Abstract：
:Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a complex with MMP-1 at the tumor cell surface. Complex formation was demonstrated by phage display, affinity chromatography, and immunocytochemistry. Presentation of MMP-1 complexed to EMMPRIN at the tumor cell surface may be important in modifying the tumor cell pericellular matrix to promote invasion.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Guo H,Li R,Zucker S,Toole BPsubject
Has Abstractpub_date
2000-02-15 00:00:00pages
888-91issue
4eissn
0008-5472issn
1538-7445journal_volume
60pub_type
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