Abstract：
:The Morris hepatocellular carcinoma 7777 is productive of extraordinarily high levels of the oncofetal protein, alpha-fetoprotein. Its chromosome composition was examined in detail since it represents the only near-diploid tumor of such productivity and has been reported to demonstrate a single unusual chromosomal alteration. The major finding is the presence of a submetacentric marker chromosome, composed of a No. 7 chromosome and a short arm that demonstrated a poorly defined banding pattern on Giemsa staining. This marker is unique to 7777 and is of particular interest in view of recent reports of an association between such unbanded chromosome arms and supraproduction of cell products.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Wolman SR,Cohen TI,Becker FFsubject
Has Abstractpub_date
1977-08-01 00:00:00pages
2624-7issue
8 Pt 1eissn
0008-5472issn
1538-7445journal_volume
37pub_type
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