Abstract：
:The importance of bystander effects is becoming more appreciated, as studies show they may affect the course of cancer and other chronic diseases. The term "bystander effects" refers to changes in naïve cells sharing the same milieu with cells that have been damaged. Bystander cells may be in contact with, or distant from, damaged cells. In addition, it has been shown in culture that not only physically damaged cells, but also cells that have become abnormal (i.e., cancerous or senescent) may induce bystander effects. Recently, we have shown a similar effect in animals. Mice harboring subcutaneous tumors exhibited elevated levels of DNA damage in distant organs. In contrast to cell culture, immune cells seemed to be involved in tumor-induced bystander effects in animals because CCL2-null tumor-bearing mice did not exhibit increased distant DNA damage. Here, we discuss some of the implications of these observations.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Martin OA,Redon CE,Nakamura AJ,Dickey JS,Georgakilas AG,Bonner WMdoi
10.1158/0008-5472.CAN-10-4579subject
Has Abstractpub_date
2011-05-15 00:00:00pages
3437-41issue
10eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-10-4579journal_volume
71pub_type
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