Abstract：
:Estrogen-stimulated cell proliferation is thought to be mediated by the induction of growth-regulatory factors. Abnormal regulation of such factors may be associated with tumorigenesis. Two such factors, vascular endothelial growth factor and c-fos, are rapidly induced in the uterus by estrogens. We show that the induction of these transcripts by 17beta-estradiol or tamoxifen is selectively blocked by the pure antiestrogen ICI 182,780 in a dose-dependent manner. This indicates that induction of the two genes requires different levels of estrogen receptor or that their induction occurs by different mechanisms. This suggests that selective dose-dependent antagonism of estrogen-dependent transcription may be possible in target tissues and tumors.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Hyder SM,Chiappetta C,Murthy L,Stancel GMsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
2547-9issue
13eissn
0008-5472issn
1538-7445journal_volume
57pub_type
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