Prostatic hexosaminidase activity in patients with benign prostatic hyperplasia and prostatic carcinoma.

abstract：:Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance. Noninvasive imaging methods that can quantify DCK activity are invaluable for assessing tumor res...

journal_title：Cancer research

authors： Han Z,Li Y,Zhang J,Liu J,Chen C,van Zijl PC,Liu G

更新日期：2019-05-15 00:00:00

abstract：:Dietary genistein, a natural flavone compound found in soy, has been proposed to be responsible for the low rate of breast cancer in Asian women. The cellular mechanisms of genistein's chemopreventive effects in vio have been largely unexplored. In our previous studies, we found that genistein exerted pronounced antip...

journal_title：Cancer research

authors： Shao ZM,Wu J,Shen ZZ,Barsky SH

更新日期：1998-11-01 00:00:00

abstract：:We analyzed a case-control study of bladder cancer in Torino (512 male and 55 female cases; 596 male and 202 female controls) with emphasis on the timing of cigarette smoking and the use of black or blond tobacco. The risk of bladder cancer was 2 to 3 times higher among smokers of black tobacco than among smokers of b...

journal_title：Cancer research

authors： Vineis P,Esteve J,Hartge P,Hoover R,Silverman DT,Terracini B

更新日期：1988-07-01 00:00:00

abstract：:Infection of the bone marrow-derived mast cell line PB-3c with a retrovirus carrying oncogenic c-Ha-ras or v-Ha-ras reduced the interleukin 3 (IL-3) growth requirement and induced a state of tumorigenicity. In contrast, normal c-Ha-ras had no effect on the IL-3 requirement of this cell line nor did the cells become tu...

journal_title：Cancer research

authors： Imber R,Fabbro D

更新日期：1991-01-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been investigated as a potent mediator of brain tumor angiogenesis, vascular permeability, and glioma growth. Using a VEGF ELISA, we determined the concentration of VEGF in the sera and tumor extracts of 19 brain tumor patients including glioblastoma, anaplastic astrocytom...

journal_title：Cancer research

authors： Takano S,Yoshii Y,Kondo S,Suzuki H,Maruno T,Shirai S,Nose T

更新日期：1996-05-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:Surface-exposed proteins of vinblastine-sensitive human lymphoid cell line of leukemic origin (CCRF-CEM) were examined by the lactoperoxidase-catalyzed iodination and two-dimensional polyacrylamide gel electrophoresis methods. Spots which comigrate with bovine brain tubulin and rabbit muscle actin were prominently lab...

journal_title：Cancer research

authors： Rubin RW,Quillen M,Corcoran JJ,Ganapathi R,Krishan A

更新日期：1982-04-01 00:00:00

abstract：:Thyroid tissues in coho salmon (Oncorhynchus kisutch) goiters showed marked regional variation in structure and ultrastructure. For the most part the follicles were small, were composed of tall epithelial cells, and contained little or no colloid material. The follicle epithelial cells were essentially similar in fine...

journal_title：Cancer research

authors： Leatherland JF,Moccia R,Sonstegard R

更新日期：1978-01-01 00:00:00

abstract：:Rat pheochromocytoma PC12 cells form tumors when placed into the brains of Sprague-Dawley rats under specific conditions. We now show that tumorigenic potential is regulated by the microenvironment of the developing cerebrum. PC12 cell aggregates were identified in the periventricular or intraventricular spaces within...

journal_title：Cancer research

authors： Hatton JD,Lechtman AN,U HS

更新日期：1992-04-01 00:00:00

abstract：:Exposure of mice to total body irradiation induces nuclear factor kappaB (NFkappaB) activation in a tissue-specific manner. In addition to the spleen, lymph nodes, and bone marrow, the tissues that exhibit NFkappaB activation now include the newly identified site of the intestinal epithelial cells. NFkappaB activated ...

journal_title：Cancer research

authors： Wang Y,Meng A,Lang H,Brown SA,Konopa JL,Kindy MS,Schmiedt RA,Thompson JS,Zhou D

更新日期：2004-09-01 00:00:00

abstract：:Four new human non-small cell lung cancer cell lines have been established in vitro. These cell lines have been characterized by (a) growth of a tumor in nude mice with histopathology similar to that of the primary, (b) isoenzyme patterns phenotypically human and distinct from each other, (c) distinguishing karyotypic...

journal_title：Cancer research

authors： Loh PM,Clamon GH,Robinson RA,White ML,Hukku B,Rossi NP,Peterson WD

更新日期：1984-08-01 00:00:00

abstract：:Small cell lung cancer (SCLC) produces several neuroendocrine peptides, including gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin. There is some evidence to support the suggestion that GRP is an autocrine regulator of SCLC growth. Therefore, we have tested the effect of bombesin and two antagonis...

journal_title：Cancer research

authors： Layton JE,Scanlon DB,Soveny C,Morstyn G

更新日期：1988-09-01 00:00:00

abstract：:Radioimmunoassay has been used to measure acetylated and deacetylated deoxyguanosine C-8 DNA adducts of 2-acetylaminofluorene in liver and kidney DNA of male Wistar-Furth rats fed a dietary regimen of 0.02 or 0.04% 2-acetylaminofluorene. When adduct formation was monitored during continuous feeding up to 60 days, subs...

journal_title：Cancer research

authors： Poirier MC,True B,Laishes BA

更新日期：1982-04-01 00:00:00

abstract：:The diagnostic value of elevated human chorionic gonadotropin (hCG) and its free alpha (hCG alpha) and beta (hCG beta) subunit serum levels as specific tumor markers for nongonadal malignancies is controversial. In the present report, different monoclonal based immunoradiometric assays specific for hCG and its free hC...

journal_title：Cancer research

authors： Marcillac I,Troalen F,Bidart JM,Ghillani P,Ribrag V,Escudier B,Malassagne B,Droz JP,Lhommé C,Rougier P

更新日期：1992-07-15 00:00:00

abstract：:Kaposi's sarcoma (KS) is seen with increased frequency in the course of the epidemic of acquired immune deficiency syndrome. In this population, KS has manifested in an aggressive and more disseminated fashion as compared to the classical type. As the epidemic of acquired immune deficiency syndrome continues to spread...

journal_title：Cancer research

authors： Safai B,Sarngadharan MG,Koziner B,Godbold J,Myskowski PL,Cunningham-Rundles S,Johnson K,Gold J,Krown S,Dupont B

更新日期：1985-09-01 00:00:00

abstract：:The role of acidic glycosphingolipids in cell growth and differentiation was investigated using the multipotent leukemia cell line K562. When GM3 was added to cell culture media, the growth of K562 cells was remarkably inhibited and the cells were shown to have megakaryocytoid morphology. Ultrastructural study demonst...

journal_title：Cancer research

authors： Nakamura M,Kirito K,Yamanoi J,Wainai T,Nojiri H,Saito M

更新日期：1991-04-01 00:00:00

abstract：:Several factors which influence the sensitivity of Chinese hamster V79 cells to cyclophosphamide (CY) have been studied in vitro in both suspension and monolayer cultures. Activated CY was obtained from the blood of mice 15 to 30 min after i.p. injection of CY (400 mg/kg). At pH 7.4, hypoxia rendered the cells more se...

journal_title：Cancer research

authors： Begg AC,Shrieve DC,Smith KA,Terry NH

更新日期：1985-08-01 00:00:00

abstract：:In an attempt to maximize the therapeutic index and to overcome the large variations in 1-beta-D-arabinofuranosylcytosine (ara-C) plasma levels and host toxicities that have been documented with standard HDara-C regimens (3 g/m2 over 3 h every 12 h x 8 or x12 doses), pediatric patients with acute lymphocytic leukemia ...

journal_title：Cancer research

authors： Avramis VI,Weinberg KI,Sato JK,Lenarsky C,Willoughby ML,Coates TD,Ozkaynak MF,Parkman R

更新日期：1989-01-01 00:00:00

abstract：:Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human o...

journal_title：Cancer research

authors： Agarwal R,D'Souza T,Morin PJ

更新日期：2005-08-15 00:00:00

abstract：:Chromosomal aberrations associated with lung cancer are frequently observed in the long arm of chromosome 6. A candidate susceptibility locus at 6q23-25 for lung cancer was recently identified; however, no tumor suppressor genes inactivated by mutation have been identified in this locus. Genetic, epigenetic, gene expr...

journal_title：Cancer research

authors： Tessema M,Willink R,Do K,Yu YY,Yu W,Machida EO,Brock M,Van Neste L,Stidley CA,Baylin SB,Belinsky SA

更新日期：2008-03-15 00:00:00

abstract：:Genetic instability has been recognized as a hallmark of human cancers. Retinoblastoma (Rb) tumor suppressor protein has an essential role in modulating cell cycle progression. However, there is no direct evidence supporting its role in maintaining genetic stability. Here, we developed a sensitive method to examine th...

journal_title：Cancer research

authors： Zheng L,Flesken-Nikitin A,Chen PL,Lee WH

更新日期：2002-05-01 00:00:00

abstract：:While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL respon...

journal_title：Cancer research

authors： Ahrends T,Bąbała N,Xiao Y,Yagita H,van Eenennaam H,Borst J

更新日期：2016-05-15 00:00:00

abstract：:Changes in the structure of the surface of mastocytoma cells were induced by hyperthermia and were investigated by means of cell electrophoresis. A decrease in the cell electrophoretic mobility was detected as early as 15 min after treatment at 42 degrees and progressed more rapidly under hypoxic conditions than under...

journal_title：Cancer research

authors： Sato C,Nakayama T,Kojima K,Nishimoto Y,Nakamura W

更新日期：1981-10-01 00:00:00

abstract：:Biallelic somatic mutations of TCF1 coding for hepatocyte nuclear factor 1alpha (HNF1alpha) are found in 50% of the hepatocellular adenoma (HCA) cases usually associated with oral contraception. In rare cases, HNF1alpha germ line mutations could also predispose to familial adenomatosis. In order to identify new geneti...

journal_title：Cancer research

authors： Jeannot E,Poussin K,Chiche L,Bacq Y,Sturm N,Scoazec JY,Buffet C,Van Nhieu JT,Bellanné-Chantelot C,de Toma C,Laurent-Puig P,Bioulac-Sage P,Zucman-Rossi J

更新日期：2007-03-15 00:00:00

abstract：:Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. To evaluate its role in lung cancer progression, we here analyzed ACLY expression in ...

journal_title：Cancer research

authors： Migita T,Narita T,Nomura K,Miyagi E,Inazuka F,Matsuura M,Ushijima M,Mashima T,Seimiya H,Satoh Y,Okumura S,Nakagawa K,Ishikawa Y

更新日期：2008-10-15 00:00:00

abstract：:It has been reported that HLA-DR is a potent inducer of thrombin generation. Human colorectal cells (GEO, WiDr, DLD-1, and MIP) that lack the constitutive expression of HLA-DR cause platelet aggregation through a thrombin-dependent mechanism. Treatment with recombinant human gamma-interferon induced the expression of ...

journal_title：Cancer research

authors： Ferroni P,Guadagni F,Spila A,Martini F,Gazzaniga PP

更新日期：1994-02-01 00:00:00

abstract：:The effect of basic fibroblast growth factor (b-FGF), one of the commonest angiogenic factors in various cancer types, on lymphocyte adhesion and transmigration across the endothelial cell monolayer was investigated using human umbilical vein-derived endothelial cells (HUVEC) and type I collagen gel. Forty-eight h exp...

journal_title：Cancer research

authors： Kitayama J,Nagawa H,Yasuhara H,Tsuno N,Kimura W,Shibata Y,Muto T

更新日期：1994-09-01 00:00:00

abstract：:Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAIL(mim/DR5)) on cancer cells in vitro and in vivo. Surface plasmon resonance re...

journal_title：Cancer research

authors： Pavet V,Beyrath J,Pardin C,Morizot A,Lechner MC,Briand JP,Wendland M,Maison W,Fournel S,Micheau O,Guichard G,Gronemeyer H

更新日期：2010-02-01 00:00:00

abstract：:We evaluated the cytotoxicity of the immunotoxin OKT1-SAP on fresh B-chronic lymphocytic leukemia (B-CLL) cells from 31 consecutive patients. OKT1-SAP comprised the OKT1 (CD5) monoclonal antibody disulfide linked to saporin-6 (SAP) ribosome-inactivating protein from the plant Saponaria officinalis. The effect of OKT1-...

journal_title：Cancer research

authors： Siena S,Bregni M,Formosa A,Brando B,Marenco P,Lappi DA,Bonadonna G,Gianni AM

更新日期：1989-06-15 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00