Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells.

abstract：:Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic...

journal_title：Cancer research

authors： Shintani S,Matsuo K,Crohin CC,McBride J,Tsuji T,Donoff RB,Posner M,Todd R,Wong DT

更新日期：1999-08-15 00:00:00

abstract：:Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and, as a result, repre...

journal_title：Cancer research

authors： Remacle AG,Golubkov VS,Shiryaev SA,Dahl R,Stebbins JL,Chernov AV,Cheltsov AV,Pellecchia M,Strongin AY

更新日期：2012-05-01 00:00:00

abstract：:The underlying mechanism regulating the expression of the cancer stem cell/tumor-initiating cell marker CD133/prominin-1 in cancer cells remains largely unclear, although knowledge of this mechanism would likely provide important biological information regarding cancer stem cells. Here, we found that the inhibition of...

journal_title：Cancer research

authors： Matsumoto K,Arao T,Tanaka K,Kaneda H,Kudo K,Fujita Y,Tamura D,Aomatsu K,Tamura T,Yamada Y,Saijo N,Nishio K

更新日期：2009-09-15 00:00:00

abstract：:Elevated levels of nitric oxide (NO) and reactive nitrogen species (RNS) may link inflammation to the initiation, promotion, and progression of cancer. Traditionally, this link has been thought to be mediated by the effects of NO/RNS in generating DNA damage. However, this damage also stimulates DNA repair responses w...

journal_title：Cancer research

authors： Yakovlev VA

更新日期：2013-01-15 00:00:00

abstract：:Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and tumors induces high-output NO production that significantly enhances tumor radioresp...

journal_title：Cancer research

authors： Cook T,Wang Z,Alber S,Liu K,Watkins SC,Vodovotz Y,Billiar TR,Blumberg D

更新日期：2004-11-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed "stromal cells") that can promote or inhibit tumorigenesis by mechanisms that have not been fully elucidated. Here, we postulated that stromal cells in the tumor microenv...

journal_title：Cancer research

authors： Zhong L,Roybal J,Chaerkady R,Zhang W,Choi K,Alvarez CA,Tran H,Creighton CJ,Yan S,Strieter RM,Pandey A,Kurie JM

更新日期：2008-09-01 00:00:00

abstract：:Prostate carcinoma is the most commonly diagnosed cancer in men and the second leading cause of death due to cancer in Western civilization. Androgen ablation therapy is effective in treating androgen-dependent tumors, but eventually, androgen-independent tumors recur and are refractory to conventional chemotherapeuti...

journal_title：Cancer research

authors： Libertini SJ,Tepper CG,Rodriguez V,Asmuth DM,Kung HJ,Mudryj M

更新日期：2007-10-01 00:00:00

abstract：:The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, bu...

journal_title：Cancer research

authors： Katagiri YU,Sleeman J,Fujii H,Herrlich P,Hotta H,Tanaka K,Chikuma S,Yagita H,Okumura K,Murakami M,Saiki I,Chambers AF,Uede T

更新日期：1999-01-01 00:00:00

abstract：:Anti-idiotype monoclonal antibodies (Mabs) to mLL2, an anti-B-cell lymphoma and CD22-specific murine IgG2a-kappa Mab, were generated by hybridoma technology from splenocytes of Copenhagen rats immunized with mLL2 F(ab')2. Mab WN, an IgG2a-kappa, was selected based on its specific binding to mLL2 and not other IgG isot...

journal_title：Cancer research

authors： Losman MJ,Leung SO,Shih LB,Shevitz J,Shukla R,Haraga L,Goldenberg DM,Hansen HJ

更新日期：1995-12-01 00:00:00

abstract：:The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 is upregulated in human colorectal cancer and promotes cell proliferation when overexpressed in a colon cancer cell line. RIPK1 interacts with mitoch...

journal_title：Cancer research

authors： Zeng F,Chen X,Cui W,Wen W,Lu F,Sun X,Ma D,Yuan Y,Li Z,Hou N,Zhao H,Bi X,Zhao J,Zhou J,Zhang Y,Xiao RP,Cai J,Zhang X

更新日期：2018-06-01 00:00:00

abstract：:To identify mechanisms of camptothecin (CPT) resistance and the relationship between CPT-resistant cells and other anticancer agents, a CPT-resistant cell line (CPT30) and its partial revertant cell line (CPT30R) were established from a human nasopharyngeal carcinoma cell line (HONE-1). CPT30 and CPT30R cells displaye...

journal_title：Cancer research

authors： Chang JY,Liu JF,Juang SH,Liu TW,Chen LT

更新日期：2002-07-01 00:00:00

abstract：:We observed stronger cytotoxic effect of CHS 828 on poly(ADP-ribose) polymerase-1(PARP-1) knock-out cells as compared with the normal counterpart. The proliferation of PARP-1 -/- cells was inhibited by a drug concentration approximately 3-fold lower than that in the normal cells. The monitoring of p53 levels revealed ...

journal_title：Cancer research

authors： Lövborg H,Wojciechowski J,Larsson R,Wesierska-Gadek J

更新日期：2002-08-01 00:00:00

abstract：:To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer cells with those of vinblastine. At their respective concentrations that result in 50% inhibition of clonogenic growth, both drugs caused an accumulation of cells blocked at mitosis and simi...

journal_title：Cancer research

authors： Dahllöf B,Billström A,Cabral F,Hartley-Asp B

更新日期：1993-10-01 00:00:00

abstract：:Well-coupled mitochondria of hematopoietic tumors were isolated from mouse erythroleukemia and rat chloroma tumors grown in male DBA/2J mice and Long-Evans rats, respectively. We used erythroleukemia and chloroma mitochondria to determine their ability to utilize glutamine as an energy source for adenosine triphosphat...

journal_title：Cancer research

authors： Abou-Khalil WH,Yunis AA,Abou-Khalil S

更新日期：1983-05-01 00:00:00

abstract：:Degradation and invasion of basement membrane by tumor cells involves the cooperative hydrolysis of proteoglycans, collagens, and glycoproteins mediated by a number of enzymes including proteases, collagenases, and glycosidases. In order to study these processes in vitro, a tissue culture system was developed in which...

journal_title：Cancer research

authors： Woynarowska B,Wikiel H,Bernacki RJ

更新日期：1989-10-15 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cel...

journal_title：Cancer research

authors： Voena C,Conte C,Ambrogio C,Boeri Erba E,Boccalatte F,Mohammed S,Jensen ON,Palestro G,Inghirami G,Chiarle R

更新日期：2007-05-01 00:00:00

abstract：:The long latency period of cancer would suggest that timely measures to reduce the risk of cancer, such as dietary guidelines to the public, be an integral component of policy on cancer. Although criteria for acceptability of scientific evidence are often defined, judgment its required in interpreting the significance...

journal_title：Cancer research

authors： Palmer S

更新日期：1983-05-01 00:00:00

abstract：:The glutathione transferase (GST) isoenzyme profile was determined in two human tumor cell lines, U1690 derived from a small cell lung cancer and U1810 derived from a non-small cell lung cancer. U1810 cells are 3.2-fold more resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) than are U1690 cells, a finding ascri...

journal_title：Cancer research

authors： Berhane K,Hao XY,Egyházi S,Hansson J,Ringborg U,Mannervik B

更新日期：1993-09-15 00:00:00

abstract：:Human cutaneous fatty acid-binding protein (C-FABP) gene is capable of inducing the metastatic phenotype when overexpressed in nonmetastatic rat Rama 37 cells. However, the mechanism of how it induces metastasis is not clear. Northern and slot blot analyses revealed that expression of the endogenous vascular endotheli...

journal_title：Cancer research

authors： Jing C,Beesley C,Foster CS,Chen H,Rudland PS,West DC,Fujii H,Smith PH,Ke Y

更新日期：2001-06-01 00:00:00

abstract：:The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of cyclophosphamide (CP) was studied in a dual culture system of rat hepatocytes and K562 human chronic myeloid leukemia cells, which have elevated aldehyde dehydrogenase activity with a corresponding insen...

journal_title：Cancer research

authors： Crook TR,Souhami RL,Whyman GD,McLean AE

更新日期：1986-10-01 00:00:00

abstract：:Gliomas are primary brain tumors with high mortality and heterogeneous biology that is insufficiently understood. In this study, we performed a systematic analysis of the intrinsic organization of complex glioma transcriptome to gain deeper knowledge of the tumor biology. Gene coexpression relationships were explored ...

journal_title：Cancer research

authors： Ivliev AE,'t Hoen PA,Sergeeva MG

更新日期：2010-12-15 00:00:00

abstract：:Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore a...

journal_title：Cancer research

authors： Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT

更新日期：2005-12-15 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:Pregnancy and development are known to modify carcinogenesis. Little is known about the mechanism for the modulation. These studies investigated the relative sensitivity of nonpregnant, pregnant, and fetal mice to the induction of covalent DNA modifications and micronucleated erythrocytes by 4-nitroquinoline 1-oxide (...

journal_title：Cancer research

authors： Lu LJ,Baxter JR,Wang MY,Harper BL,Tasaka F,Kohda K

更新日期：1990-10-01 00:00:00

abstract：:CBLC (CBL proto-oncogene c) belongs to the CBL protein family, which has E3 ubiquitin ligase activity toward activated receptor tyrosine kinases. CBLC is frequently upregulated in non-small cell lung cancer (NSCLC), yet very little is known about the functions of CBLC in tumorigenesis. Here we show that CBLC is an epi...

journal_title：Cancer research

authors： Hong SY,Kao YR,Lee TC,Wu CW

更新日期：2018-09-01 00:00:00

abstract：:We constructed a genome-wide transcriptome map of non-small cell lung carcinomas based on gene-expression profiles generated by serial analysis of gene expression (SAGE) using primary tumors and bronchial epithelial cells of the lung. Using the human genome working draft and the public databases, 25,135 nonredundant U...

journal_title：Cancer research

authors： Fujii T,Dracheva T,Player A,Chacko S,Clifford R,Strausberg RL,Buetow K,Azumi N,Travis WD,Jen J

更新日期：2002-06-15 00:00:00

abstract：:The formation of tumors in adult nude mice from transformed human mammary epithelial cells was drastically inhibited (greater than 80%) both after coinjection of tumoral cells and virus or after a single s.c. injection of parvovirus H-1 at the site of cell implantation prior to tumor formation. Moreover, when injected...

journal_title：Cancer research

authors： Dupressoir T,Vanacker JM,Cornelis JJ,Duponchel N,Rommelaere J

更新日期：1989-06-15 00:00:00

abstract：:The characteristics of EMT6 tumors in young adult (3- to 4-month-old) and aged (20- to 28-month-old) BALB/c KaRw mice were compared. The number of tumor cells implanted s.c. necessary to cause tumors in 50% of the injection sites was lower in aging than in young adult mice (69 and 138 cells for young adult mice versus...

journal_title：Cancer research

authors： Rockwell S

更新日期：1981-02-01 00:00:00

abstract：:Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). We found that loss of HPK1 protein expression correlated significantly with ...

journal_title：Cancer research

authors： Wang H,Song X,Logsdon C,Zhou G,Evans DB,Abbruzzese JL,Hamilton SR,Tan TH,Wang H

更新日期：2009-02-01 00:00:00