Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity.

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:KAI1 (CD82) belongs to the transmembrane 4 superfamily in which members have inhibitory effects on tumor cell motility and metastasis. During reverse transcription-PCR analysis, we found a splice variant of KAI1 (spliced-KAI1) in which exon 7 was deleted. This exon encodes the 28 amino acids that span from the distal ...

journal_title：Cancer research

authors： Lee JH,Seo YW,Park SR,Kim YJ,Kim KK

更新日期：2003-11-01 00:00:00

abstract：:R115777 [(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] is a potent and selective inhibitor of farnesyl protein transferase with significant antitumor effects in vivo subsequent to oral administration in mice. In vitro, using isolated human farnesyl prote...

journal_title：Cancer research

authors： End DW,Smets G,Todd AV,Applegate TL,Fuery CJ,Angibaud P,Venet M,Sanz G,Poignet H,Skrzat S,Devine A,Wouters W,Bowden C

更新日期：2001-01-01 00:00:00

abstract：:The cytotoxic activity against human tumor cells of toxic conjugates of Pseudomonas exotoxin with anti-transferrin receptor antibody or epidermal growth factor was potentiated up to 10 to 20-fold by the calcium antagonists verapamil, D-600, and diltiazem and by the lysosomotropic agent beta-glycylphenyl-naphthylamide....

journal_title：Cancer research

authors： Akiyama S,Seth P,Pirker R,FitzGerald D,Gottesman MM,Pastan I

更新日期：1985-03-01 00:00:00

abstract：:A common pathobiological feature of malignant gliomas is the insidious infiltration of single tumor cells into the brain parenchyma, rendering these deadly tumors virtually incurable with available therapies. In this study, we report that ADP-ribosylation factor 6 (ARF6), a Ras superfamily small GTPase, is abundantly ...

journal_title：Cancer research

authors： Hu B,Shi B,Jarzynka MJ,Yiin JJ,D'Souza-Schorey C,Cheng SY

更新日期：2009-02-01 00:00:00

abstract：:Xeroderma pigmentosum (XP) is a sun-sensitive, cancer-prone genetic disorder characterized by a defect in nucleotide excision repair. The human nucleotide excision repair and transcription gene ERCC2 is able to restore survival to normal levels after exposure to UV light in XP complementation group D cells. No enhance...

journal_title：Cancer research

authors： Takayama K,Salazar EP,Lehmann A,Stefanini M,Thompson LH,Weber CA

更新日期：1995-12-01 00:00:00

abstract：:The cytoskeleton, the shape, and the adhesion complexes of MCF-7 breast carcinoma cells have been studied by fluorescence, phase contrast, and interference reflection microscopy. Cells have been grown in media containing different concentrations of estrogen and with or without the addition of the antiestrogen tamoxife...

journal_title：Cancer research

authors： Sapino A,Pietribiasi F,Bussolati G,Marchisio PC

更新日期：1986-05-01 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:Meningiomas constitute the second most common central nervous system tumor, and yet relatively little is known about the molecular events that are important for the pathogenesis and malignant progression of these tumors. We have used serial analysis of gene expression to compare the transcriptomes of nonneoplastic men...

journal_title：Cancer research

authors： Cuevas IC,Slocum AL,Jun P,Costello JF,Bollen AW,Riggins GJ,McDermott MW,Lal A

更新日期：2005-06-15 00:00:00

abstract：:MLH1 is an integral part of the mismatch repair complex, and the loss of this protein is associated with the acquisition of a mutator phenotype, microsatellite instability, and a predisposition to cancer. Deficiencies in the mismatch repair complex, including the loss of MLH1, result in elevated resistance to specific...

journal_title：Cancer research

authors： Hardman RA,Afshari CA,Barrett JC

更新日期：2001-02-15 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer treatment. This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments for this drug toxicity. Int...

journal_title：Cancer research

authors： Smith JA,Benbow SJ

更新日期：2015-09-15 00:00:00

abstract：:Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors might contribute to the process of tumor promoter-induced transformation. To establish a stable reporter cell system, two report...

journal_title：Cancer research

authors： Li JJ,Westergaard C,Ghosh P,Colburn NH

更新日期：1997-08-15 00:00:00

abstract：:This report describes an early and direct action of oncogenic agents and its apparent consequences. Chemical carcinogen has been found to interact principally with a specific polypeptide in livers of normal rats. Short-term ingestion of carcinogen causes marked reductions in the concentrations of both the carcinogen:p...

journal_title：Cancer research

authors： Blackburn GR,Andrews JP,Rao KV,Sorof S

更新日期：1980-12-01 00:00:00

abstract：:The human papillomavirus type 16 (HPV-16), the type most often associated with cervical cancer, immortalizes primary keratinocytes and inhibits serum/calcium-stimulated differentiation in culture. In this study, we have used a model of keratinocyte immortalization based upon HPV-16 to analyze perturbation of function ...

journal_title：Cancer research

authors： Wilding J,Vousden KH,Soutter WP,McCrea PD,Del Buono R,Pignatelli M

更新日期：1996-11-15 00:00:00

abstract：:Variant cell lines that are sensitive to density-dependent inhibition of growth have been isolated from three of four SV40-transformed human fibroblast cell lines. Variants were isolated by plating the transformed cells at low density, by treating them with 5-fluorodeoxyuridine, or by growing them on glutaraldehyde-fi...

journal_title：Cancer research

authors： Rosenberg N,Schaeffer WI,Diamond L

更新日期：1975-08-01 00:00:00

abstract：:The anticancer effects of red wine have attracted considerable attention. Resveratrol (3,5,4'-trihydroxy-trans -stilbene) is a well-known polyphenolic compound of red wine with cancer chemopreventive activity. However, the basis for this activity is unclear. We studied leukotriene A(4) hydrolase (LTA(4)H) as a relevan...

journal_title：Cancer research

authors： Oi N,Jeong CH,Nadas J,Cho YY,Pugliese A,Bode AM,Dong Z

更新日期：2010-12-01 00:00:00

abstract：:Persistent bronchial dysplasia is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. In this study, we hypothesized that differences in gene expression profiles between persistent and regressive bronchial dysplasia would identify cellular processes that underlie progressio...

journal_title：Cancer research

authors： Merrick DT,Edwards MG,Franklin WA,Sugita M,Keith RL,Miller YE,Friedman MB,Dwyer-Nield LD,Tennis MA,O'Keefe MC,Donald EJ,Malloy JM,van Bokhoven A,Wilson S,Koch PJ,O'Shea C,Coldren C,Orlicky DJ,Lu X,Baron AE,Hickey

更新日期：2018-09-01 00:00:00

abstract：:Using in vitro double labeling with two different doses of [3H]thymidine, we measured the S-phase duration and the labeling index in biopsy samples taken from human rectal and colonic adenocarcinomas. Samples from the adjacent healthy mucosa, taken at the same time as the tumor samples, were simultaneously subjected t...

journal_title：Cancer research

authors： Bleiberg H,Galand P

更新日期：1976-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-C is a lymphangiogenic factor implicated in lymphatic metastasis. In this study, we investigated the role of the type I insulin-like growth factor receptor (IGF-IR) in the regulation of VEGF-C expression. We used Lewis lung carcinoma subline M-27 cells transfected with human I...

journal_title：Cancer research

authors： Tang Y,Zhang D,Fallavollita L,Brodt P

更新日期：2003-03-15 00:00:00

abstract：:Dendritic cells (DCs) need activation for the priming of antigen-specific immune responses. Recently activated DCs were described to prime in vitro strong T helper cell type 1 (Th(1)) responses, whereas at later time points, the same cells preferentially prime Th(2) cells [Langenkemp, A. et al., Nat. Immunol. 1: 311-3...

journal_title：Cancer research

authors： Camporeale A,Boni A,Iezzi G,Degl'Innocenti E,Grioni M,Mondino A,Bellone M

更新日期：2003-07-01 00:00:00

abstract：:The estimated growth rates for five lines of human fibroblasts (Human Genetic Mutant Cell Repository designations 0011, 2936B , 0038A , 2912A , and 3529), during the first few population doublings after establishment of the lines, were within the expected range, i.e., equivalent to doubling times from 16 to 28 hr, wit...

journal_title：Cancer research

authors： Tamm I,Kikuchi T,Wang E,Pfeffer LM

更新日期：1984-06-01 00:00:00

abstract：:DNA methylation patterns are established and maintained by three DNA methyltransferases (DNMT): DNMT1, DNMT3A, and DNMT3B. Although essential for development, methylation patterns are frequently disrupted in cancer and contribute directly to carcinogenesis. Recent studies linking polycomb group repression complexes (P...

journal_title：Cancer research

authors： Jin B,Yao B,Li JL,Fields CR,Delmas AL,Liu C,Robertson KD

更新日期：2009-09-15 00:00:00

abstract：:In vivo tumor cells interact with a variety of host cells such as endothelial cells and platelets, and these interactions are mediated by integrins GPIIb/IIIa and alphavbeta3. We used chimeric (c) 7E3 Fab (ReoPro) and murine (m) 7E3 F(ab')(2) to elucidate the role of these integrins in angiogenesis, tumor growth, and ...

journal_title：Cancer research

authors： Trikha M,Zhou Z,Timar J,Raso E,Kennel M,Emmell E,Nakada MT

更新日期：2002-05-15 00:00:00

abstract：:Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers. A buffer c...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1993-05-15 00:00:00

abstract：:Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). We found that loss of HPK1 protein expression correlated significantly with ...

journal_title：Cancer research

authors： Wang H,Song X,Logsdon C,Zhou G,Evans DB,Abbruzzese JL,Hamilton SR,Tan TH,Wang H

更新日期：2009-02-01 00:00:00

abstract：:In our previous studies carried out on inbred rats of the Sprague-Dawley strain (L. Gross and Y. Dreyfuss, Proc. Natl. Acad. Sci. USA, 76: 5910-5913, 1979), the tumor incidence was increased following irradiation (150 rads, 5 times, at weekly intervals), from 22 to 93% in females and from 5 to 59% in males. Experiment...

journal_title：Cancer research

authors： Gross L,Dreyfuss Y,Faraggiana T

更新日期：1988-05-01 00:00:00

abstract：:We have examined the properties of the estrogen receptor and progesterone receptor in MDA-MB-134 human breast cells and have evaluated the effects of estrogen on cell proliferation and progesterone receptor levels in these cells as indices of hormonal sensitivity. These cells contain high levels of estrogen receptor (...

journal_title：Cancer research

authors： Reiner GC,Katzenellenbogen BS

更新日期：1986-03-01 00:00:00

abstract：:Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty in efficient expansion in ex vivo culture. To resolve this issue, several groups have proposed that induced pluripotent stem cell technol...

journal_title：Cancer research

authors： Maeda T,Nagano S,Ichise H,Kataoka K,Yamada D,Ogawa S,Koseki H,Kitawaki T,Kadowaki N,Takaori-Kondo A,Masuda K,Kawamoto H

更新日期：2016-12-01 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:Treatment of non-T/non-B human leukemic cell line REH with 5 X 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) at 37 degrees resulted in their adherence to culture flasks by 24 to 36 hr and, after 72 hr, the entire surface of the flask/coverslips became covered with macrophage-like cells containing pseudopodia. Wr...

journal_title：Cancer research

authors： Srivastava BI,Koga M,Srivastava P

更新日期：1984-07-01 00:00:00