A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer.

abstract：:The present studies were designed to examine the influence of dietary selenite supplementation on the initiation phase of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis and to correlate selenite-induced changes in the binding of DMBA metabolites to rat mammary cell DNA with the ultimate tumor inc...

journal_title：Cancer research

authors： Liu JZ,Gilbert K,Parker HM,Haschek WM,Milner JA

更新日期：1991-09-01 00:00:00

abstract：:Daunorubicin is biotransformed anaerobically by rat liver microsomes with a reduced nicotinamide adenine dinucleotide phosphate-generating system to form a series of aglycones. The first reaction, reductive cleavage of daunosamine (at C-7 in ring A) to form the 7- deoxyaglycone , is followed by reduction of the C-13 k...

journal_title：Cancer research

authors： Schwartz HS,Paul B

更新日期：1984-06-01 00:00:00

abstract：:In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The alphavbeta3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in tumor cell invasion and...

journal_title：Cancer research

authors： Zhao Y,Bachelier R,Treilleux I,Pujuguet P,Peyruchaud O,Baron R,Clément-Lacroix P,Clézardin P

更新日期：2007-06-15 00:00:00

abstract：:Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory ...

journal_title：Cancer research

authors： Hosoi A,Takeda Y,Furuichi Y,Kurachi M,Kimura K,Maekawa R,Takatsu K,Kakimi K

更新日期：2008-05-15 00:00:00

abstract：:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

journal_title：Cancer research

authors： Winkelhake JL,Elcombe BM,Hodach A

更新日期：1979-08-01 00:00:00

abstract：:Fumitremorgin C (FTC) is a potent and specific chemosensitizing agent in cell lines selected for resistance to mitoxantrone that do not overexpress P-glycoprotein or multidrug resistance protein. The gene encoding a novel transporter, the breast cancer resistance protein (BCRP), was recently found to be overexpressed ...

journal_title：Cancer research

authors： Rabindran SK,Ross DD,Doyle LA,Yang W,Greenberger LM

更新日期：2000-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid analogue edelfosine accumulates in the ER of solid tumor cells. This ER accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, G(2)-M arrest, depletio...

journal_title：Cancer research

authors： Nieto-Miguel T,Fonteriz RI,Vay L,Gajate C,López-Hernández S,Mollinedo F

更新日期：2007-11-01 00:00:00

abstract：:In summary, analysis of the P01 program indicates that differences exist in scores and funding requirements between purely basic and translational P01s; P01 funding has been stable and the P01 policies consistent; growth in average costs for P01s has lagged compared to R01s; P01 grantees have a higher success rate tha...

journal_title：Cancer research

authors： Broder S,Cushing M

更新日期：1993-02-01 00:00:00

abstract：:Activities of the adenine purine nucleotide cycle enzymes, i.e., adenylosuccinate (SAMP) synthetase, SAMP lyase, and adenosine 5'-monophosphate deaminse, were determined in hepatic tissue of rats fed and/or given injections of 3'-methyl-4-dimethylaminoazobenzene, 4'-methyl-4-dimethylaminoazobenzene, thioacetamide, eth...

journal_title：Cancer research

authors： Smith LD,Emerson RL,Nixon LK

更新日期：1979-06-01 00:00:00

abstract：:The in vitro antiproliferative effect of highly purified recombinant human gamma-interferon was studied with special reference to specific binding to tumor cells of interferon (IFN) labeled with 125I. Recombinant human gamma-interferon markedly suppressed the growth of 6 of 10 human epidermal tumor cell lines tested; ...

journal_title：Cancer research

authors： Nagao S,Sato K,Osada Y

更新日期：1986-07-01 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Estrogen receptor (ER) agonists and antagonists elicit distinct responses in non-small cell lung cancer (NSCLC) cells. To determine how such responses are generated, the expression of ERalpha, ERbeta, and ER coregulators in human lung fibroblasts and human NSCLC cell lines was evaluated by immunoblot. Ligand-dependent...

journal_title：Cancer research

authors： Hershberger PA,Vasquez AC,Kanterewicz B,Land S,Siegfried JM,Nichols M

更新日期：2005-02-15 00:00:00

abstract：:Nonmyeloablative hematopoietic cell transplantation can cure patients with hematologic malignancies but has reported limited success against solid tumors. This is possibly because of profound peripheral tolerance mechanisms and/or suboptimal tumor recognition by effector T lymphocytes. We report that in mice developin...

journal_title：Cancer research

authors： Hess Michelini R,Freschi M,Manzo T,Jachetti E,Degl'Innocenti E,Grioni M,Basso V,Bonini C,Simpson E,Mondino A,Bellone M

更新日期：2010-05-01 00:00:00

abstract：:By molecular genetic approach using polymorphic DNA markers which detect allelic deletion at specific chromosomal loci, we analyzed 30 human stomach cancers for possible loss of chromosomal heterozygosity. We analyzed 25 loci on 18 different chromosomes covering regions frequently deleted in several types of cancers. ...

journal_title：Cancer research

authors： Wada M,Yokota J,Mizoguchi H,Sugimura T,Terada M

更新日期：1988-06-01 00:00:00

abstract：:Although it is generally acknowledged that cytokines regulate normal hematopoiesis in an autocrine/paracrine fashion, their possible role in chronic myelogenous leukemia (CML) and resistance to imatinib mesylate treatment remain poorly investigated. Here, we report that CD34(+) progenitors from patients with CML at di...

journal_title：Cancer research

authors： Levescot A,Flamant S,Basbous S,Jacomet F,Féraud O,Anne Bourgeois E,Bonnet ML,Giraud C,Roy L,Barra A,Chomel JC,Turhan A,Guilhot F,Girard JP,Gombert JM,Herbelin A

更新日期：2014-05-15 00:00:00

abstract：:Lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human T-cell leukemia virus III, were studied with regard to histopathology, immunohistology, and T-cell subsets in cell suspensions. All acqui...

journal_title：Cancer research

authors： Biberfeld P,Porwit-Ksiazek A,Böttiger B,Morfeldt-Månsson L,Biberfeld G

更新日期：1985-09-01 00:00:00

abstract：:The evidence for tumor suppressor genes at 8p is well supported by many somatic deletion studies and genetic linkage studies. However, it remains a challenge to pinpoint the tumor suppressor genes at 8p primarily because the implicated regions are broad. In this study, we attempted to narrow down the implicated region...

journal_title：Cancer research

authors： Chang BL,Liu W,Sun J,Dimitrov L,Li T,Turner AR,Zheng SL,Isaacs WB,Xu J

更新日期：2007-05-01 00:00:00

abstract：:Immunophotodiagnosis uses a fluorescence-labeled monoclonal antibody (MAb) that recognizes a tumor-associated antigen to image the fluorescence emitted from the fluorophore-bound MAb that has localized in the tissue. It may be used to diagnose malignant or precancerous lesions, to delineate the margins for tumor resec...

journal_title：Cancer research

authors： Soukos NS,Hamblin MR,Keel S,Fabian RL,Deutsch TF,Hasan T

更新日期：2001-06-01 00:00:00

abstract：:The effect(s) of treadmill exercise and type and amount of dietary fat on the process of mammary tumorigenesis was investigated. Female Sprague-Dawley rats were fed a purified 5% fat diet (AIN-76A) from 21 to 64 days of age. At 50 days of age each rat was intubated p.o. with 5 mg 7,12-dimethylbenz(a)anthracene (DMBA)....

journal_title：Cancer research

authors： Thompson HJ,Ronan AM,Ritacco KA,Tagliaferro AR

更新日期：1989-04-15 00:00:00

abstract：:Increased expression of cyclooxygenase (COX) and overproduction of prostaglandins (PGs) have been implicated in the development and progression of colorectal cancer (CRC). Nonsteroidal anti-inflammatory agents (NSAIDS) inhibit growth of various CRC cell lines by both COX-dependent and COX-independent pathways. To spec...

journal_title：Cancer research

authors： Chinery R,Coffey RJ,Graves-Deal R,Kirkland SC,Sanchez SC,Zackert WE,Oates JA,Morrow JD

更新日期：1999-06-01 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:N-Demethylated metabolites of the antineoplastic agent hexamethylmelamine were synthesized, and their toxicities and antitumor activities were determined in vivo. Determinations of the lethal dose for 10% of the male C57BL X DBA/2 F1 (hereafter called BD2F1) mice showed hexamethylmelamine toxicity to be decreased by N...

journal_title：Cancer research

authors： Lake LM,Grunden EE,Johnson BM

更新日期：1975-10-01 00:00:00

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:Suppression of gluconeogenesis elevates glycolysis and is commonly observed in tumors derived from gluconeogenic tissues including liver and kidney, yet the definitive regulatory mechanism remains elusive. Here, we screened an array of transcription regulators and identified the enhancer of zeste homolog 2 (EZH2) as a...

journal_title：Cancer research

authors： Liao K,Deng S,Xu L,Pan W,Yang S,Zheng F,Wu X,Hu H,Liu Z,Luo J,Zhang R,Kuang DM,Dong J,Wu Y,Zhang H,Zhou P,Bei JX,Xu Y,Ji Y,Wang P,Ju HQ,Xu RH,Li B

更新日期：2020-02-15 00:00:00

abstract：:Indirect immunofluorescence staining with a large battery of monoclonal antibodies of primary and autologous metastatic lesions removed from seven patients with melanoma has detected heterogeneity in the expression of various types of melanoma-associated antigens (MAAs), of distinct determinants of the high molecular ...

journal_title：Cancer research

authors： Natali P,Bigotti A,Cavaliere R,Liao SK,Taniguchi M,Matsui M,Ferrone S

更新日期：1985-06-01 00:00:00

abstract：:We evaluated the effects of local X-irradiation on microscopic or small macroscopic primary melanomas in the feet of C57BL/6 mice and the subsequent development of spontaneous femoral lymph node (LN) metastases. Doses of 30, 40, 55, 62.5, or 72.5 Gy often cured the foot tumor and metastases to regional femoral lymph n...

journal_title：Cancer research

authors： Nathanson SD,Westrick P,Anaya P,Hetzel FW,Jacobsen G

更新日期：1989-08-15 00:00:00

abstract：:In the era of omics-driven research, it remains a common dilemma to stratify individual patients based on the molecular characteristics of their tumors. To improve molecular stratification of patients with breast cancer, we developed the Gaussian mixture model (GMM)-based classifier. This probabilistic classifier was ...

journal_title：Cancer research

authors： Prabakaran I,Wu Z,Lee C,Tong B,Steeman S,Koo G,Zhang PJ,Guvakova MA

更新日期：2019-07-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T) is a human disease characterized by high cancer risk, immune defects, radiation sensitivity, and genetic instability. Although A-T homozygotes are rare, the A-T gene may play a role in sporadic breast cancer and other common cancers. Abnormalities of DNA repair, genetic recombination, chrom...

journal_title：Cancer research

authors： Meyn MS

更新日期：1995-12-15 00:00:00

abstract：:A deletion in an Alu repetitive sequence in the fifth intron of the c-sis gene of meningioma patients was previously described (M. Smidt et al., J. Clin. Invest., 86:1151-1157, 1990). The authors analyzed the structure of this intron in DNA from peripheral blood leukocytes and tumor samples of 86 patients with sporadi...

journal_title：Cancer research

authors： Smidt M,Dumanski JP,Collins VP,Ratner L

更新日期：1991-08-15 00:00:00

abstract：:In the past 3 years, altered expression of the HEF1/CAS-L/NEDD9 scaffolding protein has emerged as contributing to cancer metastasis in multiple cancer types. However, whereas some studies have identified elevated NEDD9 expression as prometastatic, other work has suggested a negative role in tumor progression. We here...

journal_title：Cancer research

authors： Izumchenko E,Singh MK,Plotnikova OV,Tikhmyanova N,Little JL,Serebriiskii IG,Seo S,Kurokawa M,Egleston BL,Klein-Szanto A,Pugacheva EN,Hardy RR,Wolfson M,Connolly DC,Golemis EA

更新日期：2009-09-15 00:00:00