Abstract:
:A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Meerabux J,Yaspo ML,Roebroek AJ,Van de Ven WJ,Lister TA,Young BDsubject
Has Abstractpub_date
1996-02-01 00:00:00pages
448-51issue
3eissn
0008-5472issn
1538-7445journal_volume
56pub_type
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