Changes in plasma membrane structure associated with malignant transformation in human urinary bladder epithelium.

abstract：:The serum levels of an adrenal sex hormone, dehydroepiandrosterone sulfate (DHEA-S), are significantly more decreased in human myelomas compared with the reduction brought by physiologic decline with age. In order to clarify the effect of DHEA on myeloma cells, we investigated whether DHEA and DHEA-S could inhibit int...

journal_title：Cancer research

authors： Liu S,Ishikawa H,Li FJ,Ma Z,Otsuyama K,Asaoku H,Abroun S,Zheng X,Tsuyama N,Obata M,Kawano MM

更新日期：2005-03-15 00:00:00

abstract：:The retinoblastoma (Rb)-E2F transcriptional regulatory pathway plays a major role in cell-cycle regulation, but its role in invasion and metastasis is less well understood. We find that many genes involved in the invasion of cancer cells, such as matrix metalloproteinases (MMP), have potential E2F-binding sites in the...

journal_title：Cancer research

authors： Johnson JL,Pillai S,Pernazza D,Sebti SM,Lawrence NJ,Chellappan SP

更新日期：2012-01-15 00:00:00

abstract：:Metabolite profiling using (1)H nuclear magnetic resonance (NMR) spectroscopy was used to investigate the metabolic changes associated with deletion of the gene for the transcriptional coactivator p300 in the human colon carcinoma cell line HCT116. Multivariate statistical methods were used to distinguish between meta...

journal_title：Cancer research

authors： Bundy JG,Iyer NG,Gentile MS,Hu DE,Kettunen M,Maia AT,Thorne NP,Brenton JD,Caldas C,Brindle KM

更新日期：2006-08-01 00:00:00

abstract：:Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with...

journal_title：Cancer research

authors： Ramqvist T,Dalianis T,Reinholdsson G,Klein G,Szigeti R

更新日期：1986-10-01 00:00:00

abstract：:Coded skin fibroblast cell strains from ataxia telangiectasia (AT) families and apparently normal individuals were obtained from two different sources. AT homozygous strains were clearly identified on the basis of marked hypersensitivity to cell killing by X-irradiation. AT heterozygotes were intermediate in their cyt...

journal_title：Cancer research

authors： Nagasawa H,Kraemer KH,Shiloh Y,Little JB

更新日期：1987-01-15 00:00:00

abstract：:The murine monoclonal antibodies TURP-27 and HNK-1 have been shown to detect antigens which are heavily expressed by benign prostatic hyperplasia and carcinoma of the prostate. Western blot analysis of prostate extracts showed that monoclonal antibodies TURP-27 and HNK-1 bound glycoproteins with molecular weights of 1...

journal_title：Cancer research

authors： Lipford GB,Wright GL Jr

更新日期：1991-05-01 00:00:00

abstract：:Treatment of human HL-60 or KG1A leukemia cells with the topoisomerase II inhibitor etoposide resulted in extensive DNA degradation. When DNA integrity was analyzed by agarose gel electrophoresis, a nucleosomal ladder became evident 1.5-2 h after addition of etoposide to cells, increased in intensity over 6 h, and per...

journal_title：Cancer research

authors： Kaufmann SH

更新日期：1989-11-01 00:00:00

abstract：:Single-chain antigen-binding proteins, or sFvs, represent potentially unique molecules for targeted delivery of drugs, toxins, or radionuclides to a tumor site. In previous studies (Cancer Res., 51:6363-6371, 1991) using a human colon carcinoma xenograft model, it was demonstrated that the sFv has an extremely rapid p...

journal_title：Cancer research

authors： Yokota T,Milenic DE,Whitlow M,Schlom J

更新日期：1992-06-15 00:00:00

abstract：:The migration of three human prostate tumor epithelial cell lines (TSU-pr1, PC-3, DU-145) in response to secreted protein from a human prostate stromal cell line was investigated by using the modified blind-well Boyden chamber assay. Migrated cells were quantified by spectrophotometrically measuring the concentration ...

journal_title：Cancer research

authors： Djakiew D,Pflug BR,Delsite R,Onoda M,Lynch JH,Arand G,Thompson EW

更新日期：1993-03-15 00:00:00

abstract：:Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-...

journal_title：Cancer research

authors： Huang Z,Fasco MJ,Spivack S,Kaminsky LS

更新日期：1997-07-01 00:00:00

abstract：:The in vivo activation of aflatoxin B1 (AFB1) was assessed by using two transgenic mouse lines, M2 and M10, in which the human fetus-specific CYP3A7 was expressed in the kidney (M2) and the liver (M10), respectively. Male mice of 8 weeks old from these two lines were treated with a single i.p. injection of AFB1 (4 mg/...

journal_title：Cancer research

authors： Li Y,Yokoi T,Katsuki M,Wang JS,Groopman JD,Kamataki T

更新日期：1997-02-15 00:00:00

abstract：:A rational monoclonal antibody (mAb)-based antitumor therapy approach has previously been shown to eradicate various established experimental and carcinogen-induced tumors in a majority of mice. This therapy comprised an agonistic mAb reactive with tumor necrosis factor-related apoptosis-inducing ligand receptor (DR5)...

journal_title：Cancer research

authors： Teng MW,Westwood JA,Darcy PK,Sharkey J,Tsuji M,Franck RW,Porcelli SA,Besra GS,Takeda K,Yagita H,Kershaw MH,Smyth MJ

更新日期：2007-08-01 00:00:00

abstract：:The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 c...

journal_title：Cancer research

authors： Chakravarty A,Shinde V,Tabernero J,Cervantes A,Cohen RB,Dees EC,Burris H,Infante JR,Macarulla T,Elez E,Andreu J,Rodriguez-Braun E,Rosello S,von Mehren M,Meropol NJ,Langer CJ,ONeil B,Bowman D,Zhang M,Danaee H,Faron

更新日期：2011-02-01 00:00:00

abstract：:The hepatocarcinogen safrole is metabolized both to 1'-hydroxysafrole, a proximate hepatocarcinogen, and to 1'-oxosafrole, which is electrophilic but has little or no carcinogenic activity in rats and mice. As a part of a study on the metabolic interrelationships of these metabolites, their biliary and urinary conjuga...

journal_title：Cancer research

authors： Fennell TR,Miller JA,Miller EC

更新日期：1984-08-01 00:00:00

abstract：:CXCL16 is a new member of the chemokine superfamily, which exists in a transmembrane as well as a soluble form. Its receptor CXCR6 is detected on CD4(+) T cells, CD8(+) T cells, and natural killer T cells. Here, we report a significant correlation of CXCL16 expression by tumor cells with the infiltration of T cells an...

journal_title：Cancer research

authors： Hojo S,Koizumi K,Tsuneyama K,Arita Y,Cui Z,Shinohara K,Minami T,Hashimoto I,Nakayama T,Sakurai H,Takano Y,Yoshie O,Tsukada K,Saiki I

更新日期：2007-05-15 00:00:00

abstract：:To better understand the events occurring during immunotherapy of liver metastases with effector cells, we have developed a clinically relevant animal model in which both effector-tumor cell interactions and survival can be evaluated. A cell line of human gastric carcinoma (HR) metastatic to the liver has been establi...

journal_title：Cancer research

authors： Yasumura S,Lin WC,Hirabayashi H,Vujanovic NL,Herberman RB,Whiteside TL

更新日期：1994-07-15 00:00:00

abstract：:Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various cell-cycle regulators in patients with cancer. Small molecule inhibitors targeting key proteins that participate in cell-cycle progression including the cyclin-depend...

journal_title：Cancer research

authors： Mills CC,Kolb EA,Sampson VB

更新日期：2018-01-15 00:00:00

abstract：:The expression of genes which may be involved in the regulation of human mammary epithelial cell growth [transforming growth factors alpha and beta] and tumorigenesis [c-myc, erbB2, epidermal growth factor receptor (EGFR), Ha-ras, pS2] has been compared in similarly cultured normal cell strains and tumor cell lines. W...

journal_title：Cancer research

authors： Zajchowski D,Band V,Pauzie N,Tager A,Stampfer M,Sager R

更新日期：1988-12-15 00:00:00

abstract：:TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor...

journal_title：Cancer research

authors： Grawenda AM,Møller EK,Lam S,Repapi E,Teunisse AF,Alnæs GI,Børresen-Dale AL,Kristensen VN,Goding CR,Jochemsen AG,Edvardsen H,Bond GL

更新日期：2015-02-15 00:00:00

abstract：:Combination of chemotherapy and immunotherapy to increase the effectiveness of an antitumor immune response is currently regarded as an attractive antitumor strategy. In a pilot clinical trial, we have recently documented an increase of melanoma antigen A (Melan-A)-specific, tumor-reactive, long-lasting effector-memor...

journal_title：Cancer research

authors： Palermo B,Del Bello D,Sottini A,Serana F,Ghidini C,Gualtieri N,Ferraresi V,Catricalà C,Belardelli F,Proietti E,Natali PG,Imberti L,Nisticò P

更新日期：2010-09-15 00:00:00

abstract：:Crude tissue or tumor extracts either do not contain sufficient inosine 5'-monophosphate dehydrogenase (IMPD) activity to be measured spectrophotometrically, or interfering enzyme activities prevent the use of a more sensitive radiochemical assay. A modified assay system which incorporates alpha, beta-methylene adenos...

journal_title：Cancer research

authors： Proffitt RT,Pathak VK,Villacorte DG,Presant CA

更新日期：1983-04-01 00:00:00

abstract：:We investigated the prognostic value of p53 mutation type for 145 soft tissue sarcoma patients. In a PCR-SSCP-sequencing analysis, 15 mutations were identified: 10 non-frameshift (non-fs) and 5 frameshift (fs) mutations. Patients possessing non-fs mutations had a significantly poorer prognosis than patients without p5...

journal_title：Cancer research

authors： Taubert H,Meye A,Würl P

更新日期：1996-09-15 00:00:00

abstract：:A slight induction of granulocytic differentiation of HL-60 cells occurred after treatment with antileukemia chemotherapeutic agents Adriamycin (ADM) and daunomycin (DM). Addition of an inhibitor (sphinganine, SP) of protein kinase C (PKC) enhanced 2-4-fold the ADM or DM-induced differentiation. This phenomenon was ac...

journal_title：Cancer research

authors： Yung BY,Luo KJ,Hui EK

更新日期：1992-07-01 00:00:00

abstract：:15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in prostate carcinoma (Pca). The mechanisms whereby reduced 15-LOX-2 may co...

journal_title：Cancer research

authors： Shappell SB,Gupta RA,Manning S,Whitehead R,Boeglin WE,Schneider C,Case T,Price J,Jack GS,Wheeler TM,Matusik RJ,Brash AR,Dubois RN

更新日期：2001-01-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:Immunohistochemical localization of CA 125 using murine monoclonal antibody OC 125 was performed on fresh frozen tissue from 44 endometrial adenocarcinomas and 26 benign endometria. Immunohistochemical evaluation incorporated both intensity and distribution of staining (CA 125 HSCORE). Thirty-seven cancers (84%) and 2...

journal_title：Cancer research

authors： Berchuck A,Soisson AP,Clarke-Pearson DL,Soper JT,Boyer CM,Kinney RB,McCarty KS Jr,Bast RC Jr

更新日期：1989-04-15 00:00:00

abstract：:Proteolysis-inducing factor (PIF) is a sulfated glycoprotein produced by cachexia-inducing tumors, which induces atrophy of skeletal muscle. PIF has been shown to bind specifically with high affinity (K(d), in nanomolar) to sarcolemma membranes from skeletal muscle of both the mouse and the pig, as well as murine myob...

journal_title：Cancer research

authors： Todorov PT,Wyke SM,Tisdale MJ

更新日期：2007-12-01 00:00:00

abstract：:Myeloid cells are capable of promoting or eradicating tumor cells and the nodal functions that contribute to their different roles are still obscure. Here, we show that mice with myeloid-specific genetic loss of the NF-κB pathway regulatory kinase IKKβ exhibit more rapid growth of cutaneous and lung melanoma tumors. I...

journal_title：Cancer research

authors： Yang J,Hawkins OE,Barham W,Gilchuk P,Boothby M,Ayers GD,Joyce S,Karin M,Yull FE,Richmond A

更新日期：2014-12-15 00:00:00

abstract：:Cyclin D1/cyclin-dependent kinase 2 (Cdk2) complexes are present at high frequency in human breast cancer cell lines, but the significance of this observation is unknown. This report shows that expression of a cyclin D1-Cdk2 fusion protein under the control of the mouse mammary tumor virus (MMTV) promoter results in m...

journal_title：Cancer research

authors： Corsino P,Davis B,Law M,Chytil A,Forrester E,Nørgaard P,Teoh N,Law B

更新日期：2007-04-01 00:00:00

abstract：:Glioblastoma multiforme lacks effective therapy options. Although deregulated kinase pathways are drivers of malignant progression in glioblastoma multiforme, glioma cells exhibit intrinsic resistance toward many kinase inhibitors, and the molecular basis of this resistance remains poorly understood. Here, we show tha...

journal_title：Cancer research

authors： Kaur A,Denisova OV,Qiao X,Jumppanen M,Peuhu E,Ahmed SU,Raheem O,Haapasalo H,Eriksson J,Chalmers AJ,Laakkonen P,Westermarck J

更新日期：2016-12-01 00:00:00