A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.

Abstract:

:A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.

journal_name

Cancer Res

journal_title

Cancer research

authors

Meerabux J,Yaspo ML,Roebroek AJ,Van de Ven WJ,Lister TA,Young BD

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

448-51

issue

3

eissn

0008-5472

issn

1538-7445

journal_volume

56

pub_type

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