Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

abstract：:We previously reported (J. Galivan et al., Proc. Natl. Acad. Sci. USA, 82: 2598-2602, 1985) the synthesis and characterization of DL-erythro,threo-gamma-fluoromethotrexate (FMTX). The individual diastereomers, DL-erythro-FMTX (eFMTX) and DL-threo-FMTX (tFMTX), and their radiolabeled counterparts have now been prepared...

journal_title：Cancer research

authors： McGuire JJ,Graber M,Licato N,Vincenz C,Coward JK,Nimec Z,Galivan J

更新日期：1989-08-15 00:00:00

abstract：:Invasive breast cancer has a high risk of recurrence to incurable disease and needs improved prognostic and therapeutic tools. Our work combines clinical and molecular analyses to show that the transcriptional repressor HBP1 may be a new target for invasive breast cancer. Previous work indicated that HBP1 regulated pr...

journal_title：Cancer research

authors： Paulson KE,Rieger-Christ K,McDevitt MA,Kuperwasser C,Kim J,Unanue VE,Zhang X,Hu M,Ruthazer R,Berasi SP,Huang CY,Giri D,Kaufman S,Dugan JM,Blum J,Netto G,Wazer DE,Summerhayes IC,Yee AS

更新日期：2007-07-01 00:00:00

abstract：:15-Lipoxygenase (15-LOX)-2 is expressed in benign prostate secretory cells and benign prostate produces 15S-hydroxyeicosatetraenoic acid (15S-HETE) from exogenous arachidonic acid (AA). In contrast, 15S-LOX-2 and 15S-HETE formation are reduced in prostate carcinoma (Pca). The mechanisms whereby reduced 15-LOX-2 may co...

journal_title：Cancer research

authors： Shappell SB,Gupta RA,Manning S,Whitehead R,Boeglin WE,Schneider C,Case T,Price J,Jack GS,Wheeler TM,Matusik RJ,Brash AR,Dubois RN

更新日期：2001-01-15 00:00:00

abstract：:Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for antibody-dependent cell cytotoxicity (ADCC). To examine factors affecting ADCC intensity and variability, we extended this study to the phenotypic and functional analysis ...

journal_title：Cancer research

authors： Varchetta S,Gibelli N,Oliviero B,Nardini E,Gennari R,Gatti G,Silva LS,Villani L,Tagliabue E,Ménard S,Costa A,Fagnoni FF

更新日期：2007-12-15 00:00:00

abstract：:Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indic...

journal_title：Cancer research

authors： Sato M,Nishigori C,Zghal M,Yagi T,Takebe H

更新日期：1993-07-01 00:00:00

abstract：:Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alteration...

journal_title：Cancer research

authors： Bolli N,Nicoletti I,De Marco MF,Bigerna B,Pucciarini A,Mannucci R,Martelli MP,Liso A,Mecucci C,Fabbiano F,Martelli MF,Henderson BR,Falini B

更新日期：2007-07-01 00:00:00

abstract：:Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic KRAS are still under investigation or awaiting clinical approval. Using a specific KRAS-dependent gene signature, we implemented a computer-assisted inspection o...

journal_title：Cancer research

authors： Mottini C,Tomihara H,Carrella D,Lamolinara A,Iezzi M,Huang JK,Amoreo CA,Buglioni S,Manni I,Robinson FS,Minelli R,Kang Y,Fleming JB,Kim MP,Bristow CA,Trisciuoglio D,Iuliano A,Del Bufalo D,Di Bernardo D,Melisi D,Dra

更新日期：2019-11-01 00:00:00

abstract：:We previously reported that thymidine kinase (TK) activity in a spontaneously TK-deficient (TK-) mouse tumor cell line (called L61-M) could be partially restored by brief exposure of the cells in vitro to the DNA-hypomethylating agent 5-azacytidine. We now show that similar results can be obtained by exposing L61-M ce...

journal_title：Cancer research

authors： Liteplo RG,Alvarez E,Frost P,Kerbel RS

更新日期：1985-11-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) is etiologically linked to the endothelial tumor Kaposi's sarcoma and with two lymphoproliferatve disorders, primary effusion lymphoma and multicentric Castleman's disease. HHV-8 infects a variety of target cells both in vivo and in vitro, binds to the in vitro targ...

journal_title：Cancer research

authors： Naranatt PP,Krishnan HH,Svojanovsky SR,Bloomer C,Mathur S,Chandran B

更新日期：2004-01-01 00:00:00

abstract：:Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ve...

journal_title：Cancer research

authors： Groothuis DR,Pasternak JF,Fischer JM,Blasberg RG,Bigner DD,Vick NA

更新日期：1983-07-01 00:00:00

abstract：:When Shionogi carcinoma 115 (SC115, an undifferentiated medullary carcinoma showing a compact cell pattern and containing androgen receptor) was transplanted into male and female DS mice, it grew only in males. In contrast with this strict androgen dependency in DS hosts, SC115 tumors grew in male and female nude athy...

journal_title：Cancer research

authors： Kitamura Y,Uchida N,Hayata I,Yamaguchi K,Okamoto S,Narita N,Matsumoto K

更新日期：1980-12-01 00:00:00

abstract：:Induction of mRNA for BIK proapoptotic protein by doxorubicin or gamma-irradiation requires the DNA-binding transcription factor activity of p53. In MCF7 cells, pure antiestrogen fulvestrant also induces BIK mRNA and apoptosis. Here, we provide evidence that, in contrast to doxorubicin or gamma-irradiation, fulvestran...

journal_title：Cancer research

authors： Hur J,Bell DW,Dean KL,Coser KR,Hilario PC,Okimoto RA,Tobey EM,Smith SL,Isselbacher KJ,Shioda T

更新日期：2006-10-15 00:00:00

abstract：:Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single constitutively expressed control gene. However, in recent years, it has become...

journal_title：Cancer research

authors： Andersen CL,Jensen JL,Ørntoft TF

更新日期：2004-08-01 00:00:00

abstract：:We used somatic cell hybridization to determine whether the regressor phenotype exhibited by UV-induced murine tumors was dominant or recessive and whether this technique could confer immunogenic properties on nonimmunogenic syngeneic tumors. We transfected a highly antigenic UV-induced C3H mouse tumor cell line (UV-2...

journal_title：Cancer research

authors： Chen PW,Kaba DS,Ananthaswamy HN

更新日期：1990-03-01 00:00:00

abstract：:Neuroblastoma arises from the embryonal neural crest secondary to a block in differentiation. Long-term patient survival correlates inversely with the extent of differentiation, and treatment with retinoic acid or other prodifferentiation agents improves survival modestly. In this study, we show the histone chaperone ...

journal_title：Cancer research

authors： Barbieri E,De Preter K,Capasso M,Chen Z,Hsu DM,Tonini GP,Lefever S,Hicks J,Versteeg R,Pession A,Speleman F,Kim ES,Shohet JM

更新日期：2014-02-01 00:00:00

abstract：:Malignant gliomas are resistant to various proapoptotic therapies, such as radiotherapy and conventional chemotherapy. In this study, we show that selenite is preferentially cytotoxic to various human glioma cells over normal astrocytes via autophagic cell death. Overexpression of Akt, survivin, XIAP, Bcl-2, or Bcl-xL...

journal_title：Cancer research

authors： Kim EH,Sohn S,Kwon HJ,Kim SU,Kim MJ,Lee SJ,Choi KS

更新日期：2007-07-01 00:00:00

abstract：:Transduction of malignant cells with toxin genes provides a novel means to promote tumor cell destruction. The efficacy of a toxin gene is dependent on the cell type targeted, the quantity of exogenous protein synthesized, and the mechanisms of growth inhibition and bystander killing. To develop gene therapy for targe...

journal_title：Cancer research

authors： Hoganson DK,Batra RK,Olsen JC,Boucher RC

更新日期：1996-03-15 00:00:00

abstract：:Many tumor types have p53 and/or RB mutations, and it is unclear what role the mutations of these tumor suppressor genes have on the efficacy of chemotherapeutic agents. The effect of p53 and RB inactivation on sensitivity to chemotherapeutic drugs was examined using a model system in which p53 or RB was inactivated i...

journal_title：Cancer research

authors： Hawkins DS,Demers GW,Galloway DA

更新日期：1996-02-15 00:00:00

abstract：:Groups of 6-wk-old male F344/NCr rats received a single i.v. injection of either vehicle or N-nitrosomethylurea (Cas: 684-93-5) (MNU) at a dose of 41.2 mg/kg body weight. Two wk later, groups of rats were placed on iodine-deficient, iodine-adequate, or commercial (Wayne Lab Blox) diets, or one of these diets and witho...

journal_title：Cancer research

authors： Ohshima M,Ward JM

更新日期：1986-02-01 00:00:00

abstract：:Exposure of tumor cells to cytotoxic agents simultaneously activates a variety of intracellular signaling pathways. Some of these pathways involve enzymes from the protein kinase C (PKC) family of serine/threonine kinases. This family includes isoenzymes that negatively influence cell death, whereas other demonstrate ...

journal_title：Cancer research

authors： Filomenko R,Poirson-Bichat F,Billerey C,Belon JP,Garrido C,Solary E,Bettaieb A

更新日期：2002-03-15 00:00:00

abstract：:C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Here, we show that when overexpressed in mammalian cells the recomb...

journal_title：Cancer research

authors： Liu L,Vo A,Liu G,McKeehan WL

更新日期：2005-05-15 00:00:00

abstract：:The tumor suppressor gene p53 is activated by reactive oxygen species-generating agents. After activation, p53 migrates to mitochondria and nucleus, a response that eventually leads to apoptosis, but how the two events are related is unknown. Herein, we show that p53 translocation to mitochondria precedes its transloc...

journal_title：Cancer research

authors： Zhao Y,Chaiswing L,Velez JM,Batinic-Haberle I,Colburn NH,Oberley TD,St Clair DK

更新日期：2005-05-01 00:00:00

abstract：:We investigated the effect of iododeoxyuridine (IdUrd) exposure on cis-diamminedichloroplatinum (CDDP) cytotoxicity in the human bladder cancer cell line 647V. Following a 48-h incubation with 2-20 microM IdUrd, a 1-h exposure to 0-120 microM CDDP produced a dose-dependent increase in CDDP cytotoxicity as measured by ...

journal_title：Cancer research

authors： Chi KH,Kunugi KA,Kinsella TJ

更新日期：1994-05-15 00:00:00

abstract：:Prostacyclin has been evaluated for its ability to inhibit tumor cell-induced platelet aggregation (TCIPA) induced by several rodent tumor lines: B16a (melanoma); 3LL (carcinoma); 15091A (adenocarcinoma); and W256 (carcinosarcoma). Aggregation of human platelets by all four lines was inhibited by prostaglandin I2 (PGI...

journal_title：Cancer research

authors： Menter DG,Onoda JM,Taylor JD,Honn KV

更新日期：1984-02-01 00:00:00

abstract：:Distant metastases are the major cause of morbidity and mortality in women with breast cancer. The ability to predict the metastatic proclivity is essential in choosing the optimal treatment. Tumor size and grade, which are frequently used markers in node-negative breast cancer patients, are inadequate markers for pro...

journal_title：Cancer research

authors： Heimann R,Lan F,McBride R,Hellman S

更新日期：2000-01-15 00:00:00

abstract：:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leverag...

journal_title：Cancer research

authors： Rao VA

更新日期：2019-12-15 00:00:00

abstract：:The flux activities of de novo and salvage purine synthesis were compared in rat hepatoma 3924A cells in various growth phases. The initial rate assays of [14C]adenine, [14C]hypoxanthine, and [14C]guanine incorporation yielded Michaelis-Menten kinetics with Kms of 5, 7, and 7 microM, respectively. After replating plat...

journal_title：Cancer research

authors： Natsumeda Y,Ikegami T,Olah E,Weber G

更新日期：1989-01-01 00:00:00

abstract：:An in vivo-in vitro approach to studying neoplastic development in carcinogen-exposed rat fibroblasts was evaluated. In the model described, oncomodulin (Mr 12,000; pI 3.9), a tumor-associated and Ca2+-binding protein, was used as a specific marker of malignant transformation. A rapidly proliferating granulation tissu...

journal_title：Cancer research

authors： Sommer EW,Heizmann CW

更新日期：1989-02-15 00:00:00

abstract：:Inhibitors of 5alpha-reductase (SRD5A) that lower intraprostatic levels of dihydrotestosterone (DHT) reduce the overall incidence of prostate cancer (PCa), but there is significant variation in chemopreventive activity between individual men. In seeking molecular alterations that might underlie this variation, we comp...

journal_title：Cancer research

authors： Mostaghel EA,Geng L,Holcomb I,Coleman IM,Lucas J,True LD,Nelson PS

更新日期：2010-02-15 00:00:00

abstract：:p53 is regulated at multiple levels. We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. These drugs reduced the basal levels of p53 protein at nanomolar concentrations in a dose-, time-, and cancer ...

journal_title：Cancer research

authors： Wang Z,Zheng M,Li Z,Li R,Jia L,Xiong X,Southall N,Wang S,Xia M,Austin CP,Zheng W,Xie Z,Sun Y

更新日期：2009-08-15 00:00:00