Potentiation of cytotoxic activity of immunotoxins on cultured human cells.

abstract：:Early growth-response (EGR) genes are nuclear transcription factors that are implicated in regulating cell proliferation. Because these genes show divergent expression in various human tumors, we sought to determine their expression in nonmalignant and malignant prostate tissues. Total RNA extracted from prostate tiss...

journal_title：Cancer research

authors： Eid MA,Kumar MV,Iczkowski KA,Bostwick DG,Tindall DJ

更新日期：1998-06-01 00:00:00

abstract：:Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence dise...

journal_title：Cancer research

authors： Yu KD,Huang AJ,Fan L,Li WF,Shao ZM

更新日期：2012-01-15 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00

abstract：:Activities of the adenine purine nucleotide cycle enzymes, i.e., adenylosuccinate (SAMP) synthetase, SAMP lyase, and adenosine 5'-monophosphate deaminse, were determined in hepatic tissue of rats fed and/or given injections of 3'-methyl-4-dimethylaminoazobenzene, 4'-methyl-4-dimethylaminoazobenzene, thioacetamide, eth...

journal_title：Cancer research

authors： Smith LD,Emerson RL,Nixon LK

更新日期：1979-06-01 00:00:00

abstract：:Two mutations of the ATM gene were recently suggested to confer breast cancer risks similar to mutations of BRCA1 or BRCA2. Here, we set out to confirm these findings in 961 families with non-BRCA1/BRCA2 breast cancer from diverse geographical regions. We did not detect the ATM 7271T-->G mutation in any family. The AT...

journal_title：Cancer research

authors： Szabo CI,Schutte M,Broeks A,Houwing-Duistermaat JJ,Thorstenson YR,Durocher F,Oldenburg RA,Wasielewski M,Odefrey F,Thompson D,Floore AN,Kraan J,Klijn JG,van den Ouweland AM,Wagner TM,Devilee P,Simard J,van 't Veer LJ,G

更新日期：2004-02-01 00:00:00

abstract：:Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may be correlated with tumor progression and/or poor clinical outcome. Therefore, neoplasias potentially sensitive to immunotherapy should be checked for their IL-15 expres...

journal_title：Cancer research

authors： Khawam K,Giron-Michel J,Gu Y,Perier A,Giuliani M,Caignard A,Devocelle A,Ferrini S,Fabbi M,Charpentier B,Ludwig A,Chouaib S,Azzarone B,Eid P

更新日期：2009-02-15 00:00:00

abstract：:Leukemia following chemotherapy for breast cancer was studied among patients diagnosed during 1973-1985 within the population-based tumor registries in the Surveillance, Epidemiology, and End Results Program. Among 13,734 women given initial chemotherapy, 24 developed acute nonlymphocytic leukemia (ANLL) compared to 2...

journal_title：Cancer research

authors： Curtis RE,Boice JD Jr,Moloney WC,Ries LG,Flannery JT

更新日期：1990-05-01 00:00:00

abstract：:RS7, a murine IgG1 antibody raised against human lung carcinoma, possesses pancarcinoma reactivity. The antigen defined by this antibody is present in tumors of the lung, stomach, bladder, breast, ovary, uterus, and prostate. Efficient targeting and therapy by radiolabeled RS7 has been demonstrated previously in anima...

journal_title：Cancer research

authors： Shih LB,Xuan H,Aninipot R,Stein R,Goldenberg DM

更新日期：1995-12-01 00:00:00

abstract：:The study by Jaratlerdsiri and colleagues represents the first whole-genome sequencing study of prostate cancer from men in sub-Saharan Africa. Preliminary findings include a higher tumor mutation burden in these tumors compared with data from other available prostate cancer cohorts. Although larger studies are needed...

journal_title：Cancer research

authors： Huang FW

更新日期：2018-12-15 00:00:00

abstract：:Preclinical studies have suggested that β-adrenergic signaling is involved in pancreatic cancer progression. Prompted by such studies, we investigated an association between beta-blocker drug use with improved cancer-specific survival in a large, general population-based cohort of patients with pancreatic ductal adeno...

journal_title：Cancer research

authors： Udumyan R,Montgomery S,Fang F,Almroth H,Valdimarsdottir U,Ekbom A,Smedby KE,Fall K

更新日期：2017-07-01 00:00:00

abstract：:The chemopreventive activity of two synthetic retinamides of relatively low toxicity against N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN)-induced urinary bladder cancer was studied in F344 rats and C57BL/6 X DBA/2 F1 mice. Female and male rats were given a total dose of either 1800 or 3200 mg OH-BBN over a period of...

journal_title：Cancer research

authors： Thompson HJ,Becci PJ,Grubbs CJ,Shealy YF,Stanek EJ,Brown CC,Sporn MB,Moon RC

更新日期：1981-03-01 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:Monoclonal antibodies (MAbs) 123C3 and 123A8 generated against a membrane preparation of a small cell lung carcinoma (SCLC) specimen recognize not only SCLC and bronchial carcinoids but also a significant portion of non-small cell lung carcinomas (non-SCLC) of various histological types. Together with 13 other monoclo...

journal_title：Cancer research

authors： Moolenaar CE,Muller EJ,Schol DJ,Figdor CG,Bock E,Bitter-Suermann D,Michalides RJ

更新日期：1990-02-15 00:00:00

abstract：:The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantabl...

journal_title：Cancer research

authors： Resnicoff M,Abraham D,Yutanawiboonchai W,Rotman HL,Kajstura J,Rubin R,Zoltick P,Baserga R

更新日期：1995-06-01 00:00:00

abstract：:Targeting of steroidogenic enzymes (e.g., abiraterone acetate targeting CYP17A1) has been developed as a novel therapeutic strategy against metastatic castration-resistant prostate cancer (CRPC). However, resistance to steroidal inhibitors inevitably develops in patients, the mechanisms of which remain largely unknown...

journal_title：Cancer research

authors： Xiao L,Wang Y,Xu K,Hu H,Xu Z,Wu D,Wang Z,You W,Ng CF,Yu S,Chan FL

更新日期：2018-05-01 00:00:00

abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

journal_title：Cancer research

authors： Ohshima H,Bartsch H

更新日期：1981-09-01 00:00:00

abstract：:Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms responsible for tumor regression occurring in these patients remain unclear. Preclinical insight into these mechanisms is limited by a paucity of orthotopic animal m...

journal_title：Cancer research

authors： Gruys ME,Back TC,Subleski J,Wiltrout TA,Lee JK,Schmidt L,Watanabe M,Stanyon R,Ward JM,Wigginton JM,Wiltrout RH

更新日期：2001-08-15 00:00:00

abstract：:Recent work has begun to explore the instrumental role that small noncoding RNA species, particularly microRNAs (miRNA), have both in classifying human tumors and in directing embryonic development. These studies suggest that developmental programs in essentially all organisms studied are set, in part, by varied expre...

journal_title：Cancer research

authors： Marsit CJ,Eddy K,Kelsey KT

更新日期：2006-11-15 00:00:00

abstract：:Bile acids increase the proliferative activity of rat colonic epithelium. However, the mechanisms responsible are unknown. The present study examined the relationships between deoxycholate (DOC) induced surface cell sloughing, as measured by loss of DNA into the lumen and by light microscopy, and the subsequent increa...

journal_title：Cancer research

authors： Craven PA,Pfanstiel J,Saito R,DeRubertis FR

更新日期：1986-11-01 00:00:00

abstract：:Resistance to chemotherapy predicts an unfavorable outcome for patients with radioiodine-insensitive thyroid cancer. To investigate the mechanisms underlying this resistance, we evaluated the expression of four different inhibitor of apoptosis proteins, and their antagonist, Smac, in thyroid cancer cells that survived...

journal_title：Cancer research

authors： Tirrò E,Consoli ML,Massimino M,Manzella L,Frasca F,Sciacca L,Vicari L,Stassi G,Messina L,Messina A,Vigneri P

更新日期：2006-04-15 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:A full-length cDNA for a novel isoform of the human receptor tyrosine phosphatase gamma gene (PTPRG) was overexpressed in Sf9 insect cells, and the gene product, PTP gamma, was purified and characterized. The protein was expressed as a M(r) approximately 185,000 protein accompanied by a M(r) approximately 120,000 puta...

journal_title：Cancer research

authors： Sorio C,Mendrola J,Lou Z,LaForgia S,Croce CM,Huebner K

更新日期：1995-11-01 00:00:00

abstract：:The retinoblastoma (Rb) family consists of the tumor suppressor pRb and related proteins p107 and pRb2/p130. Ectopic expression of pRb and p107 results in a growth arrest of sensitive cells in the G1 phase of the cell cycle. We demonstrated here that the growth-suppressive properties of pRb2/p130 were also specific fo...

journal_title：Cancer research

authors： Claudio PP,De Luca A,Howard CM,Baldi A,Firpo EJ,Koff A,Paggi MG,Giordano A

更新日期：1996-05-01 00:00:00

abstract：:The effect of an i.p. injection of glucose on the thermal response of murine tissues was studied. Animal tumors were early generation isotransplants of a spontaneous fibrosarcoma, FSa-II. Tumors were transplanted into the foot pad, and hyperthermia was given by immersing the foot into a constant-temperature water bath...

journal_title：Cancer research

authors： Urano M,Montoya V,Booth A

更新日期：1983-02-01 00:00:00

abstract：:The Inflammation and Cancer Think Tank Meeting was organized by the National Cancer Institute with the purpose of identifying research advances, gaps, and opportunities for the study and clinical application of the role of inflammation on tumorigenesis. The format of this meeting consisted of brief presentations that ...

journal_title：Cancer research

authors： Peek RM Jr,Mohla S,DuBois RN

更新日期：2005-10-01 00:00:00

abstract：:The study of DNA tumor viruses has been invaluable in uncovering the cellular nodes and pathways that contribute to oncogenesis. Perhaps one of the best-studied oncoproteins encoded by a DNA tumor virus is adenovirus E1A, which modifies the function of key regulatory proteins such as retinoblastoma (Rb) and the chroma...

journal_title：Cancer research

authors： Chakraborty AA,Tansey WP

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of treatment with recombinant interleukin-2 (rIL-2) and lymphokine-activated killer cells in patients with advanced bladder cancer and to study the induced changes in the distribution of leukocyte subsets in blood and tumor. Nine patients with metastatic transitio...

journal_title：Cancer research

authors： Hermann GG,Geertsen PF,von der Maase H,Steven K,Andersen C,Hald T,Zeuthen J

更新日期：1992-02-01 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, inhibited B16 melanoma-induced angiogenesis in chick embryo chorioallantoic membrane and subsequently the growth of the tumor on the chorioallantoic membrane. These inhibitions were reversed by exogenous putrescine and spermidi...

journal_title：Cancer research

authors： Takigawa M,Enomoto M,Nishida Y,Pan HO,Kinoshita A,Suzuki F

更新日期：1990-07-01 00:00:00

abstract：:The correlation between telomerase activity, telomere lengths, and cellular replicative capacity has led to the theory that maintenance of telomere lengths by telomerase acts as a molecular clock to control replicative capacity and senescence. Regulation of this molecular clock may have applications in the treatment o...

journal_title：Cancer research

authors： Ulaner GA,Hu JF,Vu TH,Giudice LC,Hoffman AR

更新日期：1998-09-15 00:00:00

abstract：:Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition of Bcl-2, Bcl-xL, and Mcl-1 is sufficient to elicit synthe...

journal_title：Cancer research

authors： Karpel-Massler G,Ishida CT,Bianchetti E,Shu C,Perez-Lorenzo R,Horst B,Banu M,Roth KA,Bruce JN,Canoll P,Altieri DC,Siegelin MD

更新日期：2017-07-01 00:00:00