Wilms' tumor 1 gene expression in hepatocellular carcinoma promotes cell dedifferentiation and resistance to chemotherapy.

abstract：:Interleukin-6 (IL-6) is a pleiotropic cytokine with a broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to a microenvironment that promotes tumor cell survival, angiogenesis, and inflammation, understanding the mechanism responsible for its production is important. In neuroblasto...

journal_title：Cancer research

authors： Silverman AM,Nakata R,Shimada H,Sposto R,DeClerck YA

更新日期：2012-05-01 00:00:00

abstract：:The tropism of breast cancer cells for bone and their tendency to induce an osteolytic phenotype are a result of interactions between breast cancer cells and stromal cells and are of paramount importance for bone metastasis. However, the underlying molecular mechanisms remain poorly understood. We hypothesize that tum...

journal_title：Cancer research

authors： Nannuru KC,Futakuchi M,Varney ML,Vincent TM,Marcusson EG,Singh RK

更新日期：2010-05-01 00:00:00

abstract：:Pancreatic cancer is highly resistant to current chemotherapy agents. We therefore examined the effects of triptolide (a diterpenoid triepoxide) on pancreatic cancer growth and local-regional tumor spread using an orthotopic model of pancreatic cancer. We have recently shown that an increased level of HSP70 in pancrea...

journal_title：Cancer research

authors： Phillips PA,Dudeja V,McCarroll JA,Borja-Cacho D,Dawra RK,Grizzle WE,Vickers SM,Saluja AK

更新日期：2007-10-01 00:00:00

abstract：:To determine alpha-fetoprotein (AFP) immunogenicity in vivo, the presence of antibodies in sera of 60 hepatocellular carcinoma, 15 liver cirrhosis, and 15 chronic hepatitis patients was evaluated by Western blotting and immunoprecipitation analyses using purified human AFP. High titers of anti-AFP immunoglobulins were...

journal_title：Cancer research

authors： Bei R,Budillon A,Reale MG,Capuano G,Pomponi D,Budillon G,Frati L,Muraro R

更新日期：1999-11-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) expression by human breast cancer has been shown to predict poor patient outcome, as has amplification of the c-erbB-2 proto-oncogene. We have developed a quantitative immunohistochemical method for measuring protein levels of both receptors and have applied this to a series of ...

journal_title：Cancer research

authors： Robertson KW,Reeves JR,Smith G,Keith WN,Ozanne BW,Cooke TG,Stanton PD

更新日期：1996-08-15 00:00:00

abstract：:Rat mammary carcinomas were induced by directly inserting activated neu or ras genes into in situ rat mammary ductal cells using replication-defective retroviral vectors. neu was over 200 times more potent than ras in inducing rat mammary carcinomas. Ovariectomy 2 days postinfection dramatically reduced the occurrence...

journal_title：Cancer research

authors： Wang B,Kennan WS,Yasukawa-Barnes J,Lindstrom MJ,Gould MN

更新日期：1992-08-01 00:00:00

abstract：:p53 alterations in human tumors often involve missense mutations that may confer dominant-negative or gain-of-function properties. Dominant-negative effects result in inactivation of wild-type p53 protein in heterozygous mutant cells and as such in a p53 null phenotype. Gain-of-function effects can directly promote tu...

journal_title：Cancer research

authors： Wijnhoven SW,Speksnijder EN,Liu X,Zwart E,vanOostrom CT,Beems RB,Hoogervorst EM,Schaap MM,Attardi LD,Jacks T,van Steeg H,Jonkers J,de Vries A

更新日期：2007-05-15 00:00:00

abstract：:Cancer is a major health concern and a leading cause of mortality. The reliable identification of carcinogens and understanding of carcinogenicity has become a main focus of biomedical research and regulatory toxicology. While biomedical research applies cellular in vitro methods to uncover the underlying mechanisms c...

journal_title：Cancer research

authors： Stolz A,Becker M,Wistorf E,Ertych N

更新日期：2020-04-15 00:00:00

abstract：:The FGFR1 gene transcript is alternatively processed to produce functionally different receptor forms. Previously, we identified a 69-nucleotide exonic splicing enhancer (ESE) required for alpha-exon inclusion in JEG3 cells. In the present study, we found that this sequence is composed of three independent elements, t...

journal_title：Cancer research

authors： Jin W,Cote GJ

更新日期：2004-12-15 00:00:00

abstract：:CUB domain-containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported previously that CDCP1 regulates anoikis resistance as well as cancer cell migration and invasion, although the underlying mechanisms have not been elucidated. In this study, we found that expres...

journal_title：Cancer research

authors： Miyazawa Y,Uekita T,Hiraoka N,Fujii S,Kosuge T,Kanai Y,Nojima Y,Sakai R

更新日期：2010-06-15 00:00:00

abstract：:One set of genes sufficient for transformation of primary human cells uses the combination of Ha-Ras-V12, the telomerase catalytic subunit hTERT, SV40 large tumor antigen (LT), and SV40 small tumor antigen (ST). Whereas SV40 LT inactivates the retinoblastoma protein and p53, the contribution of ST is poorly understood...

journal_title：Cancer research

authors： Moreno CS,Ramachandran S,Ashby DG,Laycock N,Plattner CA,Chen W,Hahn WC,Pallas DC

更新日期：2004-10-01 00:00:00

abstract：:The renal handling of cis-diamminedichloroplatinum (CP) was investigated by measuring the renal clearance of creatinine, inulin, and free platinum in ten cancer patients. Free platinum clearances exceeded the glomerular filtration rate in all time periods. For example, at 1 to 2 hr, the mean clearance of free platinum...

journal_title：Cancer research

authors： Jacobs C,Coleman CN,Rich L,Hirst K,Weiner MW

更新日期：1984-08-01 00:00:00

abstract：:This report describes the development and validation of quantitative microsatellite analysis (QuMA) for rapid measurement of relative DNA sequence copy number. In QuMA, the copy number of a test locus relative to a pooled reference is assessed using quantitative, real-time PCR amplification of loci carrying simple seq...

journal_title：Cancer research

authors： Ginzinger DG,Godfrey TE,Nigro J,Moore DH 2nd,Suzuki S,Pallavicini MG,Gray JW,Jensen RH

更新日期：2000-10-01 00:00:00

abstract：:The metabolism and disposition of LY186641, a diarylsulfonylurea with antineoplastic activity identified in preclinical tests, was determined in 21 patients who received 23 courses of orally administered drug. A linear correlation was found between the dose of drug administered and LY186641 peak plasma concentrations ...

journal_title：Cancer research

authors： Hande KR,Kuttesch J,Hamilton M,Satterlee W,Jackson L,Grindey G,Hainsworth JD

更新日期：1990-07-01 00:00:00

abstract：:Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small cell lung cancers (57.4% stage 1, 16.7% stage 2, and 25.9% stage 3) to...

journal_title：Cancer research

authors： Esposito V,Baldi A,De Luca A,Groger AM,Loda M,Giordano GG,Caputi M,Baldi F,Pagano M,Giordano A

更新日期：1997-08-15 00:00:00

abstract：:The major heat shock protein Hsp72 is constitutively expressed in many tumor cell lines and biopsies, and its expression correlates with poor prognosis in several types of cancer. Hsp72 was suggested to play an important role in neoplastic transformation and tumor development. We addressed the role of Hsp72 in cancer ...

journal_title：Cancer research

authors： Yaglom JA,Gabai VL,Sherman MY

更新日期：2007-03-01 00:00:00

abstract：:During the development of neoplasia, epithelial tissues undergo biochemical and structural changes that can manifest in tissue fluorescence. There have been several reports on different in vivo fluorescence characteristics between normal and precancerous (dysplastic) tissues. However, it has been difficult to identify...

journal_title：Cancer research

authors： Georgakoudi I,Jacobson BC,Müller MG,Sheets EE,Badizadegan K,Carr-Locke DL,Crum CP,Boone CW,Dasari RR,Van Dam J,Feld MS

更新日期：2002-02-01 00:00:00

abstract：:Both gastrin and Helicobacter pylori have been shown capable of up-regulating gene expression and protein shedding of heparin-binding epidermal growth factor (HB-EGF). Furthermore, the bacteria have previously been shown to induce serum hypergastrinemia in infected individuals. The aim of this work was to assess the e...

journal_title：Cancer research

authors： Dickson JH,Grabowska A,El-Zaatari M,Atherton J,Watson SA

更新日期：2006-08-01 00:00:00

abstract：:A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a lambda gt10 rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this cl...

journal_title：Cancer research

authors： Roth JS,Hsieh LL,Peraino C,Weinstein IB

更新日期：1990-03-15 00:00:00

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cel...

journal_title：Cancer research

authors： Voena C,Conte C,Ambrogio C,Boeri Erba E,Boccalatte F,Mohammed S,Jensen ON,Palestro G,Inghirami G,Chiarle R

更新日期：2007-05-01 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in ...

journal_title：Cancer research

authors： Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Y

更新日期：1993-11-01 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14. Recent studies have demonstrated that TWEAK can stimulate numerous cellular responses in...

journal_title：Cancer research

authors： Ho DH,Vu H,Brown SA,Donohue PJ,Hanscom HN,Winkles JA

更新日期：2004-12-15 00:00:00

abstract：:Successful treatment of many patients with osteosarcoma requires more effective chemotherapy. Since new agents are needed, we have developed an immunotoxin using TP-3, an IgG2b mAb which recognizes human and canine osteosarcomas and budding capillaries of tumors. The plant hemitoxin, pokeweed antiviral protein (PAP), ...

journal_title：Cancer research

authors： Anderson PM,Meyers DE,Hasz DE,Covalcuic K,Saltzman D,Khanna C,Uckun FM

更新日期：1995-03-15 00:00:00

abstract：:There is a paucity of data on whether or not women can be reinfected with human papillomavirus (HPV) types to which they were exposed to earlier in life and on the role of natural immunity. The observation of HPV infection at older ages may be explained by the reactivation of a latent infection or new exposure from se...

journal_title：Cancer research

authors： Trottier H,Ferreira S,Thomann P,Costa MC,Sobrinho JS,Prado JC,Rohan TE,Villa LL,Franco EL

更新日期：2010-11-01 00:00:00

abstract：:A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC wit...

journal_title：Cancer research

authors： Meerabux J,Yaspo ML,Roebroek AJ,Van de Ven WJ,Lister TA,Young BD

更新日期：1996-02-01 00:00:00

abstract：:A previous study demonstrated inhibition of growth of primary rat mammary carcinomas after infusion of tumor-bearer plasma absorbed against Sepharose derivatives. In this report we have quantitated changes in individual complement components that occur during absorption of rat plasma with Sepharose derivatives and def...

journal_title：Cancer research

authors： Nakanishi K,Zbar B,Borsos T

更新日期：1985-09-01 00:00:00

abstract：:Many but not all of the cell surface antigens studied were released into tissue culture medium of human colorectal carcinoma and melanoma cells maintained in vitro. Two groups of monoclonal antibody-defined antigens are described. One group is composed of molecules that are released easily and in large quantitites int...

journal_title：Cancer research

authors： Steplewski Z,Chang TH,Herlyn M,Koprowski H

更新日期：1981-07-01 00:00:00

abstract：:Addition of the tumor promoter of 12-O-tetradecanoylphorbol-13-acetate (TPA) to C3H/10T1/2 cells after exposure to either X-rays or to fission-spectrum neutrons increases significantly the frequency of transformation without any effect on cell survival. However, treatment of unirradiated cells with 0.1 micrograms of T...

journal_title：Cancer research

authors： Han A,Elkind MM

更新日期：1982-02-01 00:00:00