ sites,...

journal_title：Cancer research

authors： Harding C,Pompei F,Lee EE,Wilson R

更新日期：2008-06-01 00:00:00

abstract：:Aberrant methylation of promoter CpG islands (CGI) is involved in silencing of tumor suppressor genes and is also a potential cancer biomarker. Here, to identify CGIs aberrantly methylated in human melanomas, we did a genome-wide search using methylation-sensitive representational difference analysis. CGIs in putative...

journal_title：Cancer research

authors： Furuta J,Nobeyama Y,Umebayashi Y,Otsuka F,Kikuchi K,Ushijima T

更新日期：2006-06-15 00:00:00

abstract：:Therapeutic strategies targeting DNA repair pathway defects have been widely explored, but often only benefit small numbers of patients. Here we characterized potential predictive biomarkers for treatment with AsiDNA, a novel first-in-class DNA repair inhibitor. We evaluated genetic instability and DNA repair defects ...

journal_title：Cancer research

authors： Jdey W,Thierry S,Popova T,Stern MH,Dutreix M

更新日期：2017-08-15 00:00:00

abstract：:We have shown that cyclophosphamide (CY) can augment the development of delayed-type hypersensitivity to a primary antigen in patients with advanced cancer. In the present study, we administered CY (1000 mg/sq m) to 19 patients with advanced, metastatic cancer and monitored the compositional and functional changes in ...

journal_title：Cancer research

authors： Berd D,Maguire HC Jr,Mastrangelo MJ

更新日期：1984-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the United States. The deoxynucleoside analogue gemcitabine is among the most effective therapies to treat PDAC, however, nearly all patients treated with gemcitabine either fail to respond or rapidly develop resistance. One hallmark of PDA...

journal_title：Cancer research

authors： Dalin S,Sullivan MR,Lau AN,Grauman-Boss B,Mueller HS,Kreidl E,Fenoglio S,Luengo A,Lees JA,Vander Heiden MG,Lauffenburger DA,Hemann MT

更新日期：2019-11-15 00:00:00

abstract：:A dose-response study was conducted in Fischer rats with nitrosodiethylamine, which was administered in regulated amounts as a solution in drinking water. Groups of 20 female rats each received a different treatment, one group consisted of 12 animals; one of the groups was untreated. The concentrations of the solution...

journal_title：Cancer research

authors： Lijinsky W,Reuber MD,Riggs CW

更新日期：1981-12-01 00:00:00

abstract：:The ability to modulate DNA repair has been proposed as an effective method to overcome cytotoxic drug resistance in human tumors. However, no studies have shown that it is possible to achieve modulation of DNA repair in humans in vivo. This study analyzes modulation of O6-alkylguanine-DNA alkyltransferase, a DNA repa...

journal_title：Cancer research

authors： Gerson SL

更新日期：1989-06-01 00:00:00

abstract：:3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

journal_title：Cancer research

authors： Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

更新日期：1997-01-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men in America. Currently, steroid receptor coactivators have been proposed to mediate the development and progression of prostate cancer, at times in a steroid-independent manner. Steroid receptor coactivator-3 (SRC-3, p/CIP, AIB1, ACTR, RAC3, and TRAM-1) is a member of th...

journal_title：Cancer research

authors： Zhou HJ,Yan J,Luo W,Ayala G,Lin SH,Erdem H,Ittmann M,Tsai SY,Tsai MJ

更新日期：2005-09-01 00:00:00

abstract：:To explore further the descriptive epidemiology of sarcomas of the uterus, we examined the distribution of marital status among 1479 white women diagnosed as having one of these tumors between January 1, 1973, and December 31, 1986, in 7 geographically defined areas of the United States. We estimated incidence rates b...

journal_title：Cancer research

authors： Schwartz SM,Weiss NS

更新日期：1990-03-15 00:00:00