Novel responses of peripheral lymphocytes of cancer patients to chemical induction of sister chromatid exchanges.

abstract：:Activated beta-catenin regulates the transcription of oncogenic target genes and is critical for tumorigenesis. Because nuclear functions are frequently coupled, we investigated whether it also has a role in alternative splicing of oncogenic genes. We showed that stabilized beta-catenin caused alternative splicing of ...

journal_title：Cancer research

authors： Lee HK,Choi YS,Park YA,Jeong S

更新日期：2006-11-01 00:00:00

abstract：:Bone marrow biopsy specimens from patients with myeloma were cultured in either 1 of 2 thin-film culture systems, a controlled environment steady state system or a rocker tube configuration of the system, for periods up to 42 days. Both functional and morphological characteristics of the myeloma cells were well-mainta...

journal_title：Cancer research

authors： Gailani S,McLimans WF,Mundy GR,Nussbaum A,Roholt O,Zeigel R

更新日期：1976-04-01 00:00:00

abstract：:The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating WOMEN FOR 40 DIFFERENT AND comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quant...

journal_title：Cancer research

authors： Buehring GC,Williams RR

更新日期：1976-10-01 00:00:00

abstract：:We examined mutations in BRAF exons 11 and 15 and N-RAS exons 2 and 3, in 77 metastatic melanoma cases and 11 melanoma cell lines. Significant differences in the mutation rates observed at different metastatic sites could not be detected. The most frequent mutation, the V599E amino acid substitution in BRAF exon 15, w...

journal_title：Cancer research

authors： Gorden A,Osman I,Gai W,He D,Huang W,Davidson A,Houghton AN,Busam K,Polsky D

更新日期：2003-07-15 00:00:00

abstract：:Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expression profiling of both mRNA and miRNAs in Wilms' tumor (WT) samples to provide the first evidence t...

journal_title：Cancer research

authors： Kort EJ,Farber L,Tretiakova M,Petillo D,Furge KA,Yang XJ,Cornelius A,Teh BT

更新日期：2008-06-01 00:00:00

abstract：:Identification of proteins that are involved in the sensitivity of radiotherapy of cancers is important to enhance the response to cancer treatment. Expression of TAp73 is associated with the sensitivity of radiotherapy in cervical cancer patients, suggesting it plays an important role in controlling radiosensitivity....

journal_title：Cancer research

authors： Leung TH,Ngan HY

更新日期：2010-08-15 00:00:00

abstract：:Fibroblast growth factor (FGF) 8, also known as androgen-induced growth factor, was originally isolated from an androgen-dependent mouse mammary Shionogi carcinoma SC-3 cell line, in which it was shown to have androgen-regulated properties. We previously demonstrated that Fgf 8 transcripts were detected in several hum...

journal_title：Cancer research

authors： Tanaka A,Furuya A,Yamasaki M,Hanai N,Kuriki K,Kamiakito T,Kobayashi Y,Yoshida H,Koike M,Fukayama M

更新日期：1998-05-15 00:00:00

abstract：:L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decreas...

journal_title：Cancer research

authors： Wang Q,Bailey CG,Ng C,Tiffen J,Thoeng A,Minhas V,Lehman ML,Hendy SC,Buchanan G,Nelson CC,Rasko JE,Holst J

更新日期：2011-12-15 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1alpha (HIF-1alpha) expression. We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signaling, on VEGF and HIF-1alpha expression and on angiogenesis, tu...

journal_title：Cancer research

authors： Pore N,Gupta AK,Cerniglia GJ,Jiang Z,Bernhard EJ,Evans SM,Koch CJ,Hahn SM,Maity A

更新日期：2006-09-15 00:00:00

abstract：:IFN regulatory factor 8 (IRF8) is a key transcription factor for myeloid cell differentiation and its expression is frequently lost in hematopoietic cells of human myeloid leukemia patients. IRF8-deficient mice exhibit uncontrolled clonal expansion of undifferentiated myeloid cells that can progress to a fatal blast c...

journal_title：Cancer research

authors： Hu X,Yang D,Zimmerman M,Liu F,Yang J,Kannan S,Burchert A,Szulc Z,Bielawska A,Ozato K,Bhalla K,Liu K

更新日期：2011-04-15 00:00:00

abstract：:Tn and sialylated Tn (sTn) are blood group-related epitopes expressed on mucins of colon carcinoma and other epithelial tumors and are, therefore, potential targets for immunological control. We have immunized 20 colorectal cancer patients at high risk for recurrence with a vaccine consisting of partially desialylated...

journal_title：Cancer research

authors： O'Boyle KP,Zamore R,Adluri S,Cohen A,Kemeny N,Welt S,Lloyd KO,Oettgen HF,Old LJ,Livingston PO

更新日期：1992-10-15 00:00:00

abstract：:Cells with a temperature-sensitive mutant of the v-abl oncoprotein (IC.DP) were treated with the anticancer drugs melphalan or hydroxyurea. At the restrictive temperature for v-ABL protein tyrosine kinase activity, drug-treated IC.DP cells died by apoptosis. In contrast, apoptotic cell death induced by either drug was...

journal_title：Cancer research

authors： Chapman RS,Whetton AD,Dive C

更新日期：1994-10-01 00:00:00

abstract：:Using 21 microsatellite polymorphic markers spanning both p and q arms, we have performed detailed deletion mapping on chromosome 9 in 18 primary nasopharyngeal carcinomas. All 18 tumors were informative at multiple loci. Eleven of the 18 cases (61%) demonstrated allelic deletion of chromosome 9. Among these 11, 6 cas...

journal_title：Cancer research

authors： Huang DP,Lo KW,van Hasselt CA,Woo JK,Choi PH,Leung SF,Cheung ST,Cairns P,Sidransky D,Lee JC

更新日期：1994-08-01 00:00:00

abstract：:Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chemistry-driven approach with the goal of designing and synthesizing nov...

journal_title：Cancer research

authors： Sekhar KR,Sonar VN,Muthusamy V,Sasi S,Laszlo A,Sawani J,Horikoshi N,Higashikubo R,Bristow RG,Borrelli MJ,Crooks PA,Lepock JR,Roti Roti JL,Freeman ML

更新日期：2007-01-15 00:00:00

abstract：:Melanoma incidence is increasing worldwide, and metastatic melanoma is almost completely resistant to every known therapy. New approaches to treating melanoma are urgently needed, and a greater understanding of the biology of melanoma invasion and metastasis will aid in their creation. A high proportion of invasive me...

journal_title：Cancer research

authors： Blackburn JS,Rhodes CH,Coon CI,Brinckerhoff CE

更新日期：2007-11-15 00:00:00

abstract：:nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellu...

journal_title：Cancer research

authors： Iizuka N,Oka M,Noma T,Nakazawa A,Hirose K,Suzuki T

更新日期：1995-02-01 00:00:00

abstract：:Communication between cancer cells and the tumor microenvironment results in the modulation of complex signaling networks that facilitate tumor progression. Here, we describe a new mechanism of intercellular communication originating from large oncosomes (LO), which are cancer cell-derived, atypically large (1-10 μm) ...

journal_title：Cancer research

authors： Minciacchi VR,Spinelli C,Reis-Sobreiro M,Cavallini L,You S,Zandian M,Li X,Mishra R,Chiarugi P,Adam RM,Posadas EM,Viglietto G,Freeman MR,Cocucci E,Bhowmick NA,Di Vizio D

更新日期：2017-05-01 00:00:00

abstract：:IgG polyclonal antiserum was generated in New Zealand White rabbits immunized with a 16-mer peptide consisting of a specific amino acid sequence at residues corresponding to the sixth to seventh predicted transmembrane domain of the human reduced folate carrier (RFC). Using Western immunoblotting to examine the cytoso...

journal_title：Cancer research

authors： Trippett TM,Garcia S,Manova K,Mody R,Cohen-Gould L,Flintoff W,Bertino JR

更新日期：2001-03-01 00:00:00

abstract：:Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

journal_title：Cancer research

authors： Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

更新日期：2018-02-01 00:00:00

abstract：:Leucine-rich repeat-containing 3B (LRRC3B) is an evolutionarily highly conserved leucine-rich repeat-containing protein, but its biological significance is unknown. Using restriction landmark genomic scanning and pyrosequencing, we found that the promoter region of LRRC3B was aberrantly methylated in gastric cancer. G...

journal_title：Cancer research

authors： Kim M,Kim JH,Jang HR,Kim HM,Lee CW,Noh SM,Song KS,Cho JS,Jeong HY,Hahn Y,Yeom YI,Yoo HS,Kim YS

更新日期：2008-09-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment and occurs through mechanistic mediators that remain unclear. Here, w...

journal_title：Cancer research

authors： Trillo-Tinoco J,Sierra RA,Mohamed E,Cao Y,de Mingo-Pulido Á,Gilvary DL,Anadon CM,Costich TL,Wei S,Flores ER,Ruffell B,Conejo-Garcia JR,Rodriguez PC

更新日期：2019-10-01 00:00:00

abstract：:TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor microenvironment. In the present study, we tested the hypothesis that TGF modulates ovarian cancer progression by modulating the contribution of cancer-associated fibroblasts...

journal_title：Cancer research

authors： Yeung TL,Leung CS,Wong KK,Samimi G,Thompson MS,Liu J,Zaid TM,Ghosh S,Birrer MJ,Mok SC

更新日期：2013-08-15 00:00:00

abstract：:The ability to modulate DNA repair has been proposed as an effective method to overcome cytotoxic drug resistance in human tumors. However, no studies have shown that it is possible to achieve modulation of DNA repair in humans in vivo. This study analyzes modulation of O6-alkylguanine-DNA alkyltransferase, a DNA repa...

journal_title：Cancer research

authors： Gerson SL

更新日期：1989-06-01 00:00:00

abstract：:Active-specific immunotherapy with dendritic cells loaded with peptide derived from the melanoma antigen, gp100, failed to mediate regression of established B16F10 melanoma in normal mice. Dendritic cell vaccination induced activation and subsequent deletion of adoptively transferred naive CD8+ T-cell receptor transge...

journal_title：Cancer research

authors： Wang LX,Li R,Yang G,Lim M,O'Hara A,Chu Y,Fox BA,Restifo NP,Urba WJ,Hu HM

更新日期：2005-11-15 00:00:00

abstract：:Cancer vaccines may have applications in the therapy and prevention of mammary carcinoma. To investigate such applications, we constructed a recombinant adenoviral vaccine expressing a kinase-inactive mutant form of human HER2 and introduced this into BALB/c wild-type (WT) or HER2 transgenic mice. Here, we report cont...

journal_title：Cancer research

authors： Triulzi C,Vertuani S,Curcio C,Antognoli A,Seibt J,Akusjärvi G,Wei WZ,Cavallo F,Kiessling R

更新日期：2010-10-01 00:00:00

abstract：:We have measured the 31P nuclear magnetic resonance spectra of EMT6/Ro multicellular tumor spheroids over a wide range of sizes under constant nutrient conditions which matched those used for culturing the spheroids. The amount of nucleotide triphosphate per cell decreased with spheroid growth, roughly in proportion t...

journal_title：Cancer research

authors： Freyer JP,Schor PL,Jarrett KA,Neeman M,Sillerud LO

更新日期：1991-08-01 00:00:00

abstract：:The effect of phenobarbital (PB) pretreatment of rats on both hepatic aflatoxin B1 (AFB1)-DNA binding and AFB1-glutathione (AFB1-SG) conjugation have been examined in studies in vivo and in vitro. Male Sprague-Dawley rats fed a commercial diet with 0.1% PB in their drinking water for 1 week had total wet liver weight ...

journal_title：Cancer research

authors： Lotlikar PD,Raj HG,Bohm LS,Ho LL,Jhee EC,Tsuji K,Gopalan P

更新日期：1989-02-15 00:00:00

abstract：:Two characteristics of immune responses to weakly immunogenic plasma cell tumors were demonstrated in this study. (a) Elevated lymphoproliferative responses following in vivo inoculation of sublethal doses of plasma cell tumors were detected by a mixed lymphocyte-tumor interaction (MLTI) assay. Specificity of elevated...

journal_title：Cancer research

authors： Boyer PJ,Fahey JL

更新日期：1976-04-01 00:00:00

abstract：:Lectin binding [concanavalin A, biotinylated ricinus communis agglutinin, and biotinylated succinylated wheat germ agglutinin (B-SWGA)] was used to detect the glycosylated proteins associated with a residual protein fraction [insoluble in 4% sodium dodecyl sulfate and termed the nuclear residual fraction (NRF)] or wit...

journal_title：Cancer research

authors： Burrus GR,Schmidt WN,Briggs JA,Hnilica LS,Briggs RC

更新日期：1988-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear receptor (NR) family of transcription factors with important regulatory roles in cellular growth, differentiation, and apoptosis. Using proteomic analysis, we showed expression of PPARgamma protein in a series of 260 newly diagnose...

journal_title：Cancer research

authors： Tsao T,Kornblau S,Safe S,Watt JC,Ruvolo V,Chen W,Qiu Y,Coombes KR,Ju Z,Abdelrahim M,Schober W,Ling X,Kardassis D,Meyer C,Schimmer A,Kantarjian H,Andreeff M,Konopleva M

更新日期：2010-06-15 00:00:00