Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells.

abstract：:The toxicity to mice of combinations of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine was investigated. The drugs were administered daily i.p. on Days 1 to 5, each drug at 10 mg/kg body weight; these dosages are small fractions of the dosages at which 10% of the treated animals died when either drug was adminis...

journal_title：Cancer research

authors： Paterson AR,Jakobs ES,Lauzon GJ,Weinstein WM

更新日期：1979-06-01 00:00:00

abstract：:The chemotherapeutic effect of B859-35, the (-)-enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethy l-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride (niguldipine), was tested on tumors induced in Syrian golden hamsters by N-nitrosodiethylamine (DEN). Periph...

journal_title：Cancer research

authors： Schuller HM,Correa E,Orloff M,Reznik GK

更新日期：1990-03-01 00:00:00

abstract：:Ascites tumor cells can be cultivated at a reduced serum concentration if cholesterol (2.50 mg per 100 ml of medium) is added to the culture medium. At serum concentrations of 3%, optimal growth properties are obtained; below 3%, cell cultures usually perish after a few days. Cells grown in the presence of added chole...

journal_title：Cancer research

authors： Haeffner EW,Hoffmann CJ,Stoehr M,Scherf H

更新日期：1984-06-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) targeted to glioma-associated antigens may allow the selective delivery of imaging and therapeutic agents to brain tumors; the use of MAb fragments may be a strategy to further improve tumor uptake of such agents relative to normal tissues. In this study, we have examined the in vivo local...

journal_title：Cancer research

authors： Colapinto EV,Humphrey PA,Zalutsky MR,Groothuis DR,Friedman HS,de Tribolet N,Carrel S,Bigner DD

更新日期：1988-10-15 00:00:00

abstract：:nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellu...

journal_title：Cancer research

authors： Iizuka N,Oka M,Noma T,Nakazawa A,Hirose K,Suzuki T

更新日期：1995-02-01 00:00:00

abstract：:Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with germline BRCA gene mutations. In hypothesizing that ad...

journal_title：Cancer research

authors： Bajrami I,Frankum JR,Konde A,Miller RE,Rehman FL,Brough R,Campbell J,Sims D,Rafiq R,Hooper S,Chen L,Kozarewa I,Assiotis I,Fenwick K,Natrajan R,Lord CJ,Ashworth A

更新日期：2014-01-01 00:00:00

abstract：:The Notch family of proteins plays an integral role in determining cell fates, such as proliferation, differentiation, and apoptosis. We show that Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines and primary human gliomas. Immunohistochemistry of a primary human glioma ti...

journal_title：Cancer research

authors： Purow BW,Haque RM,Noel MW,Su Q,Burdick MJ,Lee J,Sundaresan T,Pastorino S,Park JK,Mikolaenko I,Maric D,Eberhart CG,Fine HA

更新日期：2005-03-15 00:00:00

abstract：:The value of extracellular pH (pH(e)) in tumors is an important factor in prognosisand choice of therapy. We demonstrate here that pH(e) can be mappedin vivo in a rat brain glioma by (1)H magnetic resonance spectroscopic imaging (SI) of the pH buffer (+/-)2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA). (1)H SI...

journal_title：Cancer research

authors： García-Martín ML,Hérigault G,Rémy C,Farion R,Ballesteros P,Coles JA,Cerdán S,Ziegler A

更新日期：2001-09-01 00:00:00

abstract：:Vaccination with irradiated tumor cells genetically modified to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF tumor vaccine) induces a potent systemic antitumor immunity. To develop a protocol for cancer therapy to further augment the host immune response, we examined the effects of the GM-CSF tumor...

journal_title：Cancer research

authors： Wakimoto H,Abe J,Tsunoda R,Aoyagi M,Hirakawa K,Hamada H

更新日期：1996-04-15 00:00:00

abstract：:We have previously described the neoplastic transformation of immortalized human bronchial epithelial cells (BEAS-2B) by the combination of the c-raf-1 and c-myc protooncogenes and the concomitant induction of neuron-specific enolase mRNA expression (A. Pfeifer et al., Proc. Natl. Acad. Sci. USA, 86: 10075-10079, 1989...

journal_title：Cancer research

authors： Pfeifer AM,Jones RT,Bowden PE,Mann D,Spillare E,Klein-Szanto AJ,Trump BF,Harris CC

更新日期：1991-07-15 00:00:00

abstract：:The effects of a combination of simvastatin, a cholesterol-lowering agent, and carmustine (BCNU; N,N'-bis(2-chloroethyl)-N-nitrosourea) on experimental C6 glioma were studied in vitro and in vivo. In vitro simvastatin and BCNU alone inhibited cell proliferation in a dose-dependent fashion. A subliminal concentration o...

journal_title：Cancer research

authors： Soma MR,Baetta R,De Renzis MR,Mazzini G,Davegna C,Magrassi L,Butti G,Pezzotta S,Paoletti R,Fumagalli R

更新日期：1995-02-01 00:00:00

abstract：:We previously showed that RhoA played an important role in the proliferation of murine We prostate cancer (TRAMP) cells (P. M. Ghosh et al., Oncogene, 18: 4120-4130, 1999). Untransfected TRAMP cells as well as those expressing constitutively active RhoA (Q63L) mutant protein (Q63L cells) were highly proliferative. In ...

journal_title：Cancer research

authors： Ghosh PM,Bedolla R,Mikhailova M,Kreisberg JI

更新日期：2002-05-01 00:00:00

abstract：:Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as...

journal_title：Cancer research

authors： Gravel SP,Hulea L,Toban N,Birman E,Blouin MJ,Zakikhani M,Zhao Y,Topisirovic I,St-Pierre J,Pollak M

更新日期：2014-12-15 00:00:00

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that BRAFV600E -mutated colorectal cancers acquire resistance to MEK1 inhibition by inducing expression of the scaffold protein CEMIP through a β-catenin- and FRA-1-dependent ...

journal_title：Cancer research

authors： Duong HQ,Nemazanyy I,Rambow F,Tang SC,Delaunay S,Tharun L,Florin A,Büttner R,Vandaele D,Close P,Marine JC,Shostak K,Chariot A

更新日期：2018-08-15 00:00:00

abstract：:The metabolism and mutagenic activation of the model carcinogens benzo(a)pyrene [B(a)P] and 2-acetylaminofluorene (AAF) by human and rat kidney cells were measured. A slicing technique followed by enzyme digestion was utilized to obtain the kidney cells. Although levels of total metabolism of B(a)P by rat and human ki...

journal_title：Cancer research

authors： Rudo KM,Dauterman WC,Langenbach R

更新日期：1989-03-01 00:00:00

abstract：:Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product/cytokine that catalyzes a step in glycolysis and gluconeogenesis, and acts as a multifunctional cytokine associated with aggressive tumors. PGI/AMF has been correlated significantly with breast cancer progression and poor progn...

journal_title：Cancer research

authors： Funasaka T,Hogan V,Raz A

更新日期：2009-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) promotes a multitude of diverse biological processes, including growth arrest of epithelial cells and proliferation of fibroblasts. Although the TGF-beta signaling pathways that promote inhibition of epithelial cell growth are well characterized, less is known about the mecha...

journal_title：Cancer research

authors： Rahimi RA,Andrianifahanana M,Wilkes MC,Edens M,Kottom TJ,Blenis J,Leof EB

更新日期：2009-01-01 00:00:00

abstract：:Testicular germ cell cancer is one of the very few cancers that are highly sensitive to and curable by cisplatin-based chemotherapy even in an advanced stage. However, in a few cases resistance to cisplatin occurs and patients subsequently die from progressive disease. The molecular basis for this resistance remains t...

journal_title：Cancer research

authors： Mueller T,Voigt W,Simon H,Fruehauf A,Bulankin A,Grothey A,Schmoll HJ

更新日期：2003-01-15 00:00:00

abstract：:Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult. Eighteen HLA A*0201(+) patients with metastatic melanoma received injections s.c. of CD34(+)progenitor-derived autologous dendritic cells (DCs), which included Langerhans cells. DCs were pulsed wi...

journal_title：Cancer research

authors： Banchereau J,Palucka AK,Dhodapkar M,Burkeholder S,Taquet N,Rolland A,Taquet S,Coquery S,Wittkowski KM,Bhardwaj N,Pineiro L,Steinman R,Fay J

更新日期：2001-09-01 00:00:00

abstract：:Altered DNA methylation is a key feature of cancer, and aberrant methylation is important in nasopharyngeal carcinoma (NPC) development. However, the methylation mechanisms underlying metastasis of NPC remain unclear. Analyzing data from public databases and conducting our own experiments, we report here that promoter...

journal_title：Cancer research

authors： Zhang J,Li YQ,Guo R,Wang YQ,Zhang PP,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

更新日期：2019-02-15 00:00:00

abstract：:Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50% inhibited by 330 microM 5-fluorouracil and 15 microM methyl-CCNU, and the HT-29 line is 50% inhibited by 85 and 140 microM,...

journal_title：Cancer research

authors： Sutton JE,Roos IA,Hillcoat BL

更新日期：1982-12-01 00:00:00

abstract：:In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the secon...

journal_title：Cancer research

authors： Stoll C,Borgaonkar DS,Levy JM

更新日期：1976-08-01 00:00:00

abstract：:Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations to sporadic colorectal tumorigenesis is unclear. We therefore used P...

journal_title：Cancer research

authors： Samowitz WS,Powers MD,Spirio LN,Nollet F,van Roy F,Slattery ML

更新日期：1999-04-01 00:00:00

abstract：:In cancer patients and in those at high risk, systemic exposure to agents for therapy or prevention is accompanied by undesirable side effects. We hypothesized that it is possible to prevent and treat breast cancer by introducing anticancer agents into the mammary ductal network. Here, we show the efficacy of intraduc...

journal_title：Cancer research

authors： Murata S,Kominsky SL,Vali M,Zhang Z,Garrett-Mayer E,Korz D,Huso D,Baker SD,Barber J,Jaffee E,Reilly RT,Sukumar S

更新日期：2006-01-15 00:00:00

abstract：:The radiation response of autochthonous tumors induced by s.c. injection of 3-methylcholanthrene in ICR/JCL mice was studied. The tumors were mostly fibrosarcomas and grew with an average volume-doubling time of 2.6 days, independently of the time tumor appearance or dose of the chemical used. The tumors were locally ...

journal_title：Cancer research

authors： Tanooka H,Hoshino H,Tanaka K,Nagase M

更新日期：1980-07-01 00:00:00

abstract：:The present study was designed to determine whether alterations in host metabolism associated with progressive tumor growth were a result of the anorexia frequently observed with cancer or could be attributed to other direct tumor effects. Rates of tyrosine flux, oxidation, and incorporation into protein, as well as f...

journal_title：Cancer research

authors： Kawamura I,Moldawer LL,Keenan RA,Batist G,Bothe A Jr,Bistrian BR,Blackburn GL

更新日期：1982-03-01 00:00:00

abstract：:Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

journal_title：Cancer research

authors： Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

更新日期：2018-02-01 00:00:00

abstract：:A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to G...

journal_title：Cancer research

authors： Sweeney C,McClure GY,Fares MY,Stone A,Coles BF,Thompson PA,Korourian S,Hutchins LF,Kadlubar FF,Ambrosone CB

更新日期：2000-10-15 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachment, migration, survival, and proliferation. However, little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We report here that DDR1 indu...

journal_title：Cancer research

authors： Das S,Ongusaha PP,Yang YS,Park JM,Aaronson SA,Lee SW

更新日期：2006-08-15 00:00:00