Abstract:
:Anticancer drug resistance results from selective pressure of chemotherapy, together with mutations or epigenetic changes that make cells refractory to treatment. In cancer cells, we report that gene expression associated with vesicle shedding correlates with chemosensitivity profiles. Experiments with doxorubicin and other small molecules confirm drug accumulation and expulsion in shed vesicles. Relative differences in the rate of vesicle shedding correspond with doxorubicin resistance across various cell lines. Moreover, accumulation of drug in membrane domains in which vesicles originate accounts for drug expulsion in shed vesicles. These observations implicate vesicle shedding as a drug efflux mechanism potentially involved in drug resistance.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Shedden K,Xie XT,Chandaroy P,Chang YT,Rosania GRsubject
Has Abstractpub_date
2003-08-01 00:00:00pages
4331-7issue
15eissn
0008-5472issn
1538-7445journal_volume
63pub_type
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