Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer.

abstract：:One of the greatest challenges in developing therapeutic regimens is the inability to rapidly and objectively assess tumor response due to treatment. Moreover, tumor response to therapeutic intervention in many cases is transient, and progressive alterations within the tumor may mask the effectiveness of an initially ...

journal_title：Cancer research

authors： Lee KC,Hall DE,Hoff BA,Moffat BA,Sharma S,Chenevert TL,Meyer CR,Leopold WR,Johnson TD,Mazurchuk RV,Rehemtulla A,Ross BD

更新日期：2006-05-01 00:00:00

abstract：:Human B-cell tumors have been established in athymic, BALB/c mice using the EBV-positive Burkitt lymphoma cell line Namalwa. One-hundred-one of 104 animals (97%) developed tumors 10-14 days following s.c. injection of a mixture of 20 x 10(6) Namalwa and 5 X 10(6) irradiated human fibrosarcoma (HT-1080) cells. Tumors d...

journal_title：Cancer research

authors： Leonard JE,Johnson DE,Felsen RB,Tanney LE,Royston I,Dillman RO

更新日期：1987-06-01 00:00:00

abstract：:We evaluated the usefulness of L-dopa decarboxylase (DDC) as a tumor marker of neuroendocrine (NE) cell differentiation by measuring its expression in 432 human tumors of diverse types and origins. A subset of these tumors and cell lines derived from them also were studied for expression of two other general NE cell m...

journal_title：Cancer research

authors： Gazdar AF,Helman LJ,Israel MA,Russell EK,Linnoila RI,Mulshine JL,Schuller HM,Park JG

更新日期：1988-07-15 00:00:00

abstract：:Multi-targeting strategies improve the efficacy of antibody and immunotoxin therapies but have not yet been thoroughly explored for HER2-based cancer treatments. We investigated multi-epitope HER2 targeting to boost photosensitizer immunoconjugate uptake as a way of enhancing photoimmunotherapy. Photoimmunotherapy may...

journal_title：Cancer research

authors： Savellano MD,Pogue BW,Hoopes PJ,Vitetta ES,Paulsen KD

更新日期：2005-07-15 00:00:00

abstract：:Analysis of human fibrosarcoma cells exposed to radiolabeled monoclonal antibody 19-24, which recognizes sarcoma-associated antigen p102, revealed that over 54% of the cell surface-bound radioactivity was internalized. No modulation of cell surface p102 antigen by monoclonal antibody 19-24 was observed in human fibros...

journal_title：Cancer research

authors： Stastny JJ,Das Gupta TK

更新日期：1993-12-01 00:00:00

abstract：:Approximately 25% of breast cancers do not express the estrogen receptor-α (ERα) and consequently do not respond to endocrine therapy. In these tumors, ERα repression is often due to epigenetic modifications such as methylation and histone deacetylation. For this reason, we investigated the ability of the histone deac...

journal_title：Cancer research

authors： Sabnis GJ,Goloubeva O,Chumsri S,Nguyen N,Sukumar S,Brodie AM

更新日期：2011-03-01 00:00:00

abstract：:Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk...

journal_title：Cancer research

authors： Traenka C,Remke M,Korshunov A,Bender S,Hielscher T,Northcott PA,Witt H,Ryzhova M,Felsberg J,Benner A,Riester S,Scheurlen W,Grunewald TG,von Deimling A,Kulozik AE,Reifenberger G,Taylor MD,Lichter P,Butt E,Pfister SM

更新日期：2010-10-15 00:00:00

abstract：:Hypoxia is a common feature of solid tumors, which controls multiple aspects of cancer progression. One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of cancer stem-like cells (CSC), a population of tumor cells that possess stem cell-like properties and drives tumor growth. A...

journal_title：Cancer research

authors： Filatova A,Seidel S,Böğürcü N,Gräf S,Garvalov BK,Acker T

更新日期：2016-10-01 00:00:00

abstract：:Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. T...

journal_title：Cancer research

authors： Husby G,Marhaug G,Sletten K

更新日期：1982-04-01 00:00:00

abstract：:The telomere-telomerase hypothesis states that the vast majority of human tumors have a prolonged replicative life span throughout expressing telomerase, which compensates the cell division-associated loss of telomere DNA. The use of telomere length and telomerase expression as new biological markers in cancer patient...

journal_title：Cancer research

authors： Bechter OE,Eisterer W,Pall G,Hilbe W,Kühr T,Thaler J

更新日期：1998-11-01 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachment, migration, survival, and proliferation. However, little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We report here that DDR1 indu...

journal_title：Cancer research

authors： Das S,Ongusaha PP,Yang YS,Park JM,Aaronson SA,Lee SW

更新日期：2006-08-15 00:00:00

abstract：:The radiation response of autochthonous tumors induced by s.c. injection of 3-methylcholanthrene in ICR/JCL mice was studied. The tumors were mostly fibrosarcomas and grew with an average volume-doubling time of 2.6 days, independently of the time tumor appearance or dose of the chemical used. The tumors were locally ...

journal_title：Cancer research

authors： Tanooka H,Hoshino H,Tanaka K,Nagase M

更新日期：1980-07-01 00:00:00

abstract：:Angiostatin, a proteolytic fragment of plasminogen, is a potent angiogenesis inhibitor able to suppress tumor growth and metastasis through inhibition of endothelial cell proliferation and migration. Previously, we showed that angiostatin binds and inhibits F(1)F(o) ATP synthase on the endothelial cell surface and tha...

journal_title：Cancer research

authors： Chi SL,Pizzo SV

更新日期：2006-01-15 00:00:00

abstract：:PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the anticipation of Phase I human investigation. The agent displayed both human and murine solid tumor selectivity in vitro in a soft agar disk diffusion assay, relative to its activity against mu...

journal_title：Cancer research

authors： LoRusso P,Wozniak AJ,Polin L,Capps D,Leopold WR,Werbel LM,Biernat L,Dan ME,Corbett TH

更新日期：1990-08-15 00:00:00

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:Osimertinib, a mutant-specific third-generation EGFR tyrosine kinase inhibitor, is emerging as the preferred first-line therapy for EGFR-mutant lung cancer, yet resistance inevitably develops in patients. We modeled acquired resistance to osimertinib in transgenic mouse models of EGFRL858R -induced lung adenocarcinoma...

journal_title：Cancer research

authors： Starrett JH,Guernet AA,Cuomo ME,Poels KE,van Alderwerelt van Rosenburgh IK,Nagelberg A,Farnsworth D,Price KS,Khan H,Ashtekar KD,Gaefele M,Ayeni D,Stewart TF,Kuhlmann A,Kaech SM,Unni AM,Homer R,Lockwood WW,Michor F,G

更新日期：2020-05-15 00:00:00

abstract：:Several studies have shown that neuroblastoma and retinoblastoma tumor cells often have elevated N-myc mRNA levels compared to normal adult neuronal or retinal tissues, and it has been suggested that increased expression of this protooncogene may play an important role in tumorigenesis or malignant progression in cell...

journal_title：Cancer research

authors： Amy CM,Bartholomew JC

更新日期：1987-12-01 00:00:00

abstract：:Glucocorticoids are widely used for the treatment of multiple myeloma. To investigate the direct actions of glucocorticoids on myeloma cells, we have used three cell lines of human multiple myeloma, OPM-1, OPM-2, and RPMI 8226. When growth curves of these cells were examined, OPM-1 cells were resistant, while OPM-2 we...

journal_title：Cancer research

authors： Gomi M,Moriwaki K,Katagiri S,Kurata Y,Thompson EB

更新日期：1990-03-15 00:00:00

abstract：:Epidemiological and animal studies (reviewed in Y. I. Kim, J. Nutr. Biochemistry, 10: 66-88, 1999; J. B. Mason and T. Levesque, Oncology, 10: 1727-1743, 1996) suggest that dietary folate intake is inversely related to the risk of colorectal cancer. However, the optimal timing of folate intervention and mechanisms by w...

journal_title：Cancer research

authors： Song J,Sohn KJ,Medline A,Ash C,Gallinger S,Kim YI

更新日期：2000-06-15 00:00:00

abstract：:The role of natural killer group 2, member D receptor (NKG2D)-expressing natural killer (NK) cells in tumor immunosurveillance is now well established. Nevertheless, tumor progression occurs despite tumor immunosurveillance, leading to cancer persistence in immunocompetent hosts. STAT3 plays a pivotal role both in onc...

journal_title：Cancer research

authors： Bedel R,Thiery-Vuillemin A,Grandclement C,Balland J,Remy-Martin JP,Kantelip B,Pallandre JR,Pivot X,Ferrand C,Tiberghien P,Borg C

更新日期：2011-03-01 00:00:00

abstract：:During the development of neoplasia, epithelial tissues undergo biochemical and structural changes that can manifest in tissue fluorescence. There have been several reports on different in vivo fluorescence characteristics between normal and precancerous (dysplastic) tissues. However, it has been difficult to identify...

journal_title：Cancer research

authors： Georgakoudi I,Jacobson BC,Müller MG,Sheets EE,Badizadegan K,Carr-Locke DL,Crum CP,Boone CW,Dasari RR,Van Dam J,Feld MS

更新日期：2002-02-01 00:00:00

abstract：:Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tum...

journal_title：Cancer research

authors： Lohr F,Lo DY,Zaharoff DA,Hu K,Zhang X,Li Y,Zhao Y,Dewhirst MW,Yuan F,Li CY

更新日期：2001-04-15 00:00:00

abstract：:Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described i...

journal_title：Cancer research

authors： Gu G,Yuan J,Wills M,Kasper S

更新日期：2007-05-15 00:00:00

abstract：:A heterotopic bladder attached to an Ommaya reservoir was transplanted to the back of a syngeneic rat. Following transplantation, the mucosa underwent ischemic necrosis. However, it was rapidly reepithelialized in 2 weeks as a result of spreading of the epithelium originating from the ureterotrigonal region. By light ...

journal_title：Cancer research

authors： Oyasu R,Manning DJ,Matsumoto M,Hopp ML

更新日期：1976-07-01 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell survival and function during oxidative stress. The role of the PI3k/Akt signaling pathway in promoting cell viability was studied in vascular endothelial cells treated wi...

journal_title：Cancer research

authors： Geng L,Tan J,Himmelfarb E,Schueneman A,Niermann K,Brousal J,Fu A,Cuneo K,Kesicki EA,Treiberg J,Hayflick JS,Hallahan DE

更新日期：2004-07-15 00:00:00

abstract：:Despite the initial efficacy of androgen deprivation therapy, most patients with advanced prostate cancer eventually progress to hormone-refractory prostate cancer, for which there is no curative therapy. Previous studies from our laboratory and others have shown the antiproliferative and proapoptotic effects of 3,3'-...

journal_title：Cancer research

authors： Bhuiyan MM,Li Y,Banerjee S,Ahmed F,Wang Z,Ali S,Sarkar FH

更新日期：2006-10-15 00:00:00

abstract：:Pheochromocytomas are tumors of the adrenal medulla originating in the chromaffin cells derived from the neural crest. Ten % of these tumors are associated with the familial cancer syndromes multiple endocrine neoplasia type 2, von Hippel-Lindau disease (VHL), and rarely, neurofibromatosis type 1, in which germ-line m...

journal_title：Cancer research

authors： Benn DE,Dwight T,Richardson AL,Delbridge L,Bambach CP,Stowasser M,Gordon RD,Marsh DJ,Robinson BG

更新日期：2000-12-15 00:00:00

abstract：:Poly (ADP-ribose) glycohydrolase (PARG) is the main enzyme responsible for catabolism of poly (ADP-ribose) (PAR), synthesized by PARP. PARG dysfunction sensitizes certain cancer cells to alkylating agents and cisplatin by perturbing the DNA damage response. The gene mutations that sensitize cancer cells to PARG dysfun...

journal_title：Cancer research

authors： Sasaki Y,Fujimori H,Hozumi M,Onodera T,Nozaki T,Murakami Y,Ashizawa K,Inoue K,Koizumi F,Masutani M

更新日期：2019-08-01 00:00:00

abstract：:Activated beta-catenin regulates the transcription of oncogenic target genes and is critical for tumorigenesis. Because nuclear functions are frequently coupled, we investigated whether it also has a role in alternative splicing of oncogenic genes. We showed that stabilized beta-catenin caused alternative splicing of ...

journal_title：Cancer research

authors： Lee HK,Choi YS,Park YA,Jeong S

更新日期：2006-11-01 00:00:00

abstract：:Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common malignancy of young men. Using genome-wide gene expression profiling, we identified >200 genes highly expressed in testicular ...

journal_title：Cancer research

authors： Almstrup K,Hoei-Hansen CE,Wirkner U,Blake J,Schwager C,Ansorge W,Nielsen JE,Skakkebaek NE,Rajpert-De Meyts E,Leffers H

更新日期：2004-07-15 00:00:00