Functional implications of altered subcellular localization of PELP1 in breast cancer cells.

abstract：:Pregnancy, parity, and circulating steroid hormone levels are associated with risk of breast cancer, but little is known about hormone concentrations during pregnancy and subsequent breast cancer risk. We evaluated early pregnancy (<140 days gestation) serum estradiol, estrone, progesterone, and testosterone and breas...

journal_title：Cancer research

authors： Fortner RT,Schock H,Kaaks R,Lehtinen M,Pukkala E,Lakso HÅ,Tanner M,Kallio R,Joensuu H,Grankvist K,Zeleniuch-Jacquotte A,Toniolo P,Lundin E,Surcel HM

更新日期：2014-12-01 00:00:00

abstract：:In humans and rabbits, differences in the rate of N-acetylation of aromatic amines are under polymorphic genetic control. Individuals are classified as either rapid or slow acetylators. In the current study, the relationship between acetylator phenotype and susceptibility to the genotoxicities of benzidine, 4-aminobip...

journal_title：Cancer research

authors： McQueen CA,Maslansky CJ,Williams GM

更新日期：1983-07-01 00:00:00

abstract：:Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach. It has been implicated in tumor growth, sensitivity to standard chemotherapy, prognosis of patients, and disease-free survival. Although the clinical use of tra...

journal_title：Cancer research

authors： Jani JP,Finn RS,Campbell M,Coleman KG,Connell RD,Currier N,Emerson EO,Floyd E,Harriman S,Kath JC,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Ralston S,Rossi AM,Steyn SJ,Wagner L,Winter SM,Bhattacharya SK

更新日期：2007-10-15 00:00:00

abstract：:Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Both EST and STS have been suggested to play important roles in regulating the in situ production of estrogens in human breast carcinoma tissu...

journal_title：Cancer research

authors： Suzuki T,Nakata T,Miki Y,Kaneko C,Moriya T,Ishida T,Akinaga S,Hirakawa H,Kimura M,Sasano H

更新日期：2003-06-01 00:00:00

abstract：:Myeloma vaccines, based on dendritic cells pulsed with idiotype or tumor lysate, have been met with limited success, probably in part due to insufficient cross-priming of myeloma antigens. A powerful method to introduce myeloma-associated antigens into the cytosol of dendritic cells is protein transduction, a process ...

journal_title：Cancer research

authors： Batchu RB,Moreno AM,Szmania SM,Bennett G,Spagnoli GC,Ponnazhagan S,Barlogie B,Tricot G,van Rhee F

更新日期：2005-11-01 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:Twenty-eight patients with metastatic malignant melanoma received anti-p97 murine monoclonal antibody (96.5) infused over 2 h at doses between 1 and 20 mg coupled to either 2.5 or 5.0 mCi of 111In by the bifunctional chelating agent diethyltriaminepentaacetic acid. Clearance of 111In from plasma closely fit an open, o...

journal_title：Cancer research

authors： Rosenblum MG,Murray JL,Haynie TP,Glenn HJ,Jahns MF,Benjamin RS,Frincke JM,Carlo DJ,Hersh EM

更新日期：1985-05-01 00:00:00

abstract：:The ING family of proteins is involved in the regulation of diverse processes ranging from cell cycle and cellular senescence to apoptosis. These effects are most likely through activation of acetylation-dependent pathways that ultimately alter gene expression. Despite reports linking ING to p53 activation, the molecu...

journal_title：Cancer research

authors： Kataoka H,Bonnefin P,Vieyra D,Feng X,Hara Y,Miura Y,Joh T,Nakabayashi H,Vaziri H,Harris CC,Riabowol K

更新日期：2003-09-15 00:00:00

abstract：:We examined the effect of rate of temperature rise on the thermosensitivity of a murine lymphoblastic leukemia. L1210 cells suspended in RPMI 1630 medium:5% fetal bovine serum at pH 7.4 were heated from 37 degrees C-42 degrees C, or 44 degrees C over variable times (immediately, 30, 60, 120, 180 min) in a circulating ...

journal_title：Cancer research

authors： Burns CP,Lambert BJ,Haugstad BN,Guffy MM

更新日期：1986-04-01 00:00:00

abstract：:The most deadly phase in cancer progression is attributed to the inappropriate acquisition of molecular machinery leading to metastatic transformation and spread of disease to distant organs. Although it is appreciated that metastasis involves epithelial-mesenchymal interplay, the underlying mechanism defining this pr...

journal_title：Cancer research

authors： Powell AE,Anderson EC,Davies PS,Silk AD,Pelz C,Impey S,Wong MH

更新日期：2011-02-15 00:00:00

abstract：:The effect of 17beta-estradiol on an estrogen receptor-positive human breast cancer cell line (MCF-7) was studied. Low concentrations (10(-9) M) of 17beta-estradiol enhanced the rate of cell proliferation; the overall cell cycle time was shortened; and the proportion of cells in the S phase increased. Higher concentra...

journal_title：Cancer research

authors： Weichselbaum RR,Hellman S,Piro AJ,Nove JJ,Little JB

更新日期：1978-08-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors...

journal_title：Cancer research

authors： Inselmann S,Wang Y,Saussele S,Fritz L,Schütz C,Huber M,Liebler S,Ernst T,Cai D,Botschek S,Brendel C,Calogero RA,Pavlinic D,Benes V,Liu ET,Neubauer A,Hochhaus A,Burchert A

更新日期：2018-11-01 00:00:00

abstract：:Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK), includ...

journal_title：Cancer research

authors： Leonard B,Brand TM,O'Keefe RA,Lee ED,Zeng Y,Kemmer JD,Li H,Grandis JR,Bhola NE

更新日期：2018-08-01 00:00:00

abstract：:Genetic immunization of mice with dendritic cells (DCs) engineered to express a melanoma antigen generates antigen-specific, MHC-restricted, CD4-dependent protective immune responses. We wanted to determine the role of CD4 cells and CD40 ligation of MART-1 gene-modified DC in an animal model of immunotherapy for murin...

journal_title：Cancer research

authors： Ribas A,Butterfield LH,Amarnani SN,Dissette VB,Kim D,Meng WS,Miranda GA,Wang HJ,McBride WH,Glaspy JA,Economou JS

更新日期：2001-12-15 00:00:00

abstract：:Treatment of male rats with the anticancer drug cisplatin leads to feminization of the profile of cytochrome P-450 and other microsomal enzymes involved in steroid hormone and drug metabolism (G.A. LeBlanc, and D.J. Waxman, J. Biol. Chem., 263: 15732-15739, 1988). The present study uses the rat model to evaluate the d...

journal_title：Cancer research

authors： LeBlanc GA,Sundseth SS,Weber GF,Waxman DJ

更新日期：1992-02-01 00:00:00

abstract：:The identification of proteins that are preferentially expressed on the membrane of metastatic tumor cells is of fundamental importance in cancer research. Here, we report the systematic comparison of the membrane proteome of two closely related murine teratocarcinoma cell lines (F9B9 and F9DR), of which only one (F9D...

journal_title：Cancer research

authors： Roesli C,Borgia B,Schliemann C,Gunthert M,Wunderli-Allenspach H,Giavazzi R,Neri D

更新日期：2009-07-01 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:In an attempt to develop better combination therapies for use with local radiation, the interaction between bleomycin and hyperthermia +/- radiation was studied in the FSaIIC tumor system. In cells exposed in vitro to bleomycin at 37 degrees C and at pH 7.40, the drug was substantially more toxic toward normally oxyge...

journal_title：Cancer research

authors： Teicher BA,Herman TS,Holden SA

更新日期：1988-11-15 00:00:00

abstract：:Intravesical mitomycin C (MMC) therapy is used to treat superficial bladder cancer. This study was to establish the intra- and intersubject variabilities in the systemic (plasma) and target site (bladder) exposure to the drug and to identify the factors which contribute to these variabilities. The pharmacokinetics of ...

journal_title：Cancer research

authors： Dalton JT,Wientjes MG,Badalament RA,Drago JR,Au JL

更新日期：1991-10-01 00:00:00

abstract：:The pharmacokinetics of melphalan following high-dose p.o. administration were determined in 17 patients with various malignancies for the purpose of assessing interpatient and intrapatient pharmacokinetic variability. All patients underwent bone marrow harvest on day -8 (relative to bone marrow reinfusion). On days -...

journal_title：Cancer research

authors： Choi KE,Ratain MJ,Williams SF,Golick JA,Beschorner JC,Fullem LJ,Bitran JD

更新日期：1989-03-01 00:00:00

abstract：:Salmonella enterica and avirulent derivatives prefer solid tumors over normal tissue in animal models. The identification of endogenous Salmonella promoters that are preferentially activated in tumors could further our understanding of this phenomenon. Toward this goal, a random library of S. enterica typhimurium 1402...

journal_title：Cancer research

authors： Arrach N,Zhao M,Porwollik S,Hoffman RM,McClelland M

更新日期：2008-06-15 00:00:00

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00

abstract：:Using a sensitive radioimmunoassay, concentrations of vincristine and its products were determined in cerebrospinal fluid (CSF) and corresponding blood samples from four patients with lymphoma and two patients with leukemia who had received i.v. bolus injection of 2 mg vincristine. Serial samples of CSF were withdrawn...

journal_title：Cancer research

authors： Jackson DV Jr,Sethi VS,Spurr CL,McWhorter JM

更新日期：1981-04-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed "stromal cells") that can promote or inhibit tumorigenesis by mechanisms that have not been fully elucidated. Here, we postulated that stromal cells in the tumor microenv...

journal_title：Cancer research

authors： Zhong L,Roybal J,Chaerkady R,Zhang W,Choi K,Alvarez CA,Tran H,Creighton CJ,Yan S,Strieter RM,Pandey A,Kurie JM

更新日期：2008-09-01 00:00:00

abstract：:Neoplastic transformation mediated by ras oncogenes is associated with down-regulation of gene expression. We have constructed a subtracted complementary DNA library from preneoplastic rat 208F fibroblasts by hybridizing with mRNA from a ras-transformed subclone. One of the complementary DNA clones identified by this ...

journal_title：Cancer research

authors： Hajnal A,Klemenz R,Schäfer R

更新日期：1993-10-01 00:00:00

abstract：:p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharo...

journal_title：Cancer research

authors： Shimada A,Kato S,Enjo K,Osada M,Ikawa Y,Kohno K,Obinata M,Kanamaru R,Ikawa S,Ishioka C

更新日期：1999-06-15 00:00:00

abstract：:A cultured renal carcinoma cell line, ACHN, continued to proliferate in the absence of exogenous growth factors supplied by fetal calf serum. ACHN cells had been previously used as the immunogen for the production of monoclonal antibody 5F4. Subsequent immunohistochemical studies showed that 5F4 strongly and selective...

journal_title：Cancer research

authors： Kochevar J

更新日期：1990-05-15 00:00:00

abstract：:We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to prote...

journal_title：Cancer research

authors： Jimenez JJ,Yunis AA

更新日期：1992-09-15 00:00:00

abstract：:Osimertinib, a mutant-specific third-generation EGFR tyrosine kinase inhibitor, is emerging as the preferred first-line therapy for EGFR-mutant lung cancer, yet resistance inevitably develops in patients. We modeled acquired resistance to osimertinib in transgenic mouse models of EGFRL858R -induced lung adenocarcinoma...

journal_title：Cancer research

authors： Starrett JH,Guernet AA,Cuomo ME,Poels KE,van Alderwerelt van Rosenburgh IK,Nagelberg A,Farnsworth D,Price KS,Khan H,Ashtekar KD,Gaefele M,Ayeni D,Stewart TF,Kuhlmann A,Kaech SM,Unni AM,Homer R,Lockwood WW,Michor F,G

更新日期：2020-05-15 00:00:00

abstract：:Cells deficient in DNA polymerase beta (beta-pol) are impaired in base excision repair (BER) and hypersensitive to various DNA damaging agents, including methylating mutagens. Hypersensitivity of beta-pol-deficient cells to methylating agents is because of induction of apoptosis (Ochs et al., Cancer Res., 59: 1544-155...

journal_title：Cancer research

authors： Ochs K,Lips J,Profittlich S,Kaina B

更新日期：2002-03-01 00:00:00