Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma.

abstract：:To determine whether the toxic effects and changes in many cell functions caused by antitumor 1-nitroacridines are related to their enzymatically mediated covalent interstrand DNA cross-linking (J. Konopa, J. W. Pawlak, and K. Pawlak. Chem.-Biol. Interact., 43: 175-197, 1983), the cross-linking potency of the derivati...

journal_title：Cancer research

authors： Pawlak K,Pawlak JW,Konopa J

更新日期：1984-10-01 00:00:00

abstract：:Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated that vascular ...

journal_title：Cancer research

authors： Langenkamp E,Zhang L,Lugano R,Huang H,Elhassan TE,Georganaki M,Bazzar W,Lööf J,Trendelenburg G,Essand M,Pontén F,Smits A,Dimberg A

更新日期：2015-11-01 00:00:00

abstract：:The anticancer effects of red wine have attracted considerable attention. Resveratrol (3,5,4'-trihydroxy-trans -stilbene) is a well-known polyphenolic compound of red wine with cancer chemopreventive activity. However, the basis for this activity is unclear. We studied leukotriene A(4) hydrolase (LTA(4)H) as a relevan...

journal_title：Cancer research

authors： Oi N,Jeong CH,Nadas J,Cho YY,Pugliese A,Bode AM,Dong Z

更新日期：2010-12-01 00:00:00

abstract：:Tumor cell interaction with endothelial cells is a crucial step leading to organ-selective metastasis. Adhesion of murine B16 amelanotic melanoma cells (B16a) to murine microvascular endothelial cells (CD3) was enhanced, in a dose- and time-dependent manner, by pretreating CD3 cells with 12(S)-hydroperoxyeicosatetraen...

journal_title：Cancer research

authors： Tang DG,Diglio CA,Honn KV

更新日期：1994-02-15 00:00:00

abstract：:To investigate the possible involvement of a tumor suppressor gene(s) on chromosome 8 in prostatic neoplasms, we performed a comprehensive loss of heterozygosity (LOH) study on 99 tumors from 97 prostate cancer patients. One of the carcinomas was a lymph node metastasis; the other 98 were primary carcinomas. Pure popu...

journal_title：Cancer research

authors： Vocke CD,Pozzatti RO,Bostwick DG,Florence CD,Jennings SB,Strup SE,Duray PH,Liotta LA,Emmert-Buck MR,Linehan WM

更新日期：1996-05-15 00:00:00

abstract：:We examined whether herpes simplex virus thymidine kinase (HSV-TK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region...

journal_title：Cancer research

authors： Koshikawa N,Takenaga K,Tagawa M,Sakiyama S

更新日期：2000-06-01 00:00:00

abstract：:DR-nm23 cDNA was cloned recently by differential screening of a cDNA library derived from chronic myelogenous leukemia-blast crisis primary cells. It is highly homologous to the putative metastasis suppressor nm23-H1 gene and the closely related nm23-H2 gene. When overexpressed in the myeloid precursor 32Dcl3 cell lin...

journal_title：Cancer research

authors： Martinez R,Venturelli D,Perrotti D,Veronese ML,Kastury K,Druck T,Huebner K,Calabretta B

更新日期：1997-03-15 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent r...

journal_title：Cancer research

authors： Huang Z,Mayr NA,Yuh WT,Lo SS,Montebello JF,Grecula JC,Lu L,Li K,Zhang H,Gupta N,Wang JZ

更新日期：2010-01-15 00:00:00

abstract：:Incubation of adherent human breast epithelial HBL100 cells with epidermal growth factor (EGF) decreased [3H]dexamethasone binding by 35% with no effect on affinity. Maximal inhibition was obtained at 3 nM EGF and the 50% effective dose was 0.2 nM EGF. Decreased dexamethasone binding induced by 3 nM EGF was maximal by...

journal_title：Cancer research

authors： Rao KV,Williams RE,Fox CF

更新日期：1987-11-15 00:00:00

abstract：:: TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here, we investigate the expression of TRIM29 in cutaneous head and neck squam...

journal_title：Cancer research

authors： Yanagi T,Watanabe M,Hata H,Kitamura S,Imafuku K,Yanagi H,Homma A,Wang L,Takahashi H,Shimizu H,Hatakeyama S

更新日期：2018-12-15 00:00:00

abstract：:A large number of studies have been carried out to identify the Friend leukemia virus (FV) target cell(s). In FV-infected mice, the kinetics of "primitive" erythroid burst-forming units (P-BFU-E) is perturbed, and their proliferative rate is enhanced. These results indirectly suggest, but do not prove, that cycling P-...

journal_title：Cancer research

authors： Colletta G,Di Fiore PP,Fusco A,Lettieri F,Covelli A,Peschle C

更新日期：1983-02-01 00:00:00

abstract：:Abnormalities of chromosome 1, including trisomy for all or a portion of the long arm, have been frequently reported in many cancers. Anomalies of chromosome 19 are far less common, although a t(1;19)(q23;p13) translocation has been reported in association with pre-B-cell leukemia. We have observed a t(1;19)(q12;p13) ...

journal_title：Cancer research

authors： Parmiter AH,Balaban G,Herlyn M,Clark WH Jr,Nowell PC

更新日期：1986-03-01 00:00:00

abstract：:Hepatocellular carcinoma is among the most common and lethal cancers in humans. Hepatocellular carcinoma is commonly associated with physical or functional inactivation of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing chronic cycles of hepatocyte death and regeneratio...

journal_title：Cancer research

authors： Farazi PA,Glickman J,Horner J,Depinho RA

更新日期：2006-05-01 00:00:00

abstract：:Anchorage-independent growth is a hallmark of tumor cells. We compared gene expression profiles of anchored and nonanchored human mammary carcinoma cells to study this phenomenon. In this study, we show that anchorage had striking effects on cell growth and morphology but altered transcript levels from a limited numbe...

journal_title：Cancer research

authors： Goldberg GS,Jin Z,Ichikawa H,Naito A,Ohki M,El-Deiry WS,Tsuda H

更新日期：2001-02-15 00:00:00

abstract：:Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small cell lung cancers (57.4% stage 1, 16.7% stage 2, and 25.9% stage 3) to...

journal_title：Cancer research

authors： Esposito V,Baldi A,De Luca A,Groger AM,Loda M,Giordano GG,Caputi M,Baldi F,Pagano M,Giordano A

更新日期：1997-08-15 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of...

journal_title：Cancer research

authors： Cheung AM,Elia A,Tsao MS,Done S,Wagner KU,Hennighausen L,Hakem R,Mak TW

更新日期：2004-03-15 00:00:00

abstract：:Eosinophilia in tissues and/or circulating blood is known to be associated with a wide variety of malignancies but the role of the eosinophil in neoplastic conditions is not known. Using the cheek pouch of the Syrian hamster as an experimental model for oral carcinogenesis, it has recently been shown that eosinophils ...

journal_title：Cancer research

authors： Ghiabi M,Gallagher GT,Wong DT

更新日期：1992-01-15 00:00:00

abstract：:Human carcinoembryonic antigen (CEA), a widely used tumor marker, and CEACAM6 [formerly nonspecific cross-reacting antigen (NCA)] are up-regulated in many types of human cancers, whereas family member CEACAM1 [formerly biliary glycoprotein (BGP)] is usually down-regulated. Deregulated overexpression of CEA/CEACAM6 but...

journal_title：Cancer research

authors： Ordoñez C,Screaton RA,Ilantzis C,Stanners CP

更新日期：2000-07-01 00:00:00

abstract：:During therapy for chronic myeloid leukemia (CML), decline of the number of BCR-ABL transcripts has been shown to follow a biphasic pattern, with a fast phase followed by a slower phase. Hence, sustained remission requires a long phase of therapy. Data indicate that a combination of different available targeted drugs ...

journal_title：Cancer research

authors： Komarova NL,Wodarz D

更新日期：2009-06-01 00:00:00

abstract：:Cell adhesion molecules have been implicated in the colonization of cancer cells to distant organs. Prostate cancer (PCa) has a propensity to metastasize to bone, and cadherin-11, which is an osteoblast cadherin aberrantly expressed in PCa cells derived from bone metastases, has been shown to play a role in the metast...

journal_title：Cancer research

authors： Huang CF,Lira C,Chu K,Bilen MA,Lee YC,Ye X,Kim SM,Ortiz A,Wu FL,Logothetis CJ,Yu-Lee LY,Lin SH

更新日期：2010-06-01 00:00:00

abstract：:The intention of this study was to estimate the pharmacological advantage of a clinically applicable method of isolated liver perfusion (ILP) over hepatic artery infusion (HAI) administering various doses of 5-fluorouracil (FUra). FUra concentrations were measured using high-performance liquid chromatography in liver ...

journal_title：Cancer research

authors： de Brauw LM,Marinelli A,van de Velde CJ,Hermans J,Tjaden UR,Erkelens C,de Bruijn EA

更新日期：1991-03-15 00:00:00

abstract：:The receptor tyrosine kinase ErbB-2 plays an important role in the regulation of growth factor-induced signal transduction cascades in the epithelium, and ErbB-2 is frequently overexpressed in epithelial tumors. Our previous studies on clinical prostate cancer specimens indicated that ErbB-2 expression was increased i...

journal_title：Cancer research

authors： Casimiro M,Rodriguez O,Pootrakul L,Aventian M,Lushina N,Cromelin C,Ferzli G,Johnson K,Fricke S,Diba F,Kallakury B,Ohanyerenwa C,Chen M,Ostrowski M,Hung MC,Rabbani SA,Datar R,Cote R,Pestell R,Albanese C

更新日期：2007-05-01 00:00:00

abstract：:Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. GPx2 silencing...

journal_title：Cancer research

authors： Emmink BL,Laoukili J,Kipp AP,Koster J,Govaert KM,Fatrai S,Verheem A,Steller EJ,Brigelius-Flohé R,Jimenez CR,Borel Rinkes IH,Kranenburg O

更新日期：2014-11-15 00:00:00

abstract：:Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines der...

journal_title：Cancer research

authors： Brown CE,Starr R,Martinez C,Aguilar B,D'Apuzzo M,Todorov I,Shih CC,Badie B,Hudecek M,Riddell SR,Jensen MC

更新日期：2009-12-01 00:00:00

abstract：:5-lodo-2'-deoxyuridine (lUdR) significantly increases the total number of spleen cells on the fourth day after administration of 100 mg/kg in normal C3HeB/FeJ male mice. The number of splenic B-cells [cells sensitive to the cytotoxic activity of a rabbit antiserum to mouse F(ab)2, plus complement] increases on the sam...

journal_title：Cancer research

authors： Anaclerio A,Leitman S,Galiette R,Heppner G,Calabresi P

更新日期：1976-01-01 00:00:00

abstract：:17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17beta-HSD12 expression was also reported in breast carcinomas but its functions have remained unknown. In this study, we examined t...

journal_title：Cancer research

authors： Nagasaki S,Suzuki T,Miki Y,Akahira J,Kitada K,Ishida T,Handa H,Ohuchi N,Sasano H

更新日期：2009-02-15 00:00:00

abstract：:Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor. This provides a mechanism t...

journal_title：Cancer research

authors： Frisch SM

更新日期：2008-06-15 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00