Role of the prostaglandin E2 receptor in mammary tumor metastasis.

abstract：:Pyruvate kinase isozymes were studied in normal brain tissue (both fetal and adult) and in meningiomas and malignant gliomas. In fetal brain five different forms could be detected by electrophoresis (K4, K3M, K2M2, KM3, and M4). In adult brain the M4-type, K3M hybrid, and K4-type are present; the M isozyme is largely ...

journal_title：Cancer research

authors： van Veelen CW,Verbiest H,Vlug AM,Rijksen G,Staal GE

更新日期：1978-12-01 00:00:00

abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

journal_title：Cancer research

authors： Ohshima H,Bartsch H

更新日期：1981-09-01 00:00:00

abstract：:Anguidine is a fungal metabolite with antitumor activity in a murine colon cancer model. Because of disappointing results in clinical trials, we analyzed the lethal and cytokinetic effects of anguidine on cultured human colon cancer cells. The studies revealed a moderate reduction in survival only after prolonged drug...

journal_title：Cancer research

authors： Dosik GM,Barlogie B,Johnston DA,Murphy WK,Drewinko B

更新日期：1978-10-01 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:Using in vitro double labeling with two different doses of [3H]thymidine, we measured the S-phase duration and the labeling index in biopsy samples taken from human rectal and colonic adenocarcinomas. Samples from the adjacent healthy mucosa, taken at the same time as the tumor samples, were simultaneously subjected t...

journal_title：Cancer research

authors： Bleiberg H,Galand P

更新日期：1976-02-01 00:00:00

abstract：:Recent expression profile analyses revealed that lung adenocarcinomas can be divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular pr...

journal_title：Cancer research

authors： Miura K,Bowman ED,Simon R,Peng AC,Robles AI,Jones RT,Katagiri T,He P,Mizukami H,Charboneau L,Kikuchi T,Liotta LA,Nakamura Y,Harris CC

更新日期：2002-06-01 00:00:00

abstract：:The use of targeted therapeutics directed against BRAF(V600)-mutant metastatic melanoma improves progression-free survival in many patients; however, acquired drug resistance remains a major medical challenge. By far, the most common clinical resistance mechanism involves reactivation of the MAPK (RAF/MEK/ERK) pathway...

journal_title：Cancer research

authors： Goetz EM,Ghandi M,Treacy DJ,Wagle N,Garraway LA

更新日期：2014-12-01 00:00:00

abstract：:The effect of intravesical Bacillus Calmette-Guérin (BCG; Pasteur strain) treatment on the frequency of implantation and growth rate of the murine transitional cell carcinoma of the bladder, MBT-2, was studied. MBT-2 cells were instilled into the bladder immediately after electrocauterization, and BCG instillations (4...

journal_title：Cancer research

authors： Shapiro A,Ratliff TL,Oakley DM,Catalona WJ

更新日期：1983-04-01 00:00:00

abstract：:A transplantable bladder tumor (Chapman R-4909) of the rat, when first received in our laboratory, grew with a complex histopathology. The predominant component was transitional cell carcinoma, but there were foci of keratinization, including pearl formation, and foci of a less well-defined cystic appearance. We repor...

journal_title：Cancer research

authors： Toyoshima K,Abaza N,Leighton J

更新日期：1976-08-01 00:00:00

abstract：:During a 2-yr study of carcinogenesis by CdCl2 in male Wistar [Crl:(WI)BR] rats, weekly clinical observations during the last 6 mo of the study revealed many cases of persistent tumor-like masses at the site of the metal identification tags in the ears of the animals. A total of 14 tumors (mostly compound osteosarcoma...

journal_title：Cancer research

authors： Waalkes MP,Rehm S,Kasprzak KS,Issaq HJ

更新日期：1987-05-01 00:00:00

abstract：:The semaphorins and their receptors, the neuropilins and the plexins, are constituents of a complex regulatory system that controls axonal guidance. Moreover, many types of tumor cells express various members of semaphorins and receptors, but the biological activities within tumor mass and the signal transduction mech...

journal_title：Cancer research

authors： Catalano A,Lazzarini R,Di Nuzzo S,Orciari S,Procopio A

更新日期：2009-02-15 00:00:00

abstract：:Wnt ligand-driven tumor growth is inhibited by the soluble Wnt inhibitor Fzd8CRD, but the mechanism through which this effect is mediated is unknown. In the MMTV-Wnt1 mouse model, regression of mammary tumors by Fzd8CRD treatment coincides with an acute and strong induction of insulin-like growth factor (IGF)-binding ...

journal_title：Cancer research

authors： Liu BY,Soloviev I,Huang X,Chang P,Ernst JA,Polakis P,Sakanaka C

更新日期：2012-03-15 00:00:00

abstract：:Acute endothelial cell apoptosis and microvascular compromise couple gastrointestinal tract irradiation to reproductive death of intestinal crypt stem cell clonogens (SCCs) following high-dose radiation. Genetic or pharmacologic inhibition of endothelial apoptosis prevents intestinal damage, but as the radiation dose ...

journal_title：Cancer research

authors： Rotolo JA,Mesicek J,Maj J,Truman JP,Haimovitz-Friedman A,Kolesnick R,Fuks Z

更新日期：2010-02-01 00:00:00

abstract：:Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk ...

journal_title：Cancer research

authors： Richman EL,Kenfield SA,Stampfer MJ,Paciorek A,Carroll PR,Chan JM

更新日期：2011-06-01 00:00:00

abstract：:Analysis of leukemic cell phenotypes using cell surface antigens and various enzymes indicates that acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease consisting of four major subclasses with additional subsets existing within these subclasses. These different types of ALL appear to reflect seq...

journal_title：Cancer research

authors： Greaves MF

更新日期：1981-11-01 00:00:00

abstract：:Hypoxia inducible factors (HIF) are critical mediators of the cellular response to decreased oxygen tension and are overexpressed in a number of tumors. Although HIF1alpha and HIF2alpha share a high degree of sequence homology, recent work has shown that the two alpha subunits can have contrasting and tissue-specific ...

journal_title：Cancer research

authors： Bertout JA,Patel SA,Fryer BH,Durham AC,Covello KL,Olive KP,Goldschmidt MH,Simon MC

更新日期：2009-04-01 00:00:00

abstract：:In female nude mice, epidermal growth factor (EGF) was present at a mean concentration of 42.8 +/- 16.9 (SD) ng/mg wet tissue in the submandibular gland and 0.28 +/- 0.13 ng/ml in the plasma. Sialoadenectomy (removal of the submandibular glands) decreased circulating EGF to undetectable levels (less than 0.1 ng/ml). T...

journal_title：Cancer research

authors： Tsutsumi O,Tsutsumi A,Oka T

更新日期：1987-09-01 00:00:00

abstract：:Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regu...

journal_title：Cancer research

authors： Hofman P,Cherfils-Vicini J,Bazin M,Ilie M,Juhel T,Hébuterne X,Gilson E,Schmid-Alliana A,Boyer O,Adriouch S,Vouret-Craviari V

更新日期：2015-03-01 00:00:00

abstract：:Mutations in the human adenomatous polyposis (APC) gene are causative for familial adenomatous polyposis (FAP), a rare condition in which numerous colonic polyps arise during puberty and, if left untreated, lead to colon cancer. The APC gene is a tumor suppressor that has been termed the "gatekeeper gene" for colon ca...

journal_title：Cancer research

authors： Oshima M,Murai N,Kargman S,Arguello M,Luk P,Kwong E,Taketo MM,Evans JF

更新日期：2001-02-15 00:00:00

abstract：:Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas IR-A rather signals proliferative effects. IR-B is predominantly expressed in the adult liver. Here, we show that the alternative splicing of IR pre-mRNA is dysre...

journal_title：Cancer research

authors： Chettouh H,Fartoux L,Aoudjehane L,Wendum D,Clapéron A,Chrétien Y,Rey C,Scatton O,Soubrane O,Conti F,Praz F,Housset C,Rosmorduc O,Desbois-Mouthon C

更新日期：2013-07-01 00:00:00

abstract：:The growth-inhibitory effect of 6-methylmercaptopurine riboside (MMPR) against leukemia L1210 cells in culture was dramatically potentiated by the addition of guanine nucleosides to the medium. In the presence of either deoxyguanosine or guanosine, the concentration of MMPR that caused 50% inhibition of growth was 35 ...

journal_title：Cancer research

authors： Grindey GB,Lowe JK,Divekar AY,Hakala MT

更新日期：1976-02-01 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most common cause of cancer-related mortality in western men. To investigate the mechanisms of prostate cancer development and progression, we did expression profiling of human prostate cancer and benign tissues. We show that the SOX4 is o...

journal_title：Cancer research

authors： Liu P,Ramachandran S,Ali Seyed M,Scharer CD,Laycock N,Dalton WB,Williams H,Karanam S,Datta MW,Jaye DL,Moreno CS

更新日期：2006-04-15 00:00:00

abstract：:A 16,500 molecular weight fraction of maleic vinyl ether (MVE-2) induced tumoristatic and tumoricidal activity in peritoneal macrophages of BALB/c and C57BL/6 mice following i.p. administration. Growth of B16 melanoma cells in vitro was inhibited up to 85% by MVE-2-activated, but not resident, peritoneal macrophages. ...

journal_title：Cancer research

authors： Loveless SE,Munson AE

更新日期：1981-10-01 00:00:00

abstract：:Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. Agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug are needed for the treatment of pancreatic cancer. Curcumin, a component of turmeric ...

journal_title：Cancer research

authors： Kunnumakkara AB,Guha S,Krishnan S,Diagaradjane P,Gelovani J,Aggarwal BB

更新日期：2007-04-15 00:00:00

abstract：:Methods to visualize metastasis exist, but additional tools to better define the biologic and physical processes underlying invasion and intravasation are still needed. One difficulty in studying metastasis stems from the complexity of the interface between the tumor microenvironment and the vascular system. Here, we ...

journal_title：Cancer research

authors： Wong AD,Searson PC

更新日期：2014-09-01 00:00:00

abstract：:Oncogenic transformation has been induced in vitro in the C3H/10T1/2 clone 8 line of mouse cells by exposure to 5-fluoro-2'-deoxyuridine (FUdR) or 5-fluorouracil. This transformation is both dose and time dependent and can be markedly decreased by simultaneous exposure of the cells to thymidine. The transformation ind...

journal_title：Cancer research

authors： Jones PA,Benedict WF,Baker MS,Mondal S,Rapp U,Heidelberger C

更新日期：1976-01-01 00:00:00

abstract：:Whole-genome sequencing studies have recently identified a quarter of cases of the rare childhood brainstem tumor diffuse intrinsic pontine glioma to harbor somatic mutations in ACVR1. This gene encodes the type I bone morphogenic protein receptor ALK2, with the residues affected identical to those that, when mutated ...

journal_title：Cancer research

authors： Taylor KR,Vinci M,Bullock AN,Jones C

更新日期：2014-09-01 00:00:00

abstract：:Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune response and improves ICB efficacy. Because ATM is an apical kinase in the radiation-induced DNA damage response, we investigated the effects of ATM inhibition...

journal_title：Cancer research

authors： Zhang Q,Green MD,Lang X,Lazarus J,Parsels JD,Wei S,Parsels LA,Shi J,Ramnath N,Wahl DR,Pasca di Magliano M,Frankel TL,Kryczek I,Lei YL,Lawrence TS,Zou W,Morgan MA

更新日期：2019-08-01 00:00:00

abstract：:Targeted therapies can be defined as drugs developed against a specific target based on its important biological function in cancer. In contrast, nontargeted therapies are drugs identified by phenotypic screening of natural products or chemical libraries against established cancer cell lines or preclinical animal mode...

journal_title：Cancer research

authors： Hait WN,Hambley TW

更新日期：2009-02-15 00:00:00

abstract：:The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 fu...

journal_title：Cancer research

authors： Lee Y,Miller HL,Russell HR,Boyd K,Curran T,McKinnon PJ

更新日期：2006-07-15 00:00:00