Abstract：
:Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved. We found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and metastasis, when compared with a nonsugar starch diet. This effect was ascribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE). We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumors. Overall, our data suggested that dietary sugar induces 12-LOX signaling to increase risks of breast cancer development and metastasis.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Jiang Y,Pan Y,Rhea PR,Tan L,Gagea M,Cohen L,Fischer SM,Yang Pdoi
10.1158/0008-5472.CAN-14-3432subject
Has Abstractpub_date
2016-01-01 00:00:00pages
24-9issue
1eissn
0008-5472issn
1538-7445pii
76/1/24journal_volume
76pub_type
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