Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: functional implications for transforming growth factor beta signaling.

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:Small cell lung cancer (SCLC) produces several neuroendocrine peptides, including gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin. There is some evidence to support the suggestion that GRP is an autocrine regulator of SCLC growth. Therefore, we have tested the effect of bombesin and two antagonis...

journal_title：Cancer research

authors： Layton JE,Scanlon DB,Soveny C,Morstyn G

更新日期：1988-09-01 00:00:00

abstract：:A mammalian cell expression plasmid, pH beta-Aro, containing the human placenta aromatase complementary DNA was constructed. The prepared plasmid was used to transfect breast cancer cells (MCF-7), noncancerous breast cells (HBL-100), and Chinese hamster ovary cells by a stable expression method. While the maximum velo...

journal_title：Cancer research

authors： Zhou DJ,Pompon D,Chen SA

更新日期：1990-11-01 00:00:00

abstract：:Endocrine therapies effectively improve the outcomes of patients with estrogen receptor (ER)-positive breast cancer. However, the emergence of drug-resistant tumors creates a core clinical challenge. In breast cancer cells rendered resistant to the antiestrogen fulvestrant, we defined causative mechanistic roles for t...

journal_title：Cancer research

authors： Shibata T,Watari K,Izumi H,Kawahara A,Hattori S,Fukumitsu C,Murakami Y,Takahashi R,Toh U,Ito KI,Ohdo S,Tanaka M,Kage M,Kuwano M,Ono M

更新日期：2017-01-15 00:00:00

abstract：:To better understand immune responses to brain tumors and to develop possible approaches for immunotherapy, we have investigated the leukocyte populations infiltrating the rat 9L gliosarcoma. By immunocytochem-ical analyses of the cells infiltrating the tumor, we observed a substantial number of cells expressing natur...

journal_title：Cancer research

authors： Chambers WH,Bozik ME,Brissette-Storkus SC,Basse P,Redgate E,Watkins S,Boggs SS

更新日期：1996-08-01 00:00:00

abstract：:Neuronal pentraxins (NPTX) and their corresponding receptors (NPTXR) have been studied as synapse-associated proteins in the nervous system, but their role in cancer is largely unknown. By applying a multidisciplinary, high-throughput proteomic approach, we have recently identified a peptide ligand motif for targeted ...

journal_title：Cancer research

authors： Bartolini A,Di Paolo D,Noghero A,Murgia D,Sementa AR,Cilli M,Pasqualini R,Arap W,Bussolino F,Ponzoni M,Pastorino F,Marchiò S

更新日期：2015-10-15 00:00:00

abstract：:Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of this study was to determine whether spontaneous fluctuations in ...

journal_title：Cancer research

authors： Kimura H,Braun RD,Ong ET,Hsu R,Secomb TW,Papahadjopoulos D,Hong K,Dewhirst MW

更新日期：1996-12-01 00:00:00

abstract：:The rat pancreatic carcinoma cell line AR4-2J was screened for growth-associated genes linked to the mitogenic effect of the novel gut brain hormone, pituitary adenylate cyclase activating polypeptide (PACAP). Using the mRNA differential display technique, we identified and sequenced an unknown rat gene, PACAP-respons...

journal_title：Cancer research

authors： Schäfer H,Trauzold A,Siegel EG,Fölsch UR,Schmidt WE

更新日期：1996-06-01 00:00:00

abstract：:The potential of transforming growth factor-alpha (TGF-alpha) to function as an autocrine growth factor was evaluated in numerous ovarian carcinoma cell lines. All 17 lines which were examined expressed the epidermal growth factor receptor and 16 cell lines, in addition, concomitantly secreted TGF-alpha. Radioimmunoas...

journal_title：Cancer research

authors： Stromberg K,Collins TJ 4th,Gordon AW,Jackson CL,Johnson GR

更新日期：1992-01-15 00:00:00

abstract：:Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption is in excess. However, the mechanism of bisphosphonate action on bone is not fully understood. Studies of direct action of bisphosphonates on bone have been limited mainly to their effects on bone-resorbing osteoclast cells, wit...

journal_title：Cancer research

authors： Reinholz GG,Getz B,Pederson L,Sanders ES,Subramaniam M,Ingle JN,Spelsberg TC

更新日期：2000-11-01 00:00:00

abstract：:Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote anisotropic fiber orientation, tw...

journal_title：Cancer research

authors： Stanisavljevic J,Loubat-Casanovas J,Herrera M,Luque T,Peña R,Lluch A,Albanell J,Bonilla F,Rovira A,Peña C,Navajas D,Rojo F,García de Herreros A,Baulida J

更新日期：2015-01-15 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the int...

journal_title：Cancer research

authors： Pasello M,Michelacci F,Scionti I,Hattinger CM,Zuntini M,Caccuri AM,Scotlandi K,Picci P,Serra M

更新日期：2008-08-15 00:00:00

abstract：:The correlation between the clinical outcome in patients with esophageal squamous cell carcinoma and coamplification of the proto-oncogenes int-2 and hst-1, which are partially homologous to angiogenesis-inducing fibroblast growth factor, was analyzed retrospectively. Coamplification of these genes was examined by slo...

journal_title：Cancer research

authors： Kitagawa Y,Ueda M,Ando N,Shinozawa Y,Shimizu N,Abe O

更新日期：1991-03-01 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:The activity of gemcitabine (dFdC), an effective agent against solid tumors, depends on the incorporation of its triphosphate into DNA. In vitro investigations demonstrated that, depending on the sequence of template DNA, polymerases may pause after incorporation of gemcitabine nucleotide at either the 3'-terminal or ...

journal_title：Cancer research

authors： Gandhi V,Legha J,Chen F,Hertel LW,Plunkett W

更新日期：1996-10-01 00:00:00

abstract：:When SV40 tumor cells (F5-1) in culture were treated with dibutyryl cyclic adenylic acid (DbcAMP),marked alterations occurred in their growth and morphology. Additionally, the incorporation or uptake of labeled thymidine, uridine, phenylalanine, and choline were reduced by this treatment. These modifications with DbcA...

journal_title：Cancer research

authors： Hannon WH,Anderson NG,Coggin JH Jr

更新日期：1976-09-01 00:00:00

abstract：:A number of metabolic inhibitors and chemotherapeutic agents have been found to increase the sensitivity of a chemically induced guinea pig hepatoma (line 1) to killing by antibody and complement. We have investigated whether the mechanism whereby these drugs increase sensitivity to killing is attributable to their pr...

journal_title：Cancer research

authors： Schlager SI,Boyle MD,Ohanian SH,Borsos T

更新日期：1977-05-01 00:00:00

abstract：:The effects of four anti-GM2 monoclonal antibodies (DMAb-1, DMAb-2, DMAb-3, and DMAb-5) were studied on spheroid cultures from a human glioma cell line (D-54 MG) that is known to express high levels of GM2. The spheroids developed central necrosis 48 h after antibody exposures at concentrations greater than 6 microgra...

journal_title：Cancer research

authors： Bjerkvig R,Engebraaten O,Laerum OD,Fredman P,Svennerholm L,Vrionis FD,Wikstrand CJ,Bigner DD

更新日期：1991-09-01 00:00:00

abstract：:Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation i...

journal_title：Cancer research

authors： Yang WC,Mathew J,Velcich A,Edelmann W,Kucherlapati R,Lipkin M,Yang K,Augenlicht LH

更新日期：2001-01-15 00:00:00

abstract：:Mucin-depleted foci (MDF) are microscopic dysplastic lesions induced in the colon of rodents by specific colon carcinogens. Most MDF show Wnt pathway activation, whereas only a subset shows mutations in the Ctnnb1 gene, coding for beta-catenin. Because Apc is a member of the Wnt pathway and the most frequent mutated g...

journal_title：Cancer research

authors： Femia AP,Dolara P,Giannini A,Salvadori M,Biggeri A,Caderni G

更新日期：2007-01-15 00:00:00

abstract：:Antineoplastic drug resistance is a major obstacle to improved treatment of most adult cancers in humans. Novobiocin, an antibacterial agent which inhibits the eukaryotic topoisomerase II enzyme, increases the cytotoxicity of several alkylating agents in vitro by the formation of lethal DNA-DNA interstrand cross-links...

journal_title：Cancer research

authors： Eder JP,Wheeler CA,Teicher BA,Schnipper LE

更新日期：1991-01-15 00:00:00

abstract：:We have used genome-wide allelotyping with 348 polymorphic autosomal markers spaced, on average, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colorectal carcinomas. We have compared instability measured by this method with that measured by inter-(simple sequence repeat) PCR...

journal_title：Cancer research

authors： Anderson GR,Brenner BM,Swede H,Chen N,Henry WM,Conroy JM,Karpenko MJ,Issa JP,Bartos JD,Brunelle JK,Jahreis GP,Kahlenberg MS,Basik M,Sait S,Rodriguez-Bigas MA,Nowak NJ,Petrelli NJ,Shows TB,Stoler DL

更新日期：2001-11-15 00:00:00

abstract：:Prostate cancer biology varies from locally confined tumors with low risk for relapse to tumors with high risk for progression even after radical prostatectomy. Currently, there are no reliable biomarkers to predict tumor relapse and poor clinical outcome. In this study, we correlated expression patterns of the androg...

journal_title：Cancer research

authors： Kahl P,Gullotti L,Heukamp LC,Wolf S,Friedrichs N,Vorreuther R,Solleder G,Bastian PJ,Ellinger J,Metzger E,Schüle R,Buettner R

更新日期：2006-12-01 00:00:00

abstract：:The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown to control constitutive Ca(2+) entry and cancer cell migration t...

journal_title：Cancer research

authors： Chantôme A,Potier-Cartereau M,Clarysse L,Fromont G,Marionneau-Lambot S,Guéguinou M,Pagès JC,Collin C,Oullier T,Girault A,Arbion F,Haelters JP,Jaffrès PA,Pinault M,Besson P,Joulin V,Bougnoux P,Vandier C

更新日期：2013-08-01 00:00:00

abstract：:The mechanism of action of the clinically used iron(III) chelator, desferrioxamine (DFO), on preventing iron (Fe) uptake from transferrin (Tf) has been investigated using the human melanoma cell line SK-MEL-28. This investigation was initiated due to the paucity of information on the mechanisms of action of DFO in neo...

journal_title：Cancer research

authors： Richardson D,Ponka P,Baker E

更新日期：1994-02-01 00:00:00

abstract：:On the basis of reports of rat mammary- and pancreas-tumor models, we hypothesized that an increase in consumption of linoleic acid (LA) would also cause an enhancement in mouse skin-tumor promotion. SEN-CAR mice were placed on diets containing 0.8%, 2.2%, 3.5%, 4.5%, 5.6%, 7.0%, or 8.4% LA, 1 week after initiation wi...

journal_title：Cancer research

authors： Fischer SM,Leyton J,Lee ML,Locniskar M,Belury MA,Maldve RE,Slaga TJ,Bechtel DH

更新日期：1992-04-01 00:00:00

abstract：:Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenovir...

journal_title：Cancer research

authors： Wei H,Wang H,Lu B,Li B,Hou S,Qian W,Fan K,Dai J,Zhao J,Guo Y

更新日期：2008-05-15 00:00:00

abstract：:SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian,...

journal_title：Cancer research

authors： Orvis T,Hepperla A,Walter V,Song S,Simon J,Parker J,Wilkerson MD,Desai N,Major MB,Hayes DN,Davis IJ,Weissman B

更新日期：2014-11-15 00:00:00

abstract：:In an attempt to develop better combination therapies for use with local radiation, the interaction between bleomycin and hyperthermia +/- radiation was studied in the FSaIIC tumor system. In cells exposed in vitro to bleomycin at 37 degrees C and at pH 7.40, the drug was substantially more toxic toward normally oxyge...

journal_title：Cancer research

authors： Teicher BA,Herman TS,Holden SA

更新日期：1988-11-15 00:00:00

abstract：:Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The development of highl...

journal_title：Cancer research

authors： Morton JJ,Bird G,Refaeli Y,Jimeno A

更新日期：2016-11-01 00:00:00