A preliminary transcriptome map of non-small cell lung cancer.

abstract：:The complement system is important in immunosurveillance against tumors. However, malignant cells are usually resistant to complement-mediated lysis. In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor H-like protein 1 (FHL-1), its alternatively spliced form, in lung...

journal_title：Cancer research

authors： Ajona D,Castaño Z,Garayoa M,Zudaire E,Pajares MJ,Martinez A,Cuttitta F,Montuenga LM,Pio R

更新日期：2004-09-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the producti...

journal_title：Cancer research

authors： Guo H,Li R,Zucker S,Toole BP

更新日期：2000-02-15 00:00:00

abstract：:Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support angiogenesis, a process involved in the progression of tumor growth and metastasis. However, it is unclear whether platelet/tumor interactions substantially contribute to tumor physiology. We inv...

journal_title：Cancer research

authors： Ho-Tin-Noé B,Goerge T,Cifuni SM,Duerschmied D,Wagner DD

更新日期：2008-08-15 00:00:00

abstract：:Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of this study was to determine whether spontaneous fluctuations in ...

journal_title：Cancer research

authors： Kimura H,Braun RD,Ong ET,Hsu R,Secomb TW,Papahadjopoulos D,Hong K,Dewhirst MW

更新日期：1996-12-01 00:00:00

abstract：:Unambiguous and sensitive methods based on gas chromatography-chemical ionization mass spectrometry have been developed to quantitate cyclophosphamide and two alkylating and cytotoxic metabolites, phosphoramide mustard and nornitrogen mustard. The levels of these materials have been determined in the plasma and urine ...

journal_title：Cancer research

authors： Jardine I,Fenselau C,Appler M,Kan MN,Brundrett RB,Colvin M

更新日期：1978-02-01 00:00:00

abstract：:Increasing evidence argues that the success of an anticancer treatment may rely on immunoadjuvant side effects including the induction of immunogenic tumor cell death. Based on the assumption that this death mechanism is a similar prerequisite for the efficacy of an active immunotherapy using killed tumor cells, we ex...

journal_title：Cancer research

authors： Zappasodi R,Pupa SM,Ghedini GC,Bongarzone I,Magni M,Cabras AD,Colombo MP,Carlo-Stella C,Gianni AM,Di Nicola M

更新日期：2010-11-15 00:00:00

abstract：:Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions to retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. In our previous study (H. Ohguro et al., Invest. Ophthalmol. Vis. Sci., 40: 82-89,...

journal_title：Cancer research

authors： Maeda A,Ohguro H,Maeda T,Wada I,Sato N,Kuroki Y,Nakagawa T

更新日期：2000-04-01 00:00:00

abstract：:Commercially available St. John's wort (Hypericum perforatum) preparations and some of their main constituents (hypericin, pseudohypericin, hyperforin, rutin, and quercetin) were examined for their potential to inhibit carcinogen activation by human cytochrome P450 1A1 (CYP1A1). We used a reconstituted system consisti...

journal_title：Cancer research

authors： Schwarz D,Kisselev P,Roots I

更新日期：2003-11-15 00:00:00

abstract：:The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new appro...

journal_title：Cancer research

authors： Gillet L,Dewals B,Farnir F,de Leval L,Vanderplasschen A

更新日期：2005-10-15 00:00:00

abstract：:Cyclophosphamide treatment of adult male rats leads to sustained decreases in several liver microsomal cytochrome P450 (CYP) activities, including CYP 2C11-catalyzed cyclophosphamide activation, via a process that is associated with a feminization of the overall pattern of liver enzyme expression (G. A. LeBlanc and D....

journal_title：Cancer research

authors： Chang TK,Waxman DJ

更新日期：1993-06-01 00:00:00

abstract：:Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands t...

journal_title：Cancer research

authors： Mutter GL,Ince TA,Baak JP,Kust GA,Zhou XP,Eng C

更新日期：2001-06-01 00:00:00

abstract：:The effect of heat on 1,4-dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]-9, 10-anthracenedione dihydrochloride (DHAD; mitoxantrone, NSC 301739) cytotoxicity was studied in V79 Chinese hamster cells. An overnight exposure to the drug at 40 degrees C enhanced drug damage in chromosome aberrations, culture growth...

journal_title：Cancer research

authors： Yang SJ,Rafla S

更新日期：1985-08-01 00:00:00

abstract：:Taxol is a novel antitumor agent with demonstrated efficacy against ovarian, breast, and non-small cell lung cancers in Phase II clinical trials, but which has been shown not to cross the blood-brain barrier. To adapt taxol as a therapy for brain tumors, we have incorporated it into a biodegradable polyanhydride matri...

journal_title：Cancer research

authors： Walter KA,Cahan MA,Gur A,Tyler B,Hilton J,Colvin OM,Burger PC,Domb A,Brem H

更新日期：1994-04-15 00:00:00

abstract：:Although adherent junctions have been extensively studied, the role of tight junctions in cancer cell invasion is not sufficiently explored. We investigated whether claudin-1, a component of tight junctions, regulated invasion activity in oral squamous cell carcinoma (OSC) cells. The expression of claudin-1, activity ...

journal_title：Cancer research

authors： Oku N,Sasabe E,Ueta E,Yamamoto T,Osaki T

更新日期：2006-05-15 00:00:00

abstract：:Patients with human papillomavirus (HPV+)-associated head and neck cancer (HNC) show significantly improved survival outcome compared with those with HPV-negative (HPV-) tumors. Published data examining this difference offers conflicting results to date. We systematically investigated the radiation sensitivity of all ...

journal_title：Cancer research

authors： Kimple RJ,Smith MA,Blitzer GC,Torres AD,Martin JA,Yang RZ,Peet CR,Lorenz LD,Nickel KP,Klingelhutz AJ,Lambert PF,Harari PM

更新日期：2013-08-01 00:00:00

abstract：:Mice lacking N-acetylglucosaminyltransferase III (GlcNAc-TIII) exhibit slightly but significantly retarded liver tumor progression after a single injection of 10 micro g/g diethylnitrosamine (DEN) and continued administration of phenobarbital (PB) in drinking water. A key question is whether the absence of GlcNAc-TIII...

journal_title：Cancer research

authors： Yang X,Tang J,Rogler CE,Stanley P

更新日期：2003-11-15 00:00:00

abstract：:In this study, we performed high-resolution array comparative genomic hybridization with an array of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted to exclude non-tumor DNA and increase our ability to detect gene copy number changes....

journal_title：Cancer research

authors： Loo LW,Grove DI,Williams EM,Neal CL,Cousens LA,Schubert EL,Holcomb IN,Massa HF,Glogovac J,Li CI,Malone KE,Daling JR,Delrow JJ,Trask BJ,Hsu L,Porter PL

更新日期：2004-12-01 00:00:00

abstract：:The antimetastatic activity of Nocardia rubra cell wall skeleton (N-CWS) with or without cyclophosphamide was examined in an experimental model of pulmonary metastasis induced by Lewis lung carcinoma in C57BL/6 mice. Lewis lung carcinoma cells were implanted into the footpads of mice, and the implanted tumors were rem...

journal_title：Cancer research

authors： Kagawa K,Yamashita T,Tsubura E,Yamamura Y

更新日期：1984-02-01 00:00:00

abstract：:Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic and chemotherapeutic significance of RECQL4 in human gastric cancer, wh...

journal_title：Cancer research

authors： Mo D,Fang H,Niu K,Liu J,Wu M,Li S,Zhu T,Aleskandarany MA,Arora A,Lobo DN,Madhusudan S,Balajee AS,Chi Z,Zhao Y

更新日期：2016-05-15 00:00:00

abstract：:Development of novel approaches for quantitative analysis of gene expression in intact tumor cells should provide new means for cancer detection and for studying the response of cancer cells to biological and therapeutic reagents. We developed procedures for detecting the levels of expression of multiple genes in fixe...

journal_title：Cancer research

authors： Peng XH,Cao ZH,Xia JT,Carlson GW,Lewis MM,Wood WC,Yang L

更新日期：2005-03-01 00:00:00

abstract：:Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neo...

journal_title：Cancer research

authors： Safaeian M,Schiffman M,Gage J,Solomon D,Wheeler CM,Castle PE

更新日期：2009-04-15 00:00:00

abstract：:We have examined the ability of ingenol to bind to and activate protein kinase C and to induce similar responses to the phorbol esters in biological systems. The rationale was that ingenol possesses the critical functionalities of the phorbol ester pharmacophore with the exception of the hydrophobic domain; it might t...

journal_title：Cancer research

authors： Hasler CM,Acs G,Blumberg PM

更新日期：1992-01-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-I has well-characterized mitogenic and antiapoptotic effects that are essential for maintenance of the normal prostate and may be important during regression of the normal prostate and/or prostate tumors induced by androgen-targeting therapies for prostate cancer. IGF-I activity is mod...

journal_title：Cancer research

authors： Nickerson T,Miyake H,Gleave ME,Pollak M

更新日期：1999-07-15 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:Fibroblast growth factor receptor 3 (FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. FGFR3 is abnormally upregulated in hepatocellular carcinoma (HCC), where it correlates positively with clinicopathologic index, HCC differentiation, and advanced nuclear grade. In this study, we ...

journal_title：Cancer research

authors： Li K,Shen B,Cheng X,Ma D,Jing X,Liu X,Yang W,Peng C,Qiu W

更新日期：2016-07-15 00:00:00

abstract：:I have attempted to illustrate the many different properties of retroviruses and their presence in a wide variety of animal species including humans. Since the turn of this century, progress in the field of retrovirology has been noteworthy and many new and important scientific observations have been made (Table 7). A...

journal_title：Cancer research

authors： Levy JA

更新日期：1986-11-01 00:00:00

abstract：:The importance of bystander effects is becoming more appreciated, as studies show they may affect the course of cancer and other chronic diseases. The term "bystander effects" refers to changes in naïve cells sharing the same milieu with cells that have been damaged. Bystander cells may be in contact with, or distant ...

journal_title：Cancer research

authors： Martin OA,Redon CE,Nakamura AJ,Dickey JS,Georgakilas AG,Bonner WM

更新日期：2011-05-15 00:00:00

abstract：:Cancer vaccines may have applications in the therapy and prevention of mammary carcinoma. To investigate such applications, we constructed a recombinant adenoviral vaccine expressing a kinase-inactive mutant form of human HER2 and introduced this into BALB/c wild-type (WT) or HER2 transgenic mice. Here, we report cont...

journal_title：Cancer research

authors： Triulzi C,Vertuani S,Curcio C,Antognoli A,Seibt J,Akusjärvi G,Wei WZ,Cavallo F,Kiessling R

更新日期：2010-10-01 00:00:00

abstract：:Recently, loss or inactivation of genes at specific chromosomal loci has been considered to be one of the important mechanisms during the development of human tumors. In order to identify tumor suppressor genes for gastric carcinoma, we performed restriction fragment length polymorphism analysis on 48 human gastric ca...

journal_title：Cancer research

authors： Sano T,Tsujino T,Yoshida K,Nakayama H,Haruma K,Ito H,Nakamura Y,Kajiyama G,Tahara E

更新日期：1991-06-01 00:00:00

abstract：:Tumor resistance to cytotoxic drugs is one of the main obstacles to successful cancer therapy. Emerging evidence suggests that chemoresistance is promoted by substances released from dead and damaged cells that activate the host repair program orchestrated by Toll-like receptor-4 (TLR4). TLR4 is often overexpressed in...

journal_title：Cancer research

authors： Ran S

更新日期：2015-06-15 00:00:00