An early event associated with liver carcinogenesis involving loss of a polypeptide that binds carcinogen.

abstract：:C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, intestinal adenomas and aberrant crypt foci were counted, and serum leve...

journal_title：Cancer research

authors： Jacoby RF,Marshall DJ,Newton MA,Novakovic K,Tutsch K,Cole CE,Lubet RA,Kelloff GJ,Verma A,Moser AR,Dove WF

更新日期：1996-02-15 00:00:00

abstract：:In cancer patients and in those at high risk, systemic exposure to agents for therapy or prevention is accompanied by undesirable side effects. We hypothesized that it is possible to prevent and treat breast cancer by introducing anticancer agents into the mammary ductal network. Here, we show the efficacy of intraduc...

journal_title：Cancer research

authors： Murata S,Kominsky SL,Vali M,Zhang Z,Garrett-Mayer E,Korz D,Huso D,Baker SD,Barber J,Jaffee E,Reilly RT,Sukumar S

更新日期：2006-01-15 00:00:00

abstract：:Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) has been reported to be overexpressed in lung cancer and in other cancers such as breast, pancreas, and liver. However, a mechanism linking hnRNP A2/B1 overexpression and progression to cancer has not yet been definitively established. To elucidate this mecha...

journal_title：Cancer research

authors： Tauler J,Zudaire E,Liu H,Shih J,Mulshine JL

更新日期：2010-09-15 00:00:00

abstract：:Three human colon cancer lines (SW 480, SW 620, WIDR) were characterized as to their production of molecules with transforming growth factor (TGF)-like activity. Production of both TGF alpha-like and TGF beta-like activity was quantitated, as were cellular receptors for these molecules, and growth response in soft aga...

journal_title：Cancer research

authors： Coffey RJ Jr,Shipley GD,Moses HL

更新日期：1986-03-01 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:The effect of dietary fat concentration and saturation on high energy phosphate metabolites and phospholipid turnover in transplanted line 168 murine mammary tumors was studied using surface coil 31P-nuclear magnetic resonance spectroscopy. Female BALB/c mice were fed one of five diets each containing at least the min...

journal_title：Cancer research

authors： Buckman DK,Erickson KL,Ross BD

更新日期：1987-11-01 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00

abstract：:Interleukin 4 (IL-4) receptors were detected by a monoclonal antibody on tumor cells of 10 of 29 squamous cell carcinomas and 6 of 17 adenocarcinomas of the lung. None of the small cell carcinomas or carcinoid tumors stained. Parallel sections stained for epidermal growth factor receptors showed that all but 2 of the ...

journal_title：Cancer research

authors： Tungekar MF,Turley H,Dunnill MS,Gatter KC,Ritter MA,Harris AL

更新日期：1991-01-01 00:00:00

abstract：:The DF3 antigen is a member of a family of high-molecular-weight glycoproteins aberrantly expressed in human breast carcinomas. Recent work has described the generation of a monoclonal antibody (MAb), designated DF3-P, that reacts with immature, underglycosylated precursors of DF3 antigen. Immunoperoxidase staining st...

journal_title：Cancer research

authors： Perey L,Hayes DF,Kufe D

更新日期：1992-11-15 00:00:00

abstract：:Effective autologous bone marrow transplantation for leukemia and lymphoma is likely to depend upon the selective removal in vitro of malignant cells from normal human bone marrow precursors. Highly specific cytotoxic conjugates formed by coupling ricin A chain to monoclonal antibodies might prove useful for the selec...

journal_title：Cancer research

authors： Bregni M,De Fabritiis P,Raso V,Greenberger J,Lipton J,Nadler L,Rothstein L,Ritz J,Bast RC Jr

更新日期：1986-03-01 00:00:00

abstract：:Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 l...

journal_title：Cancer research

authors： Bae E,Sato M,Kim RJ,Kwak MK,Naka K,Gim J,Kadota M,Tang B,Flanders KC,Kim TA,Leem SH,Park T,Liu F,Wakefield LM,Kim SJ,Ooshima A

更新日期：2014-11-01 00:00:00

abstract：:Constitutively active RAS small GTPases promote the genesis of human cancers. An important goal in cancer biology is to identify means of countervailing activated RAS signaling to reverse malignant transformation. Oncogenic K-RAS mutations are found in virtually all pancreatic adenocarcinomas, making the RAS pathway a...

journal_title：Cancer research

authors： Schmidt RL,Park CH,Ahmed AU,Gundelach JH,Reed NR,Cheng S,Knudsen BE,Tang AH

更新日期：2007-12-15 00:00:00

abstract：:A subline of H35 hepatoma cells has been developed which exhibits 80-fold resistance to 5,10-dideazatetrahydrofolate, an antifolate which inhibits glycinamideribonucleotide transformylase. The cells are cross-resistant to methotrexate, an inhibitor of dihydrofolate reductase and 10-propargyl-5,8-dideazafolate and its ...

journal_title：Cancer research

authors： Rhee MS,Wang Y,Nair MG,Galivan J

更新日期：1993-05-15 00:00:00

abstract：:DAB389 GRP is composed of the catalytic and transmembrane domains of diphtheria toxin fused to gastrin-releasing peptide (GRP). DAB389 GRP is selectively targeted to, and inhibits protein synthesis in, cell lines expressing GRP receptors. Protein synthesis in 5'ET4 cells (BALB/3T3 fibroblasts transfected with the gene...

journal_title：Cancer research

authors： vanderSpek JC,Sutherland JA,Zeng H,Battey JF,Jensen RT,Murphy JR

更新日期：1997-01-15 00:00:00

abstract：:Culture of human peripheral blood leukocytes with interleukin 2 (IL-2) stimulates their differentiation into lymphokine-activated killer (LAK) cells, with a broad range of cytotoxicity against fresh tumor cells and tumor cell lines (Grimm et al., J. Exp. Med., 155: 1823-1841, 1982). We chose to utilize a molecular app...

journal_title：Cancer research

authors： Kovacs EJ,Beckner SK,Longo DL,Varesio L,Young HA

更新日期：1989-02-15 00:00:00

abstract：:Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a)...

journal_title：Cancer research

authors： Yasuda M,Takenoyama M,Obata Y,Sugaya M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2002-03-15 00:00:00

abstract：:We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploi...

journal_title：Cancer research

authors： Kaneko Y,Rowley JD,Variakojis D,Chilcote RR,Check I,Sakurai M

更新日期：1982-07-01 00:00:00

abstract：:ABCG2 is an ATP-binding cassette transporter that confers resistance to various chemotherapeutic agents. Recent studies have established that an Arg (wild-type) to Gly mutation at amino acid 482 in ABCG2 alters substrate specificity. Here, we explored the role of this G482 mutation in antifolate resistance using a cli...

journal_title：Cancer research

authors： Shafran A,Ifergan I,Bram E,Jansen G,Kathmann I,Peters GJ,Robey RW,Bates SE,Assaraf YG

更新日期：2005-09-15 00:00:00

abstract：:The reason for estrogen independence of C3H mouse mammary tumors has been sought in the initial steps of estradiol action. The characteristics of the estrogen receptors were similar to those observed in estrogen-responsive tissues: high affinity and binding specificity, DNA binding and 8S sedimentation constant as sho...

journal_title：Cancer research

authors： Vignon F,Rochefort H

更新日期：1978-06-01 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00

abstract：:Patients with disseminated Ewing's family of tumors (ESFT) often experience drug-resistant relapse. We hypothesize that targeting minimal residual disease with the cytotoxic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR; fenretinide) may decrease relapse. We determined the following: (a) 4-HPR cytotoxicity against 12...

journal_title：Cancer research

authors： Batra S,Reynolds CP,Maurer BJ

更新日期：2004-08-01 00:00:00

abstract：:Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, the physiologic roles of this event in cell cycle are incompletely understood. Here, we show that SRPK2 bind...

journal_title：Cancer research

authors： Jang SW,Yang SJ,Ehlén A,Dong S,Khoury H,Chen J,Persson JL,Ye K

更新日期：2008-06-15 00:00:00

abstract：:The prostate-specific antigen (PSA) promoter (PSA-P) has been identified, characterized, and determined to be tissue specific. Compared with high expression of the genomic PSA gene in prostate cells, expression of the transgene driven by the putative PSA promoter is low. This suggests that the identified promoter may ...

journal_title：Cancer research

authors： Pang S,Dannull J,Kaboo R,Xie Y,Tso CL,Michel K,deKernion JB,Belldegrun AS

更新日期：1997-02-01 00:00:00

abstract：:Human lymphoblastoid cell lines from normal individuals and from patients with ataxia telangiectasia were either proficient or deficient in their ability to repair the mutagenic DNA adduct O6-methylguanine that is induced by methylating carcinogens. There was no relationship between the capacity to repair O6-methylgua...

journal_title：Cancer research

authors： Shiloh Y,Becker Y

更新日期：1981-12-01 00:00:00

abstract：:It has been proposed that cellular retinoic acid binding protein is essential for retinoid-induced differentiation of embryonal carcinoma line PCC4.aza1R. To assess the generality of this proposal, we have tested for the presence of cellular retinoic acid binding protein activities in several other embryonal carcinoma...

journal_title：Cancer research

authors： Matthaei KI,McCue PA,Sherman MI

更新日期：1983-06-01 00:00:00

abstract：:In order to test the contention that metastasis is a selective process and that therefore metastases might show a more restricted pattern of phenotypic and genotypic characteristics than primary tumors, we compared the expression of carcinoembryonic antigen, Ca 19-9, secretory component, serotonin, and mucin productio...

journal_title：Cancer research

authors： Arends JW,Schutte B,Wiggers T,Verstijnen CP,Blijham GH,Bosman FT

更新日期：1987-08-15 00:00:00

abstract：:The Wilms' tumor 1 gene (WT1) encodes a transcription factor involved in cell growth and development. As we previously reported, WT1 expression is hardly detectable in normal hepatic tissue but is induced in liver cirrhosis. Although WT1 has been found to be overexpressed in a number of malignancies, the role of WT1 i...

journal_title：Cancer research

authors： Perugorria MJ,Castillo J,Latasa MU,Goñi S,Segura V,Sangro B,Prieto J,Avila MA,Berasain C

更新日期：2009-02-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options, yet its molecular underpinnings remain largely unknown. Microrchidia family CW-type zinc finger 2 (MORC2) is a newly identified chromatin remodeling protein who...

journal_title：Cancer research

authors： Zhang FL,Cao JL,Xie HY,Sun R,Yang LF,Shao ZM,Li DQ

更新日期：2018-10-15 00:00:00

abstract：:An in vivo transplantation technique has been developed which can be utilized to determine the reproductive survival of parenchymal hepatocytes exposed either in vitro or in vivo to both physical and chemical genotoxic agents. We have used this assay system to determine the survival of liver cells exposed to sparsely ...

journal_title：Cancer research

authors： Jirtle RL,Michalopoulos G,McLain JR,Crowley J

更新日期：1981-09-01 00:00:00

abstract：:Normal or immortal epithelial cells are sensitive to a form of apoptosis, commonly referred to as anoikis, which is induced by detachment from the extracellular matrix (ECM). In contrast, development of carcinomas is associated with acquisition of cellular resistance to anoikis. However, whether human cancer cells dep...

journal_title：Cancer research

authors： Frankel A,Rosen K,Filmus J,Kerbel RS

更新日期：2001-06-15 00:00:00